Department Of Neuroscience Research Articles

Cingulate Epilepsy: A Not so Singular World.

*Montreal University Health Center, Montreal, Quebec, Canada; †Department of Neurosciences, University of Montreal, Montreal, Quebec, Canada; and ‡Canada Research Chair in Epilepsy and Functional Anatomy of the Human Brain, Montreal, Quebec, Canada.

Linguistic profile automated characterisation in pluripotential clinical high-risk mental state (CHARMS) conditions: methodology of a multicentre observational study

IntroductionLanguage is usually considered the social vehicle of thought in intersubjective communications. However, the relationship between language and high-order cognition seems to evade this canonical and unidirectional description (ie, the...

Comparison of Graft Outcomes Reusing Original Intermediate-Term Cold Storage Solution for Entire Corneal Donor Storage Period With Exchanged Fresh Storage Solution After Donor Preparation in the Cornea Preservation Time Study.

Department of Ophthalmology and Visual Neuroscience, University of Minnesota, Minneapolis, MN Financial disclosures/conflicts of interest: None reported.

A solved puzzle: Familial adult myoclonus epilepsy is a new expansion repeats disorder.

EpilepsiaAccepted Articles SPECIAL ISSUE ARTICLEOpen Access A solved puzzle: Familial Adult Myoclonus Epilepsy is a new expansion repeats disorder Antonietta Coppola, Corresponding Author Antonietta Coppola antonietta.coppola1@gmail.com orcid.org/0000-0002-4845-4293 Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy Correspondence Antonietta Coppola, MD PhD, Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Via Pansini 5, 80131 Napli Italy. Email: antonietta.coppola1@gmail.comSearch for more papers by this authorLeonilda Bilo, Leonilda Bilo Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, ItalySearch for more papers by this authorPasquale Striano, Pasquale Striano orcid.org/0000-0002-6065-1476 Pediatric Neurology and Muscular Diseases Unit, "G. Gaslini" Institute, Genova Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genova, ItalySearch for more papers by this author Antonietta Coppola, Corresponding Author Antonietta Coppola antonietta.coppola1@gmail.com orcid.org/0000-0002-4845-4293 Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy Correspondence Antonietta Coppola, MD PhD, Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Via Pansini 5, 80131 Napli Italy. Email: antonietta.coppola1@gmail.comSearch for more papers by this authorLeonilda Bilo, Leonilda Bilo Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, ItalySearch for more papers by this authorPasquale Striano, Pasquale Striano orcid.org/0000-0002-6065-1476 Pediatric Neurology and Muscular Diseases Unit, "G. Gaslini" Institute, Genova Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genova, ItalySearch for more papers by this author First published: 13 February 2023 https://doi.org/10.1111/epi.17545 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/epi.17545. AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Accepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset version of record will appear in the future. RelatedInformation

Adult-Onset Idiopathic Lower Limb Dystonia during Stair Descent Treated with Botulinum Toxin Injection.

Movement Disorders Clinical PracticeEarly View CLINICAL VIGNETTE Adult-Onset Idiopathic Lower Limb Dystonia during Stair Descent Treated with Botulinum Toxin Injection Cezar Thomas Suratos MD, Corresponding Author Cezar Thomas Suratos MD ctrsuratos@gmail.com Department of Neurology, National Hospital Organization Utano Hospital, Kyoto, Japan Correspondence to: Dr. Cezar Thomas Suratos, Department of Neurosciences, De La Salle Medical and Health Sciences Institute, Governor D. Mangubat Avenue, Dasmariñas Cavite, Philippines. E-mail: ctrsuratos@gmail.comSearch for more papers by this authorToshiaki Takeuchi MD, PhD, Toshiaki Takeuchi MD, PhD Department of Neurology, National Hospital Organization Utano Hospital, Kyoto, JapanSearch for more papers by this authorRyuji Kaji MD, PhD, Ryuji Kaji MD, PhD Department of Neurology, National Hospital Organization Utano Hospital, Kyoto, JapanSearch for more papers by this author Cezar Thomas Suratos MD, Corresponding Author Cezar Thomas Suratos MD ctrsuratos@gmail.com Department of Neurology, National Hospital Organization Utano Hospital, Kyoto, Japan Correspondence to: Dr. Cezar Thomas Suratos, Department of Neurosciences, De La Salle Medical and Health Sciences Institute, Governor D. Mangubat Avenue, Dasmariñas Cavite, Philippines. E-mail: ctrsuratos@gmail.comSearch for more papers by this authorToshiaki Takeuchi MD, PhD, Toshiaki Takeuchi MD, PhD Department of Neurology, National Hospital Organization Utano Hospital, Kyoto, JapanSearch for more papers by this authorRyuji Kaji MD, PhD, Ryuji Kaji MD, PhD Department of Neurology, National Hospital Organization Utano Hospital, Kyoto, JapanSearch for more papers by this author First published: 26 January 2023 https://doi.org/10.1002/mdc3.13670 Relevant disclosures and conflict of interest are listed at the end of this article. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Early ViewOnline Version of Record before inclusion in an issue RelatedInformation

Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer's disease.

Alzheimer's disease (AD) is the leading cause of dementia worldwide, but its pathophysiological phenomena are not fully elucidated. Many neurophysiological markers have been suggested to identify early cognitive impairments of AD. However, the diagnosis of this disease remains a challenge for specialists. In the present cross-sectional study, our objective was to evaluate the manifestations and mechanisms underlying visual-spatial deficits at the early stages of AD. We combined behavioral, electroencephalography (EEG), and eye movement recordings during the performance of a spatial navigation task (a virtual version of the Morris Water Maze adapted to humans). Participants (69-88 years old) with amnesic mild cognitive impairment-Clinical Dementia Rating scale (aMCI-CDR 0.5) were selected as probable early AD (eAD) by a neurologist specialized in dementia. All patients included in this study were evaluated at the CDR 0.5 stage but progressed to probable AD during clinical follow-up. An equal number of matching healthy controls (HCs) were evaluated while performing the navigation task. Data were collected at the Department of Neurology of the Clinical Hospital of the Universidad de Chile and the Department of Neuroscience of the Faculty of Universidad de Chile. Participants with aMCI preceding AD (eAD) showed impaired spatial learning and their visual exploration differed from the control group. eAD group did not clearly prefer regions of interest that could guide solving the task, while controls did. The eAD group showed decreased visual occipital evoked potentials associated with eye fixations, recorded at occipital electrodes. They also showed an alteration of the spatial spread of activity to parietal and frontal regions at the end of the task. The control group presented marked occipital activity in the beta band (15-20 Hz) at early visual processing time. The eAD group showed a reduction in beta band functional connectivity in the prefrontal cortices reflecting poor planning of navigation strategies. We found that EEG signals combined with visual-spatial navigation analysis, yielded early and specific features that may underlie the basis for understanding the loss of functional connectivity in AD. Still, our results are clinically promising for early diagnosis required to improve quality of life and decrease healthcare costs.

February Literature Synopses.

HomeStrokeVol. 54, No. 2February Literature Synopses No AccessReview ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessReview ArticleRequest AccessFull TextFebruary Literature Synopses Shameena Bake and Farida Sohrabji Shameena BakeShameena Bake Department of Neuroscience and Experimental Therapeutics, Women’s Health in Neuroscience Program, Texas A&M Health Science Center College of Medicine, Bryan. Search for more papers by this author and Farida SohrabjiFarida Sohrabji Correspondence to: Farida Sohrabji, PhD, Department of Neuroscience and Experimental Therapeutics, Women’s Health in Neuroscience Program, 8447 Riverside Pkwy, Bryan, TX 77807-3260, Mail Stop 1359. Email E-mail Address: [email protected] https://orcid.org/0000-0002-6960-3411 Department of Neuroscience and Experimental Therapeutics, Women’s Health in Neuroscience Program, Texas A&M Health Science Center College of Medicine, Bryan. Search for more papers by this author Originally published23 Jan 2023https://doi.org/10.1161/STROKEAHA.122.041849Stroke. 2023;54:e42–e43"February Literature Synopses." Stroke, 54(2), pp. e42–e43FootnotesFor Sources of Funding and Disclosures, see page e43.Correspondence to: Farida Sohrabji, PhD, Department of Neuroscience and Experimental Therapeutics, Women’s Health in Neuroscience Program, 8447 Riverside Pkwy, Bryan, TX 77807-3260, Mail Stop 1359. Email [email protected]edu Previous Back to top Next FiguresReferencesRelatedDetails February 2023Vol 54, Issue 2 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/STROKEAHA.122.041849PMID: 36689594 Originally publishedJanuary 23, 2023 PDF download Advertisement

