Design Improvements Research Articles

Calibration of parameters and predictive control strategy of a wind turbine for improvement of energy harvesting

Applied mathematical modeling of the various energy resources has contributed widely in their design and operation improvements. Among renewable energy sources, wind energy systems have gained a significant attention for their rapid and continuous growth, which resulted from their cost effectiveness and clean power generation. However, research effort on the industry and university levels is still needed to enhance the characteristics of existing wind turbines and allow larger amounts of their share. This thesis presents an accurate model of a wind turbine (TWT-1.65) system for time-based dynamic simulations. The parameters of the power coefficient have been identified, calibrated and verified using different meta-heuristic optimization techniques, which are the Wild Horse Optimizer (WHO), Whale Optimizer (WO), and Genetic Algorithm (GA) to enhance the model accuracy over the previously related studies. The new version of the parameters has resulted in a higher accuracy while being practically meaningful, with the best achieved MSE of 0.006. The system model has been then integrated with two predictive controllers which are the linear Model Predictive Control (MPC) and Neural Network Predictive Control (NNPC) to regulate the pitch angle trends for the target of maximum energy harvesting. With proper selection of the controllers’ parameters, off-line simulation studies have shown improved production trends of the power output with constrained and safe trajectory of the pitch angle, which can be translated to be an improve in the total average harvested power of 34% and 44.5% over the complete time window of 5760 min using NNPC and Linear MPC respectively.

Assembly processes inferred from eDNA surveys of a pond metacommunity are consistent with known species ecologies

Technological advances are enabling ecologists to conduct large‐scale and structured community surveys. However, it is unclear how best to extract information from these novel community data. We metabarcoded 48 vertebrate species from their eDNA in 320 ponds across England and applied the ‘internal structure' approach, which uses joint species distribution models (JSDMs) to explain compositions as the result of four metacommunity processes: environmental filtering, dispersal, species interactions, and stochasticity. We confirm that environmental filtering plays an important role in community assembly, and find that species' estimated environmental preferences are consistent with known ecologies. We also detect negative biotic covariances between fish and amphibians after controlling for divergent environmental preferences, consistent with predator–prey interactions (likely mediated by predator avoidance behaviour), and we detect high spatial autocorrelation for the palmate newt, consistent with its hypothesised relict distribution. Promisingly, ecologically and spatially distinctive sites are better explained by their environmental covariates and geographic locations, respectively, revealing sites where environmental filtering and dispersal limitation act more strongly. These results are consistent with the recent proposal that applying JSDMs to species distribution patterns can help reveal the relative importance of environmental filtering, dispersal limitation, and biotic interaction processes for individual sites and species. Our results also highlight the value of the modern interpretation of metacommunity ecology, which embraces the fact that assembly processes differ among species and sites. We discuss how novel community data allow for several study design improvements that will strengthen the inference of metacommunity assembly processes from observational data.

An evolutionary tale on clinical trials in hidradenitis suppurativa.

The therapeutic pipeline for moderate-to-severe hidradenitis suppurativa (HS) is robust. Successes and lessons learned have led to improvements in trial designs aimed at avoiding prior pitfalls, as well as high placebo response in HS, which remains a fundamental threat to drug development. Herein, we review the evolutions in HS trials over the last 20 years with respect to overall design, sample size, diversity in enrolment, inclusion criteria, concomitant medications, rescue therapy, endpoints and statistical design analysis plans. Areas of focus that merit future consideration are also highlighted.

Loss and Downtime Assessment of RC Dual Wall–Frame Office Buildings Toward Resilient Seismic Performance

This study quantitatively assesses the impact of seismic design strategies on the performance of reinforced concrete (RC) dual wall–frame office buildings by comparing direct and indirect economic losses and downtime in life-cycle terms. A high-rise archetype building located in Santiago, Chile, on stiff soil was evaluated as a benchmark case study. Three design strategies to potentially enhance the seismic performance of a building designed conventionally were explored: (i) incorporating fluid viscous dampers (FVDs) in the lateral load-resisting structure; (ii) replacing conventional non-structural components with enhanced ones (ENCs); and (iii) a combination of the previous two strategies. First, probabilistic structural responses were estimated through incremental dynamic analyses using three-dimensional nonlinear models of the archetypes subjected to a set of hazard-consistent Chilean ground motions. Second, FEMA P-58 time-based assessment was conducted to estimate expected annual losses (EALs) for economic loss estimation. Finally, for downtime assessment, a novel probabilistic framework, built on the FEMA P-58 methodology and the REDi guidelines, was employed to estimate the expected annual downtimes (EADs) to achieve specific target recovery states, such as reoccupancy (RO) and functional recovery (FR). Results revealed that seismically enhancing RC dual wall–frame buildings with FVDs significantly improves resilience by reducing loss and downtime. For example, the enhanced building with FVDs achieved an EAL of 0.093% and EAL of 8.6 days for FR, compared to the archetype base building without design improvements, which exhibited an EAL of 0.125% and an EAD of 9.5 days for FR. In contrast, the impact of ENCs alone was minor, compared to the effect of FVDs, with an EAL of 0.106% and an EAD of 9.1 days for FR. With this detailed recovery modeling, probabilistic methods, and a focus on intermediate recovery states, this framework represents a significant advancement in resilience-based seismic design and recovery planning.

