Surface Modification Of Dental Implants Research Articles

Implant Microdesigns and Their Impact on Osseointegration

Researchers are in constant search for the ideal implant surface condition in an attempt to improve osseointegration of the implant and to increase bone-to-implant contact. Although introduction of rough surfaces was able to overcome a lot of limitations that presented with machined surfaces, they are still incapable of ensuring predictable results and guaranteed success. Various techniques in implant surface modifications have been proposed, all aimed at improving bone formation around dental implants. Understanding how surface modification of dental implants can impact osseointegration might help the clinician to maximize the success rate of implants and diminish the complications that can be encountered after their placement. In view of that, this article is aimed at assessing the different surface conditioning techniques available and will present a review of the literature that focuses on the influence of microdesign of dental implants on their osseointegration.

Enhanced attachment, proliferation, and differentiation of human gingival fibroblasts on titanium surface modified with biomolecules

Surface modification of dental implants with biomolecules is of particularly interest recently. To mimic the structure and function of native extracellular matrix (ECM), a derivative of hyaluronic acid (HA), HA-GRGDSP, was synthesized, Arg-Gly-Asp (RGD)-containing collagen (Col)/HA multilayer polyelectrolyte films (MPFs) coating was fabricated on titanium (Ti) through alternate deposition of Col and HA-GRGDSP with 4.5 assembly cycles; moreover, bioactive molecule, basic fibroblast growth factor (bFGF), was also incorporated into such coating. This coating was then carefully characterized using scanning electronic microscope (SEM) and scanning force microscopy (SFM); bFGF release from the coating was also evaluated. (Col + bFGF)/HA-RGD coating was successfully deposited on Ti surface, and about 300 pg of bFGF could be slowly released from this coating for a week. This coating significantly promoted the initial cell attachment of human gingival fibroblasts (HGFs) compared with other groups (p < 0.05), and HGFs adhered and spread better on this coating than other groups (p < 0.05). Regarding cell proliferation and differentiation of HGFs, they were greatly stimulated when cultured on this coating (p < 0.05). These results indicated that surface modification of Ti using biomolecules might improve the sealing between the neck section of a dental implant and the soft tissue.

A novel technique for tailored surface modification of dental implants – a step wise approach based on plasma immersion ion implantation

A novel technique based on plasma immersion ion implantation (PIII) is presented to modify titanium implant surfaces. Initially, the implants are cleaned with argon to remove contaminants and the nanostructures are created by the bombardment of the surface with a mix of noble gases. Desired crystal structure of the titanium is obtained by the implantation of oxygen on the contaminant-free surface with particular nanostructures. In this study, turned implants modified by PIII revealed a high density of rutile-TiO2 nanostructures. Turned implants used as control revealed mainly microstructures and amorphous crystal structure. Surface roughness values were similar at the microscale for both turned and turned+PIII implants. Bone response was evaluated by removal torque tests of implants placed in the rabbit tibia and femur. After 4weeks of healing, turned+PIII demonstrated higher removal torque values (P=0.001) compared to turned implants. The presence of rutile-TiO2 nanostructures may explain the improved bone formation to turned+PIII implants.

A Hydrophilic Dental Implant Surface Exhibit Thrombogenic Properties In Vitro

Surface modifications of dental implants have gained attention during several years and the thrombotic response from blood components with these materials has become more important during recent years. The aims of this study were to evaluate the thrombogenic response of whole blood, in contact with clinically used dental surfaces, Sandblasted Large grit Acid etched titanium (SLA) and Sandblasted Large grit Acid etched, and chemically modified titanium with hydrophilic properties (SLActive). An in vitro slide chamber model, furnished with heparin, was used in which whole blood came in contact with slides of the test surfaces. After incubation (60-minute rotation at 22 rpm in a 37°C water bath), blood was mixed with ethylenediaminetetraacetic acid (EDTA) or citrate, further centrifuged at +4°C. Finally, plasma was collected pending analysis. Whole blood in contact with surfaces resulted in significantly higher binding of platelets to the hydrophilic surface, accompanied by a significant increase of contact activation of the coagulation cascade. In addition, the platelet activation showed a similar pattern with a significant elevated release of β-TG from platelet granule. The conclusion that can be drawn from the results in our study is that the hydrophilic modification seems to augment the thrombogenic properties of titanium with implications for healing into bone of, that is titanium dental implants.

