Due to the unclear tectonic setting of the Jurassic ophiolites within the Bangong-Nujiang suture, how and when intra-oceanic subduction initiated within the Bangong Meso-Tethys remain controversial. Based on the new petrological, geochemical, and geochronological data reported in this paper, ∼190–180 Ma MORB-like ophiolites and OIB-like mafic rocks were identified from the Shiquanhe ophiolitic complex in the western Bangong-Nujiang suture. The MORB-like gabbros exhibit strong light rare earth elements (LREEs) and heavy rare earth elements (HFSEs) depletion and were derived from partial melting of a highly refractory depleted mantle source with limited slab-derived fluids. The OIB-like mafic rocks are enriched in LREEs and HFSEs and were originated from the melting of upwelling asthenospheric mantle without subduction additions. The data for the MORB-like ophiolites reported in this paper and previously published data demonstrate the formation of Early Jurassic fore-arc ophiolites in response to the Early Jurassic intra-oceanic subduction initiation within the Bangong-Nujiang suture. The Early Jurassic OIB-like rocks formed in the extensional tectonic setting, together with regional geological evidence, suggest that the Early Jurassic initial subduction event within the Bangong Meso-Tethys resulted in broad upper plate extension. Our study not only reveals the intra-oceanic subduction initiation age of the Bangong Meso-Tethys but also implies that subduction initiation can cause strong extension in a wider region of the upper plate in the Tethys oceanic system, not just in the fore-arc region.