AbstractThe objective of this study is to conduct a thorough hazard analysis specifically tailored to identify hazards and suggest precautions associated with the intricate process of dimethyl ether (DME) production. This exothermic nature of DME production introduces the critical concern of thermal runaway. Furthermore, the DME synthesis process demands precise control over both pressure and flow rate. These parameters are important for increasing DME selectivity and CO conversion. Inadequate monitoring of these values may not only prevent the synthesis from proceeding but may also lead to major risks to health and safety. For this reason, proactive measures must be implemented to eliminate or minimize the risks. The significance of such measures cannot be overstated, as they serve to safeguard not only the integrity of the synthesis process but also the surrounding environment and human health. To delve deeper into the hazard evaluation, a comprehensive Hazard and Operability (HAZOP) analysis has been carried out, focusing specifically on the reactor within the DME process. This methodical examination involves a systematic review of potential deviations, identifying the associated hazards, and proposing effective preventive measures. The HAZOP analysis serves as a pivotal tool in ensuring the overall safety and reliability of the DME process.