The unique complexities of the outer-skin curtain wall (CW) system of the Shanghai Tower increase the difficulty in evaluating its seismic performance. To assess such seismic performance, it is important to understand the floor acceleration demand under expected earthquake actions. Acceleration demand of the CW system consists of floor acceleration amplification (FAA) and floor response spectrum (FRS), which are closely related to the equivalent static seismic design force and the dynamic properties of the CW system. For estimating the FAA and FRS, code spectra compatible ground motions are selected and input to a finite element model of the building structure. The floor responses of key stories are analyzed. Normalized distribution of the horizontal FAA demand is estimated and shows that the obtained values exceed those proposed by current code provisions for low-intensity earthquake excitations. It is noted that the vertical FAA demand has a different distribution profile than the horizontal one. The results indicate that FAA demand under three-dimensional earthquake excitation is larger than that for 1D excitation. Moreover, the prime period range is up to 4.0 s for the horizontal FRS and up to 1.0 s for the vertical FRS. Horizontal and vertical FRS is proposed for dynamic analysis of the outer-skin CW system of the Shanghai Tower.