Use Of Deodorants Research Articles

Use of Antiperspirant Products and Risk of Breast Cancer: A Meta-Analysis of Case-Control Studies

Although several observational studies have reported a link between the use of underarm cosmetic products and the risk of breast cancer, the findings remain inconsistent. This study aimed to investigate these associations using a meta-analysis of observational studies. In the meta-analysis of seven case-control studies, we found no association between the use of underarm antiperspirants or deodorants and the risk of breast cancer (OR = 0.96, 95%CI 0.78–1.17; I 2 = 60.0%). Further prospective cohort studies that provide a higher level of evidence are warranted to confirm our findings.

Deodorant use and related adverse effects: A cross-sectional survey among Palestinian students.

Deodorants are widely used to mask unpleasant body odors. They are reported to cause some adverse effects depending on the form and ingredients. The purpose of this study was to assess the prevalence of deodorant use and related adverse effects among Palestinian students. This cross-sectional study was carried out at An-Najah National University from Aug 2018 to Mar 2020. A questionnaire was constructed using a Google survey form. All analyses were done using SPSS 21.0, Fisher test was used for comparative analysis and the P-value < 0.05 was considered as statistically significant. A total of 554 students participated in the study. About 93% of the participants were using deodorants and adverse effects were reported by 25% of the participants. The reported adverse effects were itching (26%), coloration (25%), sneezing (21%), and eye redness (8%). Only 4.1% of the participants visited a physician for counselling regarding various adverse effects. Deodorants were widely used by Palestinian students with reported adverse effects, but these side effects rarely prompted the participants to seek medical advice.

Antimicrobial Properties Related to Anti-Acne and Deodorant Efficacy of Hedychium coronarium J. Koenig Extracts from Pulsed Electric Field Extraction.

This study investigated the potential of pulsed electric field (PEF) extraction in enhancing the antimicrobial properties related to anti-acne and deodorant properties of Hedychium coronarium extract. The dried leaf and rhizome of H. coronarium were extracted using 95% v/v ethanol through both conventional solvent extraction and PEF extraction techniques (10, 14, and 20 kV/cm). The chemical composition of the extracts was analyzed. The antimicrobial activities, specifically in relation to acne treatment against Cutibacterium acnes and deodorant properties against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Pseudomonas aeruginosa, and Escherichia coli, were determined. The irritation profile of was evaluated using the hen's egg chorioallantoic membrane test. The results showed that PEF extraction increased the extract yield, particularly at an electric field strength of 20 kV/cm. Furthermore, PEF extraction significantly enhanced the ellagic acid content, particularly in the leaf extract. Furthermore, the leaf extract demonstrated stronger inhibitory effects against microorganisms associated with body odor and acne compared to the rhizome extract. Notably, all extracts exhibited no signs of irritation, indicating their safety. Overall, the findings suggest that PEF extraction from H. coronarium enhances yield, bioactive compound content, and antimicrobial effects. This indicates the potential of the extract for acne treatment and deodorant use.

Indoor Air Pollution: A Review on the Challenges in Third World Countries

Background: The challenges of third-world countries toward curbing indoor air pollution seem insurmountable as its solution is closely linked to their economic incapacities, lifestyle, and existing outdoor air quality. The economic incapacities include types of the cookstove, fuel sources, types of insecticides and pesticides, building patterns, indoor fermentation activities (such as leaving dirty plates and biological waste in the house for a long time), and regulation on the use of deodorants. Aside from the common pollutants from these sources, the reactive chemistry of pollutants leads to other kinds of pollutants which have been reported to be short-lived but dangerous. Objectives: The objectives of the study are to: profile emerging indoor pollutants; examine the pollutant dynamics and their impact on unplanned regions of developing countries; offer solutions to curb indoor pollution in the identified region; elaborate on the cost analysis of existing solutions and how irrelevant they may be due to the rising poverty index; and project how government policies could help in reducing indoor pollution. Design: This paper is a review that wholistically examined indoor pollution. A total of fifty-six articles was reviewed in addition to the data obtained from MERRA-2. Results: The study observed that indoor air pollution dynamics are more complex—compared to outdoor air pollution. It was observed that the possibility to control indoor air pollution is based on the type of pollutants, the reactive chemistry of the pollutants, and ventilation in the building. This review shows that poverty is one of the many reasons why indoor air pollution would be a source of menace for a long time in third-world countries. Several solutions to curbing indoor air pollution were considered with a principal focus on cost and availability. Limitations: Most experimental results that were used to corroborate postulates were obtained from the literature. The accuracy of those experiments and the sensitivity of the equipment used cannot be verified. Conclusion: The plant-based technique was identified as a perfect solution to indoor air pollution control in third-world countries but the local architecture and lifestyle of most third-world countries constitute a threat to its adoption. It was observed that less than 8% of third-world countries have specific Air Quality Acts which have not been amended for decades. Most third-world countries have a general Environmental Act with air quality as a sub-section in the Act with very low fines for violators. The inclusion of indoor air quality as a vital public health issue in third-world countries is necessary for the preservation of lives and posterity.

