Prevalence Of Depression Research Articles

Associations between magnesium depletion score and depression among individuals aged 20 to 60 years

BackgroundMagnesium is closely associated with depression. The study aims to explore the relationship between magnesium depletion score (MDS), used to evaluate the body’s magnesium deficiency status, and depression. MethodsThis population-based cross-sectional study used data from the National Health and Nutrition Examination Survey in 2005-2018 and included adults aged 20 to 60 years. Depression was determined using the Patient Health Questionnaire-9 (PHQ-9). MDS was a practical assessment instrument used to assess the status of magnesium deficiency. Multivariable logistic and restricted cubic spline models were used to assess the associations between MDS and depression. ResultsAmong the 18247 adults, 1753 participants were diagnosed with depression. Multivariable logistic regression analysis indicated that when MDS was treated as a continuous variable, each one-unit increase in MDS was associated with an odds ratio (OR) for depression of 1.15 (1.04, 1.26). When MDS was considered a categorical variable, compared to participants with MDS of 0, the ORs for depression for those with MDS of 1, 2, and ≥3 were 1.03 (0.87, 1.21), 1.41 (1.12, 1.78), and 1.58 (1.06, 2.35), respectively. Restricted cubic spline analysis showed that there was no non-linear relationship between MDS and the prevalence of depression. Subgroup analyses indicated the positive associations between MDS and depression were generally similar in different populations. ConclusionsMDS may be positively associated with the prevalence of depression. In the future, additional longitudinal studies are needed to validate our findings and investigate potential mechanisms.

Depression and Anxiety Among Arab Individuals in the United States: A Meta-analysis.

Emerging research suggests that the increasing population of Arab immigrants and refugees living in the United States (U.S.) has a greater risk for depression and anxiety than other groups. The purpose of this meta-analysis was to estimate the prevalence of depression and anxiety for Arabs in the U.S., to examine the moderating effects of key demographic variables (gender, immigration status, ethnicity) and study characteristics (research design and quality) on the prevalence of anxiety and depression, and to evaluate the direct effects of additional demographic and study characteristics on prevalence rates. Using guidelines from the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P), we searched PubMed, Embase, CINHAL, ProQuest, and the Web of Science databases for articles published between January 2000 and March 2023. Two reviewers each individually extracted the articles' data and evaluated the reported study's methodological quality using a well-established checklist. Statistical analyses consisted of random effects models to estimate the pooled prevalence of depression and anxiety across all studies, separate random effects models for distinct demographic (e.g., immigration status) and methodologic (e.g., study quality) subgroups that might have unique prevalence rates, and a meta-regression to identify additional variables (e.g., age of individuals) that might influence prevalence rates. Our review included 17 studies with a total sample population size of 22, 558 participants. Results indicated that the estimated prevalence of depression overall was 48% (CI 34, 63%) and 58% (CI 33, 83%) for the prevalence of anxiety. Our subgroup analyses uncovered notable variations in prevalence rates based on gender composition, immigration status, ethnicity, and research quality while results of the meta-regressions demonstrated effects of publication year and age of the Arab individual on the estimated prevalence of depression and anxiety. The high prevalence rates for depression and anxiety identified through this meta-analysis are very concerning and underscore the urgent need to address mental health concerns in Arab communities. Results of subgroup and meta-regression analyses suggest that refugees, individuals from specific countries of origin, and younger Arabic persons may need particular attention by clinicians in screening for and treating their depression and anxiety. Our results also signify the need for further high-quality studies to more rigorously assess prevalence of these mental health problems, since we found evidence of potential publication bias and approximately one third of the studies in the review had less optimal methodological quality based on our evaluation. Ultimately, in-depth research regarding the causes of anxiety or depression among Arab individuals will be essential to the development of culturally competent interventions that may reduce their very high prevalence rates.

Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study

ObjectivesThis study aimed to assess the prevalence of treatment-resistant depression (TRD) and associated factors among patients with major depressive disorder (MDD) on follow-up at Amanuel Mental Specialised Hospital, Addis Ababa,...

Depression screening model for middle-aged and elderly diabetic patients in China.

