Department Of Science Research Articles

Sequential CD7 CAR T-Cell Therapy and Allogeneic HSCT without GVHD Prophylaxis

BackgroundPatients with relapsed or refractory hematologic cancers have a poor prognosis. Chimeric antigen receptor (CAR) T-cell therapy as a bridge to allogeneic hematopoietic stem-cell transplantation (HSCT) has the potential for long-term tumor elimination. However, pre-HSCT myeloablation and graft-versus-host disease (GVHD) prophylaxis agents have toxic effects and could eradicate residual CAR T cells and compromise antitumor effects. Whether the integration of CAR T-cell therapy and allogeneic HSCT can preserve CAR T-cell function and improve tumor control is unclear.MethodsWe tested a novel “all-in-one” strategy consisting of sequential CD7 CAR T-cell therapy and haploidentical HSCT in 10 patients with relapsed or refractory CD7-positive leukemia or lymphoma. After CAR T-cell therapy led to complete remission with incomplete hematologic recovery, patients received haploidentical HSCT without pharmacologic myeloablation or GVHD prophylaxis drugs. Toxic effects and efficacy were closely monitored.ResultsAfter CAR T-cell therapy, all 10 patients had complete remission with incomplete hematologic recovery and grade 4 pancytopenia. After haploidentical HSCT, 1 patient died on day 13 of septic shock and encephalitis, 8 patients had full donor chimerism, and 1 patient had autologous hematopoiesis. Three patients had grade 2 HSCT-associated acute GVHD. The median follow-up was 15.1 months (range, 3.1 to 24.0) after CAR T-cell therapy. Six patients remained in minimal residual disease–negative complete remission, 2 had a relapse of CD7-negative leukemia, and 1 died of septic shock at 3.7 months. The estimated 1-year overall survival was 68% (95% confidence interval [CI], 43 to 100), and the estimated 1-year disease-free survival was 54% (95% CI, 29 to 100).ConclusionsOur findings suggest that sequential CD7 CAR T-cell therapy and haploidentical HSCT is safe and effective, with remission and serious but reversible adverse events. This strategy offers a feasible approach for patients with CD7-positive tumors who are ineligible for conventional allogeneic HSCT. (Funded by the National Natural Science Foundation of China and the Key Project of Science and Technology Department of Zhejiang Province; ClinicalTrials.gov numbers, NCT04599556 and NCT04538599.)

Drug utilization and prescribing pattern in the treatment of urolithiasis: a perspective on World Health Organization recommendations

Background: Drug utilization research (DUR) is essential in promoting rational use of medicine, aimed at understanding the patterns of prescription, administration, and utilization of medications. It provides valuable insights into the actual drug usage patterns for specific disease conditions. To evaluate the current utilization pattern of drugs in patients of urolithiasis in the Department of General Medicine and Surgery at Integral Institute of Medical Science and Research Hospital, Lucknow. Methods: Following the approval of the institutional ethics committee, a prospective observational study was conducted at Integral Institute of Medical Science and Research Department of general medicine and surgery over a six-month period. Urolithiasis patients’ prescriptions were analyzed to study the prescribing patterns. Information about patient demographics, co-morbidities, and the number and types of medications prescribed were collected and analyzed. Results: Out of 102 patients studied, a female preponderance over male patients was observed. The co-morbidities that are encountered most commonly were hydronephrosis, cystitis, and renal cyst. There is averaged 7 medicines per prescription, 15.25% of medicines written by the generic name, 83.33% of patients receiving antibiotics, 54.70% of patients receiving injections, and 83% of drugs prescribed are mentioned in the essential medicine list. Analgesics, antibiotics, nutritional supplements, antiemetic, alkalizing agents, and antispasmodics were among the class of medicines given. Conclusions: This study highlights the current use of medicines and drug utilization in urolithiasis management. The findings show important insights for healthcare professionals to enhance medication therapy, encourage cost-effective healthcare delivery and improve quality of patient in urolithiasis management.