How do people with Parkinson’s disease perceive challenges in handling cutlery? – A mixed study

Aim: Investigate the experiences, challenges, and difficulties faced by people with Parkinson’s disease (PD) when using standard cutlery during meals and explore their preferences for features in assistive cutlery. Methods: This study employed a mixed-methods, narrative, and descriptive approach using phenomenological methodology. Data were collected in two phases: Phase 1 focused on understanding participants’ experiences and difficulties through phone or video interviews, while Phase 2 involved home visits to evaluate their preferences for cutlery features. Structured interviews with open- and closed-ended questions were transcribed and analyzed thematically. Analyst triangulation was employed to ensure reliability. Results: Phase one included 41 participants, while phase two included 15. Most participants reported difficulties using standard cutlery, citing challenges such as spills and reduced grip stability. Despite these difficulties, few had prior experience with assistive devices. Barriers to using adaptive cutlery included lack of awareness, limited access, cost, and concerns about its appearance. Some participants reported feeling embarrassed, which led them to avoid dining with others. Suggestions for improving regular cutlery focused on increasing the depth of forks and spoons to minimize spills. Most participants expressed a preference for cutlery with textured handles, deeper bowls, and medium size and weight. Conclusion: People with PD experience difficulties using regular cutlery, and few are aware of or use assistive devices. Participants expressed a desire for improvements in cutlery design that could improve their dining experience. Textured handles, medium size and weight, and deeper bowls were the most popular preferences among participants.These design improvements have the potential to enhance the dining experience and promote greater social participation among individuals with PD.

Superheated steam can rapidly inactivate bacteria, but manual operation of commercial units resulted in limited efficacy during dry surface sanitization.

Although bench-scale studies have shown that superheated steam is effective for microbial inactivation on surfaces, commercial systems in the hands of human operators have not been evaluated. The first aim of this study was to characterize the temperature of stainless-steel surfaces treated with a commercial unit. The geometric center of the stainless-steel surface was treated with superheated steam at 400°C from a fixed position. Surface temperatures exceeded 300°C at the impingement point during 5 min exposure but decreased as surface thickness and distance increased. Ambient temperature (23.5, 12.8, 4°C) negatively impacted surface temperatures. Next, we evaluated the thermal inactivation of spot-inoculated Enterococcus faecium NRRL B-2354 on stainless steel surfaces. Inactivation of E. faecium decreased from 9.6 ± 0.1 log CFU/cm2 after 10 s of treatment at the point of impingement to 2.8 ± 0.7 log CFU/cm2 after 10 s of treatment at a distance 4.6 cm away from the impingement point (p<0.05). Finally, we assessed the effects of training on manual operation by human subjects. Human subjects (N=24) who completed trainings were asked to treat inoculated stainless-steel surfaces. While training improved manual operation of the unit and microbial inactivation of E. faecium (p<0.05), the highest average reduction achieved by human subjects was only 3.6 ± 1.3 log CFU/cm2. These findings suggest that the tight radius of high surface temperatures around the nozzle limits the effectiveness of manually operated superheated steam units for microbial inactivation. Thus, equipment design improvements are needed to ensure uniform treatment and adequate surface sanitation.

