Demographic Responses Research Articles

Menstrual challenges in puberty: Investigating menorrhagia in adolescent girls

Menorrhagia, defined as excessive or prolonged menstrual bleeding, poses a significant challenge during this developmental stage, potentially impacting the health and well-being of adolescent girls. Despite its prevalence, comprehensive studies on menorrhagia in this specific demographic are scarce. This study aims to address this gap by investigating the underlying causes and treatment outcomes of puberty menorrhagia.A six-month observational study involving 50 adolescent girls presenting with menorrhagia was conducted at the Department of Obstetrics and Gynecology in a tertiary care center. The study utilized consecutive enumerative sampling and included a thorough investigation of participants, collecting data on demographic profiles, symptom severity, anemia levels, diagnoses, therapy requirements, and responses to conservative management. Baseline investigations encompassed a range of tests, including pregnancy exclusion, complete blood count, coagulation profile, and hormonal assays.The study cohort of 50 participants revealed varying characteristics: 24% were under 14 years, 34% were between 14-16 years, and 42% were aged 17-19 years. BMI distribution showed 14% below 18.5, 76% between 18.5 and 25, and 10% exceeding 25. Symptom duration included 20% reporting less than 6 months, 34% between 6-12 months, and 46% over 12 months. Etiology analysis indicated 60% with ovulatory dysfunction. Hemoglobin level analysis illustrated the prevalence and severity of anemia. Diverse treatments, including hormonal and non-hormonal interventions, were administered.This study provides insights into the causes of puberty menorrhagia, emphasizing the need for a holistic treatment. Future research should delve deeper into identified associations and clinical variants to enhance our understanding and guide effective interventions. Management should be directed to the cause.

Landscape heterogeneity buffers the impact of an extreme weather event on wildlife.

Extreme weather events are becoming more frequent, with poorly known consequences for wildlife. In December 2021, an atmospheric river brought record-shattering amounts of rain and snow to interior Alaska, creating conditions expected to cause mass mortality in grazing ungulate populations that need to access ground forage. We characterized snowpack conditions following the storm and used a 36-year monitoring dataset to quantify impacts on caribou (Rangifer tarandus) and their primary predator, wolves (Canis lupus). December precipitation was 7.3 SD above the 99-year mean and 2.5-fold higher than the prior record, with a return period of 333 years. However, ice thickness within the snowpack was highly variable across vegetation types, and caribou shifted to use higher elevations that can blow free of snow. Caribou and wolf mortality rates were 1.3-1.8 SD above normal and caribou population growth rates were low but similar to recent years, indicating a surprisingly weak demographic response. These findings indicate that landscape diversity may bolster resistance of wildlife populations to short-term, potentially devastating effects of extreme weather.

Quality of Life in Patients with Endodontically Treated Teeth: A Retrospective Study at an Educational Hospital

Background/Objectives: Root canal treatment (RCT) is a crucial procedure for preserving dental health. While its clinical success rates are well documented, patient-reported outcomes regarding quality of life remain less explored. This study aimed to assess the long-term impact of RCT performed in an educational hospital on patients’ oral-health-related quality of life (OHRQoL) using the Oral Health Impact Profile-14 (OHIP-14). Methods: A total of 1500 patients who underwent non-surgical RCT between April 2018 and February 2023 were called and invited for a follow-up visit. During the visit, all teeth that had undergone RCT were assessed clinically and radiographically by two calibrated examiners to evaluate RCT quality and pre- and post-treatment periapical index (PAI) scores. Demographic information and OHIP-14 responses were collected, and the data were recorded. Results: Patients reported high levels of satisfaction (95%) and no negative impact on their OHRQoL. Statistical analysis revealed that post-operative periapical index (PAI) scores (p < 0.001), patient gender (p = 0.003) and nationality (p = 0.029) significantly influenced OHRQoL perceptions; Conclusion: These findings emphasize the effectiveness of RCT in enhancing patients’ quality of life and highlight the impact of demographic factors—such as gender and whether the patient is a resident or a national of the country, along with post-treatment severity of the disease—on patient-reported outcomes.