ANALYSIS OF NOVASAR-1 S-BAND DATA IN DEVELOPING AN ALTERNATIVE LAND COVER MAPPING

Abstract. The Advanced Science and Technology Institute of the Department of Science and Technology (DOST-ASTI), through its Synthetic Aperture Radar and Automatic Identification System (SARwAIS) Project, has gained access to S-Band SAR images acquired by the NovaSAR-1 satellite of UK’s Surrey Satellite Technology Ltd. (SSTL) To help maximize the utility of these images especially in the aspect of terrain-related applications, their viability as potential alternatives to datasets like optical satellite images and other SAR images in characterizing land cover types was evaluated. Statistical analyses on the backscatter values from the tri-polarization ScanSAR datasets using Multivariate Analysis of Variance (MANOVA) and its corresponding post-hoc tests showed that there is a significant difference on the mean backscatter values at 0.05 level of significance. Moreover, Tukey’s honestly significant difference (Tukey’s HSD) test determined which pairs contribute to the significant difference. Using the Random Forest algorithm resulted in an accuracy of 66.93% without further optimization and/or reduction in the number of land covers being classified. Despite the relatively unremarkable accuracy score, it still showed potential for data augmentation with optical satellites for land cover mapping and other terrain-related applications.

AUGMENTING THE PHILIPPINES’ DOST-ASTI’S POTENTIAL FLOOD EXTENTS MAPPING SERVICE WITH S-BAND NOVASAR-1 IMAGES

Abstract. The Philippines’ Advanced Science and Technology Institute under the Department of Science and Technology (DOST-ASTI) has developed an AI-based and near real-time flood extent mapping service that utilizes C-Band Sentinel-1 SAR images. However, this method is limited by the availability of the Sentinel-1 images during flooding events. To address this issue, the institute, through its SARwAIS Project, utilized the S-Band NovaSAR-1 satellite, which was designed and launched by Surrey Satellite Technology, Ltd. With a 10% share to NovaSAR-1’s imaging capacity, the country can task image acquisitions that could help augment the Sentinel-1 datasets. Successfully captured images are prepared using the institute’s developed pre-processing workflow. Afterwards, a thresholding method, adopted from UN-SPIDER’s recommended practices for flood mapping, is employed to identify potentially flooded areas from these images. Generated products are then assessed to determine their relative accuracy in detecting potential floods. Satisfactory products are then distributed to relevant disaster management agencies and are also published in the agency’s social media page for further information dissemination. Python scripts were then developed to automate the established workflows, which were initially done manually. These scripts also help expedite the generation of flood maps especially when processing multiple SAR images. The acquisition and utilization of NovaSAR-1 images substantially help the country address the gaps on the availability of workable data for a more informative disaster response especially during flooding events.

Research on Lifelong Learning Tendencies of University Students

Research on Lifelong Learning Tendencies of University Students

Fingerprint Correlation Between Twins

CODY BARNES, KRISTY HENSON, MARK FLOOD, Department of Natural Sciences, Fairmont State University, Fairmont, WV, 26201 Fingerprint correlation between identical twins When teaching about the uniqueness of fingerprints it is commonly said that identical twin fingerprint characteristics are not identical however, limited research has been conducted to determine if there are any correlations between similar print characteristics. In the recent past unrelated individuals have been misidentified based on fingerprint similarities in forensics cases and this may be more likely among twins. This research case study’s objective is to determine if there are any correlations between fingerprint characteristics of identical twins and the probability of misidentification. Identical twin fingerprints were rolled and collected onto 10 print cards then blindly analyzed using Henry Classification, AFIS, and NCIC techniques. Preliminary results indicate a strong relationship between characteristics, but it is not significant (0.49; p = 0.35); fingerprint characteristics between hands were not significantly different (R: p = 0.75, L: p = 0.24). Results indicate there could be a possibility of misidentification, but more twin fingerprints should be analyzed.

Evaluation of biocontrol efficacy of trichoderma harzianum against fusarium oxysporium in tomatoes ( <i>Solanum esculentum L.</i>)

