Description Of Landscape Research Articles

Window Expeditions: A playful approach to crowdsourcing natural language descriptions of everyday lived landscapes

Measuring what citizens perceive and value about landscapes is important for landscape monitoring. Capturing temporal, spatial and cultural variation requires collection of data at scale. One potential proxy data source are textual descriptions of landscapes written by volunteers. We implemented a gamified application and crowdsourced a multilingual corpus of in-situ descriptions of everyday lived landscapes. Our implementation focused on the aesthetics of exploration, expression and fellowship in the mechanics, dynamics, aesthetics (MDA) framework. We collected 503 natural language landscape descriptions from 384 participants in English (69.7%), German (25.1%) and French (5.3%) and most contributions were made in urban areas (54.7%). The most frequent noun lemma in English was “tree” and in German “Fenster” (window). By comparing our English collection to corpora of everyday English and landscape descriptions, we identified frequent lemmas such as “tree”, “window”, “light”, “street”, “garden” and “sky” which occurred significantly more than expected. These terms hint as to important components of the everyday landscapes of our users. We suggest a number of ways in which our corpus could be used in ongoing research on landscapes, complementing existing PPGIS approaches, providing data for domain specific lexicons for landscape analysis and as an input to landscape character assessment.

Identification of the immunosuppressive effect of γδ T cells correlated to bone morphogenetic protein 2 in acute myeloid leukemia

Description of immune landscapes in malignant microenvironment is critical to the improvement of therapeutic strategies for various tumors. Acute myeloid leukemia (AML) remains a severe life-threatening malignancy and often confronts treatment dilemma in clinic. Although γδ T cells exhibit independent and potent cytotoxicity against leukemic cells in vitro and in the mouse models, efficacy of γδ T cell-based immunotherapy on AML patients has seemed unsatisfying so far. How the anti-AML capacity of γδ T cells is suppressed in vivo remains elusive. Herein, we found an aberrant γδ T cells subset expressing CD25+CD127lowVδ2+ in the bone marrows of patients with newly diagnosed AML. The emergence of this subset was significantly associated with disease status and risk stratification as well as with the abnormally increased bone morphogenetic protein 2 (BMP2). Mechanistically, BMP2 could directly induce CD25+CD127lowVδ2+ γδ T cells (named as Reg-Vδ2) in vitro. The immunosuppressive features of Reg-Vδ2 cells were identified by combining immunophenotypical and functional data. Furthermore, inhibition of BMP2 pathway significantly blocked the emergence of Reg-Vδ2 cells and enhanced the anti-AML immunity in humanized mice. These findings not only provide a novel insight into the mechanisms of immunosuppression in the context of leukemia, but also suggest potential targets for the treatment of AML and other hematopoietic malignancies.

The 1257 CE cataclysmic eruption of Samalas volcano (Indonesia) revealed by indigenous written sources: Forgotten kingdoms, emergency response, and societal recovery

Historical and archaeological findings have revealed that many human civilizations have been strongly affected by natural hazards, such as volcanic eruptions. An issue that still lacks attention is the response of ancient populations following eruptions as well as their resilience strategies. Three written sources from Lombok, Indonesia, provide descriptions of the ancient landscape of Lombok and the population's response to the Samalas volcano eruption in 1257 CE. The sources depict the conditions of Lombok and the surrounding areas during the pre-, onset-, and post-eruption phases of a catastrophic volcanic eruption with a volcanic explosivity index 7. Various responses of the inhabitants to the eruption are described in the sources, such as fleeing to the hills, avoiding hazards, and escaping to neighboring villages or islands. Several geographic features and toponyms are mentioned, allowing us to reconstruct the evacuation process during the crisis period. The sources also describe recovery strategies in the post-eruption period, including governance strategies, the rebuilding of cities and villages, and agriculture. The historical record suggests that Lombok may have taken up to a century to recover from the eruption and that new kingdoms and principalities became established by the fourteenth century. Disaster management related to the eruption is described in the texts from Lombok, but not in older written sources from Indonesia.

