Basis For Design Research Articles

Oscillatory Active State of a Pd Nanocatalyst Identified by In Situ Capture of the Instantaneous Structure-Activity Change at the Atomic Scale.

Identifying the active phase with the highest activity, which is long-believed to be a steady state of the catalyst, is the basis of rational design of heterogeneous catalysis. In this work, we performed detailed in situ investigations, successfully capturing the instantaneous structure-activity change in oscillating Pd nanocatalysts during methane oxidation, which reveals an unprecedented oscillatory active state. Combining in situ quantitative environmental transmission electron microscopy and highly sensitive online mass spectrometry, we identified two distinct phases for the reaction: one where the Pd nanoparticles refill with oxygen, and the other, a period of abrupt pumping of oxygen and boosted methane oxidation within about 1 s. It is the rapid reduction process that shows the highest activity for total oxidation of methane, not a PdO or Pd steady state under the conditions applied here (methane:oxygen = 5:1). This observation challenges the traditional understanding of the active phase and requires a completely different strategy for catalyst optimization.

Thermodynamic Study on the Vortex Teeth of Electric Scroll Compressors Based on Gradient Tooth Height

Through the analysis of the adhesion between the tooth head and axial clearance leakage attributed to vortex tooth shape deformation, an innovative tooth shape design concept has been introduced entitled “progressive change tooth high vortex tooth”. This unique design includes a gradual change in tooth height and an elevated vortex tooth profile, using temperature-sensitive materials to enhance the resolution of temperature loading on the vortex disc. By refining the process of resolving the temperature loading on the vortex disc, the mean temperature function of the fluid domain along the wall of the vortex tooth is calculated, and a steady-state temperature distribution model for the solid domain of the vortex tooth is formulated. Subsequently, a finite element model for the high eddy current disc is constructed using Abaqus 2021 finite element software, which facilitates the calculation of stress–strain distribution within the high eddy current disc under both gas pressure and temperature field loads. The results show that, especially under conditions of low speed and low exhaust pressure, the temperature load mainly influences the maximum deformation and stress distribution of the vortex tooth. Specifically, under the influence of heat-solid coupling, the maximum deformation of the progressive change tooth high vortex tooth occurs in close proximity to the central compression cavity, reaching up to 13 microns. These results provide a crucial theoretical basis for the structural design and performance optimization of the compressor.

Accurate modeling of thermal-optical performance for a lightweight SiC mirror

The SiC mirror has excellent structural rigidity and thermal stability, making it widely applicable in high-power optical systems. This manuscript aims to establish a coupled analysis model of thermal-optical performance for a lightweight SiC reflector under high-power laser irradiation. First, based on the Fourier principle, the transient temperature rise of the mirror is analyzed using the finite element method, considering boundary conditions such as heat source and convective radiation. A transient thermal response model for the mirror is established. Then, the reflective surface deformation is solved based on the mirror temperature field. By processing the data of node deformation, the decrease in the mirror surface shape accuracy (RMS) value is obtained. Finally, the experimental platform is built to measure the transient temperature rise and wavefront aberration change of the mirror after high-power laser excitation. Based on the deviation between the calculated data of the analysis model and the measured data, thermodynamic parameters in the analysis model are adjusted according to the principle of minimum residual. The research findings of this manuscript can be utilized for accurately predicting the temperature rise and optical degradation of SiC mirrors under high-power laser irradiation and provide a theoretical basis for the subsequent design of actively compensating methods for thermal-induced distortions.

Preparation and properties of tellurite glass-based CsPb(BrCl)3@glass fluorescent film for a white light emitting diode color converter

Perovskite nanocrystal glass has the advantages of narrow-band emission, easy tuning, and stable structural, physical, and chemical properties, and can be used to mix with other colored materials for white light modulation. The current white light mode widely adopts the packaging method of blue light chip and yellow phosphor, which has the problem of a blue-yellow cavity and low light quality. In this work, the central wavelength of CsPb(BrCl)3 can be adjusted continuously ranging from 463 nm to 486 nm by adjusting the relative ratio of bromine to chlorine in nanocrystals. On the basis of the previous design of YAG:Ce phosphor-in-glass, perovskite nanocrystal glass powder as a color compensator was introduced into the tellurite glass matrix to form a doubly encapsulated system by low-temperature co-sintering. The yellow phosphor and perovskite nanocrystal glass maintain good structural integrity in the glass matrix. By combining the double-package fluorescent material with the blue chip, the continuous adjustment of chromaticity coordinates along the saddle line is realized, and the color-rendering index is also improved to 81.3.

