To study the seismic response of the thermal anchor pipe frame supporting permafrost slope system, the coupled dynamic interaction model of the permafrost slope with the thermal anchor pipe frame in thawing and freezing periods was established by taking into account the stratification characteristics of the permafrost slope in different typical seasons, respectively. Based on D'Alembert's principle and Dirac's function, the coupled vibration equilibrium differential equations are given and the seismic response of the system is analyzed for different periods. The reliability of the proposed model was further verified through shaking table tests. The results show that the acceleration response at different positions during both freezing and thawing periods is similar to the initial loading seismic wave shape. The peak acceleration and velocity during the thawing period is greater than that during the freezing period. The shear force and bending moment of the frame column are distributed alternately positive and negative along its height. The incremental dynamic shear force and bending moment are greater during the thawing period. However, the peak bending moments and shear forces are greater during the freezing period when the combined effects of frost and earthquakes. The peak bending moment occurs at the position of the first layer of the thermal anchor pipe, and the shear force suddenly changes near the thermal anchor pipe. In seismic design, attention should be paid to checking the internal force of the frame column during the freezing period to prevent plastic bending failure. The results contribute to further understanding the dynamic interaction mechanism of the thermal anchor pipe frame permafrost slope system, which has important practical significance for its seismic resistance.