Subjective Structure of “Mass Sentimentalism” Travels (P. I. Shalikov “Journey to Malorossia”)

The results of the study on the subjective structure of diology “Journey to Malorossia” by P. I. Shalikov are presented. Particular attention is paid to the analysis of the multilevel model of the subject of consciousness and the subject of speech in conjunction with spatial and temporal components of the text. The novelty of the study lies in the fact that for the first time the specificity of the subject is characterized in the prose of “mass sentimentalism” as “I” of an individual, “I” of a citizen and “I” of a litterateur — a “sentimental traveller”. The relevance of the study is due to the permanent interest in understanding the category of the author in a broad theoretical context, inter alia, by means of system-subjective approach. It is argued that in “Journey to Malorossia” the subject of consciousness and the subject of speech are actualized primarily as an individual, despite the author’s desire to follow the tradition of the sentimental prose. It is shown that the spatio-temporal organization of the text is simplified, landscape descriptions are schematic and the absence of temporal markers indicates a contradiction between the intention of being “in the flow of feeling” versus everyday narrative. The article concludes that the attempt of P. I. Shalikov to embed an individual artistic system into the paradigm of sentimentalism (from the individual author to the system author) is unsuccessful.

THE TOPOS OF KHMELNYTSKY IN OLGA SALYPA’S NOVEL «THE HOUSE ON APTEKARSKA»

Literature of the beginning of the 21st century. is marked by dynamic processes of expansion of trends in the emergence of urbanism. The works of modern Ukrainian writers present the topos of the cities of Kyiv, Lviv, Ivano-Frankivsk (Stanislavov), Zhytomyr, Rivne, Ternopil, Kharkiv, and Chernivtsi. Literary researchers have repeatedly addressed the problem of the formation and establishment of urban literature. However, the work of Olga Salipa – an original artist of the word, the author of a number of novels and novels, and the winner of the «Coronation of the Word” contest – remains outside the attention of literary critics. In the article, we focus on the urban portrait of Proskurov at the turn of the 19th-20th centuries and Khmelnytskyi at the beginning of the 21st century. In Olga Salipa’s novel “The House on Aptekarska”, the life of the city is conveyed through the perception and feelings of two women – the pharmacist’s wife Mykhailyna Derevoyed and Ulyana (Lyana) Yakovenko. The author, drawing urban pictures, depicts the city as an environment where a person seeks to find himself, establish himself and realize his place in the world. Various locations of the city appear on the pages of the work, we meet detailed descriptions of urban landscapes. Olga Salipa provides an interesting description of Proskurov, which allows the reader to immerse himself in the atmosphere of city life at the end of the 19th century, and the novel clearly outlines the modern trends of city life. The writer, first of all, reflects the city as an environment where a person seeks to find himself, establish himself and realize his place in the world. The city has the ability to preserve and transmit from generation to generation informational and cultural codes, which are the basis of civilizational development. The feeling and perception of the city are consonant with the mental visions and experiences of the main characters, which proves the tendency to psychologize the narrative. The creativity of Olga Salipa witnessed the further expansion of the thematic horizons of modern Ukrainian prose and the renewal of its genre palette.

‘Still Repeated Circles’: William Cowper’s The Task and the Shape of Habit

Weaving between georgic, satire, and religious epic over the course of six books of blank verse, William Cowper’s The Task (1784) would not seem to reward the reader who hunts for a presiding argument or theme. It does, however, offer a set of motifs as a means of guiding the reader through its network of associations. The most prevalent of these motifs is the rural walk, which appears as both a narrative device and a recurring metaphor of poetic form. Book III, for example, opens with the speaker describing himself It is a fitting simile, as Cowper steers his argument away from the apocalyptic visions of Book II and back onto the homely ground of rural retirement and cucumber production. However, it is also somewhat misleading. Books I, V, and VI of The Task narrate Cowper’s experience of his regular walk through the village of Olney and the neighbouring estate of Weston Underwood, as he associatively interweaves descriptions of landscape with personal, religious, and political reflections.2 In contrast to Cowper’s sense of the ‘rambling’ nature of poetic composition, those parts of the poem that actually narrate his walks reveal a powerful concern with habit and repetition. In Books I, V, and VI, he portrays walking as a practice which he cultivates for the purpose of maintaining both bodily and mental health. These sections reveal a preoccupation with what we might call the ‘shape’ of habit:

Somatic Mutational Landscape in Mexican Patients: CDH1 Mutations and chr20q13.33 Amplifications Are Associated with Diffuse-Type Gastric Adenocarcinoma.

