Prevalence Of Depression Research Articles

Depressive symptoms among rural left-behind children and adolescents in China: a large-scale cross-sectional study

BackgroundLeft-behind children(LBC) in rural China are at increased risk for mental health problems, including depression. This study aimed to estimate the prevalence of depression and identify key associate factors among Chinese rural LBC.MethodsA cross-sectional study was conducted using data from 36,612 LBC aged 6 to 18 years old across 596 data collection sites in Nanchong, Sichuan Province, China. Participants completed questionnaires assessing individual factors, family parenting situation, living events, and health-related data. Depression was measured using the Center for Epidemiological Studies-Depression Scale (CES-D). T-tests, chi-square, and logistic regression were performed to identify factors associated with depression.ResultsThe overall prevalence of depression among LBC was 6.75%. Logistic regression analysis revealed that family parenting situations, such as being from blended families (OR = 1.45) or being cared for by other family members (OR = 1.64), and dissatisfaction with the parenting situation (OR = 1.57) were significantly associated with higher odds of depression. Living events, including being misunderstood (OR = 1.82) and having disputes (OR = 1.48), and health-related factors, such as chronic diseases and regular medication use (OR = 2.38), also increased the risk of depression.ConclusionsThis study highlights the high prevalence of depression among Chinese rural LBC and identifies key associate factors, including family parenting situation, negative living events and health-related factors. Targeted interventions and policies addressing these factors are needed to promote the mental health of this vulnerable population.

Association between physical activity patterns of working-age adults and social jetlag, depressive symptoms, and presenteeism.

This study aimed to evaluate the association of physical activity with social jetlag, depressive symptoms, and presenteeism. This cross-sectional study included 8,247 working-age adults (females, 44.6%; age, 20-64 years). Social jetlag was defined as the absolute difference between the midpoint of bedtime and wake time on workdays and free days. Depression symptoms were assessed using the Center for Epidemiologic Studies Depression Scale, and presenteeism was evaluated using the Work Functioning Impairment Scale. Exercise habits were classified into four groups based on the World Health Organization guidelines: non-active (NA; n=4,223), insufficiently active (IA; n=3,009: exercise below guideline levels), weekend warriors (WW; n=220: exercise 1-2 times per week meeting guideline levels), and regularly active (RA; n=793: exercise at least 3 days per week meeting guideline levels). Using multiple and Poisson regression analyses, we examined the association between exercise habits and each outcome. Social jetlag, depression, and presenteeism were more favorable with shorter sedentary times and longer durations of moderate- and vigorous-intensity exercise. Compared with the RA group, the NA group had a significantly higher prevalence of social jetlag (prevalence ratio [PR]=1.30), depression (PR=1.31), and presenteeism (PR=1.35). The IA group had a significantly higher prevalence of depression (PR=1.33) and presenteeism (PR=1.38). Exercising with a certain frequency and intensity may help prevent symptoms of depression and social jetlag, and consequently prevent presenteeism.

Emerging role of microglia in the developing dopaminergic system: perturbation by early life stress.

Early life stress correlates with a higher prevalence of neurological disorders, including autism, attention-deficit/hyperactivity disorder, schizophrenia, depression, and Parkinson's disease. These conditions, primarily involving abnormal development and damage of the dopaminergic system, pose significant public health challenges. Microglia, as the primary immune cells in the brain, are crucial in regulating neuronal circuit development and survival. From the embryonic stage to adulthood, microglia exhibit stage-specific gene expression profiles, transcriptome characteristics, and functional phenotypes, enhancing the susceptibility to early life stress. However, the role of microglia in mediating dopaminergic system disorders under early life stress conditions remains poorly understood. This review presents an up-to-date overview of preclinical studies elucidating the impact of early life stress on microglia, leading to dopaminergic system disorders, along with the underlying mechanisms and therapeutic potential for neurodegenerative and neurodevelopmental conditions. Impaired microglial activity damages dopaminergic neurons by diminishing neurotrophic support (e.g., insulin-like growth factor-1) and hinders dopaminergic axon growth through defective phagocytosis and synaptic pruning. Furthermore, blunted microglial immunoreactivity suppresses striatal dopaminergic circuit development and reduces neuronal transmission. Furthermore, inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons, inhibiting dopamine synthesis, reuptake, and receptor activity. Enhanced microglial phagocytosis inhibits dopamine axon extension. These long-lasting effects of microglial perturbations may be driven by early life stress-induced epigenetic reprogramming of microglia. Indirectly, early life stress may influence microglial function through various pathways, such as astrocytic activation, the hypothalamic-pituitary-adrenal axis, the gut-brain axis, and maternal immune signaling. Finally, various therapeutic strategies and molecular mechanisms for targeting microglia to restore the dopaminergic system were summarized and discussed. These strategies include classical antidepressants and antipsychotics, antibiotics and anti-inflammatory agents, and herbal-derived medicine. Further investigations combining pharmacological interventions and genetic strategies are essential to elucidate the causal role of microglial phenotypic and functional perturbations in the dopaminergic system disrupted by early life stress.

