From a conceptual point of view, in some ruby and garnet deposits of the Lalamo Supergroup – Cabo Delgado Nappes Complex, Northern Mozambique – the structural control of the primary mineralization seems to be spatially and geochemically related to the genesis of calcsilicate rocks, also with gemstones. Two main locations, with contrasting paragenesis, were studied in detail – Miteda area and Micute to N’Djekwa sector. Structural and paragenetic analysis, departing from high-resolution cartography, fabric microanalysis, SEM microscopy and mineral identification by X-ray diffractometry, were used with a major incidence in outcrops and small-scale mine diggings. Regional Neoproterozoic formations, especially its metacarbonate members, host Mg, B - rich skarns, bearing dravite and B-Mg-calc-silicate gemstones, especially in Micute and N’Djekwa area. Following the composition of the probable lithological precursor, these minerals, consistently, reveal a geochemical Mg - B signature that could have been inherited from an evaporite type ancestor, inter-stratified with carbonate rocks in the protolithic Lalamo sequence. The focus of hydrothermal circulation in multistage shear zones is invoked as the main pathway to interpret the complex mineralization observed in Miteda. In this case, the structure of a corundum + garnet major spot is coherent with a pull-a- part dilation associated with sinistral shear. There is a relation between red color saturation of ruby and the content of Cr in corundum. Cr can be leached from the meta-ultramafic host-rocks as a byproduct of desilication. Calcsilicate metasomatism could trigger Si sequester, producing metamorphic desilicated fluids. The focus of hydrothermal circulation in shear zones is invoked as the main pathway for the entrapment of metamorphic and metasomatic gem deposits. These occur in corridors of anomalous host-lithologies and vein swarms where peraluminous paragenesis are located inside highly modified meta-ultramafic or metacarbonate rocks. Skarn like lithologies result from reaction with a sedimentary carbonate protolith and gem deposition is mainly metasomatic. Veining affecting metaultramafic sequences of amphibolitic to granulitic facies show occasional, metasomatically affected, eclogite. For the contrasting styles of deposits represented in Micute – N’Djekwa and in Miteda, although the corresponding paragenesis are separated in space, their deposition can be situated in a conceptual model characterized by a geochemical interdependency and time proximity.