One of the most common symptoms in anorectal diseases which encounters in routine clinical practice is Kshata guda, that is, Parikartika, mentions in Ayurved Samhitas. Parikartanam means excessive cutting pain around the anus. Pain is the most important clinical symptoms in this disease. Anal fissure is one of the eloquent causes of pain with per rectum bleeding, sphincter spasm in the anal region at times. Fissure is a crack or a split in the lower end of anal canal. Bailey and Love (1968) have described fissure-in-ano as an elongated ulcer in long axis of anal canal. It is mostly due to constipation. Exact etiology is obscure, one theory is that the fissure-in-ano is caused by overstretching of the epithelial lining of the anal canal by the pressure of a hard fecal mass during defecation against the posterior wall of anorectal junction which is relatively poor supported by musculature on this aspect of the rectum and anal canal. In this case series, the cases are observe symptomatically for the drug healing properties and the objective of the hypothetical parameters shows fruitful results with the application of Yashtimadhu tail (medicated oil) in the management of Parikatika (Fissure-in-ano), leading to non-surgical management of Parikatika (Fissure-in-ano) in very cost-effective way.