Description Of Symptoms Research Articles

Dante's cardiology

Untethered from the more common literary metaphor that sees it as the traditional seat of feelings, what is the image of the heart that Dante's literature delivers to us? And is there an evolution in that image, or does the heart remain the same throughout Dante's poetry? Looking back over the works written by Dante Alighieri in the course of his literary career, we can discover that the heart is a central organ in all his poetry and also in his long and bumpy path to salvation, from hell to heaven; and that this path could also be understood as a path to healing, in which there is no lack of descriptions of symptoms, medicines and doctors to whom we can entrust our health.

The Outpatient Approach to Dizziness

The evaluation of the dizzy patient is complicated by many common pitfalls. The patient's description of symptoms and the standard neurologic examination are often nonspecific or unrevealing, and neuroimaging is most often normal. Over the past several years, research has demonstrated that a refocusing of history taking results in more reliable and diagnostically helpful information. This can guide a targeted expansion of the exam, often with an emphasis on eye movements.

Influence of Internet Language Violence on Young Students' Mental Health and Intervention Countermeasures.

With the development of the Internet, it has increasingly become an indispensable product in people's lives, but many problems have arisen with it. Internet language violence is one of them. At present, the main Internet users in my country are young people, and online language violence brings extremely serious psychological problems to young students. In order to understand the current mental health of young students and the impact of online language violence on them, this article investigates the students in the city's no. 1 middle school, filters the data through decision tree analysis, and judges online language through the psychological symptoms self-rating scale. The mental health symptom self-rating scale has the characteristics of large capacity, abundant symptoms, and more accurate description of the subject's conscious symptoms. It contains a wide range of psychiatric symptoms, from feelings, emotions, thinking, consciousness, and behavior to life habits, interpersonal relationships, eating, and sleeping, and it uses 10 factors to reflect the psychological symptoms in 10 aspects. It has good distinguishing ability for people with psychological symptoms (that is, they may be on the edge of psychological disorder or mental disorder). The chi-square statistical method is used to analyze the basic characteristics of different youth groups of verbal violence. For the research content, the school surveys all schools and adopts questionnaire surveys and case studies to analyze the factors that influence youths' attribution of online violence behaviors and make recommendations. The impact of violence on young students will be analyzed later through psychological intervention. The results of the study found that online language violence caused serious harm to young people's psychology and caused students' depression, anxiety, and other mental illnesses. Active psychological interventions can effectively alleviate students' mental health. The improvement of students' mental health is the most obvious. The score improved by nearly 10%.

A novel event-related fMRI supervoxels-based representation and its application to schizophrenia diagnosis

Background and Objective: The schizophrenia diagnosis represents a difficult task because of the confusing descriptions of symptoms given by the patient, their similarity among several disorders, the lower familiarity with genetic predisposition, and the probably inadequate response to the treatment. Neuro-biological markers of schizophrenia, as a quantitative relationship between the psychiatrist’s reports and the biology of the brain, could be used. Functional Magnetic Resonance Imaging (fMRI) obtain the subject’s performance in cognitive tasks and may find significant differences between the patient’s data and controls. The input data of classifiers may imply alterations in diagnosis; therefore, it is essential to ensure an adequate representation to describe the entire dataset classified.Methods: We propose a supervoxels-based representation calculated by two main steps: the short-range connectivity, supervoxels’ generation using a Fuzzy Iterative Clustering algorithm, and the long-range connectivity, employing Detrended Cross-Correlation Analysis among supervoxels. The unrelated supervoxels, through a statistical test based on critical points calculated empirically, are removed. The remainder supervoxels are the input for feature selectors to extract the discriminative supervoxels. We implement support vector machine classifiers using the correlation coefficient of the significant supervoxels. The dataset of 1.5 Tesla was downloaded from the SchizConnect site, where the fMRI data, during an auditory oddball task, was acquired. We calculate the performance of the classifiers using a leave-one-out cross-validation and compute the area under the Receiver Operating Characteristic curve and a permutation test to ensure no bias in the classifiers.Results: According to the permutation test, with p-values less than the significance level of 0.05, the classifiers extract discriminative class structure from data where no bias is shown. Our supervoxels-based representation gets the maximum values of sensitivity, specificity, and accuracy of 92.9%, 100%, and 96.4%, respectively. The discriminative brain regions, to discern among patients and controls, are extracted; these regions also are mentioned by the related works.Conclusions: The proposed representation, based on supervoxels, is a data-driven model that does not use predefined models of the signal nor pre-relocated brain regions of interest. The results are competitive against the related works, and the relevant supervoxels are related to the schizophrenia diagnosis.

