Depressive Symptoms In Men Research Articles

Heterogeneity in the association between social support and mental distress in old-age retirees – a computational approach using longitudinal cohort data

BackgroundMental distress among retirees and older people is a severe public health challenge, and information on new risk groups is needed. This study aims to identify subgroups of old-age retirees with varying associations between low social support and mental distress by applying model-based recursive partitioning (MOB).MethodsWe used the Helsinki Health Study follow-up survey data of old-age retired former municipal sector employees of the City of Helsinki, Finland. Phase 1 data were collected in 2000–2002, when all participants were employed, Phase 2 in 2007, Phase 3 in 2012, Phase 4 in 2017, and Phase 5 in 2022 (n = 4,466, 81% women). Social support and covariates were measured at each Phase 1–5 and the outcome, mental distress (Depression Anxiety Stress Scales [DASS-21]) was measured at a single occasion, during Phase 5. The three subscales and the common factor of general distress were analysed separately. An approach rooted in computational statistics was used to investigate risk factor heterogeneity in the association of low social support and mental distress. MOB combines decision trees with regression analysis to identify subgroups with the most significant heterogeneity among risk factors.ResultsMedian (IQR) general distress score from DASS-21 was 5.7 (3.0, 9.0), while Social Support Questionnaire number-score (SSQN) was 1.5 (1.15, 2.05). The primary effect modifier for the association between social support and general distress was education (p < 0.001). Those with high education had a different association of low social support and general distress than those with low or medium education. Additionally, the subgroup with low and medium education had a significant effect modification for age (p = 0.01). For the association between low social support and depressive symptoms, the moderating effect of education was dependent on gender, as men with medium–high education had the weakest association, while for women with medium–high education the association was strongest.ConclusionsOur results suggest that stratification by sociodemographic variables is justifiable when investigating risk factors of mental distress in old-age retirees. The incongruent association of low social support and depressive symptoms in men with medium–high education compared to women with medium–high education is a promising target for confirmatory research.

Shame and depressive symptoms in men: The moderating role of environmental mastery and purpose in life.

Feelings of shame are linked to increased risk for depression. Little is known about protective factors that may buffer this effect, particularly in men. Using prospective data from a community sample of Australian men, we examine the extent to which shame is associated with depressive symptoms, and the protective role of psychological wellbeing, specifically environmental mastery and purpose in life. Participants (n = 448) were from the longitudinal Men and Parenting Pathways (MAPP) Study. Measures were the Event Related Shame and Guilt Scale for shame, the DASS-21 for depressive symptoms and Ryff's Scales of Psychological Well-Being for environmental mastery and purpose in life. Linear regressions were used to test associations between shame and depressive symptoms concurrently and 1-year later, and the moderating effects of mastery and purpose in life. Shame was strongly associated with concurrent depressive symptoms (βunadj = .76, p < .001; βadj = .63, p < .001). This effect was weaker in men with high compared to low environmental mastery (β+1SD = .46, p < .001; β-1SD = .55, p < .001) and purpose in life (β+1SD = .48, p < .001; β-1SD = .62, p < .001). Shame also predicted subsequent depressive symptoms after adjustment for prior depressive symptoms (βunadj = .59, p = .001; βadj = .34, p = .004), although environmental mastery or purpose in life did not moderate these associations. Our findings suggest that promoting a sense of psychological wellbeing in men may confer protective proximal effects in the context of shame, potentially attenuating depression severity. The current study aligns with calls for strength-based approaches to reducing mental health problems in men.

Towards effective screening for paternal perinatal mental illness: a meta-review of instruments and research gaps.

