Objective: This study aimed to determine the prevalence and factors associated with depression symptoms among aquaculture workers in Hai Phong, Vietnam. Material and Methods: The study involved 1,220 aquaculture workers in coastal and offshore areas of Hai Phong, Vietnam; from March 2022 to September 2022. It was a cross-sectional descriptive epidemiological study, utilizing direct interviews with aquaculture workers to identify depression symptoms and associated factors. The Depression-Anxiety- Stress Scale (DASS 21) was used to assess depression symptoms. Results: The prevalence of depression symptoms among aquaculture workers was 28.7%, with 20.9% experiencing mild depression, 6.3% moderate depression and 1.5% severe depression. Several factors were associated with depression symptoms; including gender (OR=2.03; 95% CI 1.56-2.63), being single or divorced (OR=1.44; 95% CI 1.04-1.99), age ≥60 (OR=1.63; 95% CI 1.05-2.55) compared to those under 40, chronic illnesses (OR=3.16; 95% CI 2.43-4.11), poor sleep quality (OR=2.84; 95% CI 2.13-3.79), alcohol abuse (OR=1.36; 95% CI 1.06-1.75), and irregular physical exercise (OR=2.09; 95% CI 1.62-2.70). Conclusion: Depression disorder is a mental health concern among aquaculture workers. To alleviate depression symptoms, workers should consider lifestyle adjustments, incorporate regular physical exercise, and undergo routine health check-ups for timely counseling and treatment.