The dependence of energy confinement time on gyroradius, , and normalized collisionality in I-mode plasmas is investigated through dedicated C-Mod experiments scanning dimensionless parameters with constant safety factor. The gyroradius scaling is calculated to be , which suggests core transport may scale with gyro–Bohm physics, indicating favorable extrapolation of the I-mode regime to future devices at low . The scaling exponent for is calculated to be small, but positive (), and the exponent for is deemed inconclusive () due to high correlation with the other two dimensionless variables in the dataset, and therefore requires further investigation. The individual dimensionless parameter scaling is compared to calculations from larger C-Mod I-mode datasets as well as multi-machine scaling laws for ELMy H-mode and L-mode plasmas. Multiple regression techniques and principal component analysis are used to clarify the single parameter scalings and analyze parameter significance within the dataset.