Profile of Cytokines and T Cell Subsets Transcription Factors in Cerebrospinal Fluid of Patients with Viral Encephalitis.

This study investigates the demographic, clinical characteristics, virological profiles, and immunological responses of patients with viral encephalitis (VE) compared with a control group. The VE group displayed a wide range of neurological symptoms. Virological analysis revealed the predominance of Herpesviridae family viruses. Immune responses in cerebrospinal fluid (CSF) from patients with VE were examined, highlighting an immunological shift toward T helper 1 (Th1) cells dominance, altered T helper 17 cells/regulatory T cells (Th17/Tregs) balance, and high interleukin-6 expression. These findings provide insights into the complex immunological landscape of VE, highlighting the role of specific cytokines and T cell subsets in its pathogenesis and potentially guiding targeted therapeutic strategies.

Historic Land Use Modifies Impacts of Climate and Isolation in Rear Edge European Beech (Fagus sylvatica L.) Populations.

Legacies of human land use have the potential to impact demographic responses to climate. However, few studies have investigated the interactive effects of land use legacies and climate change on tree demography. The demographic performance of rear edge populations in particular is an important determinant of a species' long-term persistence. In this study, we investigated whether human land use legacies affect demographic responses to climate and population isolation in rear edge European beech populations (Fagus sylvatica L.) at the temperate-Mediterranean transition zone in the NE Iberian Peninsula. We utilised data from the Spanish Forest Inventory and generalised linear mixed models to compare the potential interactions across four different demographic rates (tree growth, survival probability, new adult recruitment and sapling recruitment). We found that the demographic rates were affected by the combination of land use legacies, climate and population isolation in different ways, which could potentially lead to complex shifts in future population dynamics under climate change. We identified that intense historic management either magnified negative relationships between tree demography and climate or population isolation, or reduced demographic performance in favourable climates to levels observed in unfavourable climates. Through either form of interaction, we found that intense historic forest management had a negative impact on tree demography, which has the potential to compromise future carbon stocks and long-term population viability. Overall, we show that disentangling human and environmental factors can enable us to better understand heterogeneous demographic performance across the rear edge of species distributions.

Commentary: Demographic response of osprey within the lower Chesapeake Bay to fluctuations in menhaden stock

Commentary: Demographic response of osprey within the lower Chesapeake Bay to fluctuations in menhaden stock

Pharmacists' Knowledge, Perception, and Prescribing Practice of Probiotics in the UAE: A Cross-Sectional Study.

The human body is a complex and interconnected system where trillions of microorganisms, collectively known as the gut microbiota, coexist with these cells. Besides maintaining digestive health, this relationship also impacts well-being, including immune function, metabolism, and mental health. As frontline healthcare providers, pharmacists are pivotal in promoting the benefits of probiotics for immune support. This study explored pharmacists' knowledge, perception, and practice behavior in the UAE towards the implication of probiotic application beyond digestive health, such as cardiovascular and mental health impacts and their diverse dosage forms. An online self-administered survey was distributed among pharmacists in the UAE. Data were collected through personal visits to pharmacies, where pharmacists were approached and asked to complete the questionnaire. The sample size included 407 pharmacists, determined using the formula for proportions with a 95% confidence level and a 5% margin of error. Statistical analysis was performed using SPSS version 29. Descriptive statistics were used to summarize demographic characteristics and survey responses. The knowledge levels were categorized into poor, moderate, and good. Chi-square analysis was employed to investigate associations between demographic factors and knowledge levels, with a significance level set at p < 0.05, enhancing the robustness of the study's findings. This study included 407 completed eligible responses. About 63.56% of participants were female, with 52.1% employed in pharmacy chains. While 91.2% of pharmacists recognized probiotics' role in immune support, only 30% were aware of their cardiovascular benefits. Moreover, chewing gum was the least known dosage form of probiotics, recognized by only 16.7% of respondents. Additionally, only 57% of the participants recognized liposomes as a dosage form. In practice, most pharmacists recommended storing probiotics at room temperature, accounting for 66.6%. The most prevalent misconception encountered in the pharmacy setting was the belief that probiotics are primarily intended for gastrointestinal tract problems, at 79.1% of the respondents. Regarding perception, the agreement was observed regarding the safety of probiotics for all ages. Perceived barriers included the high cost of probiotics, with the majority (86.5%) indicating this as a significant obstacle, while lack of demand was identified as the minor barrier by 64.6%. Additionally, an association was found at a significance level of p < 0.05 with knowledge, gender, educational level, type and location of pharmacy, and source of information. The study highlights knowledge gaps in pharmacists' understanding of probiotic applications beyond digestive health, particularly cardiovascular health and depression. Targeted educational interventions are necessary to address these gaps. The findings underscore the importance of ongoing professional development for pharmacists, enhancing their role in patient education and the promotion of probiotics for overall health.