Anxiety and depression in people with epilepsy during andone year after the COVID-19 pandemic.

Compare the prevalence and severity of anxiety and depression among people with epilepsy (PWE) evaluated by telemedicine during the initial stages of the COVID-19 pandemic and follow up on their status 15 months later. We conducted a prospective, observational, and analytical study at the Epilepsy Clinic of the National Institute of Neurology and Neurosurgery (NINN) in Mexico City during the COVID-19 pandemic. HADS-A and HADS-D instruments were administered to adult patients diagnosed with epilepsy, initially through telemedicine and later through in-person visits or phone calls after one year. A sample of 115 patients was obtained, with 62.5% being women. The mean age of the patients was 33.6 years (± 12), and the mean age of epilepsy onset was 16.82 years (± 13.82). The majority of patients had focal epilepsy (78.3%), and only 42% reported being seizure-free. The results from the HADS-A scale showed that 48.69% of the patients had anxiety. On the HADS-D scale, 29.56% of the patients were found to have depression. At follow-up, the HADS-A results indicated that 50.64% of the patients had anxiety, and the HADS-D results showed that 36.36% had depression. An analysis of associations between sociodemographic or clinical variables and the presence of anxiety and/or depression in PWE revealed no statistically significant results, except for the clinical variable of patients taking anxiolytic or antidepressant medications during the assessment. These patients had lower HADS-A and HADS-D scores, with a statistically significant p-value of 0.0001. Comparing these findings with a previously published paper by our group showed a significant increase in both depression and anxiety, which were already prevalent in the earlier study. In conclusion, PWE exhibited high levels of anxiety and depression during and one year after the pandemic, despite receiving appropriate treatment. These symptoms, present before the pandemic, have been further exacerbated and continue to persist. This study examined anxiety and depression in patients with epilepsy (PWE) during the COVID-19 pandemic at the National Institute of Neurology and Neurosurgery in Mexico. Using the HADS-A and HADS-D scales, 115 patients were assessed over a year. Results showed that 48.69% had anxiety and 29.56% had depression, with both increasing to 50.64% and 36.36%, respectively, after one year. The only significant finding was that patients on anxiolytic or antidepressant medication had lower scores for anxiety and depression. The study concludes that anxiety and depression in PWE worsened during the pandemic and persisted despite treatment.

The impact of digital communication and offline social interactions on depressive symptoms in Chinese older people.