Utilizing biological techniques to manage plant diseases has demonstrated efficacy in fostering ecosystem sustainability and augmenting agricultural output and quality. A study was undertaken at the Department of Plant Science and Biotechnology, Imo State University, Owerri, Nigeria to evaluate the suppressive impact of T. harzianum on the proliferation of F. oxysporusm f. sp. lycopersici, and the advancement of F. oxysporum infection in tomato plants. The trial comprised culturing only T. harzianum in the Petri dish, culturing T. harzianum and F. oxysporum in the Petri dish (dual culture), and culturing only F. oxysporum in the petri dish, and with Mancozeb. The influence of T. harzianum on the advancement of F. oxysporum infection in tomato plants comprises of four distinct concentrations (1g, 2g, 3g, and 4g) of T. harzianum extract. The results revealed that the dual culture of T. harzianum and F. oxysporum successfully suppressed the mycelial growth of F. oxysporum. On the seventh day, the level of antagonistic activity exhibited by T. harzianum against F. oxysporum peaked at 9.05mm. Leaf yellowing and severe wilting, indicative of Fusarium wilt, were seen during the monitoring period. Tomato disease incidence and severity exhibited a consistent linear decline with increasing concentrations of T. harzianum. The disease severity reached its maximum level, (31.6%) on week four. Mancozeb treatment compared favorably with 4g T. harzianum in decreasing the mycelial growth of F. oxysporium, and reducing wilt incidence and severity. Therefore, T. harzianum can function as a biocontrol agent, providing a sustainable substitute for synthetic fungicides in the control ofFusariumoxysporium wilt disease.

A Discussion of Year 3 Results of the NSF S-STEM Scholarship Program at Shepherd University

The Track II NSF S-STEM Program in the Computer Sciences, Mathematics, and Engineering Department at Shepherd University started in October 2021 and has thus far supported 22 scholars majoring in computer science, mathematics, data analytics, or engineering. The overall goal of the program is to increase the number and quality of STEM graduates in the STEM workforce by providing financial, academic, and social support, which enables qualified students to overcome certain barriers that prevent them from meeting their educational and career goals. In this poster, the most significant activities and outcomes of the program since its inception are presented. Survey results and outcomes from the last academic year, along with initiatives that increase, retain, and support students in CME fields, are also discussed. This program has been supported by the NSF S-STEM Grant (award No. DUE-2130267).

Are Professional Skills Learnable? Beliefs and Expectations Among Computing Graduates

Integrating graduate education with professional skills development is still a challenge. People's beliefs about learning impact their learning processes. Therefore, we need to understand the mindset of graduates to determine best practices for promoting professional skills development. In this study, we explore the perspective of computing graduates within an Engineering educational program. This study aims to answer the following research questions: Which skills do computing graduates perceive they need in the workplace, and how do they position themselves regarding these skills? What learning beliefs do computing graduates hold regarding the skills required in the workplace? The research team conducted semistructured interviews with computing graduates within an Engineering program to analyze their experiences. The interviews were analyzed using grounded theory. As a result, the participants viewed professional and technical skills as independent, with professional skills perceived as more relevant to work success. The participants considered themselves to possess these skills. Our findings identify four learning beliefs within a fixed and growth mindset: (1) An essential personal characteristic that context may influence; (2) a learning outcome determined by early experiences; (3) a learning process associated with informal learning experiences; and (4) a learning process associated with formal learning experiences. We acknowledge the differences in perception between alums and the industry regarding possessing essential professional skills. We also highlight the need to position these skills as learnable during lectures contributing to Computing and Engineering Education.

Constructively Aligned Instructional Design for Oral Presentations

In the paper "Constructively Aligned Instructional Design for Oral Presentations," the authors explore the implementation and outcomes of the 'General, Particular Specific' (GPS) model as a framework for curriculum instructional design for oral presentations within STEM education at an R1 Polytechnic University. Objective: This study aims to investigate the impact of the 'General, Particular Specific' (GPS) model on the enhancement of constructive alignment in curriculum instructional design for oral presentations in STEM education to improve students' oral communication skills and their effectiveness in technical communication. Theoretical Framework: Constructive alignment, curriculum-based Assessment, and curriculum and instructional design stand out, providing a solid basis for understanding the context of the investigation. The literature includes foundational texts on marketing management, center-based engineering research, Bloom's taxonomy of educational objectives, and the principles of enhancing teaching through constructive alignment. Additionally, it acknowledges the multifaceted nature of instructional design, emphasizing the widespread adoption of the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation), showcasing a structured, comprehensive approach to educational planning and execution. Method: The methodology adopted for this research comprises a qualitative study design, utilizing case study approaches within the Humanities and Social Science department at an R1 Polytechnic University. Data was collected through classroom observations, instructor interviews, and analysis of student presentation outcomes before and after implementing the GPS model. Results and Discussion: The results revealed significant improvements in students' abilities to think critically about content alignment with audience expectations and effectively communicate technical information. In the discussion section, these results are contextualized in light of the theoretical framework, underscoring the effectiveness of the GPS model in fostering clear, explicit instruction and scaffolding in oral presentation skills. The study acknowledges possible limitations, including its scope within a single institution and the need for broader empirical validation. Research Implications: This research's practical and theoretical implications are discussed, providing insights into how the results can be applied or influence practices in STEM education. These implications could encompass curriculum development, pedagogical strategies, and enhancing communication skills in STEM fields. Originality/Value: This study contributes to the literature by highlighting the originality of applying the GPS model within the context of oral presentation instruction, marking a significant shift from traditional, less structured approaches to a more scaffolded and constructively aligned methodology. The relevance and value of this research are evidenced by its potential to impact pedagogical practices, particularly in enhancing the oral presentation capabilities of STEM students, thereby addressing a critical gap in STEM education and communication training.

