Background: Dentistry’s evolving focus on fixed prostheses contrasts with the relative infancy of the jaw-related concepts in removable complete dentures, particularly in determining the vertical dimension of occlusion (VDO). The criticality of VDO in prosthetic rehabilitation underscores the need for stable parameters. However, due to the lack of a stable paradigm, the precise determination of VDO remains a contentious issue. This study proposes the utilization of lateral profile photographs (LPPs) to estimate VDO in edentulous patients. Methods: A cross-sectional study was conducted at the College of Medical Sciences, Bharatpur, Chitwan, Nepal. Using non-probability convenience sampling, 50 participants aged 20-30 years with specific dental parameters were selected. LPPs were obtained, and angular measurements were recorded to establish correlations and regression models. Results: Statistical analysis revealed a significant correlation between measured angles and VDO. Strong and positive relationships were identified between Stn-Stsn-Stgn and Stn-Stsn-Stg angles and between Stp-Stg-Stgn and Stp-Stg-Stsn angles. The study’s regression models successfully predicted Stn-Stsn-Stgn and Stp-Stg-Stgn angles using Stn-Stsn-Stg and Stp-Stg-Stsn as predictor variables. Conclusions: The study underlines the potential of LPPs as a practical tool for estimating VDO, presenting an accessible alternative to conventional techniques. The observed correlations emphasize the intricate interplay of craniofacial parameters, reinforcing the importance of accurate VDO determination for successful dental treatments.