In a special period of lack of offline social interaction (pandemic), the mentality of older people is changing quietly. This study aims to dissect the impact of these changes on their mental health. Utilizing data from the China Health and Retirement Longitudinal Study (CHARLS 2020), this research included 7,784 participants aged over 60 years. It evaluated the prevalence of depressive symptoms, and assessed the relative effects of these interactions on depressive symptoms. (1) a depressive symptom prevalence of 40.65%; (2) a modest engagement in digital communication, with only 20.39% of the older participating; (3) varying prevalences of depressive symptoms across groups, with notable differences depending on the type and combination of social interactions. Specifically, the prevalence was 21.7% among those engaging only in digital communication, and varied from 21.7 to 32.0% among other groups, highlighting the significant impact of social interaction patterns on depressive symptoms. Statistical analysis confirmed the significance of these findings (χ 2 = 42.415, p < 0.001). (4) In the first model, digital communication was associated with a lower likelihood of depressive symptoms (OR = 0.820, 95%CI: 0.707-0.950, p < 0.05). The second model showed no significant effect of offline social interactions on depressive symptoms (OR = 0.124, 95%CI: 0.917-1.143, p = 0.678). The third model demonstrated that the inclusion of offline social interaction variables did not significantly alter the beneficial effect of digital communication (OR = 0.820, 95%CI: 0.707-0.952, p < 0.05). (5) The results of the 1:1 matching analysis indicated that digital communication significantly alleviated depressive symptoms in older people (ATT = -0.054, p < 0.05). Conversely, offline social interactions did not significantly affect the depressive symptoms of this demographic (ATT = -0.028, p > 0.05). The depressive symptoms among older people in China has greatly increased during 2020 which year the COVID-19 pandemic was in the early stage, accompanied by considerable changes in their modes of social interaction. Our findings suggest that the influences of digital communication and offline social interactions on depressive symptoms may have operated independently during the pandemic. The potential of digital communication engagements in enhancing mental health, particularly in exceptional circumstances such as during a pandemic, underscores the need for further exploration.

Determination of the Prevalence of Postpartum Depression and Its Affecting Factors in Turkish Mothers and Syrian Refugee/Asylum Seeker Mothers.

This study aimed to determine the prevalence of postpartum depression and the factors that influence postpartum depression in Turkish and Syrian refugee mothers. The participants were administered the Personal Information Form and the Edinburgh Postnatal Depression Scale in the 6th week of the postpartum period. While the number of Turkish mothers participating in the study was 66, the number of Syrian mothers was 71. The study was conducted in Çubuk Halil Şıvgın State Hospital in 2022. The postpartum depression prevalence was found to be 16.7% in Turkish mothers and 0% in Syrian mothers. Turkish mothers' postpartum depression mean score was found to increase due to factors such as being exposed to social violence by the spouse, having had an abortion before, having had a stillbirth before, living in a nuclear family, losing a child before, having an acute social problem in the postpartum period, having full-term delivery, and being primipara. Syrian mothers' postpartum depression mean score (p < .05) was found to increase due to factors such as having had an abortion before, experiencing problems during pregnancy, experiencing an acute social problem in the postpartum period, being primigravida, and losing a child before. The postpartum depression rate was found to be 2.29 times higher in Turkish mothers compared to Syrian mothers.

University students who were men who had sex with men (MSM) in Sichuan, China had a higher prevalence of insomnia and probable depression than their non-MSM counterparts: mediation via emotional dysregulations

BackgroundMen who have sex with men studying in universities (MSM-US) frequently face multiple sexual minority stressors that potentially lead to maladaptive emotional regulations and mental problems. This study compared the prevalence of depression/insomnia between MSM-US and non-MSM male university students (NUS) and hypothesized that the potential differences would be mediated via emotional dysregulation styles (rumination and catastrophizing).MethodsThe study design was a cross-sectional study. NUS were recruited from a university-based survey using cluster sampling in three universities in China from June to October 2018, while MSM-US from the same university-based survey and the other community-based survey using convenience sampling. The effective samples size was 2,531 (292 MSM-US and 2,239 NUS). Structural equation modeling (SEM) was performed.ResultsMSM-US had significantly higher prevalence of both probable depression (55.1% versus 35.7%; OR = 4.85, 95% CI: 3.38–6.94) and moderate-to-severe clinical insomnia (17.3% versus 4.1%; OR = 2.21, 95% CI: 1.73–2.83) than NUS. MSM-US were also more likely than NUS to use emotional dysregulation styles (rumination/catastrophizing), which were correlated with probable depression/insomnia (r = 0.17 to 0.31). In the SEM, the differences in depression/insomnia between MSM-US and NUS were partially mediated by the latent variable of emotional dysregulation (rumination and catastrophizing), with effect sizes of 55.0% for probable depression and 33.6% for insomnia, respectively.ConclusionsDepression and insomnia were prevalent among male university students in Sichuan, China. Furthermore, MSM-US were at increased risk than NUS for both mental problems; emotional dysregulation partially explained such differences. Future studies are warranted to confirm the findings, develop tailored interventions to address general and MSM-specific stressors and reduce rumination and catastrophizing, and examine whether similar patterns exist in other sexual minority groups.