Paternal perinatal mental illness (PPMI), which affects around one in 10 fathers, is under-recognised despite increasing awareness of men's mental health in the perinatal period. Social stigma and men's reluctance to seek help exacerbate this gap. Neglecting the mental health needs of new fathers not only puts them at increased risk for mental illness themselves, but also has a profound and long-lasting impact on their families, children and their own self-esteem as they navigate their new role in the family dynamic. This meta-review systematically identifies instruments assessing PPMI symptoms, evaluates their psychometric properties and applicability, presents key findings from studies using these tools, and identifies gaps and limitations in the literature on PPMI symptom assessment. A systematic literature review was conducted using search strategies applied to PubMed, PsycNet APA, Cochrane, and Web of Science, supplemented by hand searches. Relevant information was extracted from each included study. Extracted data were analysed narratively to address the research questions. Findings identified limitations and gaps in current screening practices. While the Edinburgh Postnatal Depression Scale (EPDS) is the most widely used screening tool for both fathers and mothers, it inadequately captures atypical depressive symptoms in men. Cutoff scores lack consensus, and instrument sensitivity varies significantly due to cultural and sociodemographic factors. A number of other screening tools have been identified, most of which are more general and not specifically designed for perinatal mental health. This meta-review broadens perspectives on PPMI screening instruments, highlighting key themes, patterns, and differences across the included reviews. While a variety of screening tools are used, the review underscores the necessity for tools specifically tailored to fathers during the perinatal period.

Depression Literacy and Depressive Symptoms: The Mediating Role of Self-Rated Mental Health Among Korean Americans

ABSTRACT Objective Depression literacy (DL) is increasingly recognized as an important predictor of mental health outcomes, but there remains a noticeable lack of scientific inquiry focusing on Korean Americans in this area. In addition, women are known to be more susceptible to depression, potentially affecting their DL and depressive symptoms differently than men. This study aimed to explore two primary objectives: (1) the potential role of self-rated mental health (SRMH) in mediating the association between DL and depressive symptoms in this population, and (2) whether gender differences exist in the presence and magnitudes of these mediation effects. Method Data were drawn from a survey with 693 Korean Americans aged 18 and older residing in New York and New Jersey. The PROCESS macro was used to test the mediation effect of self-rated mental health on the relationship between depression literacy and depressive symptoms in men and women. Results Self-rated mental health was found to mediate the relation between depression literacy and depressive symptoms in women but not in men. Conclusions Providing evidence-informed, culturally tailored and gender specific depression literacy education and programs for the KA communities may be an important strategy to reduce depressive symptoms in this group.

When love hurts: Testing the stress generation hypothesis between depressive symptoms, conflict behaviors, and breakup rumination in romantic couples

Introduction: In this study we investigated the stress generation hypothesis in romantic relationships, testing how individuals’ depressive symptoms can lead to interpersonal stress that worsens their depressive symptoms. Interpersonal stress was operationalized as conflict enactment (critical, hostile, and rejecting behaviors toward one's romantic partner) and breakup rumination (persistent and intense thoughts of ending the relationship). Methods: Participants included 226 heterosexual adult romantic couples, with a mean age of 21.48 years for women and 22.35 years for men. A short-term longitudinal design was employed, involving three waves of data collection, including a daily diary portion. Depressive symptoms were measured in the lab at the beginning of the study (Wave 1) and again one month later (Wave 3). Following Wave 1, conflict enactment and breakup rumination were measured online over a 14-day period (Wave 2) through daily diary entries, which were then averaged across the 14 days into a single score for each construct. Results: Using actor-partner interdependence mediation modelling, we found women's and men's depressive symptoms at Wave 1 positively predicted their own conflict enactment and breakup rumination at Wave 2, as well as their own depressive symptoms at Wave 3 (actor effects). Women's depressive symptoms at Wave 1 positively predicted men's conflict enactment at Wave 2 (partner effect). Additionally, women's conflict enactment at Wave 2 positively predicted their own depressive symptoms at Wave 3 (actor effect) and mediated the increase in their own depressive symptoms from Wave 1 to 3 (indirect effect). Discussion: Findings illustrate how depressive symptoms are embedded in an interpersonal context and exacerbated by conflictual behaviors within romantic relationships over a period of one month.

Depressive Syndromes in Men With Hypogonadism in the TRAVERSE Trial: Response to Testosterone-Replacement Therapy.

