The objective of this article is to elucidate the fundamental components of the mechanism for formulating criminological policy in the context of combating transnational organised crime. In addition, it aims to analyse the subjective composition of the counteraction to such criminal offences and to identify the measures that are necessary to neutralise threats and risks to national security. The article presents a scientific discussion of the mechanism of formation and implementation of criminological policy. It is determined that the nationwide system of combating transnational organised crime can counteract the systemic threats reflected in the Strategy for Combating Organised Crime. This necessitates the establishment of a singular entity: a state body endowed with distinctive status, entrusted with the requisite authority over other entities, including competence related to the budget allocation process and control over its implementation in terms of combating such crime. This entity must possess a sufficient information and analytical component, the result of which should be both the assurance of the agency's ongoing activities and the preparation of strategic programme documents on combating transnational organised crime in general and in its individual areas. These documents must then be approved by the President of Ukraine, who serves as the guarantor of national security. Results. The author develops a scientific concept of the criminological policy of combating transnational organised crime based on the system of coordinated measures to ensure criminological security. This concept has been tested by domestic and foreign practice, with the development and implementation of a set of strategic legal, economic and social measures in the activities of entities involved in combating transnational organised crime (decisions, recommendations, and methodologies) at the legislative and governmental levels. These measures are aimed at identifying criminogenic factors and making effective legal and regulatory, organisational and managerial decisions, including departmental (and interdepartmental) decisions, by authorised entities on this basis.