Research on design strategies for wellness towns from the perspective of spatial resilience

ABSTRACT Based on spatial resilience theory, this paper explores strategies for enhancing the design of wellness towns. With the intensification of population aging in China, the wellness industry has experienced significant development opportunities, leading to rapid advancements in wellness town construction. However, the planning and development of wellness towns are currently hindered by issues such as severe homogeneity, limited disturbance resistance, and inadequate functionality, which contribute to increased spatial vulnerability. To address these challenges, this study incorporates spatial resilience theory to establish a spatial resilience evaluation system for wellness towns and proposes corresponding design enhancement strategies. Using the Analytic Hierarchy Process, the spatial resilience evaluation system for wellness towns is constructed, encompassing three dimensions: environment, facilities, and society. Design improvement strategies are proposed in three key areas: enhancing spatial stability, fostering spatial diversity, and establishing spatial recovery capacity. This research provides theoretical guidance for the design and construction of wellness towns, and the proposed spatial resilience evaluation system and design strategies offer practical value. However, given the inherent complexity of spatial planning in wellness towns, future studies should further refine the evaluation index system to enhance the scientific rigor and practical applicability of the research.

Transportation Load Effects on Urban Design in M.P. Nagar, Bhopal

The research is focuses on the transportation load effect over urban design in MP Nagar, Bhopal, is the very nerve of its commerce and businesses. With an exponentially increasing population, urbanization, and vehicular traffic, there is a huge transportation load on this region that severely challenges its design of urban settings and livability. This paper explores the impact of transportation load on urban design in MP Nagar by analyzing traffic patterns, pedestrian mobility, infrastructure, environmental issues, and the role of public transportation. Using a mixed-methods approach, combining traffic analysis, surveys, interviews, and GIS mapping, this study identifies key challenges and provides recommendations for addressing the adverse effects of transportation load on urban design. The results indicate that high congestion, inadequate infrastructure, environmental pollution, and the lack of pedestrian-friendly spaces are major issues that need urgent attention. This paper concludes by proposing a series of urban design improvements aimed at making MP Nagar more sustainable, accessible, and livable. (Affairs., 2020.) Key Words: Transportation load, Urban design, MP Nagar, Bhopal, Traffic congestion, Infrastructure, Environment

Application of Ear-EEG and Other Wearable Systems in Sleep Assessment

Nowadays, about one-third of adults have the symptoms of insomnia. To assess these issues, one of the traditional methods used is polysomnography (PSG). However, it is expensive and not widely accessible, highlighting the urgent need for advancements in wearable technology to provide a more practical alternative for continuous sleep monitoring at home. This paper aims to explore various sleep assessment methods, including electrocardiography (ECG), photoplethysmography (PPG), and actigraphy, which measure heart activity, pulse wave, and muscle movement, respectively. By evaluating these methods, the paper analyses their advantages and challenges, particularly focusing on their accuracy in sleep stage classification and comfort levels. At the same time, this study compares Ear-EEG systems with other methods to assess their effectiveness in sleep monitoring. The future development directions for Ear-EEG in sleep monitoring are also discussed, encompassing aspects such as age variability, design improvements, and integrating advanced algorithms. Future advancements in at-home sleep assessments are expected to treat sleep disorders more efficiently and conveniently through early detection of disorders and improved user-friendliness compared to PSG.

Addressing the Need for a Specialized Disconnection Device in Catheter Connection Management: A Case Study of User-Centered Medical Device Innovation

Background/Objectives: Improvements in catheter connection design intended to increase safety have resulted in connections that are difficult to release manually. No medical device exists to safely disconnect catheter connections. Nurses and other users have developed workarounds including use of hemostats, tourniquets, and wrenches. These workarounds are not always successful for performing this task and can break catheters and catheter connections. This study aimed to evaluate a disconnection device to safely disconnect catheter connections. Methods: This is a mixed-methods study using a user-centered design approach with triangulation of quantitative and qualitative data mapped to Valdez’s sociotechnical framework. Nurses (N = 139) from units across two academic medical centers encompassing diverse patient populations engaged in usability testing and surveys. Data about users’ past catheter disconnection experiences and usability of the specialized disconnection device were collected and analyzed. Triangulation of quantitative data and qualitative themes was mapped using Valdez’s socio-technical framework to complement and strengthen the final design generated for nurses’ user requirements. Results: Ninety-five percent of nurses reported previous difficulty with disconnecting luer connections; 93% of those reporting difficulty improvised with readily available medical devices or products to better grip the connected parts. Over 85% of nurses reported positive experiences using the specialized disconnection device; others suggested design improvements for better performance. Conclusions: The nurses who tested the developed disconnection device reported high acceptability, accessibility, ease of use, and improved task performance. Moreover, as workarounds develop at points of practice where no systematic solution exists, aiming product development activities at these points help close gaps in achieving and maintaining patient safety. This study was not registered.

