The injection of filler substances is one of the most common procedures in cosmetic surgery. In 2003, the number of nonsurgical procedures increased 22% from 2002. 1 American Society for Aesthetic Plastic Surgery. Available at: http://www.surgery.org/press/statistics-2003.php. Accessed March 28, 2004 Google Scholar The last 5 years have brought about an extreme interest in minimally invasive rejuvenation techniques. The ease and popularity of Botox (Allergan Inc, Irvine, CA) has popularized and expanded the use of rejuvenative injections. 2 Niamtu J. Botulinum Toxin A A review of 1,085 oral and maxillofacial patient treatments. J Oral Maxillofac Surg. 2003; 61: 317 Abstract Full Text Full Text PDF PubMed Scopus (41) Google Scholar , 3 Niamtu J. The use of botulinum toxin in cosmetic facial surgery. Oral Maxillofac Surg Clin North Am. 2000; 12: 596 Google Scholar , 4 Niamtu J. Aesthetic uses of botulinum toxin A. Oral Maxillofac Surg. 1999; 57: 1228 Abstract Full Text PDF Scopus (40) Google Scholar This, coupled with the introduction of multiple new products, has increased the number of treatment options for cosmetic patients. Multiple substances are available to inject into facial wrinkles, folds, lips, traumatic defects, and depressed scars, and to augment facial form (Table 1). Table 1SOME OF THE NEWER FILLER SUBSTANCES CURRENTLY IN USE AROUND THE WORLD Product Source Manufacturer Restylane Non-human hyaluronic acid Medicis Inc, Scottsdale, AZ Restylane Fine Line Non-human hyaluronic acid Medicis Inc Perlane Non-human hyaluronic acid Medicis Inc Cosmoplast Human-derived collagen Inamed Inc, Santa Barbara, CA Cosmoderm Human-derived collagen Inamed Inc Radiesse Hydroxyappetite BioForm Medical Inc, San Mateo, CA Hyalform Hyaluronic acid Inamed Inc Artecol PMMA beads in hyaluronic acid Artes Medical Inc, San Diego, CA Artefil PMMA beads in bovine collagen Artes Medical Inc Silikon Liquid injectable silicone Alcon Labs Inc, Ft. Worth TX Sculptra Polylactic acid Aventis Pharm Inc, Bridgewater, NJ Isolagen Cultured autologous fibroblasts Isolagen Inc, Huston, TX Autologen Autolougous collagen Collagenesis Inc, Beverly, MA Joseph Niamtu. Restylane in Cosmetic Facial Surgery. J Oral Maxillofac Surg 2006. Open table in a new tab Joseph Niamtu. Restylane in Cosmetic Facial Surgery. J Oral Maxillofac Surg 2006.