Dengue Fever In Children Research Articles

Association of Liver Function Tests With the Severity and Outcome of Dengue Fever in Children.

Background Dengue is one of the most common vector-borne diseases in India, and it is transmitted by Aedes family mosquitoes. Hepatic injury is known to occur from dengue infection. Direct hepatotoxicity and deranged host immune responses to the virus are responsible for this hepatic dysfunction. Hence, the study was undertaken to understand the deranged hepatic enzymes using liver function tests (LFTs)and the severity and outcome of dengue fever in children. Methods This study is an observational-descriptive study conducted between June 2022 and May 2024. The study population includes children between the ages of one month and 16 years who have been diagnosed with dengue fever andadmitted to pediatric wards and pediatric intensive care units (PICUs), with a sample size of 151. Informed consent from guardians and institutional ethical clearance were obtained. Results A total of 4.8% (N = 7) mortality was seen in this study with dengue patients. Hepatomegaly was seen in34% (N = 49)of cases. There is a clear statistical significance that is seen among the non-survived and survived dengue patients with a 10-fold increase in serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels, respectively, along with total bilirubin, activated partial thromboplastin time(APTT), and prothrombin time (PT). Conclusions The current study shows that deranged LFTs are associated with more severe disease with more PICUadmissions and mortality of the disease. The evidence clearly indicates the inclusion of LFTs as a routine investigation to understand the severity of the disease and the prognosis of the outcome.

The study of clinical profile and management of dengue fever in children

The study of clinical profile and management of dengue fever in children

Analysis of Risk Factors for Dengue Hemorrhagic Fever in Children: An Observational Study in Batang Regency, Indonesia

Dengue hemorrhagic fever (DHF) is a significant public health problem in Indonesia, including in Batang Regency. This study aims to analyze the risk factors associated with the incidence of dengue fever in children in Batang Regency, Indonesia. A cross-sectional observational study was conducted on 258 child subjects in Batang Regency. Data was collected through structured interviews with parents or guardians, direct observation of the home environment, and laboratory tests to confirm the diagnosis of dengue fever. Data analysis included univariate, bivariate (Chi-square test), and multivariate (logistic regression) analyses to identify independent risk factors. Univariate analysis showed a relationship between the incidence of dengue fever and age, gender, parental education, parental occupation, residential density, presence of mosquito larvae in water reservoirs, habit of hanging clothes, history of mosquito bites, and nutritional status. Bivariate analysis identified several statistically significant risk factors, including high residential density (OR=2.87; 95% CI: 1.65-5.01), presence of mosquito larvae (OR=3.21; 95% CI: 1.89-5.45), habit of hanging clothes (OR=2.87; 95%CI:1.32-5.21), and history of mosquito bites (OR=2.54; 95%CI: 1.48 -4.36). Multivariate analysis confirmed that high residential density and the presence of mosquito larvae were independent predictors of dengue incidence. High residential density and the presence of mosquito larvae in the home environment are the main risk factors for the incidence of dengue fever in children in Batang Regency. Public health interventions that focus on vector control and improving environmental sanitation are critical to reducing the dengue burden in this area.

Correlation of Platelet Parameters With the Severity of Thrombocytopenia in Dengue Fever in Children Aged Less Than 18 Years at a Tertiary Care Centre: A Cross-Sectional Study.

Introduction Dengue is a tropical viral disease caused by dengue virus with varied severity ranging from dengue fever to dengue shock syndrome. In dengue infection, there is thrombocytopenia with platelet activation. According to various proposed theories, activation of platelets during thrombocytopenia leads to changes in platelet parameters like mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and platelet index (PI). So,this study was conducted to correlate platelet parameters with the severity of thrombocytopenia in children with dengue fever at a tertiary care hospital. Methods An observational cross-sectional study was conducted on 72 children below 18 years admitted with dengue infection at a tertiary care hospital. All 72 patients were divided into three groups depending on platelet count. Group I included individuals with a platelet count less than 50000/mm3, while group II comprised patients with platelet counts ranging between 50001/mm3 and 100000/mm3, and group III encompassed individuals with platelet counts exceeding 100001/mm3. Platelet parameters like MPV, PDW, PCT, and PI were analyzed on day one and day three of admission. These parameters on day one and day three were correlated with the severity of thrombocytopenia in all three groups. Results PCT values on day one and day three were statistically significant (p<0.05) in all three groups with p-value <0.001 withprofound positive correlation, which means PCT value decreases with increasing severity of thrombocytopenia. PI in group I was statistically significant on day one (p=0.009) but not on day three (p=0.063). PI in group II was statistically significant(p<0.05) on day three (p=0.002), while in group III, PI was significant statistically on day one (p<0.001). MPV in group I, on day one(p=0.006) and in group II, on day three(p= 0.049) were statistically significant(p<0.05).PDW was statistically significant only on day one (p=0.031) in group I, while was not significant in groups II and III. Conclusion MPV, PDW, and PCT increasewith a decrease in platelet count, whereas there isan increase in PI. These platelet indices could be used to predict the severity of thrombocytopenia and severity of the dengue fever. Along with MPV and PDW, PCT could be used to assess the severity of the disease progression.