The Effectiveness of Using the SCAMPER Programme to Learn the Basic Fundamentals of Gymnastics

The current research aimed to identify the effectiveness of using the SCAMPER strategy to learn the research problem is to demonstrate the importance of the impact of the proposed intervention. The research problem addressed that the repeated failure of learners when performing the basic skills of the futsal game prompted the study of this issue and develop appropriate solutions through the development of exercises on the SCAMPER scrambler that will improve the basic skills of futsal. The research sample included students of the Department of Sport and Exercise Science, who numbered (30) students and were divided into two experimental and control groups, each group (15 students). (15) female students, and the researcher applied the research experiment using the methodology described above, and through the results, the researcher found that Scamper has a key role in developing creative abilities, developing independence to reach goals, and investing time and effort The researcher recommended the need to emphasis the use of SCAMPER as a tool for learning how to play the game in the gym.

A logic framework for addressing medical racism in academic medicine: an analysis of qualitative data

BackgroundDespite decades of anti-racism and equity, diversity, and inclusion (EDI) interventions in academic medicine, medical racism continues to harm patients and healthcare providers. We sought to deeply explore experiences and beliefs about medical racism among academic clinicians to understand the drivers of persistent medical racism and to inform intervention design.MethodsWe interviewed academically-affiliated clinicians with any racial identity from the Departments of Family Medicine, Cardiac Sciences, Emergency Medicine, and Medicine to understand their experiences and perceptions of medical racism. We performed thematic content analysis of semi-structured interview data to understand the barriers and facilitators of ongoing medical racism. Based on participant narratives, we developed a logic framework that demonstrates the necessary steps in the process of addressing racism using if/then logic. This framework was then applied to all narratives and the barriers to addressing medical racism were aligned with each step in the logic framework. Proposed interventions, as suggested by participants or study team members and/or identified in the literature, were matched to these identified barriers to addressing racism.ResultsParticipant narratives of their experiences of medical racism demonstrated multiple barriers to addressing racism, such as a perceived lack of empathy from white colleagues. Few potential facilitators to addressing racism were also identified, including shared language to understand racism. The logic framework suggested that addressing racism requires individuals to understand, recognize, name, and confront medical racism.ConclusionsOrganizations can use this logic framework to understand their local context and select targeted anti-racism or EDI interventions. Theory-informed approaches to medical racism may be more effective than interventions that do not address local barriers or facilitators for persistent medical racism.

Yield and Bio-Chemical Parameters of Onion (Allium Cepa L.) and Consequences of Saline Irrigation Water on It

At Department of Agricultural Chemistry and Soil Science a pot experiment was conducted during the rabi, season of 2017-18. Department of Agricultural Chemistry and Soil Science situated at College of Agriculture, Junagadh Agricultural University, Junagadh, Gujarat. The objective of the study is to assess the consequences of saline irrigation water on yield of Onion (Allium Cepa L.) varieties. The study also possess the growth and nutrients composition of Onion (Allium Cepa L.) varieties and effect of saline irrigation water on it. Four levels of salinity are contained viz., < 2.0, 4.0, 6.0 and 8.0 dS m-1. GJWO-3, GJRO-11, Talaj red, Pilli patti and PWF-131 these five varieties comprised in factorial completely randomized design with three replications. It found that the yield of chlorophyll a (5.77 mg/gf.wt), chlorophyll-b (4.22 mg/gf.wt), and total chlorophyll were significantly influenced by different levels of salinity, whereas; yield of fresh straw (37.03 g/pot), bulb (37.49 g/pot), RWC, proline (0.96 µmole/gf.wt), were significantly influenced among different varieties of onion tested.