Gas chromatography-flame ionization detector for sweat based COVID-19 screening

Simple approach for rapid screening of corona virus disease 2019 (COVID-19) has been developed. This applied gas chromatography-flame ionization detector (GC-FID) analyzing the potential compound marker in sweat samples obtained from COVID-19 positive and negative volunteers in Bangkok, Thailand. The samples were collected by using cotton rods for 15 min, heated at 90 °C for 5 min, and the volatile compounds in the headspace (HS) were injected (5.00 mL) at 150 °C and separated within 13.7 min. The marker peak was tentatively identified as p-cymene by the authentic standard injection and comparison with the GC-mass spectrometry (GC-MS) and comprehensive two-dimensional GC (GC × GC)-MS analysis. Possible mechanisms for the presence of p-cymene were proposed. The marker peak area thresholds were then varied and optimized via construction of the receiver operating characteristic (ROC) curve. With the optimum threshold, the established method offered the accuracy, sensitivity and specificity of 96 %. This method was insignificantly affected (p-value >0.05) by genders, body mass indices, ages, and use of deodorants as well as the p-cymene containing food. However, the performance could be affected by the population with personal hygiene or experiencing the microbiomes producing p-cymene.

Shedding light on the management of acute radiation dermatitis: insight from the MASCC Oncodermatology study group.

This paper highlights a collection of eleven recently published manuscripts on the prevention and management of acute radiation dermatitis. These meta-analyses provide additional evidence for the updated clinical practice guidelines by the Multinational Association of Supportive Care in Cancer (MASCC) Oncodermatology study group for prevention and management of acute radiation dermatitis. The collection of papers elucidate the currently available evidence on acute radiation dermatitis, highlighting consolidated knowledge, effective treatments, and proposed areas for future clinical trials. Overall, a total of 51 randomized controlled trials were retrieved and included for quantitative analysis of an initial systematic review of literature from 1946 to January 2023. Discussion of the clinical impact of various therapeutic interventions include: antiperspirant and deodorant use, barrier films and dressings, natural and miscellaneous agents, photobiomodulation therapy, topical corticosteroids, topical non-steroidal agents, skin hygiene and washing, as well as StrataXRT and Mepitel film in breast cancer patients. The comprehensive nature of the meta-analyses and their related findings may help reduce the discrepancies in in treatment of acute radiation dermatitis and facilitate consistency of therapeutic interventions employed in clinical practice worldwide.

Risk assessment, surveillance, and nonpharmaceutical prevention of acute radiation dermatitis: results of amulticentric survey among the German-speaking radiation oncology community.