Changing Trend of Dengue Fever in Children

Changing Trend of Dengue Fever in Children

To study ultrasound and chest X-ray findings and their role in the diagnosis of dengue fever in children.

Dengue fever is a fatal viral illness affecting almost all age groups and is seen in almost all tropical countries. Ultrasonography (USG) can be a useful tool for the assessment and diagnosis of dengue fever. The study aimed to evaluate X-ray and ultrasound findings in children with dengue fever. This was a prospective and cross-sectional study that was carried out in a hospital in Mumbai for over one year. All relevant data were collected, validated, and analyzed statistically on the software Epi Info 7. Abnormal X-ray findings noticed were pleural effusion, pneumonia, and bilateral nodular opacities. Pleural effusion and respiratory complications were more common in severe dengue (P < 0.05). Out of the 37 patients on whom USG was done, 33 (89.18%) had abnormal and 4 (10.81%) had normal USG findings. Of the 17 patients with dengue who showed warning signs, 16 (89.9%) had abnormal USG findings. Plasma leakage in the form of ascites and effusion was commonly seen. One hundred percent of patients with severe dengue had abnormal USG findings. The abnormal USG findings were more commonly detected between 5-7 days and were more commonly associated with IgG + IgM-positive serology. Ultrasonography is a good modality for the diagnosis and evaluation of dengue patients. Serial ultrasound should be done for the assessment and evaluation of said patients.

Clinical Profile, Laboratory Findings and Outcome of Severe Dengue Infection among Children Admitted at a Tertiary Care Hospital in Bangladesh

Background: Dengue infection is endemic in Bangladesh and presents with varying degrees of severity of illness in children. Objective: The purpose of the present study was to assess the common clinical profile, biochemical findings and outcome of severe dengue fever in children. Methodology: This prospective cohot study was conducted on dengue NS1 or IgM or RT-PCR positive admitted children up to 14 years of age from April 2019 to October 2019 for a period of 6 months at the Pediatrics Department of Evercare Hospital, Dhaka. Data were analyzed after collection of demographic variables, presenting complaints and examination findings of 75 enrolled children. Results: A total of 75 cases were classified as severe dengue fever. The most common age of presentation was 4 to 7 years. The most common presenting symptom of severe dengue cases were fever (97.3%), abdominal pain and vomiting (77.3%) and shock (62.7%). Pleural effusion was the most common physical findings seen in 35 cases (46.6%) followed by ascites in 26 cases (34.7%). Elevation in aspartate amino transaminase AST (IU/L) was found in 82.6%, low albumin was found in 78.7% of the cases. Hypernatremia was the most common electrolyte abnormality found in 35 cases (46.7%). Regarding coagulation profile, raised D-dimer &amp; low fibrinogen were found in 53 (70.7%) &amp; 42 cases (56.0%) respectively. Activated partial thromboplastin time (aPTT) was prolonged in 37.3%. Case fatality rate (CFR) was 5.3%. Conclusion: In conclusion, raised AST and D-dimer, low fibrinogen &amp; albumin level as well as hyponatremia are significant laboratory findings indicating severity of the disease. Shock is a common presentation of severe dengue in children. Bangladesh Journal of Infectious Diseases, December 2022;9(2):40-46

The Level of Knowledge of Parents about Dengue Fever Prevention at Puskesmas II South Denpasar