The effect of testosterone on depressive symptoms in men with hypogonadism remains incompletely understood. We assessed the effects of testosterone-replacement therapy (TRT) in improving depressive symptoms in hypogonadal men with and without depressive symptoms enrolled in the TRAVERSE cardiovascular safety trial. A randomized, placebo-controlled, double-blind study was conducted at 316 trial sites. Participants included men, aged 45 to 80 years, with 2 fasting testosterone levels less than 300 ng/dL, 1 or more hypogonadal symptoms, cardiovascular disease (CVD), or increased risk of CVD. We evaluated 3 subgroups of participants: (1) men with rigorously defined, late-life-onset, low-grade persistent depressive disorder (LG-PDD, previously "dysthymia"); (2) all men with significant depressive symptoms (Patient Health Questionnaire-9 Score >4); and (3) all randomly assigned men. Intervention included 1.62% transdermal testosterone or placebo gel. Outcome measures included the proportions of participants (1) meeting criteria for LG-PDD or (2) with significant depressive symptoms; and changes in depressive symptoms, energy, sleep quality, and cognition in testosterone-treated vs placebo-treated men in the 3 subgroups. Of 5204 randomly assigned participants, 2643 (50.8%) had significant depressive symptoms, but only 49 (1.5%) met rigorous criteria for LG-PDD. Among those with LG-PDD, there was no significant difference in any outcome measure between the TRT and placebo groups, possibly reflecting low statistical power. In men with significant depressive symptoms (n = 2643) and in all randomly assigned participants (n = 5204), TRT was associated with modest but significantly greater improvements in mood and energy but not cognition or sleep quality. Depressive symptoms are common in middle-aged and older men with hypogonadism but LG-PDD is uncommon. TRT is associated with small improvements in mood and energy in hypogonadal men with and without significant depressive symptoms.

Association between precarious employment and the onset of depressive symptoms in men and women: a 13-year longitudinal analysis in Korea (2009-2022).

Increasing social concern surrounds the potential adverse health effects of precarious employment (PE). In this study, we explored the association between PE and the onset of depressive symptoms. A total of 11,555 Korean waged workers (5700 females) contributed 62,217 observations from 2009 to 2022. PE was operationalized as a multidimensional construct, including employment insecurity, income inadequacy and lack of rights and protection. Depressive symptoms were evaluated using the Center for Epidemiological Studies-Depression Scale (11-item version). The association between PE and the onset of depressive symptoms in the subsequent year was estimated using generalized estimating equations. Effect sizes were reported as odds ratio (OR) and 95% confidence interval (CI). The overall incidence of depressive symptoms was 8.3% during the study period. In cross-sectional analysis, daily employment, disguised employment, lower monthly wages and lack of social insurance coverage were associated with concurrent depressive symptoms in both men and women. Longitudinally, fixed-term employment (OR: 1.17, 95% CI: 1.07-1.29), daily employment (OR: 1.64, 95% CI: 1.45-1.85) and disguised employment (OR: 1.36, 95% CI: 1.17-1.57) were associated with the onset of depressive symptoms among the overall sample. Among men, the lowest quartiles of wage were associated with the onset of depressive symptoms (OR: 1.34, 95% CI: 1.13-1.60), while the absence of a trade union was associated among women (OR: 1.18, 95% CI: 1.01-1.39). Employment insecurity, inadequate income and lack of rights and protection may contribute to depressive symptoms. Therefore, PE serves as a significant social determinant of mental health among workers in Korea. Active policy efforts are warranted to improve the overall quality of employment in the workforce.

The association between depression and the cortisol awakening response is moderated by loneliness in men from a non-clinical sample

Previous studies investigating cortisol levels in people with depression or depressive symptoms have provided mixed findings. It has been suggested that the difficulty to generalize findings across studies in this field might be related to interindividual variability in experiencing depressive symptoms in terms of clinical and social contexts. Therefore, in the present study we aimed to test the association of morning cortisol levels and depressive symptoms in a non-clinical sample of young men taking into consideration the level of perceived loneliness. We hypothesized that the level of loneliness might moderate the association between morning cortisol levels and depressive symptoms. A total of 102 participants (aged 29.9 ± 5.0 years) completed questionnaires measuring the levels of depressive and anxiety symptoms, perceived stress, and loneliness. Cortisol levels were determined in four morning samples of saliva. There were significant positive correlations of the cortisol awakening response (CAR) and the mean increase in cortisol levels during the measurement period (MnInc) with the levels of depressive symptoms and loneliness. Moreover, a significant association of the depressive symptoms by loneliness interaction with the CAR and the MnInc was found. Specifically, the correlation of depressive symptoms with the CAR and the MnInc appeared to be significant and negative at high levels of loneliness. No significant association between depressive symptoms and the CAR was observed in men with low levels of loneliness. There were no significant associations of depressive symptoms, loneliness and the depressive symptoms by loneliness interaction with cortisol levels at awakening. In conclusion, findings from the present study indicate the importance of social contexts in understanding the association between altered activity of the hypothalamic-pituitary-adrenal axis and depressive symptoms in men.