Norman Dott's dome-shaped neurosurgical operating theatres in Edinburgh (1960-2020) - End of an era.

When the new twin operating theatres at the Edinburgh Department of Surgical Neurology opened for the first time on 1 July 1960, they revealed a revolutionary space-pod design. The new department had been designed to firmly establish the specialty in Scotland and the UK, setting the stage for a period of real progress. The most distinctive feature of the two operating theatres was their egg shape, including domed ceilings pierced with operating lights, general lighting, ventilation grilles and viewing ports for visitors. Norman Dott (1897-1973) and his colleagues set the foundation for prosperity and success that lasted decades. However, 60 years after their opening, the DCN theatres at Western General Hospital shut forever, as the department moved to the new Department of Clinical Neurosciences, at the new Royal Infirmary Edinburgh. Echoes of the old theatres will live on in the new; the boldness of the design of the original theatres reflected the close cooperation between clinician-teachers, architects and administrators for the public good. This tradition of tangible confidence and optimism will hopefully carry into a new era, in the new hospital.

Acute and Interventional Treatments.

HomeStrokeVol. 54, No. 2Acute and Interventional Treatments No AccessArticle CommentaryRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessArticle CommentaryRequest AccessFull TextAcute and Interventional Treatments Bruce C.V. Campbell, Michael D. Hill, Thanh N. Nguyen and Joseph P. Broderick Bruce C.V. CampbellBruce C.V. Campbell Correspondence to: Bruce C.V. Campbell, MBBS, PhD, Department of Neurology, Royal Melbourne Hospital Victoria, Australia. Email E-mail Address: [email protected] https://orcid.org/0000-0003-3632-9433 Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia (B.C.V.C.). Search for more papers by this author , Michael D. HillMichael D. Hill https://orcid.org/0000-0002-6269-1543 Department of Clinical Neurosciences, University of Calgary, Alberta, Canada (M.D.H.). Search for more papers by this author , Thanh N. NguyenThanh N. Nguyen https://orcid.org/0000-0002-2810-1685 Departments of Neurology and Radiology, Boston Medical Center, MA (T.N.N.). Search for more papers by this author and Joseph P. BroderickJoseph P. Broderick https://orcid.org/0000-0002-7323-7709 Department of Neurology, University of Cincinnati Gardner Neuroscience Institute, OH (J.P.B.). Search for more papers by this author Originally published23 Jan 2023https://doi.org/10.1161/STROKEAHA.122.041254Stroke. 2023;54:591–594FootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 594.Correspondence to: Bruce C.V. Campbell, MBBS, PhD, Department of Neurology, Royal Melbourne Hospital Victoria, Australia. Email bruce.[email protected]org.au

Ulnar Nerve Entrapment at Elbow, a Retrospective Clinical Observational Study.

