BackgroundDepression is a significant contributor of global disease burden. Previous studies have revealed cross-cultural and gender differences in the presentation of depressive symptoms. Using the Center for Epidemiologic Studies-Depression Scale (CES-D), the present study examined differences in self-reported somatic, negative affective, and anhedonia symptoms of depression among Egyptian and Canadian university students. MethodsA total of 338 university students completed study questionnaires from two major universities in Egypt (n=152) and Canada (n=186). Symptom domains were calculated based on the 14-item model of the CES-D. ResultsWe found significant culture by gender interactions of total CES-D scores, wherein Egyptian females reported higher scores compared to their Canadian and Egyptian male counterparts. LimitationsLimitations include using analogue student samples and using only one self-report measure to examine different depressive symptom domains. ConclusionsFindings of this study provided support that males and females may differentially report depressive symptoms across cultures. Implications of these results are further discussed.