Childhood Parental Disfavoritism and Chinese Adults' Psychological Well-Being in Middle and Later Life: The Moderating Effect of Gender.

Parental differential treatment of children, particularly disfavoritism, has been found to detrimentally affect adult children's psychological well-being in the United States. However, no study has investigated the long-reaching influence of parental disfavoritism in China, where there is an absence of equal treatment norms. Drawing from theories of social comparison, life course, and gender dynamics in China, we tested how perceptions of childhood parental disfavoritism affect midlife and older Chinese adults' depressive symptoms, and how the effects differ by own and parent's gender. Random-intercept models were used based on a sample of 17,682 midlife and older Chinese adults, drawn from 5 waves of China Health and Retirement Longitudinal Study. Recollections of childhood parental disfavoritism were associated with higher depressive symptoms among Chinese adults. Perceptions of paternal disfavoritism predicted both men's and women's depressive symptoms, whereas perceptions of maternal disfavoritism predicted women's depressive symptoms only. Paternal disfavoritism was more detrimental than maternal disfavoritism, but only for men. Maternal disfavoritism was more detrimental for women than men. These findings shed light on the universality of the long-reaching detrimental effect of perceptions of parental disfavoritism across cultures as well as the unique gendered patterns in China shaped by patriarchy. Findings suggest that the implementation of Three-Child Policy in China should be accompanied with parental education programs involving fathers on equal treatment of children.

Prospective associations between hand grip strength and subsequent depressive symptoms in men and women aged 50 years and older: insights from the Survey of Health, Aging, and Retirement in Europe.

In previous cross-sectional and longitudinal studies, depressive symptoms have been associated with lower hand grip strength (HGS), which is a convenient measure of overall muscular strength and serves as a marker of poor health. Most studies have considered low sample sizes or highly selective patient cohorts. We studied the association between depressive symptoms (EURO-D) and HGS in three waves from the cross-national panel dataset Survey of Health, Aging, and Retirement in Europe (SHARE). Linear regressions and Generalized Estimating Equations (GEE) were conducted to determine factors associated with depressive symptoms and investigate whether HGS predicts future depressive symptoms. Cross-sectional HGS explained 7.0% (Wave 4), 5.7% (Wave 5), and 6.4% (Wave 6) of the EURO-D variance. In the GEE, we analyzed people without depression in Wave 4 (N = 39,572). HGS predicted future EURO-D (B = -0.21, OR = 0.979, 95%CI (0.979, 0.980), p < 0.001) and remained a significant predictor of future depressive symptoms after adjustment for age, sex, psychosocial and physical covariates. Muscle strength is a known marker for physical health, but a relation with mental health has also been proposed previously. This study confirmed the link between HGS and depressive symptoms in men and women aged ≥50 years in a large longitudinal dataset. Further research is required to understand the mechanisms behind this link to determine whether HGS can serve as a specific marker of depressive symptomology, or whether they coexist due to common underlying disease processes.

Weight stigma from romantic partners: Its relations with maladaptive and adaptive coping and depressive symptoms.

Social devaluation of being overweight is common in daily life, but little is known about the weight stigma in romantic relationships. The present study investigated the roles of maladaptive and adaptive coping strategies in the relation between the experience of weight stigma in romantic relationships and depressive symptoms in men and women, respectively. Analyses of gender differences and structural equation modeling yielded several findings. First, while men and women experienced similar levels of weight stigma from their romantic partners, women were more likely to use exercise avoidance, disengagement coping, and reappraisal coping strategies, and to exhibit more depressive symptoms than men. Second, men who experienced weight stigma tended to cope with it through exercise avoidance and disengagement coping, which were related to greater depressive symptoms. Men also coped with weight stigma adaptively via reappraisal coping, which was additionally associated with more positive affect. Third, the relation between the experience of weight stigma and depressive symptoms in women was only explained by using disengagement coping. These findings extend the understanding of weight stigma to a specific context and provide some insight that future interventions to reduce the impacts of weight stigma should be tailored accordingly for men and women.

Financial and instrumental support for adult children and depressive symptoms among older adults in China: Does gender make a difference?

