Abstract Objectives: The aim of the study was to evaluate the variables that define the facial profile of a sample of the population in the centre of Romania, and to compare male’s and female’s soft tissue profile. These values could be useful in elaborating the aesthetic objectives for treating the population in this area. Material and methods: Fifty subjects were included in the study - patients and students of the University of Medicine and Pharmacy of Tîrgu Mureș (29 females and 21 males) between 18 to 28 years of age, having dental class I and a balanced profile. The photographs were taken in the natural head position (NHP). The anthropometric points were recorded and four of the angles that characterize a harmonious profile were traced and measured: the nasofrontal angle (G-N-Nd), the nasolabial angle (Cm-Sn-Ls), the mentolabial angle (Li-Sm-Pg), and the facial angle (G-Sn-Pg). Results: The values obtained for the two sexes were compared using the t-student test. All angles had values that were larger for females (nasofrontal: females 137.1 degrees, males 135.79 degrees, p = 0.0019; nasolabial: females 105.3 degrees, males 102.19 degrees, p = 0.00002; mentolabial angle: females 126.07 degrees, males 118.27 degrees, p = 0.000009; facial angle: females 170.32 degrees, males 168.85 degrees, p = 0.0033). Conclusions: Differences between the two sexes were obtained, all angles were statistically significant larger in females. These results show that for the population in the centre of Romania the treatment objectives are different for females and for males. The angular values range between those that characterize the Caucasian population.