Characterization and Theoretical Analysis of the Venus Flytrap Trigger Hair

The Venus flytrap, which possesses a number of mechano-sensitive trigger hairs, is a typical carnivorous plant that effectively senses and catches insects to survive in nutrient-poor habitats. When insects touch the trigger hairs on a leaf, once they reach the threshold, the Venus flytrap induces an action potential and sharply closes to capture the prey. In this paper, the trigger hairs obtain a special cantilever beam structure with a stiff hair lever and a flexible basal podium, and there is a noticeable notched structure at the basal podium, which differs from a common homogeneous hair. Based on the characteristics of the Venus flytrap trigger hairs, we established a three-dimensional model and conducted theoretical and finite element analysis. The results show that the unique hollow heterogeneous cantilever structure of the Venus flytrap trigger hair can achieve high sensitivity and optimal tactile perception. Overall, the morphology, structure and mechanical characteristics of Venus flytrap trigger hairs were characterized in detail, which may provide a deeper understanding of the trigger hairs’ tactile perception mechanism. And the mechanical simulation and optimization analysis of Venus flytrap trigger hairs had an important theoretical basis and parameter support for the further design of state-of-the-art tactile sensors with high sensitivity inspired by Venus flytrap trigger hairs.

A Comparation Study of Transmission Line Routing Based on A* and RRT Algorithms

Transmission line design is an important part of power grid engineering design, and transmission line path selection is the basis of line design. Transmission line route selection is to select a line path that can not only meet the requirements of power transmission and consumption, but also consider the cost control of the line, and avoid the farmland, highways, ecological exclusion zone between the start and end of the transmission line. The path scheme is constrained by geographical factors, project cost, construction conditions, operation and maintenance conditions, which makes the path selection show the characteristics of comprehensive diversity, spatial complexity, policy influence and so on. In the traditional route selection of transmission lines, line design specialists need to go through blind route selection, site survey and other steps to determine the path scheme, but because of insufficient effectiveness of the map, it is difficult to reflect the real environmental information, resulting in repeated route selection work to determine the final path scheme. In this paper, the selection principle of transmission line path is introduced first. Then, two path optimization algorithms, i.e. A* algorithm and rapidly expanding random tree (RRT) algorithm, are used to select transmission lines respectively. Finally, the advantages and disadvantages of these two algorithms in practical engineering line selection design are comparatively analyzed. Compared with the way of A* algorithm, RRT algorithm is more suitable for practical application of power system. It aims to provide a reference for the method of intelligent line selection in subsequent transmission design.

Experimental Study on Bearing Capacity Reduction of the Steel Wire-Rings in Flexible Barriers Due to Corrosion

Flexible barriers mitigate geological hazards, relying crucially on wire-ring nets to intercept rockfalls and debris. However, constant exposure to natural environments renders their metal components susceptible to corrosion, affecting the protective efficacy. To investigate the changes in mechanical properties of wire-ring nets resulting from corrosion, the neutral salt spray tests followed by quasi-static tests on uncoated, Zinc-coated, and Galfan-coated high-strength steel wires and wire-rings were conducted. These tests established the correlation between the steel wire's breaking force and its weight loss rate, ultimately facilitating the creation of a pertinent mathematical model. The decline in the breaking force of various types of wire-rings due to corrosion was compared, indicating the influence of corrosion duration, number of winding turns, winding techniques, and coating types on the wire-ring's mechanical performance. Subsequently, the formula for calculating the breaking force of wire-rings in relation to the weight loss rate of the steel wire was derived. Finally, based on the linear relationship between the capacity of single wire-rings and wire-ring nets, a formula was established to estimate the puncturing force of wire-ring nets under different atmospheric corrosion periods. This predictive model provides a basis for the durability design of flexible barrier with different anti-corrosion measures under various atmospheric conditions, and also offers specific insights into maintenance strategy for the existing flexible barriers.