Suboptimal health among Chinese middle school students may be associated with psychological symptoms and sleep duration: a cross-sectional survey in China

BackgroundSuboptimal health status (SHS) is an intermediate status between ideal heath and illness, it is characterized by the perception of health complaints, general weakness, decreased immunity and low energy. An increasing number of Chinese middle school students are suffering from psychological symptoms (PS), particularly anxiety and depression. The relationship between SHS and PS is unclear in adolescents. This study aimed to investigate the prevalence of SHS and the correlation between SHS and PS among Chinese middle school students and to identify the SHS-related risk factors from the perspective of public health.MethodsA cross-sectional study was conducted with the cluster sampling method among 1955 middle school students in Shantou, China. SHS was assessed by Suboptimal Health Status Questionnaire-25 (SHSQ-25). And the PS of anxiety and depression were assessed with Generalized Anxiety Disorder Scale (GAD-7) and Beck Depression Inventory-II Scale (BDI-II) self-assessment questionnaires. Variate logistic analysis was applied to explore risk factors of SHS. The relationship between SHS and PS among Chinese middle school students was subsequently analyzed.ResultsAmong the 1955 participants, 1904 middle school students were finally included in the analysis, the effective response rate was 97.39%. The prevalence of SHS was 10.3% (197/1904) while the prevalence of anxiety and depression was 30.7% (585/1904) and 34.1% (649/1904), respectively. A strong correlation was identified between SHS and PS among middle school students. With the aggravation of anxiety and depression, the probability of suffering from SHS increased (both P<0.01). The scores for various dimensions of SHS among the depression and anxiety groups were higher compared to those of the non-depression and non-anxiety groups (all P<0.01 ). Multivariate regression showed that compared with sleeping less than six hours, 6–8 h is a protective factor for SHS (OR = 0.486, 95%CI = 0.278–0.851).ConclusionsAttention should be given to SHS and PS in Chinese middle school students, as they are strongly associated. Lack of sleep is a risk factor for SHS, so sufficient sleep should be recommended to prevent it. Identifying additional risk factors and promoting adequate sleep will improve adolescent health.

Association between triglyceride glucose-body mass index and depression among US adults: A cross-sectional study

ObjectivesThe triglyceride glucose-body mass index (TyG-BMI) is a well-established surrogate marker for insulin resistance. While an association between insulin resistance and depression has been identified, that between TyG-BMI and depression remains unclear. Therefore, we used data from the National Health and Nutrition Examination Survey (NHANES) database to investigate this. Study designThis cross-sectional study included 9673 adults (aged ≥20 years) from the NHANES in the United States from 2011 to 2020. MethodsDepressive symptoms were assessed using a nine-item version of the Patient Health Questionnaire. The covariates included age, sex, race/ethnicity, marital status, educational level, poverty-income ratio, smoking status, alcohol intake, diabetes status, cardiovascular disease, hypertension, physical activity, high-density lipoprotein, low-density lipoprotein, and total cholesterol. Multivariate logistic regression models, subgroup analyses, and threshold saturation effect analyses were conducted. ResultsAfter adjusting for age, sex, race/ethnicity, marital status, education level, poverty-income ratio, smoking status, drinking status, diabetes status, cardiovascular disease, hypertension, physical activity, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, the threshold saturation effect showed a TyG-BMI inflection point of 174.4. Below the inflection point, a 10-unit increase in TyG-BMI was associated with a 12 % lower prevalence of depression. Above the inflection point, each 10-unit increase in TyG-BMI was associated with a 4 % increase in prevalence of depression. ConclusionsTyG-BMI had a U-shaped relationship with prevalence of depression. There was a significant link between higher TyG-BMI levels and increased prevalence of depression. When the TyG-BMI value was below 174.4, any further increase in TyG-BMI was associated with a significantly lower prevalence of depression.

Prevalence of major depression, suicidal ideation, and mental health treatment among cancer survivors.