Knowledge, Attitude, and Practices of Dentists in Maharashtra Regarding Sharing Patients’ Data on Social Media: A Questionnaire-Based Study

Background: Social media has become an integral part of dental practice, offering opportunities for professional interaction and patient engagement. However, it raises significant ethical concerns, particularly regarding patient confidentiality. Objective: To gauge the knowledge, attitude, and practice of dental professionals in Maharashtra regarding the sharing of patient data on Social media, and to assess the ethical considerations associated with this practice. Methods: A cross-sectional study was conducted among dental professionals in Maharashtra from October to December 2023. Participants were recruited from six dental institutions and various private clinics. A self-structured questionnaire was validated and distributed via Google Forms. Data were analyzed using MedCalc Statistical Software, with demographic characteristics and response frequencies summarized in tables and graphs. Results: Of the 312 participants, 265 completed the survey (response rate: 84.94%). WhatsApp (88.3%) was the most preferred platform, followed by Facebook (54.34%) and Instagram (54.34%). The majority rarely shared patient data on SM. Marketing (63.4%), showcasing treatment results (46.79%), and educating colleagues (46.79%) were primary motivations. While 56.98% agreed that sharing patient data infringes privacy, only 46.04% consistently obtained patient consent. A significant portion (92%) supported establishing guidelines for social media usage. Conclusion: Dental professionals in Maharashtra frequently use SM for professional purposes, with WhatsApp being the most popular platform. Despite recognizing privacy concerns, there is a lack of consistent patient consent practices. The findings highlight the need for clear guidelines to balance the benefits of social media with ethical obligations to patient confidentiality and professional conduct.

Intraspecific body size variation across distributional moments reveals trait filtering processes.

Natural populations are composed of individuals that vary in their morphological traits, timing and interactions. The distribution of a trait can be described by several dimensions, or mathematical moments-mean, variance, skew and kurtosis. Shifts in the distribution of a trait across these moments in response to environmental variation can help to reveal which trait values are gained or lost, and consequently how trait filtering processes are altering populations. To examine the role and drivers of intraspecific variation within a trait filtering framework, we investigate variation in body size among five wild bumblebee species in the Colorado Rocky Mountains. First, we examine the relationships between environmental factors (climate and floral food resources) and body size distributions across bumblebee social castes to identify demographic responses to environmental variation. Next, we examine changes in the moments of trait distributions to reveal potential mechanisms behind intraspecific shifts in body size. Finally, we examine how intraspecific body size variation is related to diet breadth and phenology. We found that climate conditions have a strong effect on observed body size variation across all distributional moments, but the filtering mechanism varies by social caste. For example, with earlier spring snowmelt queens declined in mean size and became negatively skewed and more kurtotic. This suggests a skewed filter admitting a greater frequency of small individuals. With greater availability of floral food resources, queens increased in mean size, but workers and males decreased in size. Observed shifts in body size variation also correspond with variation in diet breadth and phenology. Populations with larger average body size were associated with more generalized foraging in workers of short-tongued species and increased specialization in longer-tongued workers. Altered phenological timing was associated with species- and caste-specific shifts in skew. Across an assemblage of wild bumblebees, we find complex patterns of trait variation that may not have been captured if we had simply considered mean and variance. The four-moment approach we employ here provides holistic insight into intraspecific trait variation, which may otherwise be overlooked and reveals potential underlying filtering processes driving such variation within populations.