Diabetes is a common global disease closely associated with an increased risk of depression. This study analyzed China Health and Retirement Longitudinal Study (CHARLS) data to examine depression in diabetic patients across China. using 29 variables including demographic, behavioral, health conditions, and mental health parameters. The dataset was randomly divided into a 70% training set and a 30% validation set. Predictive factors significantly associated with depression were identified using least absolute shrinkage and selection operator (LASSO) and logistic regression analysis. A nomogram model was constructed using these predictive factors. The model evaluation included the C-index, calibration curves, the Hosmer-Lemeshow test, and DCA. Depression prevalence was 39.1% among diabetic patients. Multifactorial logistic regression identified significant predictors including gender, permanent address, self-perceived health status, presence of lung disease, arthritis, memory disorders, life satisfaction, cognitive function score, ADL score, and social activity. The nomogram model showed high consistency and accuracy, with AUC values of 0.802 for the training set and 0.812 for the validation set. Both sets showed good model fit with Hosmer-Lemeshow P > 0.05. Calibration curves showed significant consistency between the nomogram model and actual observations. ROC and DCA indicated that the nomogram had a good predictive performance. The nomogram developed in this study effectively assesses depression risk in diabetic patients, helping clinicians identify high-risk individuals. This tool could potentially improve patient outcomes.

A prospective study of antenatal anxiety and depression in pregnant women with polycystic ovary syndrome.

Women with polycystic ovary syndrome (PCOS) experience higher rates of depression and anxiety. There is limited research relating to perinatal mental health in women with PCOS. Studies suggest PCOS is associated with a higher prevalence of perinatal mental health disorders. Perinatal guidelines currently do not recognise PCOS as a risk factor for perinatal mental health disorders. We aimed to prospectively assess the prevalence of mental health disorders in pregnant women with PCOS. Consenting pregnant women, with and without PCOS, were invited to participate. Standardised validated questionnaires were carried out including Generalised Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9) and Edinburgh Postnatal Depression Scale (EPDS). Fifty-one with PCOS and 49 without PCOS responded. Pregnant women with PCOS had a higher mean (SD) anxiety score (GAD-7) than those without PCOS (8.2 [6.7] vs. 5.89 [4.7], p = 0.04). Pregnant women with PCOS had higher mean (SD) depression scores than those without PCOS on EPDS (9.1 [6.4] vs. 6.4 [4.5], p = 0.02) but not PHQ-9 score (median (IQR) 4 (3-9) vs. 4 (2-7.5), p = 0.25). Women with PCOS were more likely to experience moderate/severe anxiety (PCOS 34%, control 20%) and moderate/severe depression (PCOS 34%, control 20%) symptoms than women without PCOS. Twenty-nine percent of pregnant women with PCOS had an EPDS score >13 showing significantly higher rates of severe depression (PCOS 29%, control 12%, p = 0.03). Our findings suggest a higher prevalence of perinatal depression and anxiety in women with PCOS. Our findings may suggest increased need for screening for mental health disorders in women with PCOS.

Prevalence and Determinants of Postnatal Depression in Ernakulam District, India: A Cross-Sectional Study

Prevalence and Determinants of Postnatal Depression in Ernakulam District, India: A Cross-Sectional Study

Psychological and behavioral assessments in girls with idiopathic central precocious puberty.

Idiopathic central precocious puberty (iCPP) is the most common cause of precocious puberty in girls. However, research on the psychological outcomes of iCPP girls is limited. To evaluated the psychological characteristics in iCPP girls in comparison to prepubertal girls throughout the first diagnosis and six-month follow-up period. Eighty-five girls, age 6-8 years, and their caregivers were enrolled to the prospective cohort study. Three Thai-standardized questionnaires were used as psychological assessment tools, including Children's Depression Inventory (CDI), Parent Screen for Child Anxiety Related Disorders (SCARED) and Parent-Strengths and Difficulties Questionnaire (SDQ). Forty-six iCPP and 39 prepuberty girls were enrolled at baseline. No significant differences in psychological and behavioral problems between iCPP and prepuberty girls. However, the iCPP group exhibited a significantly higher proportion of "risk and problem" for emotional problems compares to the prepuberty group (7 vs. 0, p 0.01) while the prepuberty group exhibits the significantly proportion of "risk" for peer problems (6 vs. 0, p 0.007). At baseline, twelve percent of iCPP girls exhibited depression and mean CDI score was 8.1±7.2 and 3.7±2.3 (p 0.007) in iCPP and prepuberty group, respectively. At the 6-month follow-up, there was no significant difference in psychological outcomes between twogroups. There were no significant differences in psychological and behavioral problems in iCPP girls compared to prepubertal girls. However, the higher prevalence of emotional problems and depression observed in iCPP girls constitutes significant psychological issues that necessitate close monitoring.