Insights into reverse oxygen spillover effect induced via CeO2 modulation to enhance the stability of CuCoOx catalysts in hydrodeoxygenation of biomass derivatives

In hydrodeoxygenation (HDO) reactions, the evolution of the chemical states of active species in the catalyst caused by the spillover effects greatly influences their catalyst performance. Herein, the HDO of guaiacol (GUA) over CuCoOx and CuCoCeOx catalysts synthesized by co-precipitation method was systematically investigated. During the HDO reaction of GUA, acid sites (Co(II)) facilitated the C-O bond (demethylation via -OCH3) cleavage, which was the rate-determining step. A series of characterizations and experimental results revealed that introducing CeO2 into the CuCoOx catalyst could enable the catalyst to undergo reverse oxygen spillover in the hydrogenation environment, promoting the regeneration of CoO in the catalyst. Therefore, the deactivation of the CuCoOx catalyst due to hydrogen spillover leading to CoO reduction could be avoided, and the catalyst stability improved. The present study methodically investigated the spillover effects induced by Cu and CeO2 and provided the theoretical basis for the structural design of heterogeneous catalysts.

On the effect of axial inlet angle on the droplet size distribution and mixing uniformity for swirl jet mixer at high phase ratios

The “short pass” problem of liquid-liquid two-phase mixing at high phase ratios limited the development and applications of jet mixer in industrial process. In this study, the effect of the axial inlet angle on the mixing characteristics of a swirl jet mixer was investigated through laser particle size analysis and computational fluid mechanics (CFD) coupled with population balance model (PBM). The result was shown that as the axial inlet angle increased, the dispersed phase droplet sizes decreased, and the droplet size distribution was widened for the fixed mixer configuration. At Re ≤ 3.000×104, tangential inlet was more conducive to improving mixing uniformity. Conversely, the axial inlet angle of 90° was optimal at Re ≥ 3.750×104. Numerical simulations revealed that the tangential inlet effectively intensified liquid-liquid interactions, including streamlines extension, increased vorticity, improved droplet size uniformity. Additionally, the increase of the axial inlet angle resulted in increased turbulence stress and shortened decay period, the reduction in droplet size, and a wide droplet size distribution. The research findings can serve as theoretical basis for the hydraulic design and promoted applications of swirl jet mixers.

The nature and magnitude of cognitive impairment in narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia: a meta-analysis

Abstract People with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH) often report cognitive impairment which can be quite burdensome but is rarely evaluated in routine clinical practice. In this systematic review and meta-analysis, we assessed the nature and magnitude of cognitive impairment in NT1, NT2, and IH in studies conducted from January 2000 to October 2022. We classified cognitive tests assessing memory, executive function, and attention by cognitive domain. Between-group differences were analyzed as standardized mean difference (Cohen’s d), and Cohen’s d for individual tests were integrated according to cognitive domain and clinical disease group. Eighty-seven studies were screened for inclusion; 39 satisfied inclusion criteria, yielding 73 comparisons (k): NT1, k = 60; NT2, k = 8; IH, k = 5. Attention showed large impairment in people with NT1 (d = –0.90) and IH (d = –0.97), and moderate impairment in NT2 (d = –0.60). Executive function was moderately impaired in NT1 (d = –0.30) and NT2 (d = –0.38), and memory showed small impairments in NT1 (d = –0.33). A secondary meta-analysis identified sustained attention as the most impaired domain in NT1, NT2, and IH (d ≈ –0.5 to –1). These meta-analyses confirm that cognitive impairments are present in NT1, NT2, and IH, and provide quantitative confirmation of reports of cognitive difficulties made by patients and clinicians. These findings provide a basis for the future design of studies to determine whether cognitive impairments can improve with pharmacologic and nonpharmacologic treatments for narcolepsy and IH.

Evaluation Method for Underwater Ultrasonic Energy Radiation Performance Based on the Spatial Distribution Characteristics of Acoustic Power.