Child Amputee Prosthetics Project—Prosthesis Satisfaction Inventory (CAPP-PSI): Validation of Italian Version in Children with Upper Limb Amputation

Background: The Child Amputee Prosthetics Project—Prosthesis Satisfaction Inventory (CAPP-PSI) is a comprehensive instrument designed to measure satisfaction across functionality, aesthetic, and service domains. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the CAPP-PSI in an Italian pediatric population. Methods: Following international guidelines, the CAPP-PSI was translated and culturally adapted. Internal consistency was evaluated using Cronbach’s alpha, while test–retest reliability was assessed with intraclass correlation coefficients (ICCs). Construct validity was measured by analyzing correlations among subscales. Results: A total of 113 children with congenital or acquired upper limb amputation, accompanied by their parents, were recruited from the Bambino Gesù Children’s Hospital in Rome. The Italian CAPP-PSI demonstrated excellent internal consistency (Cronbach’s alpha = 0.913) and strong test–retest reliability (ICC = 0.966). Subscale correlations showed strong relationships between child and parent satisfaction (r = 0.724, p &lt; 0.01) and parent satisfaction with service (r = 0.612, p &lt; 0.01), while moderate correlations were observed between child satisfaction and service (r = 0.434, p &lt; 0.01). Conclusions: The Italian version of the CAPP-PSI is a reliable and valid tool for assessing prosthetic satisfaction in pediatric populations. It provides valuable insights for clinicians and researchers, supporting patient-centered care and targeted improvements in prosthetic design and services. Future studies should explore longitudinal outcomes and the role of psychosocial factors in prosthetic acceptance.

Low-loss on-chip superconducting microwave circulator assisted by shunting capacitors

Ferrite-free circulators that are passive and readily integratable on a chip are highly sought-after in quantum technologies based on superconducting circuits. In our previous work, we implemented such a circulator using a three-Josephson-junction loop that exhibited unambiguous nonreciprocity and signal circulation, but required junction energies to be within 1% of design values. This tolerance is tighter than standard junction fabrication methods provide, so we propose and demonstrate a design improvement that relaxes the required junction fabrication precision, allowing for higher device performance and fabrication yield. Specifically, we introduce large direct capacitive couplings between the waveguides, which based on the modeling we describe here, requires less stringent junction fabrication tolerance. We implement the design, and measure enhanced “circulation fidelity” above 97%, with optimized on-resonance insertion loss of 0.2 dB, isolation of 18 dB, and power reflectance of −15dB, in good agreement with model calculations. Published by the American Physical Society 2025

Advances in RNA therapy for the treatment of autoimmune diseases.

Autoimmune diseases (ADs) are a group of complex, chronic conditions characterized by disturbance of immune tolerance, with examples including systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, and psoriasis. These diseases have unclear pathogenesis, and traditional therapeutic approaches remain limited. However, advances in high-throughput histology technology and scientific discoveries have led to the identification of various pathogenic factors contributing to ADs. Coupled with improvements in RNA nucleic acid-based drug synthesis, design, and delivery, RNA-based therapies have been extensively investigated for their potential in treating ADs. This paper reviews the progress in the use of miRNAs, lncRNAs, circRNAs, siRNAs, antisense oligonucleotides (ASOs), aptamers, mRNAs, and other RNA-based therapies in ADs, focusing on their therapeutic potential and application prospects, providing insights for future research and clinical treatment of autoimmune diseases.

Evaluating the Safety and Usability of an Over-the-Counter Medical Device for Adults With Mild to Moderate Hearing Loss: Formative and Summative Usability Testing.

