Dermal Decontamination Research Articles

Reducing Systemic Absorption from Monochloracetic Acid Exposure Through Dermal Decontamination: Use of the Pig Ear Organ Culture System

AbstractSevere systemic intoxication may occur after skin contamination with monochloracetic acid (MCA). For this reason the effects of decontaminating with either water (most commonly used) or bicarbonate on the rates of percutaneous penetration and dermal accumulation of radiolabeled MCA were measured using the blood-perfused pig ear model. The rate of percutaneous penetration of a 40% solution of MCA was measured after exposure times of 1, 3, and 10 min. Maximal rates of percutaneous penetration (ng/min/cm2; mean ± SEM) were 891 ± 335 for a 1 min exposure; 947 ± 191 for a 3 min exposure; and 3221 ± 515 for a 10 min exposure. Although the initial rate of percutaneous absorption (first 30 min) was directly related to the exposure time, there was no difference in maximal rates of percutaneous penetration for 1 and 3 min exposures. It appears, that for short exposure times, the percutaneous penetration rate is determined by both the rate of penetration into the skin and the rate of diffusion from dermal st...

Dermal decontamination of [ 3H]T-2 mycotoxin in rats : B. L. Bunner, R. W. Wannemacher Jr, R. E. Dinterman and F. H. Broski (Field Medical Material Development Division, U.S. Army Biomedical Research and Development Laboratory and U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, U.S.A.)

Dermal decontamination of [ 3H]T-2 mycotoxin in rats : B. L. Bunner, R. W. Wannemacher Jr, R. E. Dinterman and F. H. Broski (Field Medical Material Development Division, U.S. Army Biomedical Research and Development Laboratory and U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, U.S.A.)