Description Of Profile Research Articles

Anthropogenic Impact on Soils of Cities Irkutsk, Angarsk

The morphological field description of soil profiles of the territory of Irkutsk region was carried out. Samples of soils, soil-forming rocks and vegetation were taken for further physical and chemical analyses to determine soil properties in the studied areas. Sample preparation of soils was carried out, phytotoxicity of soils was analyzed. Processing of the obtained data was carried out, as a result of which the percentage of germination of radish seeds in the upper horizons of soils of the key areas of Irkutsk and Angarsk cities was revealed, the length of shoots and the length of roots in the soils of the studied samples were measured, the index of soil toxicity was calculated.

Cardiovascular Imaging in the Era of Precision Medicine: Insights from Advanced Technologies - A Narrative Review.

Cardiovascular diseases are responsible for a high mortality rate globally. Precision medicine has emerged as an essential tool for improving cardiovascular disease outcomes. In this context, using advanced imaging exams is fundamental in cardiovascular precision medicine, enabling more accurate diagnoses and customized treatments. This review aims to provide a concise review on how advanced cardiovascular imaging supports precision medicine, highlighting its benefits, challenges, and future directions. A literature review was carried out using the Pubmed and Google Scholar databases, using search strategies that combined terms such as precision medicine, cardiovascular diseases, and imaging tests. More advanced analysis aimed at diagnosing and describing cardiovascular diseases in greater detail is made possible by tests such as cardiac computed tomography, cardiac magnetic resonance imaging, and cardiac positron emission tomography. In addition, the aggregation of imaging data with other omics data allows for more personalized treatment and a better description of patient profiles. The use of advanced imaging tests is essential in cardiovascular precision medicine. Although there are still technical and ethical obstacles, it is essential that there is collaboration between health professionals, as well as investments in technology and education to better disseminate cardiovascular precision medicine and consequently promote improved patient outcomes.

Characterization and monitoring of changes during lactation in the profile of multiple bioactive compounds of milk from grazing mares.

Mare milk has often been considered a food product with potential functional properties. However, the bioactive compound composition of mare milk, including vitamins and other minor bioactive compounds, as well as factors affecting this composition have scarcely been studied. Therefore, the present study aimed to characterize the changes during lactation in the content of water- and fat-soluble vitamins and total polyphenols, and the total antioxidant capacity of mare milk from semi-extensive farms. A total of 310 individual milk samples from 18 mares belonging to three commercial farms and 12 lactation times were analyzed. Ascorbic acid (vitamin C), thiamine (vitamin B1), riboflavin (vitamin B2), nicotinic acid and niacinamide (vitamins B3), pantothenic acid (vitamin B5), pyridoxal and pyridoxine (vitamins B6), folic acid (vitamin B9), cyanocobalamin (vitamin B12), tocopherols and tocotrienols (vitamin E) and retinol and retinyl esters (vitamin A) were quantified using liquid chromatography. Total polyphenols and antioxidant capacity assays were analyzed using spectrophotometry. The concentration of most bioactive compounds tended to decline as lactation progressed, with the exception of polyphenols and the total antioxidant capacity that oscillated during lactation. On the other hand, the effect of the different semi-extensive management of the farms was only significant for vitamin B3 content. To the best of our knowledge, the present study provides the most in-depth description of the vitamin profile of mare milk as well as new insights into polyphenol content and antioxidant capacity of mare milk. © 2024 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

¬¬The socio-economic profile of hikers in the mountains of Valencia Region, Spain: a comparative study between the perceptions of hikers' accommodation entrepreneurs and the hikers’ profile