The Hispanic population, compared with other ethnic groups, presents a more aggressive gastric cancer phenotype with higher frequency of diffuse-type gastric adenocarcinoma (GA); this could be related to the mutational landscape of GA in these patients. Using whole-exome sequencing, we sought to present the mutational landscape of GA from 50 Mexican patients who were treated at The Instituto Nacional de Cancerología from 2019 to 2020. We performed a comprehensive statistical analysis to explore the relationship of the genomic variants and clinical data such as tumor histology and presence of signet-ring cell, H. pylori, and EBV. We describe a potentially different mutational landscape between diffuse and intestinal GA in Mexican patients. Patients with intestinal-type GA tended to present a higher frequency of NOTCH1 mutations, copy number gains in cytobands 13.14, 10q23.33, and 12q25.1, and copy number losses in cytobands 7p12, 14q24.2, and 11q13.1; whereas patients with diffuse-type GA tended to present a high frequency of CDH1 mutations and CNV gains in cytobands 20q13.33 and 22q11.21. This is the first description of a mutational landscape of GA in Mexican patients to better understand tumorigenesis in Hispanic patients and lay the groundwork for discovering potential biomarkers and therapeutic targets.

Epigenetic Reprogramming Leads to Downregulation of CD4 and Functional Changes in African Green Monkey Memory CD4+ T Cells.

African green monkeys (AGMs), Chlorocebus pygerythrus, are a natural host for a lentivirus related to HIV, SIV. SIV-infected AGMs rarely progress to AIDS despite robust viral replication. Though multiple mechanisms are involved, a primary component is the animals' ability to downregulate CD4 expression on mature CD4+ Th cells, rendering these cells resistant to infection by SIV. These CD8αα+ T cells retain functional characteristics of CD4+ Th cells while simultaneously acquiring abilities of cytotoxic CD8αβ+ T cells. To determine mechanisms underlying functional differences between T cell subsets in AGMs, chromatin accessibility in purified populations was determined by assay for transposase-accessible chromatin sequencing. Differences in chromatin accessibility alone were sufficient to cluster cells by subtype, and accessibility at the CD4 locus reflected changes in CD4 expression. DNA methylation at the CD4 locus also correlated with inaccessible chromatin. By associating accessible regions with nearby genes, gene expression was found to correlate with accessibility changes. T cell and immune system activation pathways were identified when comparing regions that changed accessibility from CD4+ T cells to CD8αα+ T cells. Different transcription factor binding sites are revealed as chromatin accessibility changes, and these differences may elicit downstream changes in differentiation. This comprehensive description of the epigenetic landscape of AGM T cells identified genes and pathways that could have translational value in therapeutic approaches recapitulating the protective effects CD4 downregulation.

Long-Term Landscape Dynamics to Assess Land Degradation Hypotheses—An Exploratory Study of Evidence from Travelers’ Narrations

The present study aims to provide a method for extending the scope of empirical landscape studies into the more distant past and to use it to contribute to the discourse on land degradation in the Mediterranean area. In many areas of the world, the lack of spatially explicit sources, such as historical land cover maps and cadasters, is an obstacle to extending the study of landscape dynamics in the past. Information mined from travelers’ texts can be used to overcome it. Landscape descriptions retrieved from W.M. Leake’s narration of his travels in Peloponnese, Greece, in 1805 and 1806, were georeferenced and used to test for the occurrence of land degradation by comparing historical to current landscapes. A widespread transition of natural vegetation to agricultural areas was found mostly in low altitudes. Limited rewilding occurred on steeper slopes. About a third of the historical Greek fir forests were degraded to open stands. A total of 40% of the locations covered by deciduous oak forests were converted to agricultural areas; most of the rest of these locations were converted to vegetation types characteristic of lower precipitation and soil fertility. Long-term dynamics can be efficiently assessed using narrations as a source of information. The comparison of early 19th century descriptions with the current condition suggests that limited land degradation did take place in the previous centuries in the study area.

Identifying Terrestrial Landscape Character Types in China

Landscape character assessment (LCA) is a widely used tool that integrates natural, cultural, and perceptual attributes to identify and portray landscape. In this study, we used the LCA method to identify the landscape characteristics of China at the national scale. Furthermore, we applied cultural and landscape structural factors along with spatial transmission to improve the identification system. First, we incorporated all the parameters in the assessment. We selected 15 landscape character factors from four factor types including nature, culture, spatial geographic co-ordinates, and landscape structure. These parameters were analysed using multilevel overlay and spatial connection tools in ArcGis 10.2, which resulted in 2307 landscape description units (LDUs). Second, the spatial structure properties of the LDUs were determined using a semivariogram and the moving window method in ArcGis 10.2 and Fragstats 4.2 software, respectively. Third, for visualisation, we applied the principal component analysis (PCA) using the SPSS software and elbow and k-means clustering methods using MATLAB to determine 110 landscape character types (LCTs) of China’s entire terrestrial landscape. Finally, we determined 1483 landscape character areas through semiautomatic segmentation and manual visual correction using eCognition. Based on the unique characteristics of the entire terrestrial landscape of China, a set of ideas and methods for the overall identification of LCTs was proposed. Our findings can be used to optimise territorial spatial planning and landscape protection and management, and promote multiscale land-use studies in China.