In recent years, underwater wireless ultrasonic energy transmission technology (UWUET) has attracted much attention because it utilizes the propagation characteristics of ultrasound in water. Effectively evaluating the performance of underwater ultrasonic wireless energy transmission is a key issue in engineering design. The current approach to performance evaluation is usually based on the system energy transfer efficiency as the main criterion, but this criterion mainly considers the overall energy conversion efficiency between the transmitting end and the receiving end, without an in-depth analysis of the characteristics of the distribution of the underwater acoustic field and the energy loss that occurs during the propagation of acoustic waves. In addition, existing methods focusing on acoustic field analysis tend to concentrate on a single parameter, ignoring the dynamic distribution of acoustic energy in complex aquatic environments, as well as the effects of changes in the underwater environment on acoustic propagation, such as spatial variability in temperature and salinity. These limitations reduce the usefulness and accuracy of models in complex marine environments, which in turn reduces the efficiency of acoustic energy management and optimization. To solve these problems, this study proposes a method to evaluate the performance of underwater ultrasonic energy radiation based on the spatial distribution characteristics of acoustic power. By establishing an acoustic power distribution model in a complex impedance-density aqueous medium and combining numerical simulation and experimental validation, this paper explores the spatial variation of acoustic power and its impact on the energy transfer efficiency in depth. Using high-resolution spatial distribution data and actual environmental parameters, the method significantly improves the accuracy of the assessment and the adaptability of the model in complex underwater environments. The results show that, compared with the traditional method, this method performs better in terms of the accuracy of the acoustic energy radiation calculation results, and is able to reflect the energy distribution and spatial heterogeneity of the acoustic source more comprehensively, which provides an important theoretical basis and practical guidance for the optimal design and performance enhancement of the underwater ultrasonic wireless energy transmission system.

Psychological Impact of Campus Football Training among Teenagers: Basis for Training Design

Student undergoing football training are exposed to stress. The lack of baseline information on assessing the relationship between profile and psychological impact in terms of sources and symptoms of stress in China led to the conduct of this study. This quantitative research was utilized a descriptive comparative research design to assess the differences between the psychological impact of campus football training to the profile of the student-respondents . Findings of the study revealed that most of the respondents were between the ages of 17-21 and just over half of the respondents were males. Further, most of the respondents were second year students. Almost half of the student had a moderate level of the sources of stress. Overall, the sources of stress had moderate impact to the students. Majority of the students had a high level of physical and mental symptoms of stress. In general , age, sex, and year level have no significant relationship with sources of stress and the mental and physical symptoms of stress. In conclusion, age, sex, and year level does not have psychological impact in terms of sources of stress and symptoms of stress. This comes to show that no matter what the person’s age, whether young or old, whether male or female, or whether first year or second year or third year or fourth year, a person can still experience a high level of psychological impact in football training, be it the source of stress or mental and physical symptoms of stress. To address the findings of the study, a football training design was created.

Timber Strength Grading as Necessary Basis for Structural Design in ex-YU Region

The aim of this paper is to contribute to the classification of structural timber in the ex-YU region into strength-class system through the application of experimentally obtained archive data in order to provide a realistic framework for most commonly used II grade (according to JUS) structural coniferous timber. The analysis of archive data was carried out on a sample of 150 specimens of structural size and based on the set of statistical requirements prescribed by EN standards, taking into account the change in disposition of loading in laboratory testing in the past and now. Statistical procedures prescribed by EN standards are given through calculation steps together with necessary adjustment factors that cover the size and number of specimens. The presented procedures given for structural-size specimens are also applicable to small clear specimens, so that a more comprehensive research and additional new examinations could be conducted with the available archive data simultaneously with the harmonization of the visual classification rules applied in the ex-YU region. The paper emphasises the direct dependence of the consistent application of the visual grading rules required by the relevant EN standard on strength-class system.

A Study on Spatial Differentiation of Landscape Pattern Based on Three-Dimensional Morphology of Urban Buildings