Psychological factors in diabetes-related foot complications: A cohort study.

Living with diabetes has been linked with an increased prevalence of psychological distress. Psychological problems may interfere diabetes-related foot complication (DRFC) self-management. We aimed to characterise psychological functioning in DRFC, and identify clinical factors that may be associated with psychological problems. Eighty-one participants (Mage = 62.8, SD = 11.3, range = 30-87) with DRFC were recruited from The Royal Melbourne Hospital. Each participant completed a battery of psychological questionnaires. DRFC participants endorsed an elevated prevalence of depression, anxiety, post-traumatic stress and diabetes distress. There were also maladaptive personality traits, differences in emotion regulation skills and negative illness perceptions. Previous mental health disorder, higher HbA1C levels and diabetes-related complications were also associated with greater psychological symptoms. Elevated prevalence of psychological symptoms is apparent in DRFC. Our study highlights the need to use targeted interventions to address psychological difficulties to help DRFC patients cope better with their condition.

Determinants of depression among ever-married adolescent girls in Bangladesh: Evidence from the Bangladesh Adolescent Health and Wellbeing Survey 2019-2020.

Common mental health disorders in early life represent a major challenge and these conditions become more complicated and substantial during the development period of adolescence. Despite the global concern over the increasing prevalence of mental health issues among adolescents, it remains largely a neglected area of research and health policy in Bangladesh, where the burden of child marriage is significantly higher. This study aimed to investigate the prevalence and factors associated with depression among married adolescent girls in Bangladesh. The study utilized the data from first-ever Bangladesh Adolescent Health and Wellbeing Survey (BAHWS), conducted in 2019-2020. A total of 1,693 married adolescent girls were included in the final analysis. Depressive symptoms were measured using the standardized Patient Health Questionnaire-9 (PHQ-9) tool. Descriptive statistics were applied to assess the prevalence of depression, while bivariate analysis was done to measure the significance of the variables. Furthermore, logistic regression was used to examine the association between any form of depression and selected covariates. The overall prevalence of mild to severe levels of depression among the participants was 53.1% (Mild: 40.3%; Moderate: 9.9%; Moderately severe: 2.3%; Severe: 0.6%). In the multivariable logistic regression model, it was found that adolescents from richest wealth quintile were 35% less likely to suffer from depression (AOR = 0.65; 95% CI = 0.45-0.92; P value = 0.02). Additionally, physical violence (AOR = 1.55; 95% CI = 1.14-2.09; P value = 0.004), sexual harassment (AOR = 1.50; 95% CI = 1.11-2.01; P value = 0.007), social bullying (AOR = 2.25; 95% CI = 1.73-2.91; P value < .001), and cyberbullying (AOR = 1.75; 95% CI = 1.10-2.77; P value = 0.01) were associated with depression. This study demonstrated that more than half of the married adolescents suffer from mild to severe levels of depression, while any form of violence and harassment significantly increases their risk of depression. Therefore, a more inclusive policy is needed, engaging with communities and local stakeholders, to lay out key actions and intervention pathways to address the issue of violence against married adolescent girls as the extent and spectrum of violence continue to evolve.