Importance: Ulnar neuropathy at the elbow is the second most frequent entrapment neuropathy, affecting 6% of the population. Surgical criteria are based on a general agreement but remain controversial about which procedure is associated with the best results and the fewest complications. This data can help evaluate the effectiveness of operative techniques in symptomatic cure.
 Material and Methods: The study analysis included 26 out of 35 patients with 'Ulnar neuropathy at elbow' diagnosis, treated between January 2017- March 2022 at the Department of Neurosciences, University Service of Neurosurgery, University Hospital Center “Mother Theresa”, Tirana, Albania.
 9 patients from the time period January-June 2018 were excluded from this study analysis due to lack of access to data. Data sources such as medical records and documentation copies of instrumental examinations were extracted from archives of Statistics Service and Hospital Registers, University Hospital Center “Mother Theresa”, Tirana, Albania. Phone follow-up was applied as well.
 Results: We report 26 patients analyzed retrospectively (female: male ratio 1:2.71). 29 operated extremities were studied: 26 with Cubital Tunnel Syndrome, of which 2 presented with ipsilateral Carpal Tunnel Syndrome and 1 bilateral; 2 with contralateral Carpal Tunnel Syndrome. There were 11 patients gr. II McGowan and 15 patients gr. III McGowan.
 There are no positive elbow flexion-extension test cases, indicative of the transposition technique. All patients were clinically evaluated at a distance of 1-3 years post-operatively and 19% presented objective symptoms. Long-term follow-up shows the motor and sensory improvement for gr. II McGowan patients, while gr. III McGowan patients show only sensory and grip improvement, with the persistence of muscular atrophy.
 The most frequent cause of compression was determined fibrosis and hypertrophy around the Osborne ligament (13/26).
 Conclusions: Clinical stage of neuropathy is the decisive factor influencing prognosis. Simple decompression in situ is sufficient in most cases. Dynamic intraoperative testing of sulcus competence, to assess (sub)luxation of the ulnar after decompression, determines the final operative technique.

Semantic wikis as flexible database interfaces for biomedical applications

Several challenges prevent extracting knowledge from biomedical resources, including data heterogeneity and the difficulty to obtain and collaborate on data and annotations by medical doctors. Therefore, flexibility in their representation and interconnection is required; it is also essential to be able to interact easily with such data. In recent years, semantic tools have been developed: semantic wikis are collections of wiki pages that can be annotated with properties and so combine flexibility and expressiveness, two desirable aspects when modeling databases, especially in the dynamic biomedical domain. However, semantics and collaborative analysis of biomedical data is still an unsolved challenge. The aim of this work is to create a tool for easing the design and the setup of semantic databases and to give the possibility to enrich them with biostatistical applications. As a side effect, this will also make them reproducible, fostering their application by other research groups. A command-line software has been developed for creating all structures required by Semantic MediaWiki. Besides, a way to expose statistical analyses as R Shiny applications in the interface is provided, along with a facility to export Prolog predicates for reasoning with external tools. The developed software allowed to create a set of biomedical databases for the Neuroscience Department of the University of Padova in a more automated way. They can be extended with additional qualitative and statistical analyses of data, including for instance regressions, geographical distribution of diseases, and clustering. The software is released as open source-code and published under the GPL-3 license at https://github.com/mfalda/tsv2swm.

Leonard E. Jarrard 1930-2022.

HippocampusVolume 33, Issue 1 p. 3-5 IN MEMORIAM Leonard E. Jarrard 1930–2022 Richard G. M. Morris, Richard G. M. Morris Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh, Edinburgh, UKSearch for more papers by this authorJ. Nicholas Rawlins, J. Nicholas Rawlins Department of Psychology, Chinese University of Hong Kong, SAR, Hong KongSearch for more papers by this authorTerry L. Davidson, Corresponding Author Terry L. Davidson [email protected] orcid.org/0000-0003-2954-3247 Center for Neuroscience and Behavior, Department of Neuroscience, American University, Washington, DC, USA Correspondence Terry L. Davidson, Center for Neuroscience and Behavior, Department of Neuroscience, American University, Washington, DC, USA. Email: [email protected]Search for more papers by this author Richard G. M. Morris, Richard G. M. Morris Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh, Edinburgh, UKSearch for more papers by this authorJ. Nicholas Rawlins, J. Nicholas Rawlins Department of Psychology, Chinese University of Hong Kong, SAR, Hong KongSearch for more papers by this authorTerry L. Davidson, Corresponding Author Terry L. Davidson [email protected] orcid.org/0000-0003-2954-3247 Center for Neuroscience and Behavior, Department of Neuroscience, American University, Washington, DC, USA Correspondence Terry L. Davidson, Center for Neuroscience and Behavior, Department of Neuroscience, American University, Washington, DC, USA. Email: [email protected]Search for more papers by this author First published: 01 December 2022 https://doi.org/10.1002/hipo.23485Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume33, Issue1January 2023Pages 3-5 RelatedInformation

