This paper examines the implementation of demand response measures, using an EnergyPlus simulation model, in a multi-purpose commercial building. The simulation model, which has been developed specifically for demand response analysis, is used to assess the effectiveness of different demand response strategies, which were considered for the building. The strategies were examined for a representative zone within the building and evaluate the contribution of the building capacitance and HVAC equipment operation, as mechanisms for shifting the building electrical demand. Associated zone temperature responses and load shifts are also quantified.