Cancer diagnosis and treatment can result in a significant psychological burden. This study sought to investigate the prevalence of major depression, associated treatments, and suicidal ideation in cancer survivors compared to a non-cancer cohort. This is a retrospective, population-based study using survey responses from the National Survey on Drug Use and Health collected from January 2015 to December 2019. Survey data sets were queried for all respondents who provided a cancer history. Respondents with a reported history of cancer ("cancer survivors") were further stratified by whether they reported a "recent" cancer diagnosis within the past 12 months. Survey responses were evaluated for recent diagnoses of and treatments for major depressive disorder and suicidal ideation. Among the 212,411 survey respondents identified, 7,635 (3.6%) reported a cancer history, with 1,486 (0.7%) reporting a recent cancer history. There were no differences in prevalence of major depression between cancer survivors and participants without cancer (9.3% vs 9.2%, p = 0.762), though the prevalence was slightly higher among recent cancer survivors (10.0% vs 9.2%, p = 0.259). Among respondents diagnosed with major depression, cancer survivors were significantly more likely to receive treatment for depression (78.6% vs 60.3%, p < 0.001). Suicidal ideation was significantly lower among cancer survivors (5.1% vs 6.2%, p < 0.001) including recent survivors (5.0% vs 6.2%, p < 0.001). There was no overall difference in the prevalence of major depression between cancer survivors and respondents without cancer. Survivors with major depression were more likely to receive treatments. Prevalence of major depression was higher in recent cancer survivors.

Transformative Therapies for Depression: Postpartum Depression, Major Depressive Disorder, and Treatment-Resistant Depression.

Depressive disorders present an enormous global public health burden. A notable treatment gap exists between the prevalence of depression and our ability to provide rapid-acting, effective treatment that achieves remission. Brexanolone and zuranolone, the first US Food and Drug Administration-approved drugs for postpartum depression, signify a critical advancement in addressing the unmet needs of a vulnerable patient population. Psilocybin shows promise for treatment-resistant depression and for those who have struggled to find relief with existing treatments. This review discusses transformative therapies that represent significant advancements in postpartum depression, major depressive disorder, and treatment-resistant depression.

Depression among Saudi international university students and its associated risk factors

IntroductionDepression disorders are one of the most widespread mental disorders among college students. In university students, depression has been associated with lower academic performance, worse work performance, and increased dropout risk. his study aims to assess the prevalence of depression and highlight risk factors among Saudi international university students (IUS) in the United States (US), the United Kingdom (UK), and Australia.Subject and methodsThis cross-sectional study was conducted among Saudi students who chose to study abroad. A self-administered online questionnaire was sent to the students using an online survey. The questionnaire includes socio-demographic data (e.g., age, gender, specialty, etc.), medical characteristics, social status, and the Patient Health Questionnaire (PHQ-8) to assess the student's depression.ResultsOf the 401 students, 52.4% were younger (age 18 – 25 years), and more than half were males (53.9%). Most of the participants were studying in the US (46.6%), followed by the UK (40.6%) and Australia (12.7%). The rate of major depression among Saudi students studying abroad was 40.4%. In univariate analysis, major depression was influenced by age, marital status, specialty, personal and family history of mental illness, contact with family and friends, and feeling like a stranger. However, after conducting multivariate regression analysis, previous diagnoses of mental illness and feeling a stranger were identified as the significant independent risk factors for major depression.ConclusionThis study provides insights into the prevalence and risk factors associated with depression among Saudi IUS. The prevalence of major depression among Saudi IUS was 40.4%. Previous history of mental illness and feeling like strangers were identified as the most prominent risk factors in this study. Identifying the prevalence and contributing factors of depression can guide academic institutions and governments in the development of effective interventions and support for IUS’s mental well-being. Future research could diversify the sample and employ longitudinal designs.

A comparison of comorbidities and their risk factors prevalence across rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis with focus on cardiovascular diseases: data from a single center real-world cohort