Definition of pelvic venous disease and the new SVP classification

Chronic pelvic pain (CPP) is often diagnosed by gynecologists. In recent years, the realization that venous insufficiency in the pelvic or retroperitoneal area can also cause CPP has led to the involvement of vascular physicians in the diagnosis and treatment. Differentiating pelvic venous disease (PeVD) from gynecological, internal or even orthopedic complaints poses a challenge. A comprehensive study of the patient"s medical history and a detailed description of symptoms are of paramount importance. The symptoms of PeVD depend on the veins involved. Whereas pelvic pain is mainly an expression of an insufficiency of the ovarian vein and/or the internal iliac vein, left flank pain and hematuria are caused by an obstruction of the renal vein. Symptoms may also be associated with atypical varicose veins in the vulva, perineum, or legs. Anatomical gaps, pelvic escape points, allow them to communicate with the branches of the insufficient internal iliac veins and with the ovarian. As an effective tool for reporting PeVD patient populations the symptoms-varicespathophysiology (SVP) classification was published in 2021. It is thought to be the initial point of both the treatment standard and identifying homogenous patient populations for clinical trials.

The real-world applications of the symptom tracking functionality available to menstrual health tracking apps.

Purpose of reviewThe goal of this review was to evaluate whether the fields available in iOS mobile phone apps for recording menstrual cycle symptoms are able to be harmonized across platforms for potential use in research, such as aggregated data analysis.Recent findingsSymptom tracking capabilities are a common feature among menstrual health apps but have been the subject of limited investigations. Apps differ with respect to which symptoms are included and the rationale for these differences is unclear. Epidemiologic studies are poised to incorporate these data; however, a thorough exploration of symptom tracking functionality across apps is required.SummaryOur review finds that the language used to describe symptoms and the specificity with which symptoms are collected varies greatly across the most used iOS tracking apps. Although some apps allow numerical and qualitative description of symptoms, such as sleep and mood, most simply record the presence or absence of a symptom. Collaborative efforts between clinicians and researchers to guide what and how data is collected may allow tracking apps to realize their potential diagnostic applicability. Regardless, with the increasing use of menstrual health tracking apps, it is imperative that data retrieved from such apps can realize its potential in the research and clinical ecosystems.

Description of Epidemiological Features, Symptoms and Mortality of the Patients with COVID-19 in Some Provinces of Iran.

Clinical manifestations of COVID-19 are different. There are some risk factors for COVID-19. This study aimed to describe the epidemiological features, symptoms and mortality of the patients with COVID-19 in Iran. This were a cohort study performed on 103,179 patients with COVID-19. The demographic and clinical data were collected in selected provinces. The required data of all patients was extracted from the COVID registry system and analyzed using STATA version 14 and Excel 2016. The mean age was 52.40 years for men and 52.41 years for women. About 55.2% of the study population were male and 44.8% were female. Totally, 60.9% (5085) of deaths happened in men and 39.1% (3263) in women. The mean time from onset of symptoms to hospitalization in men and women were 3.47 and 3.48 days, respectively. The mean time from onset of symptoms to isolation was 2.81 days in men and was 2.87 days in women, from onset of symptoms to death was 9.29 and 9.54 days, respectively, from onset of symptoms to discharge was 7.47 and 7.39 days, and from hospitalization to death was 6.76 and 7.05 days. Cough and shortness of breath were the most common symptoms in the patients. According to the results, the overall mortality rate was higher in men than women. Women with cardiovascular disease and diabetes were more likely to die. The mean time from onset of symptoms to hospitalization, isolation, and discharge was similar in men and women.