Abstract. Urban buildings are an important part of urban morphology, and building height has an important impact on the three-dimensional spatial morphology of cities. At present, research on the two-dimensional morphology of cities is relatively abundant, but there are fewer studies on the characteristics of the three-dimensional undulating morphology of cities and their spatial distribution patterns, and thus knowledge of the degree of utilization of the airspace above the city and its developmental pattern is still relatively lacking.Based on the multi-scale urban agglomeration, the landscape pattern is converted from two-dimensional to three-dimensional, and the overall spatial differentiation can be analyzed more intuitively. The purpose of this paper is to explore the three-dimensional spatial differentiation law of urban architectural landscape pattern. Through in-depth spatial analysis of the architectural landscape in urban areas, it is found that the landscape patterns in different areas show significant differences, and the interrelationship between them and the urban landscape pattern is revealed through the study of three-dimensional characteristics of urban buildings, such as height, density, form and layout. It is found that the different characteristics of urban buildings have a significant impact on the landscape pattern, which leads to the differentiation of urban space. This study provides more comprehensive spatial information for urban planning, contributes to a better understanding of the complexity of urban architectural landscapes, and provides a scientific basis for future urban design and planning.

Study on coupled mode flutter parameters of large wind turbine blades

As the size of wind turbine blades increases, the flexibility of the blades increases. In actual operation, airflow flow can cause aerodynamic elastic instability of the blade structure. Long blades may experience coupled mode flutter due to the bending torsion coupling effect, leading to blade failure. Based on Euler Bernoulli beam theory combined with Theodorsen non directional aerodynamic loads, a blade flutter characteristic equation is established through finite element method. Taking NREL 5 MW wind turbine blades as an example, analyze the influence of parameter changes in different regions of the blades on flutter characteristics. Research has found that paramter changes in the tip region of blade have the greatest impact on flutter characteristics. The vibration frequency shows an overall upward trend with the increase of waving stiffness and torsional stiffness. The flutter velocity of the three regions tends to stabilize as the bending stiffness decreases. The blade flutter speed increases with the increase of torsional stiffness. The radius of gyration is inversely proportional to the flutter frequency and flutter velocity. The impact of centroid offset on blade structure flutter frequency is minimal, but the centroid offset in the tip region has a greater impact on flutter velocity. Increasing the torsional frequency can prevent coupled mode flutter and provide a theoretical basis for blade flutter prevention design.

The research on the effect of dynamic tilt variation on the phase of cold atomic gravimeter

In recent years, absolute gravity comparison experiments between cold atomic gravimeter and traditional gravimeter have been carried out by combining cold atomic gravimeter with stable platform. Due to the working characteristics of the stable platform, the tilt angle of the cold atomic gravimeter will change slightly in the process of dynamic measurement, and the measurement noise will be introduced. In order to improve the accuracy of dynamic measurement, this paper first analyzes the trajectory of the mirror and atom in the atomic gravimeter combined with carrier motion information, obtains the phase expression of the atomic interferometer using the translation and rotation matrix, evaluates the main terms of the gravity deviation using the 20-min navigation data on the ship in the South China Sea, and simplifies the higher-order small-terms in the main terms to deduce the simplified form of the gravity deviation. Then, the Fourier transform is used to transform the simplified expression into the power spectrum expression of phase noise, the corresponding noise sensitivity function is used in the form of trigonometric. The 20-min data is divided into 10 intervals, the root-mean-square (RMS) value of the overall gravity deviation is 1.5–3 mGal using the power spectrum of the platform angle, angular velocity and carrier acceleration in each interval. The variation fluctuation of the RMS value is consistent with the fluctuation of solving the gravity deviation through the trajectory. The conclusion provides the calculation method of gravity noise caused by dynamic tilt change and horizontal acceleration, and also provides the basis for platform design.

Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high fatality rate of up to 30% caused by SFTS virus (SFTSV). However, no specific vaccine or antiviral therapy has been approved for clinical use. To develop an effective treatment, we isolated a panel of human monoclonal antibodies (mAbs). SF5 and SF83 are two neutralizing mAbs that recognize two viral glycoproteins (Gn and Gc), respectively. We found that their epitopes are closely located, and we then engineered them as several bispecific antibodies (bsAbs). Neutralization and animal experiments indicated that bsAbs display more potent protective effects than the parental mAbs, and the cryoelectron microscopy structure of a bsAb3 Fab-Gn-Gc complex elucidated the mechanism of protection. In vivo virus passage in the presence of antibodies indicated that two bsAbs resulted in less selective pressure and could efficiently bind to all single parental mAb-escape mutants. Furthermore, epitope analysis of the protective mAbs against SFTSV and RVFV indicated that they are all located on the Gn subdomain I, where may be the hot spots in the phleboviruses. Collectively, these data provide potential therapeutic agents and molecular basis for the rational design of vaccines against SFTSV infection.