Radiation dermatitis (RD) represents one of the most frequent side effects in radiotherapy (RT). Despite technical progress, mild and moderate RD still affects major subsets of patients and identification and management of patients with ahigh risk of severe RD is essential. We sought to characterize surveillance and nonpharmaceutical preventive management of RD in German-speaking hospitals and private centers. We conducted asurvey on RD among German-speaking radiation oncologists inquiring for their evaluation of risk factors, assessment methods, and nonpharmaceutical preventive management of RD. Atotal of 244health professionals from public and private institutions in Germany, Austria, and Switzerland participated in the survey. RT-dependent factors were deemed most relevant for RD onset followed by lifestyle factors, emphasizing the impact of treatment conceptualization and patient education. While abroad majority of 92.8% assess RD at least once during RT, 59.0% of participants report RD at least partially arbitrarily and 17.4% stated to classify RD severity solely arbitrarily. 83.7% of all participants were unaware of patient-reported outcomes (PROs). Consensus exists on some lifestyle recommendations like avoidance of sun exposure (98.7%), hot baths (95.1%), and mechanical irritation (91.8%) under RT, while deodorant use (63.4% not at all, 22.1% with restrictions) or application of skin lotion (15.1% disapproval) remain controversial and are not recommended by guidelines or evidence-based practices. Identification of patients at an increased risk of RD and subsequent implementation of adequate preventive measures remain relevant and challenging aspects of clinical routines. Consensus exists on several risk factors and nonpharmaceutical prevention recommendations, while RT-dependent risk factors, e.g., the fractionation scheme, or hygienic measures like deodorant use remain controversial. Surveillance is widely lacking methodology and objectivity. Intensifying outreach in the radiation oncology community is needed to improve practice patterns.

The effect of antiperspirant and deodorant use on acute radiation dermatitis in breast cancer patients during radiotherapy: a systematic review and meta-analysis.

While some authors have investigated the impact of antiperspirant /deodorant on the development of acute radiation dermatitis (RD) among patients undergoing radiotherapy (RT) for breast cancer, recommendations supporting the use of antiperspirant/deodorant during breast RT remain highly variable. This systematic review and meta-analysis aims to evaluate the evidence investigating the effect of antiperspirant/deodorant on the development of acute RD during post-operative breast RT. A literature search has been performed using OVID MedLine, Embase, and Cochrane databases (1946 to September 2020) to identify randomized controlled trials (RCTs) that have investigated deodorant/antiperspirant use during RT. The meta-analysis was conducted using RevMan 5.4 to calculate pooled effect sizes and 95% confidence intervals (CI). Five RCTs met the inclusion criteria. The use of antiperspirant/deodorant did not significantly affect the incidence of grade (G) 1 + RD (OR 0.81, 95% CI 0.54-1.21, p = 0.31). Prohibition of deodorant use did not significantly prevent the occurrence of G2 + acute RD (OR 0.90, 95%, CI 0.65-1.25, p = 0.53). No significant effect was reported in preventing G3 RD between the antiperspirant/deodorant and control groups (OR 0.54, 95%, CI 0.26-1.12, p = 0.10). There was no significant difference in pruritus and pain between patients undergoing skin care protocols with or without antiperspirant/deodorant (OR 0.73, 95% CI 0.29, 1.81, p = 0.50, and OR 1.05, 95% CI 0.43-2.52, p = 0.92, respectively). The use of antiperspirant/deodorant during breast RT does not significantly affect the incidence of acute RD, pruritus, and pain. As such, the current evidence does not support recommendation against antiperspirant/deodorant use during RT.

Life Habits, Frequency of Application and Long-Term Exposure to Cosmetic Products Containing Parabens Can Cause Higher Breast Cancer Risk among Women

Background: Modern lifestyle involves everyday use of cosmetic products containing various sources of Endocrine Disruptors (EDs), parabens being the most common ones. Growing cancer burden globally, namely the increased breast cancer incidence, suggests a lifestyle cause. Could the continuous and prolonged exposure to parabens be accountable for the higher breast cancer risk on a global scale? Methods: A Questionnaire was filled out on the subjects' anamnestic data, anthropometric measurements, sociodemographic characteristics, the presence of risk factors for the development of breast cancer, and the beginning and frequency of use of deodorants, body lotions and antiperspirants. Total of seventy-two (n = 72) patients were enrolled in the study. All obtained data was compared with risk factors for the development of breast cancer. Results: Women with breast cancer have longer been exposed to cosmetic products usage (an average of 36 years in total) in comparison to healthy women (an average of 24 years in total). Healthy women tend to start using cosmetic products earlier, at the average age of 16, and tend to use them more often as part of their everyday routine. In contrast, women with breast cancer start later on, at the average age of 19. Conclusion: Our study supports the fact that the most important risk factor for breast cancer is age, but also suggests that long term exposure to parabens could play a crucial role in breast cancer manifestation, even more so at an earlier age. Shift to healthier alternatives to parabens in cosmetic products would contribute to both disease prevention as well as greener environment.