The main objective of this study is to compare the perceptions of the socioeconomic profile that tourism operators have about their hikers/visitors with the socioeconomic profile of hiking users in the mountains of Valencia region (Spain). A mixed methodology has been used. First, 15 semi-structured interviews were conducted with entrepreneurs in the tourism industry. Secondly, 154 surveys were carried out with hikers to characterize their profile. Both samples were cross-checked to see the similarities and differences between the perceptions of both groups. The results indicate that changes in consumer trends, with the emergence of new market niches that are very interesting from a tourism point of view, such as the public new and very interesting market niches from a tourism point of view, such as women and senior female and senior public, as well as the local tourist or one-day hikers. These market segments represent an opportunity to consolidate an increasingly growing market.an increasingly growing market. The results indicate that there are some similarities between some of the demographic and economic variables studied. However, in other variables there is a misperception of practitioners by employers. This information can help to better target potential tourists. This study also provides a very detailed description of specific profiles of hikers. This information can be very useful both for private sports tourism companies to be able to segment their clients and launch very specific promotional strategies. Keywords: Sports Tourism; Tourism Industry Perceptions; Hikers Profile, Hiking, Spain

Development of an Untargeted Method for the Analysis of the Volatile Profile of Onions via Solid-Phase Microextraction Arrow-Headspace-Gas Chromatography-Mass Spectrometry Using Design of Experiments.

The distinctive aroma of onions, consisting primarily of sulfur-containing compounds, is one of the reasons for the popularity of the vegetable. The rapid enzymatic and chemical reactions that occur after the destruction of onion bulb tissue render the analysis of the volatile profile challenging. Therefore, sample preparation is a crucial step in the analysis of the onion volatilome, but it often does not receive the necessary attention in the literature. In this work, we focused on two aspects: Firstly, we compared different sample preparation approaches to maximize the volatile yield and to enable the description of the onion volatile profile as it would emerge after a solid-phase microextraction (SPME) Arrow sampling procedure. For headspace (HS)-gas chromatography-mass spectrometry analysis, onion juice with the addition of an ammonium sulfate solution proved to be the best option. Secondly, we optimized the HS sampling and desorption parameters (enrichment time, enrichment temperature, agitator speed, desorption time) for onion volatiles using the efficient design of experiments (DoE) approach. The optimal conditions for the analysis with HS-SPME Arrow were an enrichment time of 75min at 60°C with an agitator speed of 713rpm and a desorption time of 120s.

KAJIAN PROFIL RUJUKAN PADA KASUS PRE EKLAMSIA DI RSUD DATU SANGGUL RANTAU

One of the complications of pregnancy/delivery is pre-eclampsia/eclampsia. Objective is knowing the description of the referral profile in the case of pre-eclampsia at Datu Sanggul Rantau Hospital. Quantitative research was conducted in February 2023. The population was all pregnant, postpartum and postpartum women with pre-eclampsia cases from January 2021 - November 2022 totaling 122 cases. The total sampling technique was analyzed using univariate. The results of the study showed that the highest number of each characteristic was the origin of referrals, namely 84 people (69%), the highest number of referrals complete with officers and referral letters, namely 89 people (73%), the age of most respondents was in the risk category > 35 years 53 people (43%), the most gestational age was term term 83 people (68%), parity was primipara 53 people (43%), the stages of delivery in the mother during intrapartum were 76 people (62%), the classification of the diagnosis of pre eclampsia in cases of pre severe eclampsia, namely 86 people (70%) and the most pre-referral action was given pre-referral action, namely 82 people (67%). The conclusion is referral profile description consists of origin, of referral completeness of referral, age, gestational age, parity, diagnosis, and pre-referral measures.

Accuracy assessment of the geomorphon approach to detect ecological sites in the Dry Chaco region of Argentina

