Factors affecting method preference for induced abortion in Britain are cost and experience in clinical trials. Demand for abortion exists regardless of access to contraception; 1 in 5 pregnancies in Britain are aborted. Since July 1991, alternatives to vacuum aspiration have become available. RU486, or mifepristone, in combination with gemeprost, a prostaglandin, 48 hours later has shown a 95% successful complete abortion rate. The actual study involve 100 women at 9 weeks' gestation receiving 600 mg of mifepristone followed by 1 mg of gemeprost pessary. The complication rate was low and the pregnancy continuation rate was 0.3% which is similar to vacuum aspiration. Almost 50% of abortion seekers in France prefer medical (drug-induced) abortions. Studies in Aberdeen have shown that about 25% desired either medical or surgical abortion and 50% had no preference. Only about 10% of abortions performed in Britain are medical abortions. The reasons medical abortion is not more widely used, regardless of its availability, may involve the organization of services for abortion: the requirement for prompt referral before 9 weeks, the special licensing required for practice of medical abortion on the premises, and higher cost. Medical abortions cost 43 pounds for the mifepristone and 21 pounds for the gemeprost, but the cost could be reduced by reducing the amount of mifepristone to 200 or 400 mg in combination with 0.5 or 1 mg of gemeprost. World Health Organization studies have found little loss in efficacy and a significant reduction in diarrhea and vomiting, which, with the reduction in cost, ought to make medical abortion more attractive to women and institutions. Studies in France an the United Kingdom have found that a synthetic prostaglandin, misoprostol, could be substituted for gemeprost and reduce the side effects associated with gemeprost. Misoprostol also costs only 1 pound for a 400-600 mg dose. Medical abortion has the advantage of not requiring highly skilled staff or special facilities; the necessary room should have couches or beds. 2 trained nurses under medical supervision could serve 6 women per morning. Three visits are required. Most of the present use is in hospitals in the UK that have conducted clinical trials.
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