Impact of COVID-19 Pandemic on Reorganization of a Rehabilitation Unit in Italy

<h3>Research Objectives</h3> To investigate and describe the changes that the COVID-19 pandemic has determined in the organization of the Rehabilitation, particularly in the rehabilitative management of patients with acute infection and Long Covid syndrome. <h3>Design</h3> A survey was performed from May to August 2020, during the first pandemic surge. <h3>Setting</h3> The study was conducted at padua General Hospital - University, namely in the Rehabilitation Unit, Department of Neuroscience. <h3>Participants</h3> Patients referred to the Rehabilitation Unit completed the survey. <h3>Interventions</h3> A questionnaire was provided to each patient who accessed our outpatient clinics or who was contacted via digital devices. Patients completed the survey before the visit. <h3>Main Outcome Measures</h3> Not applicable. <h3>Results</h3> Overall, 121 questionnaires completed by patients were analysed. The study participants were 91 female and 30 male patients. The reorganization of the activities by establishing treatment priorities and continuing to ensure early rehabilitative interventions in acute conditions has been essential to rationalize the deployment of staff and personal protective equipment in the emergency. Patients with acute infections were generally rehabilitated in hospital settings, but patients with Long Covid syndrome were largely rehabilitated in out-of-hospital settings. During the pandemic surge, the volume of ambulatory visits had decreased by 70%. Of the remaining visits, approximately 50% were performed via e-mail, 30% telephonically and 20% (nonpostponable evaluations) in person. Data have shown that 81% of patients preferred face-to-face visits rather than alternative communication methods and only 9% preferred to avoid the ambulatory visit because of the fear of contagion. <h3>Conclusions</h3> As in-person evaluations and treatments have proven to be preferred by patients and hospitals cannot deal with the patient load during the pandemic, out-of-hospital alternatives, may be necessary, for example, to take care of patients with persistent outcomes after recovery from acute COVID-19 infection, such as fatigue or neurocognitive deficits. <h3>Author(s) Disclosures</h3> No conflict of interests to declare.

Commentary: Surgical Management of Peripheral Nerve Pathology in Patients With Neurofibromatosis Type 2.

*Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; ‡Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada Correspondence: Rajiv Midha, MD, MSc, Foothills Medical Centre, University of Calgary, 1195-1403 29 St NW, Calgary, ABT2N 2T9, Canada. Email: [email protected]

Of glue and pot: Endocannabinoid signaling in glial cells.

GliaVolume 71, Issue 1 p. 3-4 FOREWORD Of glue and pot: Endocannabinoid signaling in glial cells Giovanni Marsicano, Corresponding Author Giovanni Marsicano [email protected] INSERM U862 NeuroCentre Magendie, Bordeaux, France Correspondence Giovanni Marsicano, INSERM U862 NeuroCentre Magendie, Bordeaux, France. Email: [email protected]Search for more papers by this authorAlfonso Araque, Alfonso Araque Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USASearch for more papers by this author Giovanni Marsicano, Corresponding Author Giovanni Marsicano [email protected] INSERM U862 NeuroCentre Magendie, Bordeaux, France Correspondence Giovanni Marsicano, INSERM U862 NeuroCentre Magendie, Bordeaux, France. Email: [email protected]Search for more papers by this authorAlfonso Araque, Alfonso Araque Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USASearch for more papers by this author First published: 04 November 2022 https://doi.org/10.1002/glia.24296Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume71, Issue1Special Issue: Special Issue on Endocannabinoid signaling in glial cellsJanuary 2023Pages 3-4 RelatedInformation

Stroke Literature Synopsis (Preclinical).

Stroke Literature Synopsis (Preclinical).