Predicting Depression in Middle-Aged Individuals in Tehran Based on Socioeconomic Status, Loneliness, Spiritual Well-Being, and Marital Satisfaction in 2023

Introduction: Information related to the amount of the most significant risk factors identified in relation to depression in middle-aged Iranian individuals is insufficient. Accordingly, the aim of this study was to predict depression in middle-aged residents of Tehran based on their socioeconomic status, feelings of loneliness, spiritual well-being, and marital satisfaction. Methods: This cross-sectional study employed a quantitative descriptive-correlational approach and regression analysis. A total of 216 middle-aged individuals visiting health centers in Tehran in 2023 were selected through convenience sampling. Participants completed questionnaires assessing marital satisfaction (Hudson), social-emotional loneliness in adults, spiritual well-being (Dehshiri et al.), socioeconomic status (SES), and the Beck Depression Inventory (BDI-II). Multiple linear regression analysis was conducted using SPSS version 24 to examine the relationship between predictor variables and depression. Rusults: Among the 216 middle-aged participants in Tehran, aged between 40 and 60 years, 47/68% were male (103 individuals) and 52/31% were female (113 individuals). The prevalence of depression among middle-aged individuals in Tehran was found to be 46/3% (100 individuals). Notably, only spiritual well-being significantly predicted the variability in depression among middle-aged individuals in Tehran (B=0/19, p&lt; 0/01). Conclusion: Contrary to previous studies, socioeconomic status, loneliness, and marital satisfaction did not statistically predict the variability in depression among middle-aged individuals in Tehran. It is recommended that further research be conducted to identify the most significant risk factors associated with depression in this demographic.

Anxiety depression levels, anxiety sensitivity, and quality of life in children with chronic spontaneous urticaria: A cross-sectional study

Existing literature offers some insights into the prevalence of anxiety and depression in children with chronic spontaneous urticaria (CSU). However, the literature on anxiety sensitivity (AS) and quality of life (QoL) in these children remains poorly understood. This study aimed to evaluate psychiatric diagnoses, anxiety and depression levels, AS, and QoL in children with CSU compared to healthy controls. The CSU group consisted of 44 children aged 8 to 17 years who were diagnosed with CSU, while the control group consisted of 44 healthy children. A child psychiatrist conducted the psychiatric assessment of the children. The Revised Child Anxiety and Depression Scales (RCADS), the Childhood Anxiety Sensitivity Index (CASI), and the Children’s Dermatology Life Quality Index (CDLQI) were administered. Multiple linear regression analysis was conducted to identify independent predictors of QoL, considering several potential factors, including the urticaria activity score, duration of urticaria, presence of a psychiatric diagnosis, scores on the RCADS major depression disorder, RCADS-total anxiety, and total CASI. A significantly higher prevalence of psychiatric diagnoses and anxiety disorders was observed in the CSU group (P &lt; .05). In the CSU group with a psychiatric diagnosis, CASI-total (0.011), CASI-physical (0.049), CASI-social (0.022), and CDLQI scores (P &lt; .001) were significantly higher than those without a psychiatric diagnosis. In the multiple linear regression analysis, only the presence of a psychiatric diagnosis was found to be a significant predictor of CDLQI scores (OR, 5.918; 95% CI, 2.505–9.330; P: .001). This study indicated that children with CSU exhibited a higher prevalence of psychiatric diagnoses than controls. Additionally, children with psychopathology in the CSU group demonstrated higher AS and greater impairment of QoL than those without psychiatric diagnoses. Furthermore, the most significant predictor of a decline in QoL was the presence of a psychiatric diagnosis.

Prevalence and determinants of antenatal depression and its association with intimate partner violence: a cross-sectional study at Hospital Melaka, Malaysia

Prevalence and determinants of antenatal depression and its association with intimate partner violence: a cross-sectional study at Hospital Melaka, Malaysia

Depression among Asian American adolescents: a multifaceted examination of risk and protective factors

ABSTRACT Depression among adolescents is a public health concern. The present study examines the impact of sex, grade level, employment status, parental support, school-related influences, engagement in prosocial activities, and participation in risky behaviors on the mental well-being of Asian American youth. A secondary data analysis of the 2020 Student Drug Use Survey was conducted. Of the N = 2332 Asian American youth, 19.6% (n = 456) reported depression. Of these, 24.2% (n = 286) identified as female, and 14.5% (n = 163) identified as male. Furthermore, univariate logistic regression analysis and logistic regression model analyses were employed. The final logistic regression model was found to be significant and suggests that lack of parental support, involvement in prosocial activities, and involvement in risky behaviors can predict depression among Asian American high school youth. The findings of this research study hold significant implications for the development of targeted interventions aimed at addressing depression among Asian American high school students. Identifying specific predictors such as the lack of parental factors, engagement in prosocial activities, and participation in risky behaviors provides valuable insights for educators, mental health professionals, and policymakers. By recognizing these influential factors, interventions can be tailored to enhance parental involvement, promote prosocial activities, and mitigate risky behaviors, thus potentially reducing the prevalence of depression among Asian American youth in high school.