The level of parental knowledge is still 24%, which is of sufficient value regarding the prevention of dengue hemorrhagic fever in children 5-14 years and this is one of the problems with dengue fever outbreaks. This study aims to determine the level of knowledge of parents about the prevention of dengue fever in children 5-14 years. The study was conducted at Puskesmas II Denpasar Selatan in February-April 2021. The population of this study are parents who have children aged 5-14 years. Research method with descriptive method, the number of samples is 58 respondents with total sampling technique. Measuring tool used is a questionnaire and analyzed with descriptive statistics. The results showed that the knowledge level of the respondents showed an average score of 20.57 (good), then the lowest score was 16 (enough) and the highest score was 25 (good), and most of them had good knowledge as many as 44 respondents (75.9%) and 14 respondents (24, 1%) sufficient knowledge. Based on the age of 36-45 years as many as 30 respondents (51.7%). Female gender as many as 31 respondents (53.4%). Jobs as private employees were 28 respondents (48.3%). SMA / SMK education as many as 22 respondents (37.9%). The conclusion of this study is that the level of knowledge of parents is still 24% of sufficient value and the others have a good level of knowledge. It is recommended to improve educational programs as a basis for preventing dengue fever in the family

Comparison of Clinical Features, Lab Parametres and Outcome of Mis-C and Dengue Fever in Children

Comparison of Clinical Features, Lab Parametres and Outcome of Mis-C and Dengue Fever in Children

Toward developing a scoring system for dengue fever in children

Background: Dengue is a rapidly increasing global public health problem especially in tropical countries. Dengue is a benign and self-limiting febrile illness in the majority of children but in some children, it can progress to severe dengue (SD) resulting in shock, hemorrhage, and death. Aims and Objectives: The aims of this study were to develop a scoring system to predict dengue infection severity. Materials and Methods: This prospective and observational study was conducted on all children admitted with dengue fever at a tertiary teaching institute in India. Daily scoring was done for pulse rate, respiratory rate, blood pressure, hematocrit, platelet count (scores 1–3), and systemic complications (0 if absent, 3 if present). Then, highest score recorded during the hospitalization period was taken for statistical analysis. Results: A total of 194 cases were classified into probable dengue (PD) 134 (69.1%), dengue with warning signs (DWS) 41 (21.1%), and SD 19 (9.8%) as per the WHO 2009 classification. Mean age of presentation was 11.5 years. The most common presenting symptoms were fever (97.9%), vomiting (73.1%) and signs noticed were flushing (63.4%), hepatomegaly (34.5%), and periorbital puffiness (27.3%). Among 134 children with PD, 116 (86.5%) had dengue severity score 5–6, with only 18 (13.5%) had score 7–13, whereas all 60 (100%) children with DWS and SD had score 7–13, none of them had score &lt;7. Hence, a severity score of &gt;7 identified all children with DWS and SD with overestimation in 13.5% children with PD. Conclusion: Daily dengue severity score of &gt;7 indicates the high probability of DWS and SD. However, this scoring system should be validated by similar studies in different settings before we can apply in routine clinical practice.

Detecting dengue fever in children using online Rasch analysis to develop algorithms for parents: An APP development and usability study.

Dengue fever (DF) is a significant public health concern in Asia. However, detecting the disease using traditional dichotomous criteria (i.e., absent vs present) can be extremely difficult. Convolutional neural networks (CNNs) and artificial neural networks (ANNs), due to their use of a large number of parameters for modeling, have shown the potential to improve prediction accuracy (ACC). To date, there has been no research conducted to understand item features and responses using online Rasch analysis. To verify the hypothesis that a combination of CNN, ANN, K-nearest-neighbor algorithm (KNN), and logistic regression (LR) can improve the ACC of DF prediction for children, further research is required. We extracted 19 feature variables related to DF symptoms from 177 pediatric patients, of whom 69 were diagnosed with DF. Using the RaschOnline technique for Rasch analysis, we examined 11 variables for their statistical significance in predicting the risk of DF. Based on 2 sets of data, 1 for training (80%) and the other for testing (20%), we calculated the prediction ACC by comparing the areas under the receiver operating characteristic curve (AUCs) between DF + and DF- in both sets. In the training set, we compared 2 scenarios: the combined scheme and individual algorithms. Our findings indicate that visual displays of DF data are easily interpreted using Rasch analysis; the k-nearest neighbors algorithm has a lower AUC (<0.50); LR has a relatively higher AUC (0.70); all 3 algorithms have an almost equal AUC (=0.68), which is smaller than the individual algorithms of Naive Bayes, LR in raw data, and Naive Bayes in normalized data; and we developed an app to assist parents in detecting DF in children during the dengue season. The development of an LR-based APP for the detection of DF in children has been completed. To help patients, family members, and clinicians differentiate DF from other febrile illnesses at an early stage, an 11-item model is proposed for developing the APP.