Nanotechnology and Dental Implants

The long-term clinical success of dental implants is related to their early osseointegration. This paper reviews the different steps of the interactions between biological fluids, cells, tissues, and surfaces of implants. Immediately following implantation, implants are in contact with proteins and platelets from blood. The differentiation of mesenchymal stem cells will then condition the peri-implant tissue healing. Direct bone-to-implant contact is desired for a biomechanical anchoring of implants to bone rather than fibrous tissue encapsulation. Surfaces properties such as chemistry and roughness play a determinant role in these biological interactions. Physicochemical features in the nanometer range may ultimately control the adsorption of proteins as well as the adhesion and differentiation of cells. Nanotechnologies are increasingly used for surface modifications of dental implants. Another approach to enhance osseointegration is the application of thin calcium phosphate (CaP) coatings. Bioactive CaP nanocrystals deposited on titanium implants are resorbable and stimulate bone apposition and healing. Future nanometer-controlled surfaces may ultimately direct the nature of peri-implant tissues and improve their clinical success rate.

The Surface Modifications of Dental Implants that are made of a Near-β Type Titanium Alloy

Abstract Titanium and its alloys are widely used as dental implant materials due to their excellent biocompatibility, mechanical properties and erosion resistance. The b type titanium alloys are becoming more promising dental implant materials for their low elastic modulus and suitable mechanical properties. Because the titanium alloys are bioinert. The dental implant’s surfaces that contact with bone tissues need modification. To bioactivate the implants, hydroxyapatite/TiO2 composite material was coated onto dental implants by sol-gel and micro arc oxidation (MAO) methods. The HA (Hydroxyapatite) was employed to enhance the bioactivity of the Ti substrate. Owning to TiO2, the HA/TiO2 composite coatings adhered tightly to the dental implants and no longer existed cracks.

The initial attachment and subsequent behavior regulation of osteoblasts by dental implant surface modification

The aim of this study was to investigate the influence of hydrophobic acid-etched (A) and coarse-blasted large-grit and acid-etched (SLA) surfaces as well as hydrophilic modified acid-etched (modA) and modified coarse-blasted large-grit and acid-etched (modSLA) surfaces on the behavior of MG63 cells grown on these surfaces through determination of cell attachment and cell proliferation, time-lapse microscopy of fluorescence-labeled cells, and determination of gene expression by reverse transcription-polymerase chain reaction (RT-PCR). No significant difference of cell attachment on various titanium surfaces was found. Increased cell proliferation was observed on the A surface and the SLA surface compared with the modA surface and the modSLA surface. After 2 days of incubation, on modSLA and modA surfaces a tendency of formation of cell clusters has been observed, which was most pronounced on modSLA surface. On the A and the SLA surface, cell cluster formation started after longer incubation periods. The expression level of the bone-associated genes (alkaline phosphatase, osteocalcin, type-I-collagen, osteoprotegerin, and glyceraldehyde-3-phosphate-dehydrogenase) detected by RT-PCR was highest on the modSLA surface. In conclusion it has been demonstrated that the modSLA surface results in an enhanced cluster formation of osteoblasts grown on this surface and in an increased expression of key osteogenic regulatory genes in osteoblasts.

Effects of a modified sandblasting surface treatment on topographic and chemical properties of titanium surface.

A modified sandblasting surface treatment (a noncoating, roughening surface modification of dental implants) has been developed that will overcome the defects of conventional coating techniques. To verify the feasibility and reliability of this method at the chemical and topographic levels, scanning electron microscopy, x-ray diffraction, and a titanium ion releasing test were used; the topography of titanium surface, the embedding of sandblasting particles, nonpollution of heteroelements, and anticorrosiveness of titanium were criteria. Results showed that the rough surface created by sandblast was rather irregular, full of sharp tips and many embedded sandblast particles, and its corrosive rate was increased. These characteristics were modified by oxalic acid attack; the contour of the rough surface became more regular and round, the embedded particles and the heteroelement pollution were thoroughly removed, and the Ti corrosive rate decreased dramatically. Oxalic acid attack modification also created numerous secondary micropores (2.0-micron diameter) on the basis of sandblasted surface macrotexture. This modified sandblasting surface treatment is feasible and reliable to apply to dental implants and does not decrease the biocompatibility of titanium.

Surface and Interface of Artificial Bio-materials. Surface Modification of Dental Implants.

Dental implants require mechanical compatibility such as strength and wear resistance as well as surface compatibility with a host tissue in order to reduce their impact as foreign bodies. To satisfy these two requirements, it is preferable to utilize metal surfaces modified with functional ceramics, polymer materials or proteins. Since dental implants are used in contact with various tissues, it is necessary to have optimum surface compatibility with the host bone tissues, subepithelial connective tissues and epithelial tissues. Furthermore, dental implants are required to remain plaque-free at the surface exposed to the oral cavity. Such materials can be created under well-controlled conditions by modifying the surface topography and surface chemistry of metals that are in contact with those tissues.