Introduction: Dermatoglyphics is scientific study of epidermal ridges and their configuration on the volar aspect offinger, palm, toes and sole. Several variation may found in the patient with thalassemia major. Aims: This study aimed to diagnose the thalassemia patient by using dermatoglyphic pattern. Material and method : The above study was carried out in deptt. Of anatomy,svngmc yavatmal and comprised of dermatoglyphic pattern of 100 patients along with 100 normal individual to serve as control against thalassemic patients. Dermatoglyphics prints was taken by ink method and studied by quantitative analysis. Result: Out of 100 cases, there is increase in the mean value of AFRC( Absolute finger ridge count)in thalassemia male and female. Total finger ridge counting shows significance increase in mean value of TFRC (Total finger ridge count). Conclusion: There is significance difference in mean value of AFRC and TFRC in thalassemic patient when compared with control. Keyword :Thalassemia major, Dermatoglyphics,Ridge,Control,ink method.