The phenotypic and demographic response to the combination of copper and thermal stressors strongly varies within the ciliate species, Tetrahymena thermophila.

Copper pollution can alter biological and trophic functions. Organisms can utilise different tolerance strategies, including accumulation mechanisms (intracellular vacuoles, external chelation, etc.) to maintain themselves in copper-polluted environments. Accumulation mechanisms can influence the expression of other phenotypic traits, allowing organisms to deal with copper stress. Whether copper effects on accumulation strategies interact with other environmental stressors such as temperature and how this may differ within species are still unsolved questions. Here, we tested experimentally whether the combined effect of copper and temperature modulates traits linked to demography, morphology, movement and accumulation in six strains of the ciliate Tetrahymena thermophila. We also explored whether copper accumulation might modulate environmental copper concentration effects on phenotypic and demographic traits. Results showed high intraspecific variability in the phenotypic and demographic response to copper, with interactive effects between temperature and copper. In addition, they suggested an attenuation effect of copper accumulation on the sensitivity of traits to copper, but with great variation between strains, temperatures and copper concentrations. Diversity of responses among strains and their thermal dependencies pleads for the integration of intraspecific variability and multiple stressors approaches in ecotoxicological studies, thus improving the reliability of assessments of the effects of pollutants on biodiversity.

EQ-5D-5L and SF-6Dv2 health utilities scores of diffuse large B-cell lymphoma patients in China

BackgroundThis study evaluates the health-related quality of life (HRQoL) of persons with diffuse large B-cell lymphoma (DLBCL) by using EQ-5D-5L and SF-6Dv2 and compares the measurement properties of the two instruments.MethodDLBCL patients were identified via a patient group and were surveyed using web-based questionnaires. Demographic information, socioeconomic status (SES), clinical characteristics, and EQ-5D-5L and SF-6Dv2 responses were collected and statistically described. The association between the EQ-5D-5L and SF-6Dv2 dimensions were analyzed using the Spearman's correlation coefficient, whereas the correlation of the utility scores was evaluated using Pearson's correlation coefficient. The agreement between the responses of the two instruments were examined using a Bland–Altman (B-A) plot. A one-way analysis of variance (ANOVA) was performed to compare the utility scores across subgroups in different clinical states (a t-test was used if there were two subgroups). In addition, the graded response model (GRM) was used to describe the discrimination ability and difficulty characteristics of the dimensions in the two instruments.ResultsIn total, 582 valid responses were collected, among which 477 respondents were associated with initial-treatment and 105 respondents were relapsed/refractory (RR) patients. The mean (standard deviation [SD]) EQ-5D-5L and SF-6Dv2 utility scores of the DLBCL patients were 0.828 (0.222) and 0.641 (0.220), respectively. The correlation between the EQ-5D-5L and SF-6Dv2 dimensions ranged from 0.299 to 0.680, and the correlation between their utility scores was 0.787. The B-A plot demonstrated an acceptable but not strong agreement between EQ-5D-5L and SF-6Dv2 utility scores. The GRM model results indicated that all dimensions of each instrument were highly discriminating overall, but EQ-5D-5L had suboptimal discriminative power among patients with good health.ConclusionBoth the EQ-5D-5L and SF-6Dv2 showed valid properties to assess the HRQoL of DLBCL patients. However, utility scores derived from the two instruments had substantial difference, thereby prohibiting the interchangeable use of utilities from the two instruments.