Automated Marking System for Essay Questions

The stress of marking assessment scripts of many candidates often results in fatigue that could lead to low productivity and reduced consistency. In most cases, candidates use words, phrases and sentences that are synonyms or related in meaning to those stated in the marking scheme, however, examiners rely solely on the exact words specified in the marking scheme. This often leads to inconsistent grading and in most cases, candidates are disadvantaged. This study seeks to address these inconsistencies during assessment by evaluating the marked answer scripts and the marking scheme of Introduction to File Processing (CSC 221) from the Department of Computer Science, University of Uyo, Nigeria. These were collected and used with the Microsoft Research Paraphrase (MSRP) corpus. After preprocessing the datasets, they were subjected to Logistic Regression (LR), a machine learning technique where the semantic similarity of the answers of the candidates was measured in relation to the marking scheme of the examiner using the MSRP corpus model earlier trained on the Term Frequency-Inverse Document Frequency (TF-IDF) vectorization. Results of the experiment show a strong correlation coefficient of 0.89 and a Mean Relative Error (MRE) of 0.59 compared with the scores awarded by the human marker (examiner). Analysis of the error indicates that block marks were assigned to answers in the marking scheme while the automated marking system breaks the block marks into chunks based on phrases both in the marking scheme and the candidates’ answers. It also shows that some semantically related words were ignored by the examiner.

Psychological endurance and its relation to the performance of high jump efficiency In the arena and field activities

The research aimed to identify the psychological endurance among students of the first stage - College of Basic Education - Department of Physical Education and Sports Sciences - University of Diyala, as well as to identify the differences in the phenomenon of psychological endurance and its relationship to the performance of the high jump event in arena and field events. The researcher used the descriptive approach in general The research reached (70) male and female students from the first stage - College of Basic Education - Department of Physical Education and Sports Sciences - University of Diyala, for the academic year 2023-2024, As for the research sample, it was randomly selected by lottery from the research community, which numbered (63) male and female students, and represents (90%) of the research community. At the conclusion of the study, the researcher concluded that there was a difference between the sexes to a high degree and in favor of males. The reason is that female students suffer from poor performance tolerance, which affects their psychological state. The study came out with a number of recommendations.

Relationship between Emotional Intelligence and Depression in Teaching Faculty of Basic Sciences at a Private Medical College: A Cross Sectional Correlational Study

Background: Emotional Intelligence (EI) spans five basic principles including awareness and management of self-emotions, ability to motivate oneself, awareness, and management of other’s emotions. EI takes a person to high level of professional as well as academic success by improving one’s cognitive performance far above the level attained by general intelligence (GI). In addition, EI enables one to control negative attributes such as anxiety, anger, and stress and highlight pragmatic and constructive feelings like congeniality, self-confidence and empathy. Objective: The current study was designed to estimate the level of emotional intelligence (EI) in teaching faculty of basic sciences at a private medical college and to check its correlation with depression. Study Design: Cross sectional correlational study. Settings: Lahore Medical & Dental College, Lahore Pakistan. Duration: December 2021- April 2022. Methods: Two questionnaires including “Leadership Toolkit Emotional Intelligence Questionnaire” and “Patient Health Care Questionnaire 9 were used to collect the data. After approval from Institutional Review Board, informed written consent was taken from the participants. Data was collected by using convenient sampling technique from faculty of basic science departments. SPSS 22 was utilized for analysis of the data. Results: In the current study a total number of 72 faculty members participated. Out of total 72 participants, 69.4% (50) were in the average EI range and 23.6% (17) had good EI with only 6.9% (5) falling in the poor EI range. The mean score for overall EI was higher in senior faculty as compared to junior members with a value of 189.7 but the difference was not statistically significant. Similarly, no significant difference was found among male and female participants regarding overall EI as well as its constructs. The sub-sections managing emotions, motivating one-self and social skills showed significant difference with a higher value in the senior faculty. Overall, EI was found to be inversely correlated with depression with a p value < 0.01. Conclusion: The score of Emotional Intelligence is reasonably good in the faculty of basic science departments. Moreover, EI has been found to be inversely correlated with depression.

