Delivery Mechanism Research Articles

Self‐Nanoformulating Poly(2‐oxazoline) and Poly(2‐oxazine) Copolymers Based Amorphous Solid Dispersions as Microneedle Patch: A Formulation Study

AbstractA pioneering approach in the domain of transdermal drug delivery systems (TDDS) is introduced by using microneedles (MNs) fabricated from an amorphous solid dispersion comprising only a model drug and an amphiphilic block copolymer to form a drug nanoformulation upon MN dissolution. To maximize drug loading and ensure consistent release, a minimalist formulation that achieves 40 wt% drug loading, which is a significant improvement over existing methods, is developed. Using scanning electron microscopy, the morphology of MNs is examined across a spectrum of drug loading ratios, demonstrating the consistency in structure and integrity. Mechanical testing confirms the MNs' proficiency in effective skin penetration. A comparative study on the formation of polymeric micelles underscores the innovative concept of a “nano‐in‐micro drug delivery system”. The results demonstrate that MNs manufactured from an amorphous solid dispersion of drug and amphiphilic block copolymer with ultra‐high loading enhance the availability and release dynamics of hydrophobic drugs, positioning them as a tool for enhancing TDDS. This study sets a new benchmark in the utilization of polymer‐drug nanoformulations for transdermal applications and underscores the capacity for high drug loading and the creation of adaptable drug delivery mechanisms for the studied amphiphilic block copolymer.

EVALUATION OF ENHANCED SOLAR DESALINATION SYSTEM PROTOTYPE

Solar desalination technology has been one of the effective solutions to tackle the problem of water scarcity. A number of studies have been conducted at our water research group to determine which variable influences the quantity of distilled water produced by an independent solar desalination unit. Aims: This study was aimed to design and optimize a novel solar desalination unit and field-tested using the best variable from the previous studies. Methodology and results: Variables used from the previous studies were evaluated to obtain the best values for each parameter, those are: glass cover inclination, gap distance between water and glass cover, insulation thickness, water depth, and water mass flow rate. Those best values were then implemented in the optimized basin design, delivery mechanisms, evaporation techniques, and heat isolation methods. The optimized design can generate up to 2,778.2 mL/m2/8hrs of distilled water with an efficiency of 23.35% in preliminary test, and was field tested at Batukaras Beach, where it produced up to 902 mL/m2/8hrs with an efficiency of 13.56%. Conclusion, significance and impact study: Meteorological parameters and environmental conditions are important factors that greatly affect the performance and productivity of the desalination unit. The relative humidity is inversely proportional to the volume of distillate water, where the smaller the value, the greater the amount of distillate water that can be produced, and it has significant impact on the productivity of the prototype. The quality of the distillate water produced still needs improvement on the parameters of pH, turbidity, and total coliform.

Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe3O4 NPs Nanocarrier.

In this work, a one-pot multicomponent synthesis of the ibuprofen-loaded Fe3O4 nanoparticles-supported zeolitic imidazolate framework-8 (Ibu-ZIF-8/Fe3O4 NPs) nanohybrid was carried out. The ZIF-8/Fe3O4 NPs nanohybrid was used as a drug carrier for the in vitro release of ibuprofen in a PBS solution. The structure and morphology of the synthesized materials were investigated by powder X-ray diffraction (PXRD) analysis, transmission electron microscopy (TEM) analysis, UV-visible absorption studies, FTIR spectroscopy, and thermogravimetric analysis (TGA). The ibuprofen release kinetics was studied by UV-visible spectroscopy. The mechanism of drug delivery was thoroughly investigated and the Higuchi model was found as the best-fitted model for the ibuprofen release study. The 20 wt % Fe3O4 NPs-supported ZIF-8 nanohybrid exhibited more than 95% ibuprofen release efficiency in phosphate buffer saline of pH 7.4 within 2 h. The separation ability of the nanohybrid was very good, and it was easily separated by a simple commercial magnet. In order to investigate the cell viability, the cytotoxicity of ZIF-8, Fe3O4 NPs, and ZIF-8/20 wt % Fe3O4 NPs was investigated using MTT assays against Leishmania donovani promastigotes. The ZIF-8/20 wt % Fe3O4 NPs nanohybrid carrier exhibited a cell growth inhibition effect with a high correlation coefficient and low probability (p) values. The high release of drug molecules may be due to the more open site of the ZIF-8/Fe3O4 NPs nanohybrid. The drug release profile suggests that the nanohybrid can be potentially used as a drug carrier for targeted drug delivery systems.