A Prospective Study on Clinical and Laboratory Predictive Markers of Dengue Fever in Children in Tertiary Care Hospital

Background: Dengue fever is the world's fastest-spreading mosquitoborne viral disease, with a 30-fold increase in global incidence over the last five decades. It is a major public health concern throughout the world's tropical and subtropical regions. 1 Dengue is classified into Dengue +/- warning signs and severe dengue, which includes Dengue shock syndrome, Respiratory distress syndrome, Dengue hemorrhagic fever, and organ failure, according to WHO 2012 guidelines. Material &amp; Methods : Study Design: Prospective Hospital based observational study. Study area: Department of Paediatrics, Siddhartha Medical College, Vijayawada, Andhra Pradesh. Study Period: 1 year. Study population: All children under the age of 13 years who had acute onset high grade fever and were Nonstructural antigen protein 1 [NS1] and/or Immunoglobulin M [IgM] positive were admitted to the paediatric ward. Sample size: study consisted a total of 150 cases. Sampling method: Purposive sampling technique on consecutive cases. The following laboratory test cut-off values are defined: leucopenia (white blood cell count &lt; 4000/mm3), thrombocytopenia (platelet count &lt; 150 103/mm3). Prolonged activated partial thromboplastin time (APTT) (&gt; 38 sec), elevated serum aminotransferase levels (AST or ALT &gt;39 U/L), and low C-reactive protein (CRP) (20 mg/L). The study compared clinical and laboratory parameters in dengue fever, dengue fever with warning signs, and severe dengue. Result: Several laboratory parameters were measured as predictors of laboratory- confirmed dengue infections. The positive predictive value of WBC was 80.6%, and NPV of 50% to differentiate the severity of three dengue groups. Whereas, PPV of platelet count was 90.8%, and NPV of platelet count was 50% to differentiate the severity of dengue groups. Conclusion: Our research discovered that a combination of commonly used blood tests, such as a white blood cell count, platelet count, liver function tests, and CRP and coagulation profiles, can help detect laboratory-confirmed dengue infection. These clinical and laboratory findings could be used as predictive markers to improve the early detection and severity of dengue infection.

POINT PREVALENCE OF PAEDIATRIC DENGUE VIRAL INFECTION

Objective: The study's objective is to evaluate the prevalence of dengue in the paediatric age group based on demographic data and clinical symptoms.&#x0D; Methods: The study was conducted in the Department of Paediatrics and Central Research Laboratory in a Tertiary Care Hospital in Visakhapatnam. Six months of data were collected from Jan 2022 to June 2022 and a maximum of 100 OPD/IPD cases have been registered during this study period. The entire medical history of all dengue cases, including signs and symptoms, method of diagnosis, management, length of stay, and clinical outcomes, were collected from patient information. NS1 antigen detection was performed by rapid test and Dengue ELISA was performed as a confirmatory test for the detection of IgG and IgM antibodies.&#x0D; Results: Among the 100 suspected cases of dengue reported to OPD/IPD, 83(83%) were confirmed as dengue positive, and 17(17%) were found to be non-dengue cases with ELISA. More cases were noticed in female children 52 (55%). Prevalence was more in the age group of 5-11 y 43 (52%). The majority number of cases were reported with fever 82 (98.8%) followed by symptoms like vomiting 41(49%), cold 19(16%), and cough 18(15%).&#x0D; Conclusion: Understanding dengue fever in children, including clinical symptoms, etiology, diagnostic testing, therapy, and prevention, is critical for lowering disease fatality rates.

Predictive Factors for the Complications of Dengue Fever in Children: A Retrospective Analysis.