Exploring barriers to measuring ROI for training and development interventions

The objective of this article is to investigate obstacles that hinder the assessment of return on investment (ROI) for academic staff development initiatives in public universities in South Africa. The primary objective of this study is to address the following research inquiry: What are the obstacles hindering the assessment of return on investment (ROI) for training and development interventions offered to academics within the higher education landscape of South Africa? The study employed a qualitative research methodology, which was based on an interpretive philosophical standpoint. The researchers employed purposive sampling to carefully select a total of fourteen participants who were selected to represent a range of cases or institutions. These included six universities and government institutions, namely the Department of Higher Education and Training (DHET), the Department of Science and Innovation (DSI), and the Education, Training, and Development Practices Sector Education and Training Authority (ETDPSETA). The interview data was subjected to thematic analysis using ATLAS.ti. The factors that hinder the measurement of ROI include the intricacy of the process, insufficient capacity, time lag between training and improved performance, lack of motivation, financial limitations, absence of processes, fragmentation of training and development interventions, interventions producing non-financial advantages, and insufficient data. The study enhanced the existing information on human resource development and practice by identifying the obstacles to measuring return on investment (ROI). Additionally, it offered practical advice and suggestions for future research.

Department of Materials Science, Graduate School of Fundamental Science and Engineering, Waseda University

Department of Materials Science, Graduate School of Fundamental Science and Engineering, Waseda University

The Relationship between Vertical Kinematic Eddy Heat Flux, Air Temperature and Turbulent Kinetic Energy in Atmospheric Boundary Layer: Baghdad City

Studying the heat flux in the boundary layer and understanding its relationship to the various atmospheric variables reflects positively on understanding the nature of turbulence in this layer and thus understanding the nature of the spread and movement of pollutants and the transmission and distribution of energy in this layer, also, the vertical heat flux is considered a significant influence on the movement of buoyancy and stability in the boundary layer and its effect on the horizontal wind movement, and therefore it is considered one of the important studies indirectly involved in the estimates of wind energy production, pollutant diffusion, and turbulence. This study involved the calculation of the Eddy Heat Flux and turbulent kinetic energy across Baghdad city. Our investigation revealed a correlation between the Eddy Heat Flux, temperature, and Turbulent Kinetic Energy (TKE). The observations have been made for wind speed with three components (u, v, w) and temperature by using a fast-response anemometer. As for the atmospheric pressure data, it was obtained from the automatic weather station located in the department of Atmospheric Sciences at Mustansiriyah University. The range of observations extended through the duration of thirty days for 24 hours from 1st July 2016 to 30th July 2016 every second. The maximum Eddy Heat Flux value was 0.092 J/(m2.s) at 10:00 on 23th July 2016, while the minimum Eddy Heat Flux value was -0.013 J/(m2.s) at 21:00 hour on 25th July 2016, the negative sign refer to a change in the direction of heat transfer,. It was also found that there is a positive relationship between the eddy heat flux and temperatures with a correlation coefficient of 0.93, as well as between the eddy heat flux and the turbulent kinetic energy with a correlation coefficient of 0.8.

Tooth Colour and Facial Attractiveness: Study Protocol for Self-Perception with a Gender-Based Approach.

(1) Background. The aim of the present protocol is to assess whether self-perception of tooth colour and facial attractiveness correlates with gender and mood state. (2) Study protocol. The protocol foresees a cross-sectional clinical study, developed by Sapienza University of Rome, Italy, Department of Oral and MaxilloFacial Sciences, and 15 UNID (Unione Nazionale Igienisti Dentali-National Union of Dental Hygienists)-affiliated clinical centers in Italy. The protocol consists of a clinical visit, during which photographic documentation of the face and smile is collected with spectrophotometric evaluation of tooth colour. During the visit, two validated questionnaires are filled in. The first one is filled by the operator for the collection of data on: i) patient's face and smile colorimetric characteristics; ii) patient's and operator's evaluations of the dental colour and smile attractiveness. The second one is completed by the patient for the assessment of his/her mood state. (3) Conclusions. This protocol highlights the importance in aesthetic dentistry of a gender-specific approach and the limitations of gender-neutral models, revealing the existing gender differences in aesthetic self-perception. In addition, the colour-matching relationships between facial and dental colour characteristics will be explored. This approach improves the accuracy and personalization of aesthetic assessments in dentistry, by addressing personalized and gender-specific needs. A gender-inclusive methodology that takes a more nuanced and culturally aware approach to aesthetic dentistry is a useful adjunct to modern clinical practices.