Hospice and palliative care clinicians’ perceptions of posttraumatic stress disorder at end-of-life in military veterans

At the end of life, individuals may re-engage with earlier life trauma as they reflect on life experiences and confront their mortality. As such, posttraumatic stress disorder (PTSD) symptoms at the end of life may worsen the quality of death experience. This is a concern for military veterans, who tend to have more trauma exposures and higher rates of PTSD, and particularly for veterans receiving care in rural areas where access to PTSD specialty services is limited. To better understand this issue, we conducted 10 focus groups with clinicians serving veterans in rural communities across five U.S. states. The aims of this project were to evaluate: (1) do hospice and palliative care providers/staff observe PTSD symptoms in veterans at the end of life? (2) if so, how are symptoms similar to and different from existing DSM-5 criteria for PTSD? We used qualitative content analysis with mixed deductive and inductive approaches to code 151 anonymized statements. Analyses found descriptions of PTSD symptoms aligned broadly with existing diagnostic nomenclature, but descriptions revealed specific presentations relevant to the end of life setting such as resistance to care, agitation, restlessness, and effects of delirium. In addition, some veterans expressed pride in service and openness to discussing military experiences. Further, clinicians noted that PTSD symptoms were relevant to family dynamics. Future research should further characterize these symptom differences through direct patient assessment and develop resources to improve quality of death experience for veterans with PTSD symptoms.

Паразитарні хвороби сигових риб (Coregoninae) (огляд)

Purpose: To analyze the specialized literature and summarize the information on the main parasitic diseases of whitefish. Findings: Whitefish are members of the Salmoniformes, which are currently represented by 3 subgroups (Salmonidae, Coregonidae, Thymallidae). Whitefishes are widespread species of fish in the subarctic and boreal zones of Europe, Asia and North America and are the most important components of the ecological system and valuable objects of local and industrial fishery. But these fishes are frequently affected by parasitic diseases. This article contains the description of most common parasitic diseases of whitefish and of the main causative agent, clinical signs of diseases, and the main preventive measures to prevent the occurrence of these diseases in whitefish culture. Aquaculture of whitefish creates a competitive food production for one or two fattening seasons with their delicacy gastronomic benefits and high economic profitability. Products of whitefish are popular on external markets that is also a good motivation for improvement of the biotechnological development for various methods of cultivation of these valuable fish. However, with increasing amounts of production, transporting fish from one farm to another and crowded stocks of fish result in problems with diseases of different etiology. The above material describes main parasitic diseases that occur in whitefish including their main symptoms, which will help to identify them in time. Practical value. Information on the main parasitic diseases of whitefish was systematized. Most of the parasitic diseases known to the whitefish are ectoparasitosis. These are ichthyobodosis (costosis), trichodinosis, chylodonelosis, ichthioftirioz, trichophthirioz and cruciformis. Proteocephalosis, acanthocephalosis, diplomystomosis are the most dangerous among helminths. The short characteristic of these diseases is described and the methods of prophylaxis of these diseases are suggested. The review can be useful both for scientists dealing with the problem of whitefish acclimatization on the territory of Ukraine and for fish breeders already engaged in the whitefish aquaculture in Ukraine and abroad. Descriptions of symptoms of diseases will be useful for preliminary diagnostics of diseases. Key words: whitefish, parasites, ectoparasites, helminthes, diseases, ichthyobodosis, trichodionosis, chylodonelosis, ichthioftirioz, trichophriosis, chloromycosis, ergazilosis, lerneosis, argulosis, roteocephalosis, mechinorinchosis, diplostomosis.

Experience of psychiatry distance teaching to english speaking international students

The article describes the difficulties of transition to distance learning (DL) at a medical university when students pass clinical disciplines, using the example of the subject of "psychiatry". The negative impact of the pandemic on international cooperation in the field of education and science was also noted, in particular, attracting foreign students to further education.
 Based on the above, the following tasks were set: to study the features of the transition to distance learning the subject of "psychiatry" at the Odessa National Medical University, to identify the features of distance work with English-speaking foreign students during their learning of this discipline and to present proposals for optimizing this process.
 During the transition to DL, a significant decrease in the quality of education was noticed during the absence of an existing learning management system, since this transition was a certain stress for all participants in the educational process, both students and teachers. Significant problems have arisen in the DL of clinical disciplines for English-speaking students. The greatest difficulty is the teaching of psychiatry, since it is difficult to explain to students in English not only the description of psychopathological symptoms and syndromes, but also the mental characteristics of people with other nationalities. It is proposed to use movies, with the main heroes suffering from mental disorders, as a thematic guide for mastering practical skills. Although some of the positive aspects of DL have been noted by medical students, they agree to DL only as a forced short-term measure.

Patients' Experiences in Transitioning to Secondary Progressive Multiple Sclerosis: Qualitative Interviews.

