This paper investigates the structural performance of novel steel-plate concrete containment structures, focusing on third-generation nuclear power plants. To address the challenges of increased complexities and costs associated with double-layer containment designs, this study explores the potential of steel-plate concrete structures to enhance safety, economic efficiency, and construction simplicity. The steel-plate concrete structure, characterized by its core concrete and dual steel plates, shows superior compressive strength, bending resistance, and elastoplasticity. Extensive numerical analyses, including finite element modeling and thermal-stress coupling, were conducted under various load conditions. Under structural integrity test conditions, the maximum radial displacement observed was 24.59 mm. Under design basis conditions, the maximum radial displacement was 47.61 mm; under severe accident conditions, it was 53.83 mm. The ultimate bearing capacity was 0.91 MPa, 2.17 times the design pressure. This study concludes that the steel-plate concrete containment structure maintains a high safety margin under all tested conditions, with stress and strain well within acceptable limits. It can effectively serve as a robust barrier against radioactive leakage and malicious impacts, providing a viable alternative to conventional containment designs.