Letters1 June 2010Efficacy of Antidepressants and USPSTF Guidelines for Depression ScreeningEvelyn P. Whitlock, MD, MPH, Elizabeth A. O'Connor, PhD, and Bradley N. Gaynes, MD, MPHEvelyn P. Whitlock, MD, MPHFrom Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research, Portland, OR 97227, and University of North Carolina School of Medicine, Chapel Hill, NC 27599.Search for more papers by this author, Elizabeth A. O'Connor, PhDFrom Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research, Portland, OR 97227, and University of North Carolina School of Medicine, Chapel Hill, NC 27599.Search for more papers by this author, and Bradley N. Gaynes, MD, MPHFrom Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research, Portland, OR 97227, and University of North Carolina School of Medicine, Chapel Hill, NC 27599.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-11-201006010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree that trade-offs may be involved in conducting targeted systematic reviews to efficiently update an evidence-based recommendation. We refer the reader to the USPSTF's procedure manual (1) for further clarification on their rationale and approach for conducting updates.Dr. Poses suggests that explicit inclusion of unpublished trials in meta-analysis would reduce current estimates of antidepressant efficacy, thus undermining the rationale for depression screening in primary care. We do not believe an overestimate has been clearly established, and if it was, there are several reasons why it would not undermine the importance of screening. First and foremost, the ...
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