Management of comorbidities is essential to a patient-centered approach to the treatment of chronic inflammatory arthritis. The aim of this study was to compare the prevalence of comorbidities and their risk factors in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA) in a single center outpatient cohort. This cross-sectional study included adult patients diagnosed with RA, PsA, and axSpA from a single rheumatology outpatient center. Comorbidities were documented by physicians, and patients were categorized into two age groups, younger (< 45 years) and older (≥ 45 years), with age- and gender-based comparisons. Disease activity, comorbidities, and cardiovascular (CV) risk factors were analyzed using chi-squared tests for categorical variables and independent samples t-tests for continuous variables, with p values < 0.05 considered statistically significant. Comorbidities were registered by physicians using GoTreatIt® Rheuma software. Among 508 RA, 267 PsA, and 285 axSpA patients, the four most common comorbidities were hypertension (36.4%, 25.1%, and 19.7%, respectively), dyslipidemia (19.5%, 15.4%, 14.7% respectively), obesity (16.9%, 22.5%, 14% respectively) and thyroid disease (21.5%, 13.9%, 11.2% respectively). Other comorbidities differed among the diseases and included osteoporosis, osteoarthritis, diabetes mellitus, arrhythmia, and asthma in RA, diabetes mellitus, depression and asthma in PsA, osteoporosis and serious infection in axSpA. RA patients, compared to axSpA had a higher prevalence of coronary artery disease (4.1% vs. 0.7%, p = 0.006), arrhythmia (6.9% vs. 2.5%, p = 0.008) and major adverse cardiac events (2.6% vs. 0.4%, p = 0.024) compared to axSpA. Osteoporosis was more frequent in RA (19.1%) and axSpA (8.4%) than in PsA (2.3%; p < 0.001) and was frequently diagnosed in patients aged < 45. Depression prevalence was surprisingly low (1.6%, 5.2%, and 1.8%, respectively). RA patients had the highest multimorbidity rate, with 26.6% reporting three or more comorbidities, compared to 16.8% in PsA and 10.6% in axSpA (p < 0.001). Health status was poorest in RA and worse in women compared to men for all diseases. RA, PsA, and axSpA share the same four most common comorbidities: hypertension, dyslipidemia, obesity, and thyroid disease but have different prevalence of other disorders and CV risk factors, indicating the need for an individual screening and prevention approach. The possible unrecognition of depression should be evaluated.

Experiences and psychological issues affecting parents of children born with atypical genitalia in India.

Parents of children with differences of sex development (DSD) are known to suffer from psychological distress at the time of diagnosis and thereafter. We analyzed the prevalence of anxiety and depression in Indian parents of children with DSD and its associated risk factors, as well as their experiences, perceptions and expectations from the healthcare system. This cross-sectional study included parents of children aged ≤6 years with atypical genitalia. Data was collected through face-to-face semi-structured interview using specially designed questionnaire. Depression and anxiety have been assessed using PHQ9 (Patient health questionnaire) and GAD-7 (Generalized anxiety disorder scale), respectively. The current mean age of the 43 children (46,XY=26, 46,XX=16 and chromosomal DSD=1) was 36.5±21.4months with a median age of diagnosis of 5months (range- 0-60months). 68 parents (35 mothers and 33 fathers) were interviewed. The score was above the cut-off for clinically significant depression in 27.2 and 25.7 % of the fathers and mothers, respectively; and for clinically significant anxiety in 15.1 and 28.6 % of the fathers and mothers, respectively. The most significant factor associated with psychological distress was rearing a boy with lower EMS in fathers and lower literacy levels (with higher perception of stigma) in mothers. Absence of family support was associated with high levels of distress in both parents. There is a high level of depression and anxiety amongst Indian parents of children born with atypical genitalia and requirement for psychological support and counseling.

Prevalence of anxiety and depression and the influence of correlates in acute coronary syndrome patients: a cross-sectional analysis

BackgroundAcute coronary syndrome (ACS) patients are vulnerable to anxiety and depression. This study aimed to assess the mental health burden among Egyptian ACS patients by assessing the prevalence and associates of these conditions. This study enrolled 212 patients who underwent coronary angiogram. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). Demographic, psychosocial, and clinical data were collected. Univariate and multivariate logistic regression analyses identified factors associated with anxiety and depression.ResultsThe mean age of the participants was 54.1 years, and 80.7% were males. More than half (58.1%) exhibited anxiety, depression, or both, with depression being more prevalent than anxiety (48.1% vs 38.2%). Past major depressive disorder was strongly correlated with both anxiety and depression. Higher anxiety scores increased the odds of depression (OR = 1.234, p < 0.001), and vice versa (OR = 1.55, p < 0.001). Hypertension and the use of antihypertensive medications were associated with increased depression. Significant associates of anxiety included increased heart rate, past use of furosemide and enoxaparin, and current polypharmacy.ConclusionsA substantial proportion of ACS patients experience comorbid anxiety and depression. Polypharmacy, past depression, and hypertension are key risk factors. Targeted interventions addressing these factors are essential for improving mental health in this vulnerable population.