The Uprooting in the Narrative Language of Foreign Land by Jonathan Raban

The language and narrative style of Jonathan Raban, a contemporary English writer author of the novel Foreign Land (1985), seem to find in the themes of uprooting and self-searching a metaphorical and existential interpretation that in the search for identity alternates the desire to return to the origins, recovering lost affections and beloved places, with the attraction to the unknown. In this oscillation, masterfully rendered by the metaphorical and figurative language of the novel, Raban tells the awareness that the return to the origins is not always a point of arrival but a further turning point in life. The article focuses on some particularly effective linguistic and semantic aspects through which the author renews and personalizes the travel novel, making it an existential, intimate tale in which the sense of estrangement and the desire to take root are intertwined with a compelling story rich in landscape descriptions and philosophical reflections.

A Secret Princess by Margaret Stohl

Reviewed by: A Secret Princess by Margaret Stohl Danica Ronquillo Stohl, Margaret A Secret Princess; by Margaret Stohl and Melissa de la Cruz. Putnam, 2022 [400p] Trade ed. ISBN 9781984812049 $18.99 E-book ed. ISBN 9781984812056 $10.99 Reviewed from digital galleys R Gr 7-10 Fifteen-year-old Mary Lennox from India attends the Select Seminary for Young Ladies and Gentlemen, a boarding school in Manchester, England, where children [End Page 366] are under the reign of the strict headmistress Minerva Minchin. Adventurous and full of wit, Mary is not afraid to speak her mind as she witnesses the injustices at the school, especially Minchin's cruel treatment towards Mary's first ever friend Sara Crewe, known as a bright little princess from the Philippines. Minchin takes away all of Sara's possessions and forces her to become a servant to pay for her school debt, while Mary's troublemaking earns her a transfer to America where her uncle lives. Not willing to be separated, Mary, Sara, and Cedric Errol, a disabled and mysterious boy who they befriended at the school, run away to Paris but end up getting sidetracked to discover a secret garden that will change their lives forever. This is a charming mash-up of Frances Hodgson Burnett's beloved classics A Secret Garden, A Little Princess, and Little Lord Fauntleroy, and all three protagonists benefit from one another's differences. The lavish descriptions of wealthy countryside landscapes and estates contrast with the accurately dreary portrayal of the 1860s, which doesn't shy away from the realities of wartime poverty and child labor. Emotionally-driven dialogue, repetition, and sophisticated language will keep readers, especially fans of Burnett's work, turning pages to see just how these distinct characters can define their futures. Copyright © 2022 The Board of Trustees of the University of Illinois

DISTRIBUTION AND MIGRATION OF CHEMICAL ELEMENTS IN THE MINOR RIVER BASINS IN THE WEST OF THE SMOLENSK-MOSCOW UPLAND AS AN INDICATOR FOR ASSESSING LANDSCAPE STABILITY

Hydrological objects link the landscape into connected basins of the paragenetic system through energy and matter migration. It determines the relevance of geochemical monitoring of minor river basins as a condition for designing an effective ecological framework for the territory. We tried to identify regularities of the spatial distribution and migration of chemical elements in the basins of minor rivers in the west of the Smolensk-Moscow Upland. The method of cross-spectrum geochemical analysis helped us to study the river basins of the Vop-Dnieper hydrological region. We compiled 47 complex landscape descriptions. Thus, the maximum calcium and movable magnesium cations values are determined in the super-aqual landscapes of the river basins under study. In the minor river valleys, we find outwash of organic compounds from the outer layers of the geochemical landscape. The research determines the maximum values of the studied elements in the soils of super-aqual landscapes through migration with subsurface and surface run-off. The minimum values are in the eluvial landscape, where there is a partial loss of geochemically movable forms of metals, which increases due to acid and weak-acid reactions of the environment. Partial outwash of metals, in particular copper and zinc, happens to organic compounds of soils. Trans-eluvial landscape loses trace elements. However, some of them are retained due to falling out of solutions and suspensions. Calculations have shown that copper (conjugation coefficient is 2–3) and zinc (conjugation coefficient is approximately 2) are most actively involved in the migration. In contrast, manganese is less active. The research results present an assessment of the features related to the landscape-geochemical differentiation of the territory of the west of the Smolensk-Moscow Upland from the upper areas of watersheds to the lower elements of landscape-geochemical catenae, including simple drainage basins of minor rivers. The research shows that the active migration of chemical elements characterizes the minor river basins. They are indicators of the geochemical state of the landscape. One can use the research results to assess a landscape-ecological condition, improve an environmental management system, and optimize the natural environment.