Ecological sites are a classification of local-land types based on differences in important environmental factors including soil properties, slope and landscape position within a geomorphologic and climatic zone. The concept is pivotal to conduct adaptative management in arid rangelands because it defines homogeneous areas over which specific soil-vegetation-disturbance dynamic occurs. Geomorphon is a computationally efficient method that uses Digital Elevation Models (DEMs) for the classification of landforms at multiple scales. The objective of this study was to evaluate the accuracy of the geomorphon approach to map ecological sites in a 11,259-ha study area within the Dry Chaco region of Argentina, utilizing local topographic positions along soil catena as a predictor of broader ecological sites classes. We used two DEM pixel resolutions (12.5 m and 30 m) and optimized the flatness threshold (t) and search radius (L) geomorphon parameters. As “ground truth” we used legacy data of 62 soil profiles descriptions. The geomorphon elements detected were reclassified into the three main ecological sites of the study area: highlands, midlands and lowlands. We used the overall disagreement (D) as the main metric for evaluating the accuracy of ecological site classifications. We found that: i) the lowest t value (0.05°) captured subtle topographical changes and thus more effectively reflected the soil-landscape relationship, and ii) larger L values paired with the lower pixel resolution (30 m) diminished the impact of minor landforms, improving the accuracy of ecological site detections. We determined that the geomorphon model with the pixel resolution of 30 m, t-value of 0.05°, and L-value of 12 produced the ecological site classification map with the highest accuracy, achieving a moderate-high accuracy (D of 33.9 %). Our study suggests that the geomorphon approach shows potential for consistent, reproducible and easily updatable ecological site mapping over larger areas.

A spatiotemporal comparative analysis on tumor immune microenvironment characteristics between neoadjuvant chemotherapy and preoperative immunotherapy for ESCC

The average five-year survival rate for esophageal cancer, a common malignant tumor of the digestive system, is barely 20%. The majority of esophageal squamous cell carcinoma (ESCC) patients had already progressed to a locally advanced or even advanced stage at initial diagnosis, making routine surgery ineffective. Chemotherapy and immunotherapy are important neoadjuvant treatments for ESCC, however, it remains unknown how treatment will affect the immunological microenvironment, especially at the spatial level. Here, we presented the TME characters of ESCC from the temporal and spatial dimensions using scRNA-seq and ST, investigated the changes of immune cell clusters in the TME under neoadjuvant chemotherapy and preoperative immunotherapy, and explored the potential mechanisms. It was found that compared with chemotherapy, immunotherapy combined with chemotherapy increased the level of T cell proliferation, partially restored the function of exhausted T cells, induced the expansion of specific exhausted CD8 T cells, increased the production of dendritic cells (DCs), and supported the immune hot microenvironment of the tumor. We also found that CD52 and ID3 have potential as biomarkers of ESCC. Particularly, CD52 may be served as a predictor of the efficacy to screen the advantaged population of different regimens. Through multiple pathways, CAF2 and CAF5’s antigen-presenting role affected the other fibroblast clusters, resulting in malignant transformation. We analyzed the immune microenvironment differences between the two regimens to provide a more thorough description of the ESCC microenvironment profile and serve as a foundation for customized neoadjuvant treatment of ESCC.

The high dimensional Fisher-KPP nonlocal diffusion equation with free boundary and radial symmetry, part 2: Sharp estimates

This is the second part of a two-part series devoted to an in depth understanding of the dynamical behaviour of the radially symmetric Fisher-KPP nonlocal diffusion equation with free boundary |x|=h(t). In Part 1 [19], we have shown that the long-time dynamics of this problem is characterised by a spreading-vanishing dichotomy, and there exists a threshold condition on the diffusion kernel J(|x|) such that the spreading speed is ∞ when this condition is not satisfied, and when it is satisfied, the finite spreading speed c0 is determined by an associated semi-wave problem established in [15]. In Part 2 here, we obtain more precise description of the spreading profile by focusing on some natural classes of kernel functions, including those satisfying J(|x|)∼|x|−β for |x|≫1 in RN. Our results for such kernels reveal a striking difference of behaviour from the pattern exhibited in the one dimension case [18] when β crosses the value N+2. More precisely, (a) when β∈(N,N+1], we show that for t≫1, h(t)∼t1/(β−N) if β∈(N,N+1), and h(t)∼tln⁡t if β=N+1, which is of the same pattern as in dimension one, namely we recover the result in [18] by letting N=1 in the above statements; (b) when β∈(N+1,N+2], the front has a finite spreading speed c0=c0(β) in the sense that limt→∞⁡h(t)/t=c0, and our results here on the order of shift c0t−h(t) are again of the same pattern as in dimension one; (c) when β>N+2, the front still has a finite spreading speed c0, but a significant change happens to the order of shift c0t−h(t) between N≥2 and N=1: for t≫1, c0t−h(t)∼ln⁡t when N≥2, but c0t−h(t)∼1 when N=1.