Prevalence of Mental Morbidities in a Tertiary Care Leprosarium in North India: A Cross-Sectional Study

Background: Leprosy is a chronic infectious disease causing substantial physical and mental morbidity. Every year around 200,000 new cases are reported globally. (WHO) Despite continuous efforts to eradicate leprosy, prevalence of the disease is still a concern especially in India. The treatment of leprosy has always focused on elimination of bacteria, correction of physical deformities and preventive aspects with little emphasis on its psychiatric implications. Therefore, it is imperative to understand the link between the disease and mental health of the patient. This study aims to estimate the prevalence of psychiatric morbidities among leprosy patients admitted in a tertiary care center in north India. Methods: Data was collected from patients admitted in a tertiary care leprosy center in North Delhi by using a well-structured questionnaire DASS-21 which included total of 21 questions, 7 questions each pertaining to depression, anxiety and stress. Findings were analyzed using SPSS version 20.0. Frequencies and percentages were used and the association between the variables was tested using the chi-square test. Results: Findings suggested that there is causal relationship between leprosy disease and mental health. Prevalence of depression, anxiety and stress was 28%, 56% and 44% respectively which significant. Of note, the prevalence was higher in adults aged between 25-35 years as compared to adults aged 35-45 years. Patients with physical deformities were found to higher prevalence of mental health issues such as depression (18%), anxiety (28%), Stress (24%). Conclusion: This study found that there was a significantly high prevalence of depression, anxiety, and stress among individuals affected by leprosy especially among those with physical deformities. Hence, appropriate psychological counselling must be considered as an essential part of therapeutic intervention for leprosy patients.

The Effect of Hypnobirthing Method to Prevent Imminent Prematural Delivery Through Reducing Stress Levels in Factory Working Mothers

Every day, a total of 800 women die from complications that occur during pregnancy and childbirth. Preterm birth is a major challenge in perinatal health care. In the United States, one in eight babies (12%) is born prematurely; of these, 80% are born at 32-36 weeks of gestation and 20% are born at 22-32 weeks. Premature babies (&lt;32 weeks) are at increased risk of neonatal mortality and morbidity. One of the factors causing premature birth is antenatal depression. A systematic review of studies conducted in developed and low-income countries reported the prevalence of antenatal depression in the range of 5% to 30% and 15.6% to 31.1%). Increased risk of premature birth 1.2 times premature birth and 1.3 times risk of low birth weight. Sociodemographic factors play a major role in the incidence of imminent premature labor. The results of a study in 2014 showed that 54.8% of mothers giving birth at Sidoarjo Regional Hospital had a heavy workload. The results of the study showed that there was a relationship between the workload of pregnant women and the incidence of preterm labor with a p value = 0.008 (P &lt;0.05). Pregnant women with heavy workloads are caused by mothers having jobs with a shift work system, long working hours &gt;7 hours/day or &gt;49 hours/week, working in factories with an average break time of 1 hour and activities such as lifting or pushing goods. In addition, after working outside the home, mothers still do household chores such as cooking, sweeping, washing without the help of others. The reason mothers work on average is to help the family economy. Other factors are anxiety in pregnancy, health risks, domestic violence, length of work per day, nutritional factors during work, length of rest at work, partner support, household income, mother's education level, mother's age, parity Hypnobirthing relaxation provides positive suggestions to the mother. This suggestion changes beta brain waves (conscious mind) into alpha waves (unconscious mind) in the cerebral cortex, then a sensory association process occurs which causes stimuli to be analyzed, understood and arranged into an object and the meaning of the stimulus. The provision of one hypnosis session referring to The Creative Psychosocial Genomic Healing Experience protocol can significantly increase immediate-early gene expression (Zif-268), increase stem cell activity, reduce stress and inflammation at the cellular level. This study aims to explain the effectiveness of the influence of hypnobirthing on reducing the scale of depression in Partus Prematurus Imminens. The expected benefits in this study are to develop the potential for preventing premature labor with the hypnobirthing method.