Revolutionizing Healthcare and Drug Discovery: The Impact of Artificial Intelligence on Pharmaceutical Development

Artificial intelligence (AI) is reshaping drug discovery and delivery in the pharmaceutical industry, fundamentally transforming traditional methods. In drug discovery, AI algorithms rapidly analyze vast biological and chemical datasets to identify potential drug candidates with unprecedented accuracy. Machine learning models predict compound efficacy and safety, accelerating earlystage drug development. AI also facilitates drug repurposing, uncovering new therapeutic uses for existing medications. At the drug delivery front, AI optimizes formulations and systems, enabling targeted and personalized approaches. Intelligent algorithms enhance the understanding of pharmacokinetics and pharmacodynamics, guiding the development of precision medicine strategies. This integration of AI not only expedites innovative drug discovery but also refines delivery mechanisms, promising more effective and tailored treatments with the potential to revolutionize patient care. The data-processing capabilities of AI drive digitalization and widespread utilization. Applications in drug discovery, development, repurposing, and clinical trials aim to alleviate human workload, expedite objectives, and foster innovation. Despite promising prospects, concerns about job displacement and stringent regulations accompany AI implementation. Emphasizing the intent to augment human labor rather than replace it entirely, the industry anticipates that AI will become a pivotal resource, propelling efficiency, innovation, and advancements in healthcare. This review emphasizes the role of AI in transforming drug discovery and delivery

Enhancing payload capacity to low earth orbit via a relay solution trajectory with laser-powered vehicles

ABSTRACT Low Earth Orbit (LEO) stands as the primary access point for deep space exploration endeavors, encompassing a variety of space missions such as communication satellites, Earth observation platforms, and scientific research missions. In light of the expanding scope of human activities in space, the cost associated with accessing LEO has emerged as a critical focal point for spacecraft designers. Within the spectrum of proposed solutions, laser-powered vehicle has emerged as a viable avenue toward achieving cost-effective launch options. In order to significantly augment the payload capacity of laser-powered launch vehicles destined for LEO, this study introduced a novel Relay Solution Trajectory Flight Scheme. Central to this scheme was the implementation of a relay mirror system affixed to a satellite, which served to stabilize the incident angle of the laser beam directed toward the laser-powered vehicle, thereby ensuring continuous alignment between the laser beam and the vehicle’s axis throughout the duration of the flight. Following the development of comprehensive structural, propulsive, aerodynamic, and trajectory models tailored for the laser-powered vehicle, an optimization of its flight trajectory was conducted, comparing this innovative strategy with two conventional flight strategies. The outcomes of this analysis showcased a notable enhancement of 269.29% in payload capacity compared to conventional strategies that lacked a relay satellite system, within a designated 400 km LEO flight scenario. This endeavor underscored the transformative potential of advanced relay systems in reshaping payload delivery mechanisms and elevating mission feasibility levels, notwithstanding the intricate coordination challenges posed by intricate satellite systems.

The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management.

Curcumin, a polyphenolic compound derived from Curcuma longa, exhibits significant therapeutic potential in cancer management. This review explores curcumin's mechanisms of action, the challenges related to its bioavailability, and its enhancement through modern technology and approaches. Curcumin demonstrates strong antioxidant and anti-inflammatory properties, contributing to its ability to neutralize free radicals and inhibit inflammatory mediators. Its anticancer effects are mediated by inducing apoptosis, inhibiting cell proliferation, and interfering with tumor growth pathways in various colon, pancreatic, and breast cancers. However, its clinical application is limited by its poor bioavailability due to its rapid metabolism and low absorption. Novel delivery systems, such as curcumin-loaded hydrogels and nanoparticles, have shown promise in improving curcumin bioavailability and therapeutic efficacy. Additionally, photodynamic therapy has emerged as a complementary approach, where light exposure enhances curcumin's anticancer effects by modulating molecular pathways crucial for tumor cell growth and survival. Studies highlight that combining low concentrations of curcumin with visible light irradiation significantly boosts its antitumor efficacy compared to curcumin alone. The interaction of curcumin with cytochromes or drug transporters may play a crucial role in altering the pharmacokinetics of conventional medications, which necessitates careful consideration in clinical settings. Future research should focus on optimizing delivery mechanisms and understanding curcumin's pharmacokinetics to fully harness its therapeutic potential in cancer treatment.