The effect of inhomogeneous terms for asymptotic profiles of solutions to second-order abstract evolution equations with time-dependent dissipation

The inhomogeneous problem of second-order evolution equations with a time-dependent dissipation term of the form u″+Au+b(t)u′=g(t) in a real Hilbert space H is considered, where A is a general nonnegative selfadjoint operator in H. The result is the explicit description of asymptotic profile of solutions of such a problem when the dissipation b provides a diffusive structure with a suitable restriction. The proof is a basic energy method with a scope of well-behaved quantity for the diffusive structure.

Attributes and Fertility Ranking of Lade Soils in the Southern Guinea Savanna of Nigeria

A major constraint restraining agricultural production in Nigeria is the scarcity of gen on soil property. The concomitant improper land use results in land degradation and dwindled agrarian efficiency. Consequently, this study seeks to assess the physicochemical attributes and classify and rank Lade soils according to fertility potential. The free survey was conducted to collect representative soil data. Six (6) profile pits designated L1 to L6 were dug to characterize the mapping units using soil samples obtained from horizons in respective profiles for the study of physical and chemical characteristics employing standard laboratory techniques. Profile description and soil classification at the Great Group level followed USDA guidelines. Fertility Capability Classification system was used to evaluate the soils for arable cropping. Soil was indicative of a relatively high structural index (>9%), strong to slightly acidic (4.0 – 6.3). Organic carbon (8.02 – 9.24 g kg -1 ), available P (9.66 – 25.76 mg kg -1 ) and total N (0.09 – 0.34 g kg -1 ) were mostly moderate. Extractable bases ranged from high to very high while soil color diverse from dark yellowish brown (10YR 4/4) on the surface to reddish brown (2.5YR 4/3) in the subsoils. Soils L1 - L6 were classified as Endoaqualfs, Kandiustalfs, Haplustalfs, Haplustalfs, Plinthustalfs and Kandiustalfs, respectively. Potential suitability for arable crop place pedons L1 and L3 in class S2 (moderately suitable), whereas other pedons were rated as S3 (marginally suitable). The study gives an insight into the judicious use of inorganic fertilizer combined with good residue management and drainage for fertility improvement of the soil. Keywords : Characterization, Fertility capability classification, nutrient status, sandstone, soil taxonomy