“A New and More Vigorous Growth”: Resilience and Southern Ecologies in Antebellum Literature

In the nineteenth century, descriptions of bleak southern landscapes were routine in abolitionist and antislavery writing, linking withered crops and the South’s soil crisis to the region’s moral and agroeconomic collapse.1 As Harriet Beecher Stowe’s description of Simon Legree’s plantation in Uncle Tom’s Cabin (1852) depicts, this decline was sometimes connoted through other kinds of environmental imagery: the voids of pine-barrens, swamps, and other places whose soil quality and terrain made agriculture difficult, if not impossible. In an era of Southern boosterism by western investors and proto-secessionists, abolitionists and antislavery activists invoked a wide variety of outwardly impoverished, wilted landscapes; from Tidewater plantation to Mississippi Valley swamp, these settings were supposed to represent slavery’s many evils and the institution’s fated end.2 Located in Red River country in Louisiana, Legree’s estate seemingly reaffirms such familiar deterministic portrayals of the South: The landscape is “broken,” “shattered,” and “rotting,” and his house, once well-tended, is in “utter decay,” next to a garden “all grown over with weeds” (290, 292). Nearly every aspect of the plantation is affected by slavery’s rot. But as much as Legree’s plantation typifies the corrosive effects of “the peculiar institution,” just as significant are the things that seemingly flourish despite—and sometimes because of—such decay. What was once a smooth-shaven lawn before the house, dotted here and there with ornamental shrubs, was now covered with frowsy tangled grass, with horse-posts set up, here and there, in it, where the turf was stamped away, and the ground littered with broken pails, cobs of corn, and other slovenly remains. Here and there, a mildewed jessamine or honeysuckle hung raggedly from some ornamental support, which had been pushed to one side by being used as a horse-post. What once was a large garden was now all grown over with weeds, through which, here and there, some solitary exotic reared its forsaken head. (292)

The EHA Research Roadmap: Malignant Lymphoid Diseases.

The EHA Research Roadmap: Malignant Lymphoid Diseases.

Kinetics of Hawking-Page phase transition with the non-Markovian effects

Based on the free energy landscape description of Hawking-Page phase transition, the transition process from the Schwarzschild-anti-de Sitter black hole to the thermal anti-de Sitter space are considered to be stochastic under the thermal fluctuations. If the correlation time of the effective thermal bath is comparable or even longer than the oscillating time of the spacetime state in the potential well on the free energy landscape, the non-Markovian model of the black hole phase transition is required to study the kinetics of the transition processes. The non-Markovian or memory effect is represented by the time dependent friction kernel and the kinetics is then governed by the generalized Langevin equation complemented by the free energy potential. As the concrete examples, we study the effects of the exponentially decay friction kernel and the oscillatory friction kernel on the kinetics of Hawking-Page phase transition. For the exponentially decayed friction, the non-Markovian effects promote the transition process, and for the oscillatory friction, increasing the oscillating frequency also speeds up the transition process.

Combining High-Pressure NMR and Geometrical Sampling to Obtain a Full Topological Description of Protein Folding Landscapes: Application to the Folding of Two MAX Effectors from Magnaporthe oryzae.

