This paper addresses the exploitation of mineral resources and suggests that an environmental management that meets a set of measures and mutual cooperation between public and private managers, civil society, and mining companies that exploit natural, renewable, and non-renewable resources is needed. Cooperation between managers and joint safety measures can prevent present and future accidents like the one that occurred in Mariana City in Minas Gerais State (MG). The questioning presented puts into discussion the disaster that occurred in Mariana City due to the rupture of the ore tailings dam (Fundão dam) in November 2015. With an estimated population of 60,000 inhabitants, Mariana City has a local economy directly linked to mining activities. Due to the impact caused by the rupture of the Fundão dam, both city and vegetation were destroyed, among other factors observed along the path followed by the tailings. However, what is discussed in this article with greater emphasis is the loss of vegetation in the watershed. The methodology compared the degree of vegetation coverage in the basin area through the analysis of the Normalized Difference Vegetation Index – NDVI for 2013, 2016, 2017, 2018, and 2019 in different months. Some images refer to August and other samples are from September, complementing the process through the use of Landsat 8 satellite images - OLI sensor, acquired from the United States Geological Survey (USGS) repository. 299 points were distributed in the quadrant to perform the analyses (n = 299). The level of significance was set at 5% with a 95% confidence, to ascertain and verify whether the data distribution is in an acceptable condition (dense or semi-dense vegetation cover). Regarding vegetation analysis, the Kolmogorov-Smirnov and Shapiro-Wilk tests were used. Both tests indicated a non-normal distribution for the NDVI data set, which indicates the absence of a vegetation index that was covered by the tailings, resulting in an area with large spaces without the coverage previously registered in 2013. We conclude that the vegetation suffered a drastic alteration provoked by the rupture of the Fundão dam which also led to homeless residents, negative impacts on the livelihood of the small farmers and fishermen, silting up of rivers and streams, death of several animal and plant species, and also affected the ecosystem and the local and regional biodiversity.