Accidental Flibanserin Ingestion in Children Causing Acute Respiratory and Central Nervous System Depression: What Health Care Professionals Need to Know.

Department of Psychiatry and Neurobehavioral Sciences, University of Virginia School of Medicine, Charlottesville, Virginia Department of Psychiatry, University of California, San Diego School of Medicine, San Diego, the Department of Psychiatry and Neuroscience, University of California, Riverside, Riverside, and the Neuroscience Education Institute, San Diego, California Guidelines for Letters. Letters posing a question or challenge to an article appearing in Obstetrics & Gynecology should be submitted within 8 weeks of the article’s publication online. Letters received after 8 weeks will rarely be considered. Letters should not exceed 350 words, including signatures and 5 references. Letters will be published at the discretion of the Editor. The Editor may send the letter to the authors of the original paper so their comments may be published simultaneously. The Editor reserves the right to edit and shorten letters. Letters should be submitted using the Obstetrics & Gynecology online submission and review system, Editorial Manager (http://ong.edmgr.com). Financial Disclosure Dr. Clayton has served as a consultant to AbbVie Inc., Brii Biosciences, Fabre-Kramer, Field Trip Health, Janssen Research & Development, LLC, Mind Cure Health, Ovoca Bio PLC, Praxis Precision Medicines, PureTech Health, S1 Biopharma, Sage Therapeutics, Takeda/Lundbeck, Vella Bioscience, Inc., and WCG MedAvante-ProPhase. She has received grants from Daré Bioscience, Janssen, Praxis Precision Medicines, Relmada Therapeutics, Inc., and Sage Therapeutics. She holds royalties/copyrights with Ballantine Books/Random House, Changes in Sexual Functioning Questionnaire, and Guilford Publications. She holds shares/restricted stock units with Euthymics, Mediflix LLC, and S1 Biopharma. Dr. Stahl has served as a consultant to Acadia, Alkermes, Allergan, AbbVie, Axsome, Clearview, Eisai Pharmaceuticals, Gedeon Richter, Intra-Cellular Therapies, Karuna, Levo Therapeutics, Lundbeck, Merck, Neurocrine, Otsuka, Relmada, Sage Therapeutics, Sunovion, Supernus, Taliaz, Teva, Tris Pharma, and VistaGen. He holds options in Genomind, Lipidio, and Delix. He has served on speakers bureaus for Acadia, Lundbeck, Otsuka, Perrigo, Servier, Sunovion, and Teva, and he has received research and/or grant support from Acadia, Allergan/AbbVie, Avanir, Braeburn Pharmaceuticals, Eisai, Eli Lilly, Harmony Biosciences, Indivior, Intra-Cellular Therapies, Ironshore, Neurocrine, Otsuka, Pear Therapeutics, Sage, Shire, Sunovion, Supernus, and Torrent. Editorial support for this Letter to the Editor was performed by Kayt Scott, PhD, Sarah A. Laredo, PhD, and Lauren Hummel, BA, each of Arbor Scientia, supported by Sprout Pharmaceuticals, Inc., according to Good Publication Practices (GPP3). All opinions, conclusions, and data interpretation lie with the authors. The authors have served in the past as consultants to Sprout but received no payment for writing this letter. Support for logistics was provided by Sprout to the agency Arbor Scientia.

Evaluation of the Efficacy of the Non-Decompressive Single Stage Bilateral Craniotomy in Treatment of Traumatic Brain Injury