Quality of Life in Patients Living with Andro-gentic Alopecia: A Cross Sectional Observational Study

Alopecia is a chronic dermatological disorder in which people lose some or all of the hair on their head and sometimes on their body as well. It is a chronic inflammatory disease that affects the hair follicles. It is neither life threatening nor painful, though there can be irritation of the skin, as well as physical problems resulting from the loss of eyelashes and eyebrows.This study aim to improve the quality of life and prescription pattern in androgenic alopecia. The goal of the study was to assess the quality of life of subjects living androgenic alopecia and to assess the prescription pattern of subjects with androgenic alopecia.This was a cross sectional observational study. The study was conducted Outpatient department of Dermatology in ESI MC PGIMSR, Rajajinagar. All the subjects (n=36) meeting the inclusion and exclusion criteria were briefed about the purpose of the study and the informed consent was obtained. The subject’s demographic details and responses were collected with the help of a standardized questionnaire. The collected data were entered in Microsoft Excel and appropriate descriptive analysis was performed. It was observed that a majority of the subjects were prescribed with minoxidil 5% (58.33%). On comparing the QOL scores, in each domain it was found that emotion has the highest average while the function has lowest average. scores in subjects of different age groups, it was found that the subjects belonging to the age groups 26-35 groups had high average scores (32.84%) and 36-45 groups had low average scores (28.96%).From this study, we got to know that the quality of life of male gender is affected more rather than female. Minoxidil 5% was most commonly prescribed drug and overall dosage form prescribed were topical agent.

413 Evaluation of utilizing personal development tools in collegiate science curriculum to enhance soft skill development

Abstract This study examines the integration of CliftonStrengths, within the Department of Animal Science at Iowa State University. In previous semesters, CliftonStrengths was introduced to freshmen, but no further application of the assessment took place. Fall 2023 incoming students completed more intensive application following completion of the assessment. The objective of this study aims to determine if students’ soft skills are enhanced through awareness and application of their own strengths. This study surveyed new and current students, analyzing their perceptions towards CliftonStrengths and their experiences in group settings. Three surveys were administered at different time points during the fall 2023 semester, one current student survey (CSS) at the start of the semester, and two new student surveys for the beginning (pre-NSS) and end (post-NSS) of the semester. Surveys captured demographic data and responses on a 0 to 10 scale. Response rates were 42% from pre-NSS, 22% CSS, and 24% from post-NSS. The pre-NSS and CSS contained 46 and 37 first-generation students, respectively. The pre-NSS consisted of 120 freshmen and 17 transfer students, and the CSS consisted of 43 sophomores, 44 juniors, and 59 seniors. Survey questions were structured around the primary domains within CliftonStrengths; strategic thinking, relationship building, influencing, and executing. Analysis of the pre-NSS responses showed 61% of new students were not familiar with CliftonStrengths and 78% have not taken the assessment. The CSS showed that 66% of current students have taken the CliftonStrengths Assessment. New students that completed intensive application of CliftonStrengths reported a 2.8-point increase from pre-NSS (4.9 ± 2.96) to post-NSS (7.7 ± 2.51) in response to identifying the value of CliftonStrengths in everyday life. New students reported being more comfortable with strengths at the conclusion of this semester with an average response of 9 ± 1.4 on a 10-point scale. The responses to “I believe someone in my career path should know their strengths” had higher average response rates from post-NSS (7.7 ± 0.26) compared with CSS (6.9 ± 0.20). Student responses to “I believe knowing my Strengths helps me at my best” also had higher average response rates from post-NSS (8.3 ± 0.24) compared with CSS (7.4 ± 0.18). Students responded to “I feel confident that I can recognize strengths in others” with higher response rates in the post-NSS (7.1 ± 0.30) compared with CSS (6.1 ± 0.18). All questions asking about the ability to identify domain types of other individuals were higher in post-NSS responses compared with CSS. The post-NSS responses to understanding how to use different domains in a group were greater for strategic thinkers, relationship builders, and influencers. In conclusion, the intensive application of CliftonStrengths in the Department of Animal Science at Iowa State University has increased familiarity, confidence, and comfort with their strengths.