Understanding Allocation and Farmers’ Access to Varied Level of Agricultural Input Subsidies from Different Tiers of Government: A Case Study in Kavrepalanchowk District, Nepal

Government support for essential agricultural services, such as agricultural input subsidies, is vital for empowering smallholder farmers. This study explores distribution and the factors affecting farmers access to varied level of government agricultural input subsidies in Kavrepalanchowk district, Nepal. The study relied on survey data from 219 randomly selected households. Results showed that 72 percent, 8 percent, and 20 percent of sampled households received less than NRs 15,000, NRs 15,000 to 30,000, and more than NRs 30,000 in input subsidies per year, respectively. Among the recipients of the input subsidy, the mean subsidy for electricity, chemical fertilizers, agricultural machinery, interest subsidy, and cash subsidy for the GI tunnel were NRs 4,061, 7,143, 35,633, 67,500, and 4,72,000, respectively. Results from a multinomial regression show that households with higher income, farms near roads, and registered farms receive a higher level of input subsidies. It is recommended that farmers register their farms either as a firm or company or as farmer's groups or cooperatives. To effectively perform their roles, there is a need to review the subsidy delivery mechanism, ensuring its reach to the most constrained farmers.

Geographic Drivers of Mercury Entry into Aquatic Food Webs Revealed by Mercury Stable Isotopes in Dragonfly Larvae.

Atmospheric mercury (Hg) emissions and subsequent transport and deposition are major concerns within protected lands, including national parks, where Hg can bioaccumulate to levels detrimental to human and wildlife health. Despite this risk to biological resources, there is limited understanding of the relative importance of different Hg sources and delivery pathways within the protected regions. Here, we used Hg stable isotope measurements within a single aquatic bioindicator, dragonfly larvae, to determine if these tracers can resolve spatial patterns in Hg sources, delivery mechanisms, and aquatic cycling at a national scale. Mercury isotope values in dragonfly tissues varied among habitat types (e.g., lentic, lotic, and wetland) and geographic location. Photochemical-derived isotope fractionation was habitat-dependent and influenced by factors that impact light penetration directly or indirectly, including dissolved organic matter, canopy cover, and total phosphorus. Strong patterns for Δ200Hg emerged in the western United States, highlighting the relative importance of wet deposition sources in arid regions in contrast to dry deposition delivery in forested regions. This work demonstrates the efficacy of dragonfly larvae as biosentinels for Hg isotope studies due to their ubiquity across freshwater ecosystems and ability to track variation in Hg sources and processing attributed to small-scale habitat and large-scale regional patterns.

The Effect of Promotion and Ease of Transaction on Purchase Decision at Shopee.co.id: A Case Study of University of Riau's Economics and Business Students

The proliferation of e-commerce has significantly influenced various facets of commercial operations, including the expansion of international trade, the adoption of bespoke manufacturing processes, and the implementation of prompt delivery mechanisms. This research was conducted to understand the effect of promotion and ease of transactions on purchase decisions at Shopee.co.id, specifically among students of the Faculty of Economics and Business, University of Riau. The present study employed quantitative research approach and will utilize a survey as the primary data collection method, whereby data will be gathered by administering questionnaires containing numerically rated items. The results show that promotion and ease of transaction have a significant impact on purchase decisions. It indicates that the greater the utilization of promotion and ease of transaction, thus purchase decisions will increase significantly. Ease of transaction has a partial effect on the purchase decision. Thus, the greater the ease of transaction on the marketplace, the greater their purchase decision.

Investigating the Effects of the Physicochemical Properties of Cellulose-Derived Biocarbon on Direct Carbon Solid Oxide Fuel Cell Performance.

This paper presents a study of the characteristic effects of the physicochemical properties of microcrystalline cellulose and a series of biocarbon samples produced from this raw material through thermal conversion at temperatures ranging from 200 °C to 850 °C. Structural studies revealed that the biocarbon samples produced from cellulose had a relatively low degree of graphitization of the carbon and an isometric shape of the carbon particles. Based on thermal investigations using the differential thermal analysis/differential scanning calorimeter method, obtaining fully formed biocarbon samples from cellulose feedstock was possible at about 400 °C. The highest direct carbon solid oxide fuel cell (DC-SOFC) performance was found for biochar samples obtained via thermal treatment at 400-600 °C. The pyrolytic gases from cellulose decomposition had a considerable impact on the achieved current density and power density of the DC-SOFCs supplied by pure cellulose samples or biochars derived from cellulose feedstock at a lower temperature range of 200-400 °C. For the DC-SOFCs supplied by biochars synthesised at higher temperatures of 600-850 °C, the "shuttle delivery mechanism" had a substantial effect. The impact of the carbon oxide concentration in the anode or carbon bed was important for the performance of the DC-SOFCs. Carbon oxide oxidised at the anode to form carbon dioxide, which interacted with the carbon bed to form more carbon oxide. The application of biochar obtained from cellulose alone without an additional catalyst led to moderate electrochemical power output from the DC-SOFCs. The results show that catalysts for the reverse Boudouard reactions occurring in a biocarbon bed are critical to ensuring high performance and stable operation under electrical load, which is crucial for DC-SOFC development.