Antimicrobial Effects of Tetraspanin CD9 Peptide against Microbiota Causing Armpit Malodour.

Synthetic peptides, including tetraspanin CD9 peptides, are increasingly coming into focus as new treatment strategies against various organisms, including bacteria, that cause underarm odour. The use of deodorants and antiperspirants is associated with side effects. Therefore, it is critical to find an alternative therapeutic approach to combat underarm odour. The aim of this study is to investigate the antibacterial effect of tetraspanin CD9 peptides against the skin microbiota that cause malodour in the underarms. The antimicrobial activity of CD9 peptides against Micrococcus luteus (M. luteus), Bacillus subtilis (B. subtilis), Staphylococcus epidermidis (S. epidermidis), and Corynebacterium xerosis (C. xerosis) was investigated by the disc diffusion method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by broth microdilution assays using CD9 peptide concentrations ranging from 1 mg/mL to 0.0078 mg/mL. In addition, the anti-biofilm activity of the CD9 peptides was determined. The CD9 peptides showed different antibacterial activity with an inhibition zone of 7.67, 9.67, 7.00, and 6.00 mm for S. epidermidis, M. luteus, C. xerosis, and B. subtilis, respectively. All bacteria had the same MBC value of 1 mg/mL. A high MIC of CD9 peptides was observed for S. epidermidis and M. luteus at 0.5 mg/mL. The MIC values of B. subtilis and C. xerosis were 0.125 mg/mL and 0.25 mg/mL, respectively. CD9 peptides significantly inhibited biofilm development of S. epidermidis, B. subtilis, and C. xerosis isolates. The CD9 tetraspanin peptide has excellent antibacterial activity against bacteria that cause underarm odour. Therefore, the CD9 tetraspanin peptide is a promising alternative to deodorants and antiperspirants to combat commensal bacteria of the skin that cause underarm odour.

Promoting Comfort: A Clinician Guide and Evidence-Based Skin Care Plan in the Prevention and Management of Radiation Dermatitis for Patients with Breast Cancer.

Patients with breast cancer may be offered adjuvant radiation therapy (RT) after surgery. Up to 95% of these patients develop radiation dermatitis (RD) during or following RT. Randomized clinical trials and other literature provide evidence that RD can be prevented or reduced. The aim of this article is to propose a Clinician Guide and Evidence-based Skin Care Plan to prevent and/or reduce radiation dermatitis and promote the comfort of breast cancer patients receiving RT. As an integrative review, the databases searched were CINAHL and Medline, using the key terms: breast cancer, skin care, radiation, radiation therapy, radiotherapy, radiation dermatitis, and radiation skin reaction, prevention, and management. Search criteria included English language, full text, published between 2012 through 2020, and peer-reviewed. The search yielded 320 articles. Relevant articles were evaluated using the Quality Assessment Tool (QAT), and highly rated articles were selected to be included in the review of literature. The outcomes were the development of a Clinician Guide to offer holistic, patient-centered care and an Evidence-based Skin Care Plan. The research literature supports a standard skin care regimen, along with use of an emollient cream to the treatment area, use of deodorants depending on patient preferences, and application of a topical steroid cream daily throughout treatment and two weeks post RT. Clinician’s weekly assessments of patients offers therapeutic support and ensures optimal skin care during and post-RT. The comfort of breast cancer patients receiving RT requires the best level of evidence regarding the efficacy of interventions, coupled with clinician’s judgement, and patient’s preferences and wishes. The clinician-patient relationship is essential in addressing the physical, emotional, social, spiritual, and functional challenges associated with a cancer diagnosis and adjunctive radiation therapy to improve long-term survival.