The Reuse of Healing Abutments: A Questionnaire-Based Survey.

Healing abutments (HA) are used in second-stage implant surgery to create the optimal peri-implant environment. Despite being a component intended only for short-term use, it remains in the mouth for a few weeks to several months and stays in close contact with organic debris, intraoral fluids, and bacteria.Reusing the HAs modifies their surfaces, expands the coating layer's porosity, and promotes bacterial colonization at the HA-implant interface in addition to the previous contamination. Therefore, the study's goals were to determine the frequency of HA reuse, examine the sterilizing and disinfection techniques employed, and examine the factors that contributed to the dental professionals in the Indian state of Maharashtra utilizing these components again when placing dental implants. For the study, 150 dentists who worked in the field of implantology were chosen. An online questionnaire issued via email and WhatsApp was used to collect data, which started in January 2023. The survey was designed to store the demographic information and responses of the participants, and it was made available through Google Forms. By the end of February 2023, the responses had been gathered.Tables and graphs were used to present the study outcomes that were based on the statistical analysis. The analysis employed the Chi-square test, with a p-value of 0.05 deemed statistically significant. There were 150 answers in all, with 44% women and 56% men. Merely 7.4% of participants do not reuse healed abutments, compared to 92.6% who follow this procedure. The respondents were also asked about the number of times theyreused the HAs, 69% of the implantologists reused the same component countless times, while 31% reused it only once. All the respondents reported sterilizing the HAs before reuse and the method used for sterilization was autoclave (96.4%) and UV chamber (3.6%). In response to a question concerning informing patients about the reuse of HAs, 77.6% of implantologists stated they do not interact with patients, while only 22.4 reported doing so. Implantologists in the state of Maharashtra, India reuse HAs and use heterogeneous methods for disinfection and autoclave sterilization.

Assessment of Hospital Medical Emergency Team Operations in a Tertiary Care Center in Turkey.

Rapid Response Teams, strategically devised to mitigate mortality and morbidity stemming from unforeseen deteriorations and cardiac arrests within healthcare facilities, are ubiquitously implemented on a global scale. The aim of the study is to compare emergency physicians (EPs) and non-EPs on management protocols of Hospital Medical Emergency Teams (HoMET). This was a retrospective cross-sectional study. The hospital archive underwent a retrospective scanning process, and patient records were meticulously examined. The assessment encompassed various facets, including demographic characteristics, activation locations, and response and intervention times of HoMET teams, composed of both EPs and other healthcare professionals. Data analysis was conducted using SPSS software version 20.0. A total of 1056 calls were included, with 52% (n = 549) involving male patients. The average age was 67.15 ± 19.45 years. EPs served as the team leader in 53% of the calls. Cardiac arrest was considered in 93.6% of the cases. The EPs group exhibited a higher average patient age, longer intervention times, and shorter arrival times (P < 0.001, P = 0.027, P < 0.001, respectively). A significant difference was observed in the locations of the calls and the groups of calls considering cardiac arrest (P < 0.001, P < 0.001, respectively). The optimization of intervention teams is imperative given the persistently high incidence and mortality rates associated with in-hospital cardiac arrests. Leveraging the expertise of EPs in the management of arrests and critical patients can potentially enhance the effectiveness of these teams. Nonetheless, further research is warranted to comprehensively explore and validate this aspect.

Developing and Validating Entrustable Professional Activities (EPAs) for Rheumatology Fellowship Training Programs in Saudi Arabia: A Delphi Study.