Theory and Experiment of the Limiting Current in Impinging Jet Electrodes

Recently, flow cells with a confined impinging jet type have emerged as a promising hydrodynamic electrochemical setup for non-conventional square model electrodes that cannot be measured in the commonly used rotating disk electrode (RDE) setup1. Due to the complex hydrodynamic flow profiles, these flow cell types usually rely on computational fluid dynamics (CFD) simulations for the description of the local current density profiles and overall current-potential characteristics2. In this work, we present an advanced analytical model of the limiting current in confined impinging jet electrodes and validate the model with experimental data and corresponding CFD simulations.Around 350 parameter sets of the confined impinging jet electrode arrangement were analyzed by varying the inlet diameter (d), distance between inlet-nozzle and electrode (H), electrode radius (RIII), and volume flow rate (V0). Figure 1 shows the proposed analytical solution which separates the electrode into three different diffusion regions: (i) wall-tube region (blue rectangle), (ii) wall-jet region (green rectangle), and finally (iii) radial channel-flow region (orange rectangle). The approach allows predicting the limiting current characteristics for a broad variety of impinging jet electrodes, including the confined impinging jet electrode type. The flow line profiles obtained by CFD simulations are in excellent agreement with the analytically determined regimes with radii RI and RII and flow regime transitions. Very importantly, for the construction of ideal wall-tube electrodes the transition point RI can now be described by our analytical model in high accuracy and requires no more in-depth numerical or experimental studies3. We determined an average relative error over all parameter points compared to the numerical CFD simulations to be 7.8 %. In contrast, the analytical formula for free wall-jets4 to the entire electrode is in the range of 29 %. Furthermore, using a 3D-printed flow cell geometry (H = 0.7 mm; d = 0.5 mm) with the confined impinging jet type, the obtained experimental data confirm the here developed analytical model. The experimental data for different electrode radii (1 mm < R < 3 mm) using the ferrocyanide/ferricyanide redox pair ([Fe(CN)6]4-/[Fe(CN)6]3-) also show good agreement to the analytical model with an average deviation of 6 %.In summary, we have developed an analytical model that allows an accurate prediction of the limiting current for different geometries of the impinging jet electrode. Based on numerical and experimental approaches, our model shows an accuracy of below 10 %, which is very remarkable compared to the current models reported in the literature. The results of this study help to improve the design and construction of electrochemical flow cells based on this electrode type as an alternative to the classic RDE setup.

Empirical approaches for non-linear site response: results for the ESG6-blind test

As a contribution to step 3 of the ESG6 blind prediction exercise, we present an application of two different, purely empirical approaches to estimate the strong ground motion at a soft site ("KUMA") from the observed ground motion at a reference rock site ("SEVO") for the two largest shocks of the Kumamoto 2016 sequence. The two methods estimate the non-linear transfer function between a reference rock and a sedimentary site by modifying the linear transfer function derived from weak motion recordings. The modification is based either on a machine learning tool based on a wide collection of Japanese weak and strong motion recordings and the associated site metadata (method 1), or on an estimate of a site-specific parameter related to an average non-linear site response (method 2). The acceleration time series are then derived at the sedimentary site of interest using an estimation of the time delay between wave arrivals at the rock and site stations, and a minimum phase assumption for the site transfer function. These predictions were made blindly, but after the ESG6 conference they could be compared both with the actual ground motion recorded at KUMA during the two shocks, and the average and range of all other predictions preformed for this benchmark. Both of these purely empirical methods provide an honorable prediction of usual engineering ground motion parameters of the two target events. The performance of these two purely empirical approaches is at least comparable to those of the numerical simulation methods for the foreshock—if not better—and slightly worse for the (largest) mainshock. As the methods required only recordings of weak motions at the target and a referent sites and very simple description of the soil profile. The use of moderate motions to constrain the frequency shift prediction for the second method and the consideration of an alternative phase modification are possible ways to improvement.Graphical

Soil resilience assessment using soil profile descriptions and Analytic Hierarchy Process in Mediterranean mountains considering diverse fire occurrences

Wildfires are complex natural phenomena that exert significant impacts on landscapes, societies, and economies. Understanding the concept of resilience is crucial in mitigating its possible negative impacts, as it involves preparing for, responding to, and recovering from wildfires. This research aims to demonstrate the utility of in situ soil profile description in assessing land use resilience using an Analytic Hierarchy Process (AHP) through an expert panel survey. The study examines a catchment located in the Balearic Islands, considering two fire occurrences (once and twice), comparing abandoned agricultural terraces and natural hillslopes. The results demonstrated that the priority ranking of variables to assess soil profile resilience against wildfires, determined by a panel of 10 experts, identified horizon depth (25.1%), slope inclination (21.5%), and hydrological connectivity (16.6%) as the most crucial factors. Other variables, such as number and size of roots, structure of pedal soil material, size class structure, and rock fragments, also contributed to resilience but to a lesser extent, with scores ranging from 5.7% to 9.6%. Analyzing the priorities established by the experts using AHP, the results showed that the least resilient soil horizon was H1 of the control hillslope, especially under high and low connectivity processes, which aligned with the loss of superficial soil horizons after one and two wildfires. Hillslopes showed greater changes in resilience after occurring wildfires compared to terraces, with the most significant alterations occurring after the second wildfire event. This study addresses a significant knowledge gap in the field by highlighting the interconnectedness of wildfires, resilience, and land use, providing insights into land management strategies for wildfire-prone regions.