Delivery of mRNA Using Biomimetic Vectors: Progress and Challenges.

Messenger RNA (mRNA) is an emerging class of therapeutic agents for treating a wide range of diseases. However, due to the instability and low cell transfection rate of naked mRNA, the expression of delivered mRNA in target cells or tissues in vivo requires delivery strategies. Biomimetic vectors hold advantages such as high biocompatibility, tissue specific targeting ability and efficient delivery mechanisms, potentially overcoming challenges faced by other delivery vectors. In this review, biomimetic vector-based mRNA delivery systems are summarized and discuss the possible challenges and prospects of such delivery systems, which may contribute to the progress and application of mRNA-based therapy in the biomedical field.

Seasonal and synoptic spatio-temporal variability on larval delivery mechanisms inferred from mussel settlement patterns in the Portuguese coast

Demographic connectivity is the process by which population persistence and growth are affected by the dispersal of individuals. In sessile marine species that disperse by planktonic larvae and form metapopulations, the interaction between oceanographic forcing and larval biology drives the spatial extent and magnitude of larval delivery to suitable habitat patches. The present study investigates the supply of Mytilus galloprovincialis larvae to rocky intertidal habitats located within and around two marine protected areas (MPA) in central Portugal, one located on the exposed coast and the other one in a sheltered bay, using time series of settlement intensity and oceanographic variables. The results indicate that larval delivery at short time scales (days) is strongly dependent on the interaction of upwelling circulation with coastline topography. In the exposed MPA, located on a coastal island, the magnitude of mussel larval delivery is limited by the dynamics of an upwelling front and filament that intercepts the island as upwelling increases and decreases. In the sheltered bay, under an upwelling shadow, the upwelling front promotes recirculation of the water mass, intensifying larval retention and settlement. The results are also consistent with larval transport distances of tens of kilometres and ongoing connectivity between the two MPA. This study highlights the relevance of coastal topography and its interaction with mesoscale hydrodynamics in the modulation of larval delivery, crucial for the persistence of populations and communities and in systematic conservation planning.

Regulating the Distribution and Accumulation of Charged Molecules by Progressive Electroporation for Improved Intracellular Delivery.

The cell membrane separates the intracellular compartment from the extracellular environment, constraining exogenous molecules to enter the cell. Conventional electroporation typically employs high-voltage and short-duration pulses to facilitate the transmembrane transport of molecules impermeable to the membrane under natural conditions by creating temporary hydrophilic pores on the membrane. Electroporation not only enables the entry of exogenous molecules but also directs the intracellular distribution of the electric field. Recent advancements have markedly enhanced the efficiency of intracellular molecule delivery, achieved through the utilization of microstructures, microelectrodes, and surface modifications. However, little attention is paid to regulating the motion of molecules during and after passing through the membrane to improve delivery efficiency, resulting in an unsatisfactory delivery efficiency and high dose demand. Here, we proposed the strategy of regulating the motion of charged molecules during the delivery process by progressive electroporation (PEP), utilizing modulated electric fields. Efficient delivery of charged molecules with an expanded distribution and increased accumulation by PEP was demonstrated through numerical simulations and experimental results. The dose demand can be reduced by 10-40% depending on the size and charge of the molecules. We confirmed the safety of PEP for intracellular delivery in both short and long terms through cytotoxicity assays and transcriptome analysis. Overall, this work not only reveals the mechanism and effectiveness of PEP-enhanced intracellular delivery of charged molecules but also suggests the potential integration of field manipulation of molecular motion with surface modification techniques for biomedical applications such as cell engineering and sensitive cellular monitoring.

CFD simulation of blood-mediated drug transport through a dense solid tumour

ABSTRACT Advancements in cancer treatment have underscored the importance of understanding the intricate interplay between tumour microenvironments and drug delivery mechanisms. This research delves into the dynamic relationship between blood-mediated drug transport and the density of the tumour matrix within solid tumours. The study seeks to unravel the effects of varying tumour matrix densities on drug transport characteristics and, subsequently, on the perfusion efficacy of therapeutic agents. Through computational fluid dynamics simulation, this research elucidates the intricate balance between transport dynamics and drug distribution within solid tumours. A simple two-dimensional circular geometry has been chosen to represent the tumour and the surrounding microcirculation. The drug molecules diffuse into the interstitial tumour matrix through the microcirculation and then from the matrix into the tumour cells. The matrix is considered to be a porous medium, and the porosity of the media has been varied to simulate the effect of the matrix density on drug perfusion. Simulation results have shown that the density significantly affects the transport flux of the drug through the tumour matrix. The outcomes of this research hold potential implications for optimising drug delivery strategies in cancer therapy possibly by designing drug molecules that can effectively diffuse through dense tumour matrices.