Prevalence and risk factors of anxiety and depression in diabetic retinopathy patients: A cross-sectional study using multiple scales.

To investigate the prevalence of anxiety and depression, and explore their related factors in all types of diabetic retinopathy (DR) patients more precisely and accurately by multiple scales. Beck anxiety inventory (BAI), self-rating anxiety scale (SAS), beck depression inventory (BDI), and self-rating depression scale (SDS) scores were assessed in 247 DR patients and 250 non-retinopathic diabetes mellitus (NRDM) patients. In DR patients, there were 32 patients with proliferative DR and 115 patients with impaired visual acuity. The prevalences (95% confidence interval) of anxiety were 38.5% (32.4%-44.6%) and 32.0% (26.2%-37.8%) by BAI and SAS, while those for depression were 31.6% (25.8%-37.4%) and 25.1% (19.7%-30.5%) by BDI and SDS in DR patients. BAI score (P = 0.003), BAI-defined anxiety rate (P = 0.010), SAS score (P = 0.001), SAS-defined anxiety rate (P = 0.006), BDI score (P = 0.005), BDI-defined depression rate (P = 0.028), and SDS score (P = 0.001) were increased in DR patients versus NRDM patients. In DR patients, proliferative DR independently related to BAI-defined anxiety (P < 0.001) and SAS-defined anxiety (P < 0.001). Female (P = 0.016) and proliferative DR (P < 0.001) independently associated with BDI-defined depression; female (P = 0.007), DM duration (P = 0.025), triglyceride (TG) (P = 0.026), and proliferative DR (P = 0.014) independently associated with SDS-defined depression. The combination of these independent factors showed acceptable abilities in predicting BAI-defined anxiety, SAS-defined anxiety, BDI-defined depression, or SDS-defined depression in DR patients, with area under curves of 0.626, 0.656, 0.696, and 0.741, respectively (all P < 0.001). Anxiety and depression are prevalent; meanwhile, proliferative DR, female, DM duration, and TG independently relate to anxiety or depression in DR patients.

Omega-3 fatty acid supplementation for depression in children and adolescents.