Only 15% of the nearly 30 million Americans with hearing loss use hearing aids, partly due to high cost, stigma, and limited access to professional hearing care. Hearing impairment in adults can lead to social isolation and depression and is associated with an increased risk of falls. Given the persistent barriers to hearing aid use, the Food and Drug Administration issued a final rule to allow over-the-counter hearing aids to be sold directly to adult consumers with perceived mild to moderate hearing loss at pharmacies, stores, and online retailers without seeing a physician or licensed hearing health care professional. We evaluated the safety and usability of an over-the-counter hearing aid prior to Food and Drug Administration approval and market release. We first conducted a formative usability test of the device and associated app with 5 intended users to identify outstanding safety and usability issues (testing round 1). Following design modifications, we performed a summative usability test with 15 intended users of the device (testing round 2). We concurrently conducted a test with 21 nonintended users (ie, users with contraindications to use) to ascertain if consumers could determine when they should not use the device, based on the packaging, instructions, and labeling (testing round 3). Participants were asked to complete 2-5 tasks, as if they were using the hearing aid in real life. After each task, participants rated the task difficulty. At the end of each session, participants completed a 10-question knowledge assessment and the System Usability Scale and then participated in debriefing interviews to gather qualitative feedback. All sessions were video recorded and analyzed to identify use errors and design improvement opportunities. Usability issues were identified in all 3 usability testing rounds. There were minimal safety-related issues with the device. Round 1 testing led to several design modifications which then increased task success in round 2 testing. Participants had the most difficulty with the task of pairing the hearing aids to the cell phone. Participants also had difficulty distinguishing the right and left earbuds. Nonintended users did not always understand device contraindications (eg, tinnitus and severe hearing loss). Overall, test findings informed 9 actionable design modifications (eg, clarifying pairing steps and increasing font size) that improved device usability and safety. This study evaluated the usability and safety of an over-the-counter hearing aid for adults with mild to moderate hearing loss. Human factors engineering methods identified opportunities to improve the safety and usability of this direct-to-consumer medical device for individuals with perceived mild-moderate hearing loss.

Effects of Leading-edge Tubercles on the Aerodynamic Performance of Rectangular Blades for low-speed Wind Turbine Applications

The rapid depletion of conventional energy resources like fossil fuels has harmed the environment. Hence, there is an urgent need to seek alternative and sustainable energy sources. Wind energy is considered one of the efficient sources of energy that can be converted to a useful form of electrical energy. Though the field of wind engineering has developed in recent years there is still scope for improvement in the effective utilization of energy. The turbine blades' aerodynamics and the turbulent fluid flow characteristics largely determine the wind turbine's energy efficiency. Hence, in the present studies, we investigated the improvement of small wind turbine blade design by incorporating bioinspired tubercles into blades. One of the issues of small wind turbines is the low-capacity factor in power. The wind in such circumstances under buildings and other adjacent obstructions for small turbines is normally weak, unstable, and turbulent in wind speed and direction. Thus, the design of small turbines needs to be improved to capture low wind speeds and to respond quickly to turbulent wind resource areas. Biomimetics is a science that helps us adapt designs from nature to solve modern problems. The wing-like flipper of the humpback whale (Megaptera novaeangliae) has a morphology with potential for aerodynamic applications. The humpback whale flipper has several sinusoidal rounded bumps, called tubercles which modify the flow over the blade surface, creating vortices between the tubercles. Therefore, we conducted an XFOIL analysis of symmetrical NACA airfoils and we observed that NACA0012 could produce the best lift/drag ratio. The airfoil was then validated using Computational Fluid Dynamics (CFD) analysis in which the results were found comparable to that of the published data. Finally, CFD analysis was conducted for tubercles with a different pitch-to-amplitude ratio (p/A) and the tubercled airfoil with p/A of 6 provided the best result.

Elegant and Innovative Recoding Strategies for Advancing Vaccine Development.

Recoding strategies have emerged as a promising approach for developing safer and more effective vaccines by altering the genetic structure of microorganisms, such as viruses, without changing their proteins. This method enhances vaccine safety and efficacy while minimizing the risk of reversion to virulence. Recoding enhances the frequency of CpG dinucleotides, which in turn activates immune responses and ensures a strong attenuation of the pathogens. Recent advancements highlight synonymous recoding's potential, offering improved genetic stability and immunogenicity compared to traditional methods. Live vaccines attenuated using classical methods pose a risk of reversion to virulence and can be time-consuming to produce. Synonymous recoding, involving numerous codon alterations, boosts safety and vaccine stability. One challenge is balancing attenuation with yield; however, innovations like Zinc-finger antiviral protein (ZAP) knockout cell lines can enhance vaccine production. Beyond viral vaccines, recoding can apply to bacterial vaccines, as exemplified by modified Escherichia coli and Streptococcus pneumoniae strains, which show reduced virulence. Despite promising results, challenges like ensuring genetic stability, high yield, and regulatory approval remain. Briefly, ongoing research aims to harness these innovations for comprehensive improvements in vaccine design and deployment. In this commentary, we sought to further engage the community's interest in this elegant approach by briefly highlighting its main advantages, disadvantages, and future prospects.