Entrustable professional activities (EPAs) define the core tasks that a graduating rheumatologist needs to perform independently in practice. The objective of this study was to develop and validate EPAs for rheumatology fellowship training programs in Saudi Arabia. Experts met to develop an initial set of potential end-of-training EPAs by conducting a comprehensive literature review of EPAs and studying the Saudi rheumatology fellowship curriculum. Then, to validate the EPAs, we conducted two rounds of the modified Delphi technique among rheumatology experts in Saudi Arabia. A response rate of 80% was considered and the minimum number of experts needed to be 25 to 30. Descriptive statistics were utilized to describe participants' demographic characteristics and group responses to each statement in all rounds. The experts were asked to rate the relevancy of each EPA using a 5-point Likert scale in both Delphi rounds. In the preliminary phase, four rheumatologists developed an initial set of 36 core EPAs for rheumatology training program in Saudi Arabia. For the two-rounds Delphi techniques, 32 experts were invited to complete the study. The response rate of the first and second round were, 78.12% (25) and 93.75% (30), respectively. The first-round Delphi resulted in a robust consensus on 31 EPAs for rheumatology training.Five EPAs were excluded,and one new EPA was proposed.In the subsequent round,all 32 EPAs achieved strong consensus.The eliminated EPAs likely fell short in one or more of the following areas: relevance to rheumatology practice in Saudi Arabia, overlapping with other EPAs, or practical challenges in the implementation. We have developed and validated a core set of EPAs for rheumatology fellowship training programs in Saudi Arabia. Mapping and identifying milestones for these EPAs are essential steps to follow to enhance workplace curriculum development.

Effect of Alcohol And Narcotic Drug Intake Among Undergraduates Of Kwara State University Malete, Nigeria

Background: Alcohol and narcotic drug use have a long history together. Students in postsecondary institutions frequently use alcohol along with other substances like cannabis, nicotine, tramadol, codeine, and other amphetamines. These substances have detrimental effects on both the user and society at large, so it is absolutely essential to discover what is causing the continued use of these substances. Aim: To determine the effect of alcohol and narcotic intake among undergraduates of Kwara state university, Malete, Nigeria Method: This study is a descriptive cross-sectional study, designed to assess the effect of alcohol and narcotic intake among undergraduates in Kwara State University, malete using a qualitative method of data collection. The questionnaire was administered to determine the sample size using a simple random technique to get the desired sample size from the study population Result: Relationship between the social demographic response of the participants regarding their knowledge, effects of narcotic drugs and alcohol on the body and types of narcotic commonly used by undergraduates and factors motivating the use of narcotic drugs alcohol. Using Chi-Square set with the level of significance p&lt;0.05 alongside with degree of freedom. Considering the relationship between the gender of the respondents towards their knowledge about drugs and narcotics among the undergraduates, 40(20%) were female respondents, while 160(80%) of them were male respondents. P. value = 0.000 &lt; 0.05, which shows that it is significant, thereby rejecting the null hypothesis. Considering the relationship between the age of the respondents and the knowledge, 17-18 years were 40 (20%), 19-20years were 80(40%) while 21 and above were 80(40%) with P-value = 0.00 &lt; 0.05 indicating that it is significant, thereby rejecting the null hypothesis. Also, regarding the relationship between religion and their knowledge about knowledge, 100(50%) of the respondents were Muslims, 60(40%) were Christians, while 20(10%) were traditional. P-value = 0.00 &lt; 0.05 meaning that it is significant, thereby rejecting the null hypothesis. Conclusion: On our campus, there is an urgent need for preventive public health measures. It is recommended to launch more awareness efforts about the harmful effects of alcohol and narcotic medications. The use of alcohol and other drugs presents a serious threat to our future generations. Every single person ought to be discouraged by it.

Experience with Pediatric Chronic Immune Thrombocytopenia over 30 Years in the Era before Eltrombopag.

There is limited information on the natural course of chronic ITP in children. We aimed to evaluate the clinical and demographic characteristics of children with chronic ITP in the era before the availability of eltrombopag. A total of 86 children with chronic ITP between 1978-2014 were included. Demographic findings, laboratory results, clinical signs, bleeding scores, response time and time of complete remission were recorded. The male/female ratio was 1.09, and median follow-up time was 3 years (range: 1.5-17 years). The median age at diagnosis of chronic ITP was 7 years (range: 2-17), and the median initial platelet count was 10 × 109/L (range: 1-66 × 109/L). Petechiae/ecchymoses were the most common clinical sign (86%) and followed by mucosal bleeding (39.5%). Severe bleeding was seen in 5% of the patients. None of them had intracranial hemorrhage. Twenty patients underwent splenectomy, and the rate of complete remission was 70%. Spontaneous complete remission was seen in 29% of the patients, and the median time to spontaneous complete remission was 3 years. Our study showed that almost one-third of patients with chronic ITP experienced spontaneous complete remission in an average of 3 years, and splenectomy provided satisfactory results in severe cases. This study demonstrates the natural history of chronic ITP in childhood before the era of eltrombopag.