IntroductionCritical gaps exist in the understanding of the continuum of multiple sclerosis (MS) progression, particularly with regard to the patient experience prior to and during the transition from relapsing–remitting MS (RRMS) to secondary-progressive MS (SPMS) stages. To date, there are no clear diagnostic criteria in the determination of the clinical transition. We report here the use of patient experience data to support the development of a qualitative conceptual model of MS that describes the patient journey of transition from active-relapsing disease to progressive MS.MethodsThe study used a single-encounter, multicenter, qualitative observational study design that included a targeted literature review and individual, in-depth interviews with adult patients with a clinically confirmed diagnosis of SPMS and their adult care partners. Descriptions of symptoms and impacts of RRMS and SPMS were extracted from the literature review and used to support development of the interview guide and conceptual model.ResultsParticipants described a slow progression in terms of change in symptoms over time, including both the development of new symptoms and the worsening of existing symptoms.ConclusionsThe conceptual model of the transitionary period from RRMS to SPMS expands the current understanding of the progression of MS from the patient and care partner perspectives.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40120-021-00265-0.

Deep Cerebral Perforators: Anatomical Distribution and Clinical Symptoms: An Overview.

The anatomic distribution of the deep cerebral perforators is considered either a given or subject to enormous variability. Most published overviews on this topic only report findings from a limited number of anatomic dissections, and no attempt has been made to date to provide a comprehensive overview of all published data. A comprehensive literature search was performed on MEDLINE, Embase, and Google Scholar with the help of an information specialist. Three types of studies were included: (1) articles that described the anatomy and distribution territories of perforator groups arising from the arteries of the circle of Willis; (2) studies that evaluated the anatomy of the deep cerebral perforators using imaging techniques; and (3) studies that evaluated either microsurgically or radiologically confirmed perforator occlusion and reported the (magnetic resonance imaging-confirmed) distribution territory of the infarction together with a description of the clinical symptoms associated as a result of the infarction. A total of 2715 articles were screened and 53 were included. Of these, 40 dealt with the anatomic and imaging anatomy of perforator groups (37 reported results of dissections and 3 results of imaging studies), with a total of 2421 hemispheres investigated. Another 13 articles with 680 patients were included that evaluated perforator infarction territories. The deep cerebral perforator distribution shows large variability with poor concordance rates among reported studies, with the exception of the posterior communicating and anterior choroidal artery perforators. Despite the assumption that cerebral perforator anatomy is a given, studies show large variability in the anatomic distribution of various perforator groups. Perforator anatomy and relationships between perforator groups, as well as potential collateral circulation in these territories should be prioritized as a research topic in cerebrovascular disease in the near future.

Superior Semicircular Canal Dehiscence Syndrome Following Head Trauma: A Multi-institutional Review.

To evaluate patients who become symptomatic from superior semicircular canal dehiscence (SSCD) following head trauma. Case series assessing patients presenting with SSCD after a trauma. A case series was completed assessing patients presenting with SSCD after trauma. Data from three academic medical centers were evaluated, including the following: imaging, videonystagmography (VNG)/vestibular evoked myogenic potential (VEMP) testing, audiometric assessment, and surgical repair. Outcome measures included the following: 1) Description of audio-vestibular symptoms, 2) mean pre- and post-operative pure tone average (PTA), word recognition score (WRS), and air bone gap (ABG). A total of 14 patients were included; 86% were male. Approximately 43% were found to have bilateral SSCD on imaging, with 57% of patients pursuing surgical management. The most common presenting symptoms included pulsatile tinnitus (93%), autophony (79%), and hearing loss (64%). Approximately 36% of patients underwent VNG/VEMP testing, with 83.3% of those demonstrating abnormal results. The mean audiometric findings on the symptomatic side included an air-conduction PTA of 38.0 dB, bone-conduction PTA of 24.3 dB, WRS of 81%, and ABG of 17.9 dB. Among patients who underwent surgery (57%), there was no significant change in the air-conduction PTA, bone-conduction PTA, or WRS (P > .05). However, there was an improvement in the ABG (preoperative=22.8 dB versus postoperative=9.7 dB; P=.005). Head trauma may be a potentiating event for SSCD syndrome. This study advances the hypothesis that these patients likely have underlying radiographic SSCD prior to their trauma, and a traumatic event increases in intra-vestibular or intracranial pressures, unmasking SSCD syndrome. 4 Laryngoscope, 131:E2810-E2818, 2021.