For this study we used the demographic data of 5,669 Chinese adults aged between 60 and 79 years, drawn from the 2018 China Family Panel Studies. The propensity score matching method was used to analyze the effect of providing financial and instrumental support for adult sons and daughters on the depressive symptoms of parents. We also tested for gender differences in this effect. The results showed that providing financial support was significantly associated with greater risk of depressive symptoms in men but not in women. By contrast, providing instrumental support reduced the risk of depressive symptoms in both men and women. These findings suggest that adult children should reduce their financial dependence on their parents and that parents should be encouraged to help their adult children by carrying out suitable instrumental support, which could promote parent???child communication and reduce risk of depressive symptoms in older adults.

Emotional dependence as a predictor of emotional symptoms and substance abuse in individuals with gambling disorder: differential analysis by sex

IntroductionEmotional dependence, anxious-depressive symptoms and substance use have been associated with gambling disorder (GD). Although anxiety and depression have been predominantly related to female gamblers and substance abuse to male gamblers, the role of emotional dependence in GD is unknown. Moreover, sex differences remain underexplored. ObjectivesFirst, to explore possible differences in emotional dependence, anxious-depressive symptoms and substance abuse by group (GD and non-GD) and sex (women vs men). Second, to analyse the predictive role of emotional dependence in alcohol and drug abuse and anxious-depressive symptoms in patients with GD as a function of sex. MethodsInstruments to measure gambling (SOGS), emotional dependence (CDE), anxious-depressive symptoms (SCL-90-R) and substance abuse (MULTICAGE CAD-4) were administered to 108 people with GD diagnosis (60 women and 48 men) and 429 without GD (342 women and 87 men). Study designThe research is an analytical cross-sectional study. ResultsThe results showed that the group with GD scored significantly higher than the non-GD group on alcohol abuse, symptoms of depression and anxiety, and emotional dependence, but not on drug abuse. In the group with GD, emotional dependence predicted alcohol and drug abuse in women, and emotional dependence predicted anxiety and depressive symptoms in men. ConclusionThe findings suggest that women with GD who consume alcohol or drugs would benefit from therapies addressing loneliness, borderline expression, attention-seeking and affective expression. Men with GD who report anxious-depressive symptomatology would benefit from therapeutic strategies to deal with separation anxiety and attention-seeking.

Social network investment of men: Cross-sectional and longitudinal associations with mental health problems.

Internationally, there is growing attention on links between social isolation and mental health problems. Here, we use unique Australian longitudinal data to investigate associations between adult men's (n = 507; age M = 29.90, SD = 1.31) social network investments and their concurrent and subsequent mental health problems. In linear regressions, using generalised estimating equations (GEEs), we examined associations between social network investment (time with friends, network size and various activities with friends) and mental health symptoms (depression, anxiety and stress) across five timepoints. Models were adjusted for waves of outcome and potential confounders. Cross-sectionally, each social network investment variable, except for drinking with friends, was negatively associated with depressive symptoms. Men's extended friendship network size and sharing a meal with friends were negatively associated with concurrent anxiety and stress. Time spent and physical activity with friends was also negatively associated with concurrent stress. In longitudinal analyses, after adjusting for prior depressive symptoms, only the number of friends in close and extended networks remained protective against depressive symptoms 1 year later. Results did not differ by fatherhood or relationship status. Programs designed to strengthen men's investment in social networks are recommended to reduce men's depressive symptoms.

Effects of college students' mindfulness on depression symptoms during the epidemic prevention and control period: The mediating effect of psychological resilience.

Depression symptoms significantly impact college students' mental health, particularly during the "closed management" period during the spread of COVID-19. Exploring the mechanism that affects college students' depression symptoms can help alleviate the impact of closed management policies on individual mental health and improve their mental health level. The onset of the COVID-19 pandemic resulted in the normalization of epidemic prevention and control in China and the implementation of the dynamic zero-COVID policy. This study used the Five-Factor Mindfulness Questionnaire-Short Form, Psychological Resilience Scale, and Beck Depression Scale to investigate the mindfulness, psychological resilience, and depression symptoms of 1,062 students under closed management conditions at Northwest Normal University. The mindfulness, psychological resilience, and depression status of students in closed management were investigated using an online questionnaire survey. Eight hundred and ten college students (M age = 20.43, SD = 1.67, range = 17-30) were selected to test the model using the structural equation model and bootstrap method. The results showed that the gender differences in mindfulness and psychological resilience were not significant. Gender differences in depression symptoms were significant, and depression symptoms in men were significantly higher than in women. Grade differences in resilience, mindfulness, and depression levels were not significant. Thus, psychological resilience is negatively associated with depressive symptoms. Psychological resilience plays a mediating role between mindfulness and depressive symptoms. This study provides reference and inspiration for improving college students' mental health under epidemic prevention and control circumstances.

