You have accessJournal of UrologyKidney Cancer: Ablative Therapy1 Apr 2017MP100-14 HIGH INTENSITY FOCUSED ULTRASOUND KIDNEY ABLATION: PRE-CLINICAL SAFETY AND EFFICACY EVALUATION IN A PORCINE MODEL USING A 15MM LAPAROSCOPIC PROBE Sameer Chopra, Inderbir Gill, Alfredo Bove, Carlos Fay, Kevin King, Vinay Duddalwar, Toshitaka Shin, Rene Arboleda, Rodrigo Chaluisan, Jesse Clanton, Jacob Carr, Christie Johnson, Ben Ettinger, Adam Morris, Roy Carlson, Narendra Sanghvi, Mark Carol, and Ralf Seip Sameer ChopraSameer Chopra More articles by this author , Inderbir GillInderbir Gill More articles by this author , Alfredo BoveAlfredo Bove More articles by this author , Carlos FayCarlos Fay More articles by this author , Kevin KingKevin King More articles by this author , Vinay DuddalwarVinay Duddalwar More articles by this author , Toshitaka ShinToshitaka Shin More articles by this author , Rene ArboledaRene Arboleda More articles by this author , Rodrigo ChaluisanRodrigo Chaluisan More articles by this author , Jesse ClantonJesse Clanton More articles by this author , Jacob CarrJacob Carr More articles by this author , Christie JohnsonChristie Johnson More articles by this author , Ben EttingerBen Ettinger More articles by this author , Adam MorrisAdam Morris More articles by this author , Roy CarlsonRoy Carlson More articles by this author , Narendra SanghviNarendra Sanghvi More articles by this author , Mark CarolMark Carol More articles by this author , and Ralf SeipRalf Seip More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.3121AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES High intensity focused ultrasound (HIFU) has established itself clinically as a viable, safe, effective, and non-invasive tissue ablation modality. Previous studies have shown that HIFU delivered laparoscopically can be used to ablate kidney tumors, potentially enabling a lower morbidity treatment with faster recovery time as compared to partial nephrectomy procedures. Challenges remain, however, including ensuring full tissue necrosis and consistent energy coupling to the target volume. The objective of this study was to evaluate whether a newly developed laparoscopic HIFU probe is able to address these challenges. METHODS A laparoscopic porcine kidney model was used to investigate the safety and efficacy of the new 15mm HIFU probe. Under ultrasound guidance, kidneys of 12 pigs were targeted and ablated with HIFU, creating on average 2 ablation zones per kidney of varying sizes and locations in order to quantify the probe′s ability to deliver HIFU to any location on the kidney. Efficacy was evaluated via the analysis of ablation volume histology slides, real-time ultrasound images collected during HIFU delivery, and MRI and ultrasound contrast images. Safety was evaluated by surviving a subgroup of the animals (2w). Gross-pathological data, sonication parameters, and workflow feedback was also collected during the study. RESULTS Repeatable lesions could be created at a rate of 0.48cm3/min and average energy densities of 584cal/cm3. Histological evaluation indicated contiguous ablated volumes using these delivery parameters, extending from the transducer′s focal zone to the kidney surface, with a maximum treatment depth of 27mm. Ablated target volumes ranged from 5.1cm3 to 24.5cm3. CONCLUSIONS The results confirm the ability of the new probe to deliver HIFU in a consistent and reliable manner. Initial dose requirements for ablating tissue at various depths were also determined. Workflow feedback has resulted in additional system user interface improvements, with all of these results paving the way for a future clinical study. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1335-e1336 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Sameer Chopra More articles by this author Inderbir Gill More articles by this author Alfredo Bove More articles by this author Carlos Fay More articles by this author Kevin King More articles by this author Vinay Duddalwar More articles by this author Toshitaka Shin More articles by this author Rene Arboleda More articles by this author Rodrigo Chaluisan More articles by this author Jesse Clanton More articles by this author Jacob Carr More articles by this author Christie Johnson More articles by this author Ben Ettinger More articles by this author Adam Morris More articles by this author Roy Carlson More articles by this author Narendra Sanghvi More articles by this author Mark Carol More articles by this author Ralf Seip More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...