Design standardisation and seismic protection of SMRs through modular metafoundations

This paper investigates the seismic protection of the Nuward™ small modular reactor (SMR) building, focusing on design loading and beyond design basis earthquake (bDBE) conditions. The study aims to achieve two primary objectives: i) to enhance seismic mitigation of a SMR building under bDBE conditions, through the use of the innovative modular single-layer (SLM) and multi-layer (MLM) metafoundations (MFs); ii) to effectively standardise and harmonise SMR building designs in locations prone to beyond design basis conditions. To accomplish these goals and demonstrate the protective capabilities of the MFs, the study employs non-linear time-history analyses (NLTHAs) for both DBE and bDBE conditions. Along these lines, a reduced-order model was developed from a refined finite element (FE) model of the SMR building using the Craig-Bampton mode synthesis technique. Then, finite locally resonant modular MFs were designed and analysed using NLTHAs. Specifically, physics-based ground motion models (GMMs) were used to generate and select seismic triplets that mimicked DBE and bDBE scenarios for NLTHAs. Successively to achieve improved seismic performance, the optimization of the MFs was pursued by targeting the optimal number of columns, resonator parameters, and unit cell dimensions. Additionally, the deployment of inerters was considered, to significantly reduce the size of the MFs and enable their application in multiple layers for ultra-low frequency attenuation. The overall findings suggest that modular MFs meet seismic protection requirements, and positively contribute to the standardization process of SMR buildings, even in areas characterized by beyond-design seismic conditions.

Multiepitope recognition technology promotes the in-depth analysis of antibody‒drug conjugates

The dynamic tracking of antibody‒drug conjugates (ADCs) in serum is crucial. However, a versatile bioanalytical platform is lacking due to serious matrix interferences, the heterogeneity and complex biotransformation of ADCs, and the recognition deficiencies of traditional affinity technologies. To overcome this, a multiepitope recognition technology (MERT) was developed by simultaneously immobilizing CDR and non-CDR ligands onto MOF@AuNPs. MERT's excellent specificity, ultrahigh ligand density, and potential synergistic recognition ability enable it to target the different key regions of ADCs to overcome the deficiencies of traditional technologies. The binding capacity of MERT for antibodies is ten to hundred times higher than that of the mono-epitope or Fc-specific affinity technologies. Since MERT can efficiently capture target ADCs from serum, a novel bioanalytical platform based on MERT and RPLC‒QTOF-MS has been developed to monitor the dynamic changes of ADCs in serum, including the fast changes of drug-to-antibody ratio from 3.67 to 0.22, the loss of payloads (maytansinol), and the unexpected hydrolysis of the succinimide ring of the linker, which will contribute to clarify the fate of ADCs and provide a theoretical basis for future design. In summary, the MERT-based versatile platform will open a new avenue for in-depth studies of ADCs in biological fluids.

Threshold displacement energy map of Frenkel pair generation in [formula omitted]-Ga2O3 from machine-learning-driven molecular dynamics simulations

β-gallium oxide (β-Ga2O3) shows great promise for electronics applications, particularly, in future space operating devices exposed to harsh radiation environments for extended times. This study focuses on crucial, yet not fully explored, aspects of radiation damage in this material, such as threshold displacement energies and formation of various radiation-induced Frenkel pairs. Analyzing over 5,000 molecular dynamics simulations based on our machine-learning potentials, we conclude that the threshold displacement energies for two Ga sites, the tetrahedral (22.9 eV) and octahedral (20 eV) ones, differ stronger than the same values for three different O sites, which range only between 17 eV and 17.4 eV. Mapping of threshold displacement energies unveils significant differences in displacements for all five atomic sites. Our newly developed defect identification methodology successfully classified multiple Frenkel pair types in β-Ga2O3, with over ten different Ga and two primary O ones with a predominant O split interstitial at the O1 site. Finally, the calculated recombination energy barriers suggest that O Frenkel pairs are more likely to recombine upon annealing than Ga. These insights are pivotal for understanding the radiation damage and defect formation in Ga2O3, providing the basis for design of Ga2O3-based electronics with high radiation resistance.