Justification: Local anaesthesia is widely used in various procedures in dental specialties. However, even though it is rare, a medical emergency may occur. Objective: The article aims to show the necessary care in the administration of local anaesthetic in dentistry and the medical emergencies, signs and symptoms and first procedures. Show the importance of the dental surgeon be alert to any signs and symptoms during the application of anaesthetic, and able to intercede in any risk to health or the patient's death and knowing the formula and possible side effects of anaesthetic use and their medicine interactions with legal and/or illegal drug. Methodology: research on the main electronic health platforms, BIREME, LILACS and Medline, using as descriptors: LOCAL ANAESTHETIC /+/ ODONTOLOGY and MEDICAL EMERGENCIES/AND/ODONTOLOGY, in Portuguese, French, Spanish and English, and the professional experience of the authors in First Aid and Medical Emergency in Dental Offices. Conclusion: There are risks in the administration of local anaesthetics, however they are minimal and can be predicted when there is a correct anamnesis and treatment plan and/or surgical adequate for each identified situation. Knowledge of the anatomy of irrigation and drainage, foramen, among others, besides of the physiology and neuroanatomy of the region where the anaesthetic will be applied, is important to minimise the risks. The dental surgeon should be alert to any signs and symptoms during the application of anaesthetic, and able to intercede in any risk to health or of the patient's death and knowing the formula and possible side effects of anaesthetic use and their medicine interactions with legal and/or illegal drug. The most serious side effects of a local anaesthetic focus on the central and peripheral nervous system, the cardiovascular tract and renal tract. Hence, there need to know both the physiology of the systems and the interaction of the medications with the specific anaesthetics. However, the patient may not always be able to receive anaesthetics with vasoconstrictors, and surgery is not always elective to know such medicine interactions, and not always is possible to know if there is any allergy to any specific anaesthetic without prior testing before surgery. Hence, there is needed to know emergency medical procedures in dental offices and clinics
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