Salicylate or Phthalate: The Main Intermediates in the Bacterial Degradation of Naphthalene

Polycyclic aromatic hydrocarbons (PAHs) are widely presented in the environment and pose a serious environmental threat due to their toxicity. Among PAHs, naphthalene is the simplest compound. Nevertheless, due to its high toxicity and presence in the waste of chemical and oil processing industries, naphthalene is one of the most critical pollutants. Similar to other PAHs, naphthalene is released into the environment via the incomplete combustion of organic compounds, pyrolysis, oil spills, oil processing, household waste disposal, and use of fumigants and deodorants. One of the main ways to detoxify such compounds in the natural environment is through their microbial degradation. For the first time, the pathway of naphthalene degradation was investigated in pseudomonades. The salicylate was found to be a key intermediate. For some time, this pathway was considered the main, if not the only one, in the bacterial destruction of naphthalene. However, later, data emerged which indicated that gram-positive bacteria in the overwhelming majority of cases are not capable of the formation/destruction of salicylate. The obtained data made it possible to reveal that protocatechoate, phthalate, and cinnamic acids are predominant intermediates in the destruction of naphthalene by rhodococci. Pathways of naphthalene degradation, the key enzymes, and genetic regulation are the main subjects of the present review, representing an attempt to summarize the current knowledge about the mechanism of the microbial degradation of PAHs. Modern molecular methods are also discussed in the context of the development of “omics” approaches, namely genomic, metabolomic, and proteomic, used as tools for studying the mechanisms of microbial biodegradation. Lastly, a comprehensive understanding of the mechanisms of the formation of specific ecosystems is also provided.

Air Quality Assessment of a School in an Industrialized Area of Southern Italy

In this study, simultaneous monitoring of indoor and outdoor Volatile Organic Compounds (VOCs) was carried out in a school, by both Radiello® cartridges and real-time monitors (Corvus, IonScience Ltd., Fowlmere UK). Moreover, an outdoor air quality assessment was performed with data from an air quality monitoring station (ARPA Puglia) located close to the school. In particular, VOCs, Benzene, Toluene, Ethylbenzene, and Xilenes concentrations, obtained by using Radiello® diffusive samplers, were monitored in two classrooms, two bathrooms, and outside of the school building for three weeks during winter 2019. Simultaneously, the Total VOC (TVOC) concentrations were measured by means of real-time monitors inside and outside the classroom in order to individuate the activation of sources during the sampling campaign days. The results evidence that indoor TVOC concentrations were bigger than those outdoors; this suggests the presence of indoor pollutant sources, both in the classrooms and the bathrooms. The results of our study can help the school management by the following recommendations: increasing ventilation in classrooms during school activities and after cleaning; involving students in discussions regarding the use of acrylic paints, permanent markers, perfumes and deodorants, and the limitation of smoking activities both in bathrooms and outdoor spaces.

Deodorants and antiperspirants: identification of new strategies and perspectives to prevent and control malodor and sweat of the body.

Excessive sweating and body odors in many cultures can cause negative perceptions of an individual and in many cases is related to poor hygiene. Personal hygiene products have been developed with the intention of preventing these undesirable issues. The aim of this paper is to review the main active ingredients used in marketed deodorant and antiperspirant formulations as well as to identify new strategies and future methods to optimize such products and prevent malodor. PubMed and ScienceDirect databases were used to search for studies reporting the use of deodorants and antiperspirants, the compounds used in the formulations, their mechanisms of action and associated controversies, as well as new trends and approaches in the area. Even today, we are still using well-known and established actives such as triclosan and aluminum salts, and these are still the most used compounds in deodorants with bactericidal and antiperspirant properties. These substances have been on the market for more than 40 years, and still there are many questions concerning the safety of both actives. There is a general increased interest globally for lifestyles that focus on sustainability and more natural products such as plant sources and the use of, for example, essential oils. The research that focuses in the area of antiperspirants and deodorants is now more focused on studies of the armpit biochemistry and function and control of the microbiota present in this area. Other possible areas of interest are biotechnological solutions and finding new compounds that will interfere with the biochemistry of the process of sweat decomposition. Further approaches include formulations with probiotics which would maintain the balance of axillary microbiota.