Background: Traumatic brain injury is one of the major health care problem around the globe. It is heterogeneous entity. Traumatic lesions including fracture and hematomas typically require surgery. Objective: The study aimed to analyze the Non-Decompressive Single Stage Bilateral Craniotomy in the patients suffering from traumatic brain injury. Study design: This prospective and single center based study was conducted at the neuroscience department of Prime Teaching Hospital/ Peshawar Medical College for the duration of the six months from January 2022 to June 2022. Material and Methods: Out of all the patients visited the neuroscience department of our institute teaching hospital, only 40 were selected for the study after analysis of the computed tomography images. These 40 fulfilled the inclusion criteria. The ethical and review board committee of our hospital approved the study. The patients willingly signed the consent. The bilateral frontal contusectomy was most commonly used surgical procedure. While other used surgical procedures were contralateral contusion and unilateral epidural hematoma. Results: Out of all the patients admitted in the hospital there were 40 that met all the requirements of the study. There were 30 men and 10 women. Most of the cases were reported in the range of 40-59 age. Middle aged men were mostly effected by the disease. The cases were almost in equal number as far as severity of the Traumatic brain injury is concerned. There were some patients that developed ventilator acquired pneumonia and some of the participants suffered from urinary tract infection along with a case of wound infection. There were some death cases reported as well. There were some of the patients who quit medical advice because of their poor financial state. Conclusion: To deal with traumatic brain injury in an effective way, SSBC can prove to be a safe and cost effective procedure, as it has multiple advantages like single incision, single anesthesia and reduced surgical charges, the management of the patient after operation is similar to that of unilateral procedure. Stay in hospital is also reduced and opposite lesion condition can also be avoided this way. Keywords: Traumatic brain, injury, surgical treatment and unilateral procedures.

P13.01.A Challenges and Solutions for Establishing a CNS Tumor Registry in Africa

Abstract Background CNS tumor registries (CTR) has evolved to a key tool for data collection, evaluation of diagnostic and treatment of patients suffering from tumors of the central nervous system (tCNS) in the U.S, but CTR in Africa does not yet exist. In comparison to high-income countries (HIC), many low- and middle-income countries (LMIC) do not yet have national or central CNS tumor registries. Furthermore, appropriate diagnostic steps like MRI and pathological analysis are still scarce in many LMIC. Improving the availability of CTR in resource- limited regions could allow better understanding of some specificities of tCNS including incidence, prevalence, mortality and morbidity. However, CTR, MRI and pathological analysis tend to be costly and thus difficult to implement in the LMIC setting. Material and Methods A review of the current body of literature on tCNS in Africa was conducted using multiple scientific online data bases. Search terms included ,,CNS tumor registry,” “developing countries,” “low and middle income,” and other related terms as starting point for future initiatives. Results It was found that more than 1,3 billion people residing in Africa lack access to a continental CTR. There is no well established standards for reporting tCNS. Most tCNS are still underreported in many countries of Africa. The exact burden of tCNS in Africa is unknown. Although many successful, long-term, initiatives for international neurological and neurosurgical collaborations are published, any CTR of Africa similarly to the Central Brain Tumor Registry of the United States (CBTRUS) is lacking. Conclusion: Disparities in access to care for patients suffering from tCNS have been well published but well established solutions are still under investigations. Partnerships between centers in LMIC and HIC are making progress to better understand the burden of disease in LMIC and to create context-specific solutions for practice in the LMIC setting. Collaboration between the World Health Organisation, national centers for disease control in Africa, departments of neuroscience in LMIC and well established registries like the CBTRUS as well as other interested groups could be meaningful strategical steps to be initiated for the establishment of CTR in Africa. A CTR for Africa could lead to better comprehension of tCNS in Africa, thus facilitate prevention, diagnostic, treatment and research.

Commentary: The Pennsylvania Postmarket Multicenter Experience With Flow Redirection Endoluminal Device.

*Neurosurgery Division, Department of Clinical Neurosciences, Spectrum Health, Grand Rapids, Michigan, USA; ‡Department of Neurosurgery, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA Correspondence: Justin Singer, MD, Division of Neurological Surgery, Department of Clinical Neurosciences, Spectrum Health Medical Group, Michigan State University, 25 Michigan St NE, Suite 6100, Grand Rapids, MI49503, USA. Email: [email protected] Twitter: @JustinSingerMD Andres F. Restrepo, MD, Division of Neurological Surgery, Department of Clinical Neurosciences, Spectrum Health/Michigan State University – College of Human Medicine, 25 Michigan St NE, Suite 6100, Grand Rapids, MI49503, USA. Email: [email protected] Twitter: @AndresRestrepMD