Background and objective Dengue fever (DF) and its complications - dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) - are major public health problems in Southeast Asia. Predicting the development of DHF and DSS using hematological parameters and ultrasonic signs of vascular leakage will help in reducing morbidity and mortality associated with these diseases. Hence, this study aimed to test the association of platelets and packed cell volume (PCV) on day one (D1) of admission with gallbladder wall thickness (GWT) and ascites, which heraldthe onset of DHF and DSS. Methods The electronic health records of 52 pediatric patients admitted during a mini-outbreak were analyzed to assess platelets and PCV on D1, laboratory and ultrasonography findings, and outcomes. Correlations between D1 hematological parameters and GWT and ascites were tested. Results There was a positive correlation between GWT of more than 5 mmand ascites. However, there was no significant correlation of platelets and PCV on D1 with either GWT or ascites and consequently DHF or DSS. All the patients responded to fluid, blood, and supportive therapy. There were no mortalities. Conclusion Patients who develop GWT after DF are at an increased risk of developing ascites that deteriorate to DHF and DSS. D1 platelets and PCV are not reliable indicators for predicting the progression or worsening of the disease in the pediatric population.

Clinical profile and outcome of dengue fever in children: In a tertiary care hospital

Background : Dengue is the most important arthropod transmitted human viral disease and constitutes an important worldwide health problem including Bangladesh. Although children are the usual victim of dengue infection, there is paucity of published data regarding its clinical profile and outcome in children in our country. Objective: Now, in case of children Dengue fever is a common cause of acute febrile illness in our country, but the magnitude of it is quite unknown. Therefore, this study aims to find out the common clinical manifestations, the early warning signs and the outcome of dengue fever in different age group of children. Materials and Methods: The present study was conducted in the Popular Medical College Hospital, Dhanmondi, Dhaka (a tertiary care private hospital) between July to September of 2019 on children of dengue fever from 1year up to 15 years of age. It is a retrospective observational study. Results: A total of 58 cases were enrolled. The common clinical presentations included fever (100%), arthralgia (81.9%), cough/ coryza (17.2%), headache/retro orbital pain (3.4%), and rash (10.3%). The common early warning signs at the time of admission were persistent vomiting (41.4%), severe abdominal pain (27.6%), Hepatomegaly (6.9%). Regarding clinical course, in Dengue fever (DF), Dengue Hemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS) total 36 (62%), 14 (24.2%), 8 (13.8%) children are affected respectively. Conclusion: The clinical manifestations of dengue fever are like other viral infections, but the disease severity is more in dengue. Thus, if we able to find out the more common clinical findings of dengue fever, it would help us in early diagnosis and early initiation of appropriate treatment. In this study we found that the most common clinical symptom was fever, found in 100% cases, arthralgia in 81.9%, cough/ coryza in 17.2%, headache / retro orbital pain in 10.3% and rash in 3.4% cases. Among the 58 cases 36 (62%) were diagnosed as DF, 14 (24.2%) as DHF and 8 (13.8%) as DSS and no death was occurred. Northern International Medical College Journal Vol. 12 No.1 July 2020, Page 499-502

To study the clinical presentation, laboratory parameters and predictors of severity in dengue fever in children in a metropolitan city in India

The Journal is the primary organ of Continuing Paediatric Medical Education in Sri Lanka. The journal also has a website. Free full text access is available for all readers.The Sri Lanka Journal of Child Health is now indexed in SciVerse Scopus (Source Record ID 19900193609), Index Medicus for South-East Asia Region (IMSEAR), CABI (Centre for Agriculture and Bioscience International Global Health Database), DOAJ and is available in Google, as well as Google Scholar.The policies of the journal are modelled on the Committee on Publication Ethics (COPE) Guidelines on Principles of Transparency and Best Practice in Scholarly Publishing. Sri Lanka Journal of Child Health is recognised by the International Committee of Medical Journal Editors (ICMJE) as a publication following the ICMJE Recommendations.

Clinical profile of dengue fever in children in a university level medical college of North India

Background: Dengue epidemics are more frequent in developing countries like India. Dengue is a self-limiting disease but its complication in children may cause high morbidity and mortality. Objective: The main objective of this study was to assess the clinical profile of dengue fever in children less than 15 years of age.Methods: This was a retrospective study done in a pediatric department of Maharishi Markandeshwar institute of medical science and research hospital, Ambala, a university level medical college of North India for a period of 17 months.Results: A total of 130 patients of dengue fever were identified in our study. Out of these 130 patients, 39 patients were included in dengue without warning signs,78 were included in dengue with warning signs and 13 in severe dengue category. The most common age group was between 5 to 10 years of age. Fever was the most common presenting symptom in all dengue patients. No mortality was observed during our study period due to dengue.Conclusions: It is one of the dreaded fevers for all the pediatric age group. So, early suspicion and effective management can reduce the severity.