Description of clinical profile, acute complications and glycemic control after Ramadan fasting in a Tunisian population of patients with diabetes

Description of clinical profile, acute complications and glycemic control after Ramadan fasting in a Tunisian population of patients with diabetes

Disentangling Anti-Tumor Response of Immunotherapy Combinations: APhysiologically Based Framework for V937Oncolytic Virus and Pembrolizumab.

Immuno-oncology (IO) is a growing strategy in cancer treatment. Oncolytic viruses (OVs) can selectively infect cancer cells and lead to direct and/or immune-dependent tumor lysis. This approach represents an opportunity to potentiate the efficacy of immune checkpoint inhibitors (ICI), such as pembrolizumab. Currently, there is a lack of comprehensive quantitative models for the aforementioned scenarios. In this work, we developed a mechanistic framework describing viral kinetics, viral dynamics, and tumor response after intratumoral (i.t.) or intravenous (i.v.) administration of V937 alone or in combination with pembrolizumab. The model accounts for tumor shrinkage, in both injected and non-injected lesions, induced by: viral-infected tumor cell death and activated CD8 cells. OV-infected tumor cells enhanced the expansion of CD8 cells, whereas pembrolizumab inhibits their exhaustion by competing with PD-L1 in their binding to PD-1. Circulating viral levels and treatment effects on tumor volume were adequately characterized in all the different scenarios. This mechanistic-based model has been developed by combining top-down and bottom-up approaches and provides individual estimates of viral and ICI responses. The robustness of the model is reflected by the description of the tumor size time profiles in a variety of clinical scenarios. Additionally, this platform allows us to investigate not only the contribution of processes related to the viral kinetics and dynamics on tumor response, but also the influence of its interaction with an ICI. Additionally, the model can be used to explore different scenarios aiming to optimize treatment combinations and support clinical development.

Long-Term Follow-Up before and during Riluzole Treatment in Six Patients from Two Families with Spinocerebellar Ataxia Type 7.

Currently no curative treatment exists for spinocerebellar ataxias (SCAs). Riluzole repurposing was proposed as a symptomatic treatment in different types of cerebellar ataxia. We report a long-term-follow up under riluzole treatment in SCA type 7. Six patients received Riluzole 50mg twice daily on a compassionate use program for a mean of 4.8 years (range 3.5-9). We measured ataxia onset and progression through the Scale for the Assessment and Rating of Ataxia (SARA), and collected extensive ophthalmological data before and after Riluzole treatment. Electrocardiogram and laboratory profile for drug safety were performed every six months. Riluzole treatment showed no effect on visual function in two patients with an advanced retinal damage. Improvements of visual function occurred in four patients followed by ophthalmologic stability up to 5 years after starting treatment. Two patients had a less steep deterioration of ataxia after treatment compared to pre-treatment, during the first 2,5 years of therapy. One showed soon after therapy an improvement of the SARA score, and then overall stability lasting 3,5 years, followed by ataxia worsening. One visually impaired patient without neurological impairment did not worse until the last visit after 3,5 years of follow-up. The remaining 2 patients showed an improvement of SARA scores soon after therapy, and an overall stability lasting respectively 5 and 3 years. No adverse event was registered during the observation period. This study suggests a possible beneficial action of Riluzole in SCA7 and provides a detailed description of the ophthalmologic profile of these patients.

