Surgically assisted mandibular arch expansion is an effective treatment modality for alleviating constriction and crowding. However, only mandibular symphyseal osteotomy is recommended for mandibular arch expansion. No relevant studies have compared the biomechanical responses of different corticotomy designs on mandibular expansion. Therefore, the aim of this study was to evaluate the effect of different corticotomy approaches and modes of loading on the expansion of adult mandibles using biomechanics. Nine finite element models including 2 novel corticotomy designs were simulated. Stress, strain, and displacement of crown, root, and bone were calculated and compared under different corticotomy approaches and loading conditions. The biomechanical response seen in the finite element models in terms of displacement on the x-axis was consistent from anterior to posterior teeth with parasymphyseal step corticotomy and tooth-borne force application. In addition, the amount of displacement predicted by parasymphyseal step corticotomy in the tooth-borne mode was greater compared with other models. These results suggest that parasymphyseal step corticotomy with tooth-borne force application is a viable treatment option for true bony expansion in an adult mandible.