Clinical Presentation with Predictors of Severity of Dengue Fever in Children of 2019, Endemic in Bangladesh

Background: Dengue fever is a serious public health problem with a wide range of clinical manifestations. In 2019, the clinical presentation of dengue infection was novel in relation to the conventional features of the previous years and also in degree of severity. So the study was done to see the varied clinical presentation, predictors of severity and outcome in pediatric population in 2019 endemic. Methods: It was a cross sectional, descriptive study conducted among 100 cases of serologically positive dengue patients from department of Paediatrics of Shaheed Suhrawardy Medical College Hospital, Dhaka from July to October, 2019.The data were collected by preformed semi-structured questionnaires and analyzed using SPSS version 16.0. Results: The mean age of the patients was 7.4 ± 3.4 years with equal male and female ratio. Children between 5-12 years were most (72%) commonly affected. Mean duration of fever was 4.5 ± 1.8 days and fever was present in 63% cases on presentation. Features of shock were present in 61% of patients who were designated as severe dengue. Most of the patients presented with abdominal pain (77%) followed by vomiting (70%), headache (35%), myalgia(32%) and retro-orbital pain(30%). Among the important clinical findings, tender hepatomegaly was present in 77% cases followed by ascites in 35% and pleural effusion in 4% cases. Melaena was found to be the most common form of bleeding manifestation. Risk factors for severe dengue were vomiting, abdominal pain, melaena, ascites and low platelet count. Majority of the patients (95%) were discharged, 4% were referred to ICU and only 1% died. Conclusion: Majority of admitted pediatric dengue patients presented with severe Dengue (Dengue Shock Syndrome). Presence of vomiting, abdominal pain, ascites and low platelet count were found to be significant in predicting severity of dengue. J Shaheed Suhrawardy Med Coll 2021; 13(1): 8-14

Clinical profile of atypical manifestations of dengue fever in children

Objectives: The objective of the study is to study the clinical profile and outcome of atypical manifestations of dengue fever in children. Methods: A case series study design was conducted in S.Nijalingappa Medical College &amp; H.S.K Hospital, Bagalkot. A detailed history was compiled, as well as the current complaints. The study subjects clinical progress was tracked until they were discharged. In all of the cases, basic tests such as a full Haemogram, Dengue serology and Daily Platelet count and Hematocrit were performed. Other tests such as LFT, USG Abdomen, Chest X-ray, ECG, 2D-ECHO and MRI brain are performed as needed in cases of Severe Dengue / Atypical symptoms. Results: The study covered 100 instances, with males accounting for 52 percent and females for 48 percent. Dengue fever, dengue fever without warning signs, and severe dengue were found in 29 percent, 43 percent, and 28 percent of the cases, respectively, in this study. Atypical signs were seen in more than half of the cases (59%) out of 100. We had 8 cases of severe dengue with SGPT/SGOT above 1000 IU in our study and two of them had Fulminant Hepatic Failure with the highest SGPT value of 6500 IU.

Relationship between Knowledge and Attitude of Mothers on Prevention of Dengue Hemorrhagic Fever in Children in the Work Area of the Kawatuna Health Center

Dengue Hemorrhagic Fever (DHF) is a viral infectious disease transmitted by the Aedes Aegypti mosquito as the main vector and Aedes Albopictus as a potential vector. The knowledge and attitudes of a mother become a benchmark for the mother's awareness of preventing transmission. Efforts to prevent transmission need to be made to reduce the risk of this disease. The purpose of this study was to determine the relationship between knowledge and mothers’ attitudes regarding the prevention of dengue fever in children in the work area of the Kawatuna Health Center 2022. The research method used was quantitative using a cross-sectional approach with a population of 35 mothers with children 6-12 years old and the sample used was 25. respondents. The measuring instrument in this study is a questionnaire and the analysis used in univariate and bivariate analysis. The results showed that the level of knowledge of the respondents in the good category, namely 22 respondents (88%), and for attitudes, namely there were 20 respondents (80%) who had a positive attitude, and there was a significant relationship between the level of knowledge of mothers' attitudes about preventing dengue fever in children. 6-12 years old in the work area of the Kawatuna Health Center with a p-value of 0.001 &lt;0.05. Mothers in the work area of the Kawatuna Health Center are in the independent category, and have a positive attitude, and there is a significant relationship between the level of knowledge and the attitude of mothers toward preventing dengue fever