Correlation between Fatigue and Quality of Life in Adolescent Oncology Patients in Jordan

Background Adolescence represents a distinct and multifaceted developmental stage characterized by profound physical and cognitive transformations. Adolescents undergoing cancer treatment frequently have unique needs that remain unmet, leading to a notable decline in their quality of life. Cancer treatment often results in problems like fatigue, which affects patients' quality of life. Assessing quality of life and fatigue among adolescent cancer patients is essential for enhancing nursing care and improving outcomes. Objective This study aimed to investigate the correlation between fatigue and quality of life among adolescent cancer patients in Jordan. Methods A “cross-sectional” study was performed, with the participation of 127 Jordanian adolescent cancer patients, and data was collected through a nameless online survey of Jordanian adolescent cancer patients. The study commenced in February 2024 and concluded in June 2024. Demographic data and responses from two self-reported questionnaires—the Arabic versions of “Pediatric Quality of Life Inventory” “Multidimensional Fatigue Scale” and “Generic Core 4.0”—were collected. Descriptive statistics of means, frequencies, standard deviations, and percentages were used with demographics while inferential statistics were conducted using independent t-tests, Spearman's rank correlation coefficients, and Kruskal-Wallis tests in SPSS, version 26. Results Significant and potent correlations were found between various types of fatigue “general, sleep/rest, cognitive, and total” and quality of life “physical, emotional, social, school, psychosocial health”. Notably, the total fatigue scores showed a potent correlation with the total summary scores (r=0.946), with a p-value significant at the &lt;0.001 level for all correlations, indicating that adolescents with cancer experienced high fatigue and low quality of life. Conclusion The study demonstrated a potent link between fatigue and quality of life. The study's outcomes can help enhance guidelines for routine evaluation of fatigue and quality of life by nurses and healthcare providers in adolescent cancer patients to implement and evaluate interventions aimed at reducing fatigue in patients, highlighting fatigue as a significant concern. Future research should explore interventions such as exercise, leisure activities, and sleep to alleviate fatigue. Longitudinal research is essential to assess fatigue at diverse times of the day and week; this could help develop tailored fatigue management strategies to augment the quality of life among adolescent oncology patients.

Intraspecific priority effects in response to egg hatching delay in a pond-breeding salamander

As reproduction phenologies shift with climate change, populations can experience intraspecific priority effects, wherein early hatching cohorts experience an advantage over late-hatching cohorts, resulting in altered demography. Our study objective was to identify how variation in egg hatching phenology alters intraspecific interactions in small-mouthed salamanders, Ambystoma texanum. We addressed two research questions: (Q1) How are demographic responses altered by variation in the temporal duration of hatching between cohorts, and (Q2) How does the seasonality of hatching delays affect demographic responses? We manipulated hatching phenologies of A. texanum eggs and reared larvae in outdoor mesocosms to metamorphosis. For Q1, hatching delay exhibited non-linear relationships with survival and body size, with the greatest asynchrony in cohort additions resulting in the highest mortality and largest body sizes. For Q2, hatching delay effects were stronger (i.e., survival was lower and body sizes larger) when they occurred later in the season, potentially due to temperature differences that larvae experienced. Overall, our results demonstrate that changes in intraspecific interactions due to phenological shifts can be context-dependent, depending on the strength (i.e., temporal duration) and seasonality of such processes. Identifying context-dependencies of phenological shifts will be critical for predicting changes in organismal demographics with climatic shifts.