Financial and instrumental support for adult children and depressive symptoms among older adults in China: Does gender make a difference?

For this study we used the demographic data of 5,669 Chinese adults aged between 60 and 79 years, drawn from the 2018 China Family Panel Studies. The propensity score matching method was used to analyze the effect of providing financial and instrumental support for adult sons and daughters on the depressive symptoms of parents. We also tested for gender differences in this effect. The results showed that providing financial support was significantly associated with greater risk of depressive symptoms in men but not in women. By contrast, providing instrumental support reduced the risk of depressive symptoms in both men and women. These findings suggest that adult children should reduce their financial dependence on their parents and that parents should be encouraged to help their adult children by carrying out suitable instrumental support, which could promote parent–child communication and reduce risk of depressive symptoms in older adults.

Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease.

The aim of the present study was to investigate the effect of multimodal exercise training (MET) on aerobic endurance, muscular strength, agility, dynamic balance, cognitive status, and depressive symptoms in men with mild-to-moderate AD. A total of 25 elderly men with a diagnosis of mild-to-moderate AD were randomly categorized into an MET or a control group. The subjects in the MET group participated in a 12-week, three sessions per week MET program that included resistance, balance, and aerobic exercises. While the participants in the control group did not perform any regular exercise training during this period. Patients' cognitive status and depressive symptoms were assessed by Mini-Mental State Examination and the Geriatric Depression Scale-15 (GDS-15) questionnaires. PF indicators such as aerobic endurance, muscular strength, agility, and dynamic balance, as well as cognitive status and depressive symptoms, were taken from all the subjects before and after MET. The participants in the MET group improved handgrip, upper and lower body strength, agility, dynamic balance, and depressive symptoms (p<0.05). The intervention had no significant effect on aerobic endurance and cognitive status (p>0.05). MET is an effective strategy to improve muscular strength, agility, dynamic balance, and depressive symptoms in men with mild-to-moderate AD. It is recommended for AD patients to engage in this type of exercise to reduce AD complications.

Male Hypogonadism (According to the Materials of the European Association of Urology)

Male hypogonadism is a clinical syndrome which is the result of insufficient production of the sex hormone testosterone by the testicles and the number of spermatozoa. The article reveals modern views on the physiology and pathophysiology of testosteroneogenesis in the male organism, provides information on the etiology, pathogenesis, classification, diagnosis and modern treatment of hypogonadism in men. Literature on the results of global and European researches in recent years, as well as materials of the Guideline of the European Association of Urology for 2022, were used in the article. An individual therapeutic approach to each patient with hypogonadism was demonstrated. The importance of diagnosis of chronic and systemic comorbid diseases that cause the risk of hypogonadism, the need to determine the body mass index and the measurement of waist circumference, the size of the testicles, the penis and the presence of secondary sexual characteristic was established. The article includes necessary biochemical and instrumental studies for the diagnosis of hypogonadism. Specific contraindications for hormone replacement therapy are identified. Absolute contraindications for testosterone therapy are indicated: topically widespread or metastatic prostate cancer (PC), breast cancer of men; men who desire to have children; hematocrit level &gt;54%; uncontrolled or poorly controlled stagnant heart failure. Relative contraindications include IPSS&gt;19, initial hematocrit of 48-50 %, venous thromboembolism in a family history. The article also provides recommendations for testosterone therapy. It has been proven that testosterone therapy improves mild forms of erectile dysfunction (ED) and libido in men with hypogonade states; improves the frequency of sexual intercourses, orgasm and general pleasure; increases low-fat mass, reduces fat and improves insulin resistance; normalizes body weight, waist circumference and lipid profile; relieves the symptoms of depression in men with hypogonadism; improves bone mineral density. It has been demonstrated that the use of testosterone therapy in eugonadal men is not indicated. Testosterone therapy should be used as first-line treatment in patients with symptomatic hypogonadism and moderate ED. In addition, it is necessary to use a combination of type 5 phosphodiesterase inhibitors and testosterone treatment in more severe ED forms. It is also necessary to use standard medical treatments for severe symptoms of depression and osteoporosis. The therapy of hypogonadism, non-medication and medication, the necessary medicines and the peculiarities of their use are widely described. The article shows that weight loss due to low calorie diet and regular physical activity leads to a slight improvement in testosterone levels, testosterone gels and prolonged injection drugs are testosterone drugs have the best safety profile, and gonadotropin treatment can be used in men with secondary hypogonadism. It is noted that before the treatment with testosterone, it is necessary to treat organic causes of hypogonadism (for example, pituitary tumors, hyperprolactinemia, etc.), improve lifestyle and reduce body weight in persons with obesity; cancel drugs that can impair testosterone production. Much attention is paid to the risk factors by the treatment with testosterone. Testosterone therapy is contraindicated for men with secondary hypogonadism who wish fertility, men with active PC or breast cancer. Restoration of testosterone concentration in serum relieves the symptoms and signs of hypogonadism in men after 3 months of treatment. Therefore, testosterone therapy leads to improvement of the quality of patient’s life.