Despite advances in experimental and computational methods, the mechanisms by which an unstructured polypeptide chain regains its unique three-dimensional structure remains one of the main puzzling questions in biology. Single-molecule techniques, ultra-fast perturbation and detection approaches and improvement in all-atom and coarse-grained simulation methods have greatly deepened our understanding of protein folding and the effects of environmental factors on folding landscape. However, a major challenge remains the detailed characterization of the protein folding landscape. Here, we used high hydrostatic pressure 2D NMR spectroscopy to obtain high-resolution experimental structural information in a site-specific manner across the polypeptide sequence and along the folding reaction coordinate. We used this residue-specific information to constrain Cyana3 calculations, in order to obtain a topological description of the entire folding landscape. This approach was used to describe the conformers populating the folding landscape of two small globular proteins, AVR-Pia and AVR-Pib, that belong to the structurally conserved but sequence-unrelated MAX effectors superfamily. Comparing the two folding landscapes, we found that, in spite of their divergent sequences, the folding pathway of these two proteins involves a similar, inescapable, folding intermediate, even if, statistically, the routes used are different.

Stakeholder analysis and landscape in a hospital project – elements and implications for value creation

PurposeThis study primarily aims to analyse stakeholder management challenges and how these emerge in the stakeholder landscape in a large hospital project. From this analysis, the authors aim to identify the implications that stakeholder management has on value creation in a hospital project.Design/methodology/approachThe research method is qualitative. Empirical data were collected in three cycles: project internal documentation, thematic interviews and survey. The literature related to hospital projects, stakeholder analysis and management, stakeholder salience and landscape is summarised, informing the qualitative design of the study.FindingsThe authors noted the importance of project-specific stakeholder identification, salience analysis and landscape description. The regulatory, formal and contractual stakeholders give an over-simplistic picture on stakeholder map. The operative stakeholder map and landscape describe the complexity, uncertainty, dynamism and institutional context inducing the challenges for the stakeholder management. There is an evident potential of utilising the stakeholder landscape and its elements in the resulting collaborative value creation in hospital projects. Multiple and changing stakeholders with differing expectations are an important opportunity to improve the value creation process.Originality/valueStakeholder management has recently attracted much attention in the industrial project setting. This research attempts to identify the operative stakeholder landscape in a large hospital project, not to mention its impact on value creation. This study offers a framework that can help academics and project management practitioners tackle the challenges amongst project stakeholders.

SOME LINGUOSTYLISTIC ASPECTS OF LANDSCAPE DESCRIPTIONS IN THE NOVEL “THE GREAT GATSBY” BY F. S. FITZGERALD

The main objectives of this study are some Linguostylistic aspects of landscape descriptions in F. S. Fitzgerald’s novel “The Great Gatsby”. Landscape descriptions here are considered as essential components of a literary work. They are not a were representation of nature but one of the means of a personage’s characterization. There is a certain approach in text linguistics regarding verbal landscape as a specific text creation with its own structure and semantics.
 Landscape description is a picture, a background of the events in the novel “The Great Gatsby” as well as a psychological reflection of its characters’ inner state. Landscape description is very often polyfunctional in the novel. One of its main functions is the function of place and time. Some descriptions are used in the function of prediction. A lot of landscape descriptions are full of visual and sound associations which correspond to the characters’ mood revealing a certain psychological parallelism and representing their psychological function. Specific features and functions of the descriptions under consideration are connected with the type of narration as everything in the novel is given through the eyes of the narrator – Nick Caraway. They say that this pact symbolizes the power of circumstances, environment which suppress an individual. Any description in the novel is able to fulfill several functions at a time. Its functions and rich imagery help us penetrate into the inner world of the inner world of the main character of the novel.

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.

Histone methylation-modifiers, such as EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated whole genome and transcriptome data of 186 mature B-cell lymphomas sequenced in the ICGC MMML-Seq project. Besides confirming common alterations of KMT2D (47% of cases), EZH2 (17%), SETD1B (5%), PRDM9 (4%), KMT2C (4%), and SETD2 (4%), also identified by prior exome or RNA-sequencing studies, we here found recurrent alterations to KDM4C in chromosome 9p24, encoding a histone demethylase. Focal structural variation was the main mechanism of KDM4C alterations, and was independent from 9p24 amplification. We also identified KDM4C alterations in lymphoma cell lines including a focal homozygous deletion in a classical Hodgkin lymphoma cell line. By integrating RNA-sequencing and genome sequencing data we predict that KDM4C structural variants result in loss-offunction. By functional reconstitution studies in cell lines, we provide evidence that KDM4C can act as a tumor suppressor. Thus, we show that identification of structural variants in whole genome sequencing data adds to the comprehensive description of the mutational landscape of lymphomas and, moreover, establish KDM4C as a putative tumor suppressive gene recurrently altered in subsets of B-cell derived lymphomas.