Pomegranate juice rescues developmental, neurobehavioral and biochemical disorders in aluminum chloride-treated male mice

PurposeAluminum (Al) is a harmful metal to organisms and is capable of entering the human body in multiple ways, such as through drinking, breathing, deodorant use, and vaccination. This study examined the prospective toxicity of Al and the protective attributes of pomegranate juice (PJ) on neurobehavioral and biochemical parameters of male mice. MethodsSix groups of male mice were treated for 35 days with 20 % PJ (group II), 40 % PJ (group III), 400 mg/kg Al (group IV), Al + 20 % PJ (group V), Al + 40 % PJ (group VI) or tap water (control, group I). Behavioral assessments were conducted for learning and memory evaluations at the end of experiment. In addition, the forebrain was isolated for biochemical analysis. ResultsThe exposure of male mice to Al decreased learning and memory retention in the shuttle box, Morris water-maze and T-Maze tests. Biochemical analysis revealed significant depletions in neurotransmitters including DA, 5-HT and AChE and oxidative proteins including GSH, GST, CAT and SOD and increased TBARES levels in Al-treated mice compared to untreated mice. Pomegranate juice provided protection against these effects after Al exposure by ameliorating learning and memory retention and oxidative state in a dose-independent manner. ConclusionOur data demonstrated that Al exposure caused behavioral and biochemical disorders. Pomegranate juice in lower dose has beneficial properties for health and can be used as a source of antioxidants to reduce the toxicity of Al and other substances.

Infantile granular parakeratosis: Case report and review of the literature

Granular parakeratosis (GP) is a benign skin disease that has been reported in adults and children. Lesions usually affect the axillae, groin, and submammary region. The primary lesions present as brown keratotic papules and can form plaques. The etiologies implicated in the development of GP include the use of topical cream and the use of deodorants, local irritation and in children, it was linked to repetitive washing of the affected area and the use of zinc oxide cream. This is a case report of GP in a 14-month-old boy noted after washing the groin area with soap and using zinc oxide cream. The lesions have improved after the discontinuation of the use of zinc oxide cream and soap in washing the affected area.

Patterns of phenol, paraben, and phthalate exposure in NYC women

TPS 622: Exposure to flame retardants and plasticizers, Johan Friso Foyer, Floor 1, August 26, 2019, 3:00 PM - 4:30 PM Background/Aims. Women are disproportionately exposed to environmental chemicals linked to adverse health outcomes through their use of personal care products. Identification of exposure patterns and associations with potential exposure sources can inform the design of targeted policies and interventions. Methods. We used information on pregnant women aged 18-35 from New York enrolled in the Mothers and Newborns cohort. Five phenols, three parabens, and nine phthalate metabolites were measured and adjusted for specific gravity in spot urine samples collected during the third trimester in 362 women. Personal care product use was assessed via questionnaire. We used principal component pursuit (PCP), a novel robust pattern recognition and dimensionality reduction technique, to simultaneously identify consistent patterns of chemical exposure and to isolate unique or extreme exposure events. We included individual pattern scores in regression models to evaluate their relationship with personal care product use. Results. Separating variance due to extreme events from common patterns, PCP explained 81% of the variance in exposure. We identified five patterns that, 1) represent overall exposure, 2) separate phthalates from phenols and parabens, 3) separate two phenols (2,4-dichloro-phenol and 2,5-dichloro-phenol) from parabens, 4) separate di(2-ethylhexyl) phthalate metabolites from other phthalates, and 5) represent disproportionately high triclosan exposure. Personal care products contain varying mixtures of these chemicals. Pattern 1 was associated with make-up, perfume, and liquid soap use. Pattern 2 was associated with eye make-up and hair gel use. Pattern 3 was associated with lotion use. Pattern 4 was associated with lotion, hair spray, and sunscreen use. Pattern 5 was associated with lipstick and deodorant use. Conclusions. Phenol, paraben, and phthalate exposure comes from various environmental sources, including personal care products. PCP serves as a useful tool to aggregate exposures into consistent patterns that, if found to be related to adverse health, are amenable to targeted public health messaging.