DEPRESSIVE SYMPTOMS AND SUBJECTIVE MEMORY AMONG MIDDLE-AGED AND OLDER MIDWESTERN COUPLES

Abstract Older adults face unique challenges with the COVID-19 pandemic and its effects on mental health and cognition (Lebrasseur et al., 2021). Across the age spectrum, depression is associated with self-reported forgetfulness (Loprinzi, 2018; Ronnlund et al., 2011), and this trend is consistent among older adults with mild cognitive impairment (Ryu et al., 2016). There is some suggestion of gender differences in prospective and retrospective memory ratings among couples (Smith et al., 2000). However, little is known about how depression relates to perceptions of everyday memory performance among couples. In the current study, 47 married or cohabiting couples completed a baseline survey. The mean age of both women and men was 62 years. An Actor-Partner Interdependence Model with latent variables was employed to examine depressive symptoms with an adapted version of the Center for Epidemiological Studies-Depression scale (CES-D; Radloff, 1977) and responses to the Prospective and Retrospective Memory Questionnaire (PRMQ; Smith et al., 2000). Both constructs were parceled separately by gender and summed prior to the analysis. For women, preliminary findings revealed that higher levels of depressive symptoms were related to a negative perception of their own memory (β = .28). Conversely, men’s memory abilities were not associated with their depressive symptoms. Lastly, higher levels of depressive symptoms in men were associated with an increase in women’s self-reported forgetfulness (β = .24). These findings are suggestive of a “couple-oriented” effect (Kenny et. al., 2006), whereas there was not a statistically significant relationship between women’s depressive symptomology and men’s cognitive functioning.

Depression among middle-aged adults in Japan: The role of the built environment design

There has been considerable interest in the effect of the built environment design on depressive symptoms. However, there are still few empirical studies on this topic, and there is a dearth of evidence among middle-aged adults. The present study examined the associations of urban design attributes with depressive symptoms among a sample of middle-aged adults in Japan. Cross-sectional data from a random sample of residents (40–64 years old) in two cities in Japan were examined. Depressive symptoms were assessed using the Centre for Epidemiological Studies Depression (CES-D) questionnaire. Two types of perceived and objective attributes of the built environment were measured. Covariate-adjusted multivariable linear and binary logistic models were used to estimate associations between perceived and objective built environment attributes and depressive symptoms. Among women, higher perceived access to public transport and total perceived walkability was associated with a decrease in depressive symptoms. Furthermore, there was a significant association between higher safety from traffic and lower odds of having mild depressive symptoms (CES-D ≥ 16) in women. Among men, higher safety from crime was associated with a decrease in depressive symptoms and with lower odds of having mild depressive symptoms. Total perceived walkability was also associated with lower odds of having mild depressive symptoms in men. None of the objective built environment attributes were associated with depressive symptoms in women or men. Our findings provide empirical evidence that improving perceptions of neighbourhood walkability and, in particular, enhancing access to public transport and safety from crime and traffic are important for improving depressive symptoms among middle-aged men and women.