The derailment of railway vehicles at a turnout is a worldwide concern. However, the derailment of empty freight trains in the switch section of a turnout in the diverging route is rarely concerned. Therefore, in order to analyse the derailment mechanism of empty freight trains in the turnout switch area and to propose appropriate preventive measures, field investigation and dynamic simulation of the derailment are carried out on the basis of an empty freight train derailment in the turnout switch area of the diverging route. Firstly, the background of the derailment is presented and the potential influencing factors of the derailment are analysed according to the field investigation. Secondly, a detailed train-turnout dynamic model is established, taking into account the variable cross-sections of the turnout switch rail and the effect of the longitudinal coupler force. Thirdly, based on the model, the derailment mechanism of the empty freight train is revealed through theoretical analysis and simulation calculation. Finally, the effect of the potential derailment influencing factors is analysed and preventive measures are proposed to reduce the derailment risk of the empty freight train at the turnout switch area in the diverging route. The results indicate that this derailment is caused by the combined effect of the inherent structural characteristics of the switch, the large longitudinal coupler force, and the high wheel rail friction coefficient. The possibility of derailment can be reduced by reducing the longitudinal coupler force and the wheel rail friction coefficient. In addition, the installation of a guard rail in front of the turnout can effectively prevent empty freight train derailment in the turnout area.