In line with the guidelines established by the American Dental Association, the American Prosthodontic Society, and materials presented in this paper, a few recommendations can be presented in regard to the post-placement care of complete and removable partial dentures. Accumulations of plaque and food should be removed daily, if not more often. This is most quickly and efficiently accomplished with a denture brush and mild soap. In addition dentures should be rinsed thoroughly after all meals. Where a brush cannot reach, and for sterilization or stain removal, a dilute solution of commercial bleach can be sparingly swabbed over the denture surface. The soaking of any appliances with chrome metal parts in solutions of sodium hypochlorite for lengthy periods of time must be avoided owing to the corrosive potential of the solution. Soaking agents are generally useful for freshening dentures, removing or masking odoriferous compounds, and to a lesser degree for removing accumulations of stain and calculus. If a patient has been or desires to use commercial cleansers, the precautions previously described should be observed. Certain special situations may require the prescription of denture cleanser use on a regular, even daily, basis. Handicapped, aged, or ill patients cannot realistically be expected, at times, to carefully employ a denture brush in any home care program. Soaking agents can be of great benefit to them in that they easily reach all surfaces of the prostheses, and present the least possibility for accidental damage as a result of mishandling. It is clear that post-placement instructions should be tailored to the individual. Physical coordination, age, the materials from which the dentures are made, and smoking and eating habits are just a few of many aspects that should be considered when developing an intelligent hygiene program. The chemistry involved in keeping dentures clean has been and continues to grow more complex. What was once a problem routinely left to a patient's own better judgment has now, owing to advertisement pressure and advances in materials science, increasingly become the dentist's responsibility. Information on many commercial products to patients is lacking and until more of this information is made available to the profession through research or through the manufacturers themselves, we will for the most part have to rely on time-tested materials and methods for denture hygiene.