Mental health disorders including major depressive disorder (MDD) are well recognized as major contributors to the global burden of disease among adolescents. The prevalence of adolescent depression is estimated to have increased by at least 25% during the COVID-19 pandemic, compounding the already challenging problem of insufficient mental health service and service accessibility that existed prepandemic. Omega-3 polyunsaturated fatty acid (PUFA) supplementation is currently recommended as a preventive treatment for depression in high-risk adults as well as a second-line monotherapy for adults with mild to moderate MDD, and adjunctive to antidepressants for adults with moderate to severe MDD. The benefits of omega-3 PUFA intake on depressive illness have been hypothesized to occur as a result of their effect on neurotransmission, maintenance of membrane fluidity, and anti-inflammatory action. A comprehensive synthesis and quantification of the existing evidence on omega-3 PUFA's efficacy in treating depression among children and adolescents is essential for clinicians to provide informed guidance to young people and their families, especially considering the absence of current guidelines for this age group. Primary objective To determine the impact of omega-3 PUFA supplementation versus a comparator (e.g. placebo, wait list controls, no treatment/supplementation, or standard care) on clinician-diagnosed depression or self-reported depression symptoms in children and adolescents. Secondary objectives To estimate the size of the effect of omega-3 PUFAs on depression symptoms. To estimate the effect of each type of omega-3 PUFA (EPA or DHA), compared with placebo, on depression. To determine if the effect is modified by dosage, format (capsule or liquid), sex, or age. To determine compliance and attrition for omega-3 PUFAs as an intervention for depression in children and adolescents. To determine the safety of omega-3 PUFAs as an intervention for depression in children and adolescents. We searched CENTRAL, MEDLINE, Embase, three other databases, reference lists of included studies, grey literature, and relevant reviews. The latest search date was 18 May 2023. We included randomized controlled trials (RCTs) involving males and females aged 19 years or younger with diagnosed depression comparing omega-3 PUFA supplementation to placebo, wait list control, no treatment/supplementation, or standard care. We used standard Cochrane methods. Our primary outcomes were self-reported depression symptoms and clinically diagnosed resolution of depression. Our secondary outcomes were attrition, adverse effects, and compliance with the intervention. We used GRADE to assess the certainty of evidence for key outcomes. We included five trials with 228 participants in our meta-analysis. All trials used a placebo comparator; intervention duration ranged from 10 to 16 weeks (median: 12 weeks). Omega-3 PUFA supplementation compared to placebo may reduce self-reported depression symptoms, but the evidence is very uncertain (standardized mean difference [SMD] -0.34, 95% confidence interval [CI] -0.85 to 0.17; lower SMD means greater improvement in depression due to omega-3 PUFA; 5 trials, 185 participants; very low-certainty evidence). Omega-3 PUFA supplementation may have little to no effect on remission of depression symptoms compared to placebo, but the evidence is very uncertain (omega-3 PUFA versus placebo: 50% versus 48%; odds ratio [OR] 1.11, 95% CI 0.45 to 2.75; 4 trials, 127 participants; very low-certainty evidence). Omega-3 PUFA supplementation may result in little to no difference in attrition (dropouts) compared to placebo (omega-3 PUFA versus placebo: 18% versus 19%; OR 0.94, 95% CI 0.46 to 1.90; 5 trials, 228 participants; low-certainty evidence). Omega-3 PUFA supplementation may result in little to no difference in adverse effects, with one study reporting more muscle cramps in the fish oil group (13/27 participants) compared to the placebo group (6/29 participants); one study reported more frequent defecation in the omega-3 group (1/29 participants) and one study identified mild skin rash and unusual/manic behavior in the placebo group (2/27 participants). None of the included studies reported serious adverse effects. Based on five small studies, omega-3 PUFA supplementation may reduce self-reported depression symptoms, but the evidence is very uncertain. Omega-3 PUFA supplementation may have little to no effect on depression remission compared to placebo, but the evidence is very uncertain. Omega-3 PUFA supplementation may result in little to no difference in attrition or adverse effects. The studies observed no serious adverse effects. This review highlights early-stage research on omega-3 PUFA and depression in young people. The evidence on the effects of omega-3 PUFA supplementation in improving self-reported depression symptoms or achieving depression remission in children and adolescents is very uncertain. While no harms are evident, more data are needed to confirm potential risks. Addressing current limitations in the evidence base through the design and conduct of methodologically rigorous studies - larger sample sizes, varied dosages, eicosapentaenoic acid/docosahexaenoic acid ratios, treatment durations, and safety profiles - is crucial to advance our understanding of the role of omega-3 PUFA supplementation for depression in children and adolescents.

The Impact of Sociodemographic Factors on Postpartum Depression in Rural Mothers

The Impact of Sociodemographic Factors on Postpartum Depression in Rural Mothers

Analysis on the Prevalence of Post-Partum Depression among the Women in Harare Zimbabwe

Analysis on the Prevalence of Post-Partum Depression among the Women in Harare Zimbabwe

Perinatal depression and associated factors in Ethiopia: a systematic review and meta-analysis