The impact of skin care products on skin chemistry and microbiome dynamics

BackgroundUse of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a facial lotion, a moisturizer, a foot powder, and a deodorant) on 11 volunteers over 9 weeks.ResultsMass spectrometry and 16S rRNA inventories of the skin revealed decreases in chemical as well as in bacterial and archaeal diversity on halting deodorant use. Specific compounds from beauty products used before the study remain detectable with half-lives of 0.5–1.9 weeks. The deodorant and foot powder increased molecular, bacterial, and archaeal diversity, while arm and face lotions had little effect on bacterial and archaeal but increased chemical diversity. Personal care product effects last for weeks and produce highly individualized responses, including alterations in steroid and pheromone levels and in bacterial and archaeal ecosystem structure and dynamics.ConclusionsThese findings may lead to next-generation precision beauty products and therapies for skin disorders.

FREQUENCY OF SOME ENVIRONMENTAL FACTORS WITH POTENTIAL RELATIONS TO BREAST DISEASES AMONG A GROUP OF EGYPTIAN FEMALES

This study was conducted to highlight the significant environmental factors that may have impacts on breast benign and malignant diseases. This study was carried out on one hundred females who came to radiology department to perform mammographic examination. A complete personal and family history of patients was taken, clinical examination was done, all cases were asked to fill a questionnaire about how often they deal with each item of the environmental factors including (alcohol, caffeine, smoking, use of some material that are commonly used in daily life and known to have estrogenic effect including (food and soda cans, plastic containers, insecticides, detergents and cleaning agent, deodorants and cosmetics) then digital mammographic examination was done for all cases. Cases with high 17b Estradiol hormone blood level were excluded from the study. The quantitative data were presented as mean and standard deviations. Also qualitative variables were presented as number and percentages. The comparison between groups regarding qualitative data was done by using Chi-square test while the comparison between more than two groups with quantitative data were done by using One Way ANOVA. The confidence interval was set to 95% and the margin of error accepted was set to 5%. So, the p-value was considered significant at the level of < 0.05. Occurrence of benign and malignant lesions, breast calcifications and axillary lymphadenopathy was significantly associated to environmental estrogens containing items namely; use of diet & soda cans, use of insecticides, use of detergents & cleaning agents, use of deodorants, use of cosmetics and use of plastic containers. Age, BMI of the patient and previous mammographic examinations was significantly associated to occurrence of benign and malignant lesions, breast calcifications and axillary lymphadenopathy. No significant association found between alcohol intake and axillary lymphadenopathy and between caffeine intake and breast calcifications. Caffeine intake, alcohol intake and smoking had no significant association with occurrence of benign and malignant lesions.

Levels, variability and determinants of environmental phenols in pairs of Norwegian mothers and children

BackgroundExposure to environmental phenols including parabens, bisphenols (BPs), oxybenzone/benzophenone-3 (BP-3) and triclosan (TCS) is ubiquitous. Due to evidence of their estrogenic activity, they have been considered as chemicals of concern. The exposure of the Norwegian population to these compounds is presently unknown. AimsTo measure urinary levels of twelve different environmental phenols including four emerging bisphenols: S, F, B and AF (abbreviated as BPS, BPF, BPB and BPAF, respectively) in a healthy Norwegian population. We have calculated short-term variability, estimated daily intakes and investigated important determinants of exposure. MethodsUrine samples were collected from mothers (n = 48) and their children (n = 56) during spring/summer 2012 in two counties in Norway. ResultsSix environmental phenols namely methyl, ethyl and propyl paraben, BPA, BP-3 and TCS were detected in almost 100% of the urine samples. Among the emerging bisphenols, BPS was detected most frequently in the urine samples (42–48%) followed by BPF (4–15%). Parabens were positively and significantly correlated to each other in both mothers and children. Levels of parabens and BP-3 were higher in mothers compared to children. All mothers and children had lower estimated daily intakes (back calculated from the urinary concentrations) of parabens and BPA than the respective acceptable and tolerable daily intakes (ADIs and TDIs) established by the European Food Safety Authority (EFSA). Observed intraclass correlation coefficients (ICCs) indicated moderate to high reliability of spot urine measurements for all the environmental phenols (ICCs: 0.70–0.97). Use of hair products, deodorants, face and hand creams were significantly associated with higher urinary levels of parabens. ConclusionsOccurrence of environmental phenols in healthy Norwegian women and children is abundant. Among emerging bisphenols, there is widespread exposure to BPS. A single spot urine sample can be used for estimating short-term exposures of environmental phenols. Urinary levels of parabens were associated with use of PCPs.