You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research I1 Apr 201221 BLADDER FUNCTION CHANGES ACCORDING TO THE DOSAGE OF TAMSULOSIN AMONG THE SPINAL CORD INJURED RATS MODEL dong yoyp han, Moon Young Lee, Hee Jong Jeong, Jeong Sik Rim, and Min Cheol Joo dong yoyp handong yoyp han iksan, Korea, Republic of More articles by this author , Moon Young LeeMoon Young Lee iksan, Korea, Republic of More articles by this author , Hee Jong JeongHee Jong Jeong iksan, Korea, Republic of More articles by this author , Jeong Sik RimJeong Sik Rim iksan, Korea, Republic of More articles by this author , and Min Cheol JooMin Cheol Joo iksan, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.064AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Purpose Studies regarding the mechanism or the dosage of Alpha blocker used for neurogenic bladder after spinal cord injury are needed. In this study, change in urination and bladder contractility of spinal cord injured rats(SCIR) according to tamsulosin dosage was observed. METHODS 55 female Sprague-Dawley rats were used for the study and they were randomly divided into 4 groups: group 1(n=10)- normal ones, group 2(n=15)-SCIR+vehicle, group 3(n=15)-SCIR+ 0.1mg/kg of tamsulosin, group 4(n=15)-SCIR+1mg/kg of tamsulosin. Spinal cord was surgically transected during the T10 level. Tamsulosin was intraperitoneally injected two times a day(at 9 AM and 6 PM) and for a week. Awaken cystometry and the organ bath study were performed after 7 days. Medicinal reactions of the change in bladder contractility according to following factors were comparatively analyzed: acetylcholine (Ach, 10-9∼10-4 M) alone, Ach with AQ-RA 741 (M2 blocker) or 4-DAMP (M3 blocker) 10-7 M pretreated. RESULTS All spinal cord injured rats showed significant decrease in the bladder function regarding awaken cystometry, compared to the control group.) Micturation duration was increased with considerable amount only in the group 3, compared to other two experimented groups.(p<0.05) Other parameters showed no significant difference.) In the organ bath study, acetylcholine-induced contractility in the SCIR groups was significantly higher than the control group.) Only group 3 showed considerable decrease in contractility by acetylcholine with 4-DAMP pretreated, among the SCIR groups. CONCLUSIONS These results suggest that neourogenic detrusor overactivity caused by denervation hypersensitivity after spinal injury can be decreased by adequate amount of tamsulosin injection(0.1 mg/kg), not high dose (1mg/kg). © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e8 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information dong yoyp han iksan, Korea, Republic of More articles by this author Moon Young Lee iksan, Korea, Republic of More articles by this author Hee Jong Jeong iksan, Korea, Republic of More articles by this author Jeong Sik Rim iksan, Korea, Republic of More articles by this author Min Cheol Joo iksan, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...