Profiling of Organosulfur Compounds in Onions: A Comparative Study between LC-HRMS and DTD-GC-MS

Onions are known not only for their culinary importance but also for their nutritional and health-promoting properties. Both properties are closely linked to their content of organosulfur compounds, which account for up to 5% of the dry weight of an onion. Given the importance of these compounds, suitable analytical methods are required for their study. Two techniques should be highlighted in this context: gas chromatography coupled to mass spectrometry (GC-MS), and liquid chromatography coupled to mass spectrometry (LC-MS). In this study, eight different onion varieties were analyzed using two distinct analytical techniques: direct thermal desorption–gas chromatography–mass spectrometry (DTD-GC-MS) and high-resolution mass spectrometry (HRMS) on an LC-ESI-QqTOF instrument. Each method identified different organosulfur compounds, with LC-HRMS targeting 15 non-volatile compounds, such as cysteine sulfoxides, and GC-MS targeting 18 volatiles, such as disulfides and trisulfides. The results obtained were studied using Pearson correlations and principal component analysis. No precise correlation was found between the initial organosulfur compounds in onions and their hydrolysates. Consequently, although GC is one of the most employed techniques in the scientific literature, the use of LC-HRMS or a combination of both techniques may offer a more comprehensive and accurate description of the metabolomic profile of onions.

Analysis of the Influence of Organizational Culture, Remuneration, and Job Satisfaction on the Performance of Education Personnel

The aim of this research is to determine: a description of the organizational culture profile and remuneration system; organizational culture influences the performance of education personnel; the remuneration system affects the performance of education personnel; the influence of the work environment on the performance of education personnel; and the influence of organizational culture, remuneration, and work environment simultaneously on the performance of education personnel. The research approach uses an associative approach. The research was conducted at the Medan Aviation Polytechnic. The research results show: (1) there are anomalies in the application of remuneration at the Medan Aviation Polytechnic; (2) individual organizational culture shows an unstandardized coefficient beta value of 0.531 and shows a significant value of &lt;0.05, then H1 is accepted. Thus, organizational culture influences performance; (3) remuneration testing shows an unstandardized coefficient beta value of 0.248 and a significant value of &lt;0.05, so H2 is accepted. Thus, remuneration influences performance; (4) if the unstandardized coefficient beta value is 0.135 and shows significance at &lt;0.05, then H3 is accepted. Thus, job satisfaction influences performance; (5) the individual influence of organizational culture on performance with job satisfaction as an intervening variable shows unstandardized beta coefficients of 0.000 and shows significance at &lt;0.05, as well as the influence of remuneration with job satisfaction as an intervening variable shows a significance &lt;0.05. Thus, it can be concluded that organizational culture and remuneration variables influence performance by intervening with job satisfaction.

Description of lymphocyte and cytokine profiles in individuals with acute myeloid leukemia associated with FLT3-ITD and NPM1 mutation status.

The pathogenesis of acute myeloid leukemia (AML) involves mutations in genes such as FLT3 and NPM1, which are also associated with the prognosis of the disease. The immune system influences disease progression, but the mechanisms underlying the interaction between the immune system and AML are not clear. In this study, the profiles of lymphocytes and cytokines were described in individuals with AML stratified by molecular changes associated with prognosis. The participants included in this study were newly diagnosed AML patients (n = 43) who were about to undergo chemotherapy. Subtypes of lymphocytes in peripheral blood, including B cells, T cells, and natural killer cells, and serum concentrations of cytokines, including Th1, Th2, and Th17, were studied by flow cytometry assays (BD FACSCanto II). The correlations between lymphocyte subsets, cytokines, and genetic/prognostic risk stratification (based on the FLT3 and NPM1 genes) were analyzed. The differences in B lymphocytes (%), T lymphocytes (%), plasmablasts (%), leukocytes (cells/µl), and tumor necrosis factor (pg/ml) were determined between groups with FLT3-ITD+ and FLT3-ITD- mutations. The presence of mutations in NPM1 and FLT3-ITD and age suggested changes in the lymphocyte and cytokine profile in individuals with AML.