Purpose This study aimed to investigate the influence of health status and types of health management on depression in middle-aged women. Methods A convenience sample of 188 participants was recruited from health centers in S city. Using a structured questionnaire, data was collected and analyzed by t-test, ANOVA, Pearson's correlation, and linear regression using SPSS/WIN 23 program. Results Results of the regression analysis showed that perceived current health status (β=-0.55, p<.001), no caregiver (β=0.47, p<.001), chronic diseases lasting more than three months (β=0.36, p<.001), perceived health status compared to peer group (β=0.32, p<.001), walking for health (β=-0.20, p=.002), caregiver except family (β=0.18, p=.001), and gastrointestinal disease (β=0.10, p=.022) influenced depression in middle-aged women. Overall, approximately 69.7% of total variance explained this model (adjusted R2=0.678, F=57.21, p<.001). Conclusion This study suggests that it is more important to understand the level of perceived health status in middle-aged women. Furthermore, it is necessary to develop programs that include various health management methods and strengthen the health care with the help of families and neighbors in order to manage depression in middle-aged women. Keywords: Health status, Health care, Depression, Middle aged Women 주ìì´: ê±´ê°ìí, ê±´ê°ê´ë¦¬íí, ì°ì¸, ì¤ë ì¬ì±