BackgroundPerinatal depression is a significant public health issue affecting one in four women globally. It occurs at a critical time of a woman’s life; affecting her relationships with family, and child’s emotional, behavioral, and cognitive development. Considering the burden of the problem to the whole family, this systematic review and meta-analysis was conducted to estimate the pooled prevalence of perinatal depression and its determinants in Ethiopia to provide up-to-date evidence at a national level.MethodsAll observational studies conducted on perinatal depression in Ethiopia were included based on the selection criteria. Data was extracted using Microsoft Excel and then exported to STATA version-11 for analysis. The random-effects model was employed to estimate the pooled effect size of perinatal depression and its determinants with 95% confidence intervals. Funnel plots analysis and Egger regression tests were conducted to check the publication bias. Sub-group and sensitivity analyses were also performed.ResultsThis systematic review and meta-analysis included thirty studies and the pooled prevalence of perinatal depression in Ethiopia was 24.29% (95% CI (21.98, 26.59)). According to the subgroup analysis, the pooled prevalence of antenatal depression and others (postnatal and perinatal depression) was 24.24% and 24.52% respectively. Regarding determinants of perinatal depression, having unplanned pregnancy [OR = 3.04 (2.2, 4.2)], intimate partner violence [OR = 3.09(2.14, 4.46)], poor social support [OR = 3.3(2.38, 4.57)], and a history of depression [OR = 3.68(2.45, 5.52)] were significantly associated with depression.Conclusion and recommendationThis study showed that the pooled prevalence of perinatal depression in Ethiopia was found to be high. To ensure the mental health of both the mother and child, health professionals should routinely screen perinatal women for depression giving special focus for those with a history of depression and managing them accordingly.

From meta-analysis to Mendelian randomization: Unidirectional perspectives on the association of glaucoma with depression and anxiety.

Glaucoma, a primary cause of blindness worldwide, has its association with depression and anxiety noted, yet the understanding of such association is still rudimentary. This study aims to provide the unidirectional perspectives on the association of glaucoma with depression and anxiety, informing public health strategies. The Meta-analysis screened observational studies from Medline, Embase, and Web of Science, using the modified Newcastle-Ottawa Scale for quality assessment. It employed R's 'meta' package to assess the association between glaucoma and depression or anxiety prevalence. The Mendelian Randomization (MR) analysis was conducted using R's 'TwoSampleMR' package, based on data from the IEU database data to explore the impact of glaucoma on depression and anxiety. This Meta-analysis included 23 out of 379 studies involving 11,845 glaucoma patients. The combined prevalence of depression among glaucoma patients, derived from 18 cross-sectional studies, stood at 19.42%. Five case-control studies indicated that glaucoma patients had a 6.17-fold higher risk of depression compared to controls. Derived from 16 cross-sectional studies, the consolidated prevalence for anxiety was 19.07%. According to five case-control studies, glaucoma patients exhibited a 4.45-fold increased risk of anxiety compared to controls. MR analysis failed to uncover a causal effect of glaucoma on depression and anxiety. This study suggests that glaucoma patients may experience higher prevalence of depression and anxiety than the general population, with no clear genetic links found. It suggests that environmental factors and non-genetic biological pathways, among others, may play significant roles in their association, though the role of genetic factors cannot be ruled out. These findings highlight the necessity of a comprehensive approach to study the complex factors influencing the association of glaucoma with depression or anxiety and underscore the importance of integrating mental health considerations into glaucoma management to improve medication adherence and disease progression.

The Incidence of Underlying Mental Health Disorders in a Facial Synkinesis Population.

Synkinesis is estimated to impact 10% to 50% of those with facial palsy. We aim to identify the incidence and factors associated with anxiety and depression in the facial synkinesis population. Prospective cohort study. Patients aged 18 and older with a diagnosis of facial synkinesis at a tertiary medical center were eligible for inclusion. Demographic variables were collected, and the following surveys were distributed: Synkinesis Assessment Questionnaire, Facial Clinimetric Evaluation Scale, Facial Disability Index, Center for Epidemiological Studies Depression Scale, and Fear of Negative Appearance Evaluation Scale. Patient videos were graded for physician perceived severity using the Electronic Facial Paralysis Assessment and Sunnybrook scale. Analysis of the overall incidence of anxiety and depression symptoms as well as the impact of demographic factors was performed using Pearson product moment correlation and regression modeling. One-hundred patients met inclusion criteria. Over 25% of patients met criteria for possible or probable depression and the most common appearance-related anxiety score was 30, indicating severe anxiety. Female gender, younger age, and previous history of anxiety and depression were associated with increased depression and anxiety scores at baseline with shorter duration of synkinesis also trending toward higher scores. Worse patient reported severity was also associated with increased depression and appearance-related anxiety scores. The overall prevalence of depression and appearance-related anxiety is relatively high in patients with facial synkinesis.