The Magnetic Application in the Loudspeaker and Headset

Loudspeakers and headsets are ubiquitous electronic devices essential to modern life, finding extensive applications in medicine, education, entertainment, and communication. This paper explores their fundamental operating principles, rooted in electromagnetic and acoustic theories, and provides a comprehensive analysis of their mechanisms. It summarizes various optimization strategies aimed at enhancing performance, including advancements in acoustic output, material innovations like carbon nanotubes, structural design improvements, and computational efficiency through algorithms such as adaptive impedance matching and genetic algorithms. The study also addresses current challenges faced by these devices, such as the trade-off between miniaturization and sound quality, escalating production costs, limited battery life, and issues related to prolonged user comfort. Furthermore, it highlights evolving user expectations for higher sound quality, longer battery life, and more ergonomic designs. By synthesizing existing research and forecasting future trends, the paper offers valuable insights into the ongoing development of loudspeakers and headsets, anticipating that innovations in artificial intelligence, smart materials, and personalized audio technology will significantly shape their future evolution

Design Improvements and Best Practices in Small-Scale Biodigesters for Sustainable Biogas Production: A Case Study in the Chillon Valley, Perú

Agribusiness ranks second as the sector with the highest greenhouse gas emissions linked to methane, constituting a crucial challenge for global sustainability. Although its impact on climate change is considerable, small rural farmers do not have effective technologies to manage the organic waste derived from their daily activities. In this context, anaerobic digestion is an innovative solution that converts waste into biogas and biofertilizers, promoting a sustainable and circular approach. However, its implementation faces significant barriers due to inadequate designs and poor operational practices, which makes its adoption difficult in rural areas. This applied theoretical research seeks to overcome these barriers by improving the design and operation of small-scale biogas plants. The system studied operates at 70% of its capacity, with a hydraulic retention time of 20 days and a feed of 4 kg organic matter. The substrates considered were 30% organic waste and 70% bovine manure, achieving an average production of 63.75 L CH4/kg of organic matter, which exceeded the usual yields of small biodigesters. A mathematical model was created and applied to the case study with an R2 correlation of 98% and a pseudo-R2 of 89.5%, evidencing a remarkable predictive capacity. This biogas plant model is efficient and sustainable, and it is presented as a viable solution for small rural farmers.

Modeling the understanding of the vector concept by a Bayesian multidimensional item response model

In this paper, we propose to use a Bayesian three-dimensional item response model to estimate the student’s understanding of the vector concept. The experiment involved administering a test with 20 items about understanding vectors to 120 undergraduate students. The understanding is considered a latent variable of three dimensions related to observable data from item responses of a vector test. The Bayesian approach was used to obtain estimations about individual parameters, which were qualitatively analyzed based on a framework for understanding concepts. According to the results, we classify students into three levels of understanding in each dimension analyzed. We observed that a high percentage of students reached a medium level of understanding, while a low percentage achieved a high level of understanding. In addition to the classification, we obtained understanding profiles to quantify the level of students’ understanding in each of the dimensions. These profiles offer a more nuanced view of students’ understanding of the concept vector, which has significant practical implications. This information can guide the improvement of teaching strategies and curriculum design, allowing educators to address specific areas of difficulty and enhance learning in the concept of vectors.

Optimising surgical efficiency by designing lightweight skull-PSI assemblies and curved fixture plates for cranial reconstruction using FEA

Cranial reconstruction using implants is critical for protecting intracranial structures and restoring cerebral hemodynamics in cases of cranial defects caused by accidents, diseases or cancer. Patient-specific implants (PSIs) made from materials such as polyether-ether-ketone (PEEK), are required to be lightweight, high in strength and capable of mimicking the natural bone structure. Effective fastening mechanisms using the required number of fixture plates are essential for seamless integration between the PSI and the cavity of a defected skull for successful cranial reconstruction. This study explores the optimal number and shape of fixture plates required to join a Skull-PSI assembly, such that the overall weight of the PSI remains minimal, and to ensure that these assemblies do not fail when subjected to heavy external loads of 950 N. PEEK material was used for PSI, natural bone for the defected skull and Titanium Alloy (Ti-6Al-4 V) for the fixture plates. Conventional straight shaped fixture plates often require manual bending for correct fitment on the Skull-PSI curved surface, which increases a surgeon's time and effort. Curved shaped fixture plates were designed, to save on this time and effort and enhance the contact surface area with the Skull-PSI surface. Four, three and two numbered, straight and curved shaped fixture plates were investigated using Finite Element Analysis (FEA) techniques. Three numbered, curved shaped fixture plates were found to be optimal, to generate a 7-gram lightweight PSI that could successfully sustain external loads up-to 950 N without failure. Ultimately, these design improvements would benefit both patient and surgeon in aspects of surgery time and patient comfort.