Language analysis of spontaneous descriptions of restless legs syndrome: Gender differences?

SummaryPatients with restless legs syndrome (RLS) use various terms when describing their symptoms. Whether gender might influence this has not been investigated so far. The aim of this study was to evaluate possible gender differences in spontaneous descriptions of RLS symptoms. This prospective study, conducted in 100 consecutive German‐speaking RLS patients, used a single standardized question. Answers were digitally recorded and transcribed. A content‐related linguistic analysis of the transcripts was performed by two independent blinded raters. The lengths of the answers and content‐related linguistic features were compared between women and men. Ninety‐eight patients were included in the final analysis, 59 women (60.2%) and 39 men (39.8%), with a median age of 62 (23–94) and 63 (31–82) years, respectively (p = 0.602). Demographic and clinical features, including educational level and RLS treatment class, did not differ between genders (p > 0.05). Total word or sentence count showed no gender differences (p = 0.159 and 0.259, respectively), although men used more words per sentence than women (p = 0.018). More men than women described quiescegenic (i.e., triggered by rest or inactivity) symptoms (p = 0.006) and successful attempts at relief (p = 0.039). There was a non‐significant trend toward a more frequent use of the first‐person perspective in men (median times used = 5 [0–10.5] vs. 3.8 [0–17.5], p = 0.068). The more frequent mention of quiescegenic symptoms and successful attempts at relief in men could indicate differences in phenotypic presentation of RLS between genders, a more precise description of RLS symptoms or a higher experience of self‐efficacy in men compared to women.

Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017.

Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease.

Can telemedicine address neurologic health disparities in rural Guatemala: a health promotor educational intervention study.

The global burden of neurologic disease is high and its impact manifests in health disparities observed in rural communities of limited resources like those surrounding San Lucas Tolimán, Guatemala. Telehealth may be one method to close these gaps by offering a virtual neurology curriculum. The goal of this project was to determine the pervasiveness of neurologic disease in San Lucas Tolimán and to increase interest and knowledge in neurology topics for local health promotors. A neurologic needs assessment was performed during the initial site visit. This information was subsequently used to create monthly health promotor neurology-based workshops and remote consultations delivered via a telehealth platform over the following year. The 29 health promotors were surveyed before and after the neurology course to measure self-reported knowledge of variable topics as well as their interest in neurology and how effective the remote lectures were. The needs assessment identified at least 68 different patients with neurologic diseases, the most common being headaches and seizures. The health promotors' knowledge of several neurologic diseases as well as their comfort level diagnosing a condition based on a description of neurologic symptoms significantly increased following the year-long neurology course. The lectures were convenient, easy to see and hear virtually, and increased the health promotors' interest in neurology. Telehealth is an acceptable and feasible method of delivering educational neurology topics relevant to rural communities. Future, longer-term studies are needed to determine if telehealth interventions such as these impact neurologic patient outcomes.

Gluten-induced Neurocognitive Impairment: Results of a Nationwide Study.

Goals:This study aimed to understand the neurocognitive symptoms associated with gluten exposure in individuals with self-reported celiac disease (CD) and nonceliac gluten sensitivity (NCGS).Background:While gluten-induced neurocognitive impairment (GINI; eg, “celiac fog” or “brain fog”) is commonly described by individuals with CD and NCGS, there are little data regarding the prevalence and symptoms associated with these experiences.Study:A 9-question online survey was accessed by 1396 individuals (1143 with CD; 253 with NCGS). Forced choice and free-response questions were asked of participants to obtain a description of neurocognitive symptoms experienced after gluten ingestion. Free-response answers were coded using a coding structure developed based on the Health-Related Quality of Life Instrument.Results:The majority of survey participants (89% of CD and 95% of NCGS) reported having GINI symptoms. When describing symptoms, the most common word descriptors for both groups were difficulty concentrating, forgetfulness, and grogginess. Timing of symptoms, including onset and symptom peak, were similar across the 2 groups. Coding of free responses found the most common references were to cognitive, physical, psychological, and overall quality of life impacts.Conclusions:This survey suggests that GINI is common and may be severe in both individuals with CD and NCGS. Cognitive impairment and decline in physical functioning may be similar to that occurring in other illnesses, such as lupus. Clinical follow-up with both individuals with CD and NCGS should include assessment of GINI symptoms. Further research is warranted, including the development of a patient-reported outcome measure including neurocognitive effects of gluten exposure.