The Mediating Role of Physical Activity and Self-Rated Health in the Association Between Depression and Quality of Life in Older Europeans: An Analysis Differentiated by Sex.

Objectives: This study investigates the mediating role of moderate physical activity (MPA), vigorous physical activity (VPA), and self-rated health (SRH) in the association between depression and quality of life (QoL) in a large sample of Europeans aged 50 and over, differentiated by sex. Methods: Data from the 2017 Survey of Health, Ageing and Retirement in Europe were analyzed, including 11,986 individuals (6843 women) aged 50 and older. All information was collected through face-to-face interviews: sociodemographic data, SRH, physical activity levels, depression (EURO-D scale), and QoL (CASP-12). Results: Comparatively, women reported a higher prevalence of depression, a lower perception of QoL, and slightly lower levels of SRH, MPA, and VPA. Parallel mediation models revealed, for both sexes, that an increase in VPA levels was more effective in benefiting SRH; and MPA proved to be a better promoter of QoL. When comparing sexes, only the path depression → VPA → QoL showed a significant difference (p < 0.001). Conclusions: These results provide valuable insights for developing physical activity interventions capable of improving mental health and promoting QoL in older European adults.

Depressive symptoms and determinants among people who inject drugs in Kaduna State, Nigeria

Background: People who inject drugs (PWID) are known to have higher rates of mental health disorders, particularly depression. Despite this, there is a lack of research on the prevalence of depression among PWID in Nigeria.Aim: This study aimed to determine the prevalence of depressive symptoms and their determinants among PWID.Setting: The study was conducted in Kaduna State, Northwest Nigeria where a needle and syringe programme (NSP) for PWID was recently initiated.Methods: A cross-sectional survey was conducted among PWID using a multi-stage sampling technique. Data were collected using structured interviews and digitalised questionnaires covering socio-demographics, depression symptoms (PHQ-9) and perceived social support (MSPSS).Results: A total of 525 participants were included in the study, with the majority being males (73.3%) aged 24–35 years (54.5%). The study revealed a high prevalence of depressive symptoms among PWID, with 47.4% reporting major symptoms. Predictors of depression identified among PWID included older age, female gender, divorce, unemployment, having primary education and moderate social support.Conclusion: The study underscored a concerning prevalence of depressive symptoms among PWID, notably linked to diverse sociodemographic factors, emphasising the need for holistic, context-specific mental healthcare approaches for this population.Contribution: This study contributes to the limited research on the mental health of PWID in Nigeria. It highlights the need for targeted mental health interventions that consider the unique sociodemographic characteristics of this population.

Morning Salivary Cortisol Has a Positive Correlation with GAD-7 Scores in Patients with Ulcerative Colitis.

Objectives: Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn's disease (CD). Earlier onset of IBD symptoms has been linked to a higher prevalence of depression and anxiety. Evidence supports that cortisol abnormalities correlate with the development and severity of autoimmune diseases. The primary aim of this study was to investigate the correlation of morning salivary cortisol levels with self-reported mood (depression and anxiety) and quality of life in patients with IBD. Methods: This was a prospective, single-center study including outpatients with IBD. Enrolled patients provided a one-time morning salivary cortisol sample and electronically completed a one-time survey encompassing self-reported quality of life (Short Inflammatory Bowel Disease Questionnaire (SIBDQ)) and mood (Patient Health Questionnaire 8 (PHQ-8), General Anxiety Disorder-7 (GAD-7)). Results: A total of 36 patients (UC, n = 21) were included in the study. There was no correlation between morning salivary cortisol and depressive symptoms (PHQ-8: r = 0.007, p = 0.968) or quality of life (SIBDQ: r = -0.095, p = 0.606). However, there was a trend towards a positive correlation between self-reported anxiety symptoms by GAD-7 and salivary cortisol (r = 0.347, p = 0.052). A subgroup analysis showed a positive correlation between morning salivary cortisol and GAD-7 scores in patients with UC (r = 0.535, p = 0.015), but not in patients with CD (r = 0.064, p = 0.843). Conclusions: This pilot study is the first to associate cortisol with anxiety symptom severity in UC. Further research is needed to investigate the link between salivary cortisol, neuropsychiatric disease, and IBD outcomes.