Icterohemorrhagic Leptospirosis in Infant: Clinical Case

Background. The importance of timely leptospirosis diagnosis and treatment has increased due to sporadic children morbidity. It is crucial in order to prevent the complications and adverse outcomes development.Clinical Case Description. The data from literature and our own clinical observation of leptospirosis with benign outcome in infant (with kidney damage, purulent meningitis, hemorrhagic syndrome and congenital heart disorder) is presented.Conclusion. The description of leptospirosis symptoms and course in the child is presented in the form of analysis of the clinical setting for further medical education, including differential diagnostics with viral hepatitis.

A LITERARY REVIEW OF VAATASTHEELA MOOTRAGHATA AND ITS MANAGEMENT W.S.R BPH

Acharya Sushruta, known as the father of ancient surgery, has given immense contribution in the field of surgery. One of the biggest contributions by Acharya Sushruta comes in the form of urological disorders mentioned by him in his classical text, Sushruta Samhita. He has contributed separate chapters describing the ailments of uri- nary system. These are mentioned under the chapters related to Mootrakricha (dysuria), Mootraghata (urinary retention) and Ashmari (Renal stone). The description of urinary retention-based symptoms is dealt in the chapter of Mootraghata. The diseases Mootraghata and Mootrakricha both are related to Mootravaha Srotas (channels of urinary system) but in Mootraghata, there is obstruction/retention of urine while in Mootrakricha there is exces- sive pain during urination. Both of these diseases are mentioned in Uttar Tantra in Sushruta Samhita. Moot- raghata can be compared with group of obstructive urinary disorders. It includes twelve subtypes, among them is Vaatastheela. Due to the anatomical mal-alignment and physiological disturbances it causes, it seems quite simi- lar to BPH. BPH is a non -malignant enlargement of the prostate gland in elderly males. It is commonly found in age group above 50. About half of the men in their fifties and about 90% men above the age of 80 suffer from this disease. Peak incidence is 60-70 age group. BPH has a multi-factorial pathogenesis caused by involvement of prostate and bladder as well as disturbance in Hypothalamus-pituitary-gonad Axis. Keywords: Mootraghata, Vaatastheela, BPH

Using patients\u2019 own knowledge of early sensations and symptoms to develop an interactive, individualized e-questionnaire to facilitate early diagnosis of lung cancer

BackgroundOne reason for the often late diagnosis of lung cancer (LC) may be that potentially-indicative sensations and symptoms are often diffuse, and may not be considered serious or urgent, making their interpretation complicated. However, with only a few exceptions, efforts to use people’s own in-depth knowledge about prodromal bodily experiences has been a missing link in efforts to facilitate early LC diagnosis. In this study, we describe and discuss facilitators and challenges in our process of developing and initial testing an interactive, self-completion e-questionnaire based on patient descriptions of experienced prodromal sensations and symptoms, to support early identification of lung cancer (LC).MethodsE-questionnaire items were derived from in-depth, detailed explorative interviews with individuals undergoing investigation for suspected LC. The descriptors of sensations/symptoms and the background items obtained were the basis for developing an interactive, individualized instrument, PEX-LC, which was refined for usability through think-aloud and other interviews with patients, members of the public, and clinical staff.ResultsMajor challenges in the process of developing PEX-LC related to collaboration among many actors, and design/user interface problems including technical issues. Most problems identified through the think-aloud interviews related to design/user interface problems and technical issues rather than content, for example we re-ordered questions to be in line with patients’ chronological, rather than retrospective, descriptions of their experiences. PEX-LC was developed into a final e-questionnaire on a touch-screen smart tablet with one background module covering sociodemographic characteristics, 10 interactive, individualized modules covering early sensations and symptoms, and a 12th assessing current symptoms.ConclusionsClose collaboration with patients throughout the process was intrinsic for developing PEX-LC. Similarly, we recognized the extent to which clinicians and technical experts were also important in this process. Similar endeavors should assure all necessary competence is included in the core research team, to facilitate timely progress. Our experiences developing PEX-LC combined with new empirical research suggest that this individualized, interactive e-questionnaire, developed through systematizing patients’ own formulations of their prodromal symptom experiences, is both feasible for use and has potential value in the intended group.