An Autonomous Implantable Device for the Prevention of Death from Opioid Overdose.

Opioid overdose accounts for nearly 75,000 deaths per year in the United States, representing a leading cause of mortality amongst the prime working age population (25-54 years). At overdose levels, opioid-induced respiratory depression becomes fatal without timely administration of the rescue drug naloxone. Currently, overdose survival relies entirely on bystander intervention, requiring a nearby person to discover and identify the overdosed individual, and have immediate access to naloxone to administer. Government efforts have focused on providing naloxone in abundance but do not address the equally critical component for overdose rescue: a willing and informed bystander. To address this unmet need, we developed the Naloximeter: a class of life-saving implantable devices that autonomously detect and treat overdose, with the ability to simultaneously contact first-responders. We present three Naloximeter platforms, for both fundamental research and clinical translation, all equipped with optical sensors, drug delivery mechanisms, and a supporting ecosystem of technology to counteract opioid-induced respiratory depression. In small and large animal studies, the Naloximeter rescues from otherwise fatal opioid overdose within minutes. This work introduces life-changing, clinically translatable technologies that broadly benefit a susceptible population recovering from opioid use disorder.

Research progress on effect evaluation and application status of acupoint drug delivery

Acupoint drug delivery is a traditional external therapy of traditional Chinese medicine(TCM). Guided by the meridian and collateral theory in TCM, it applies medications to the skin at acupoints, exerting a dual therapeutic effect by stimulating the acupoints and the conduction of meridians. Acupoint drug delivery is widely used in clinical practice. Different from traditional oral admi-nistration and injection, it absorbs medications through the skin, effectively avoiding the first-pass effect of drugs and the toxic side effects caused by injection. Acupoint selection and transdermal drug absorption are pivotal factors affecting the efficacy of acupoint drug delivery. Recent research on acupoint drug delivery mainly focuses on the evaluation of clinical efficacy, yet the systematic investigations on acupoint selection and pharmacodynamic factors are scarce. This study reviews the mechanism, efficacy evaluation and application status of acupoint drug delivery. It integrates the theory of TCM with modern medicine to explore the mechanism of acupoint drug delivery, evaluate its clinical efficacy, and assess the transdermal penetration in vivo and in vitro. The application status of acupoint drug delivery is also summarized, including the selection of acupoints, application dosage form, application time and the absorption of acupoints. This review aims to offer insights and references for the research, development and clinical application of acupoint drug delivery products.

Enhancing circulatory myokines and extracellular vesicle uptake with targeted exercise in patients with prostate cancer (the MYEX trial): a single-group crossover study

IntroductionPhysical activity is associated with improved disease progression and cancer-specific survival in patients with prostate cancer (PCa). However, the mechanisms underlying these associations remain unclear, while the relative impact of exercise modes is unknown. This study aims to examine the differential impact of exercise mode on tumour-suppressive skeletal muscle-associated systemic molecules as well as their delivery mechanism. This study will compare the effects of the two main exercise modes, aerobic and resistance, on (1) circulatory myokine levels, (2) skeletal muscle-induced extracellular vesicle abundance and cargo contents, and (3) uptake of extracellular vesicles (EVs) in PCa cells in patients with localised or advanced PCa.MethodsA single-group cross-over design will be used for patients at opposite ends of the disease spectrum. A total of 32 patients (localised PCa, n = 16; metastatic castrate-resistant PCa, n = 16) will be recruited while capitalising on two ongoing studies. Ethics amendment has been approved for two ongoing trials to share data, implement the acute exercise sessions, and collect additional blood samples from patients. The patients will undertake two exercise sessions (aerobic only and resistance only) in random order one week apart. Blood will be collected before, after, and 30 min post-exercise. Circulating/EV-contained myokine levels (irisin, IL-6, IL-15, FGF-21, and SPARC) and plasma skeletal muscle-induced EVs will be measured using ELISA and flow cytometry. PCa cell line growth with or without collected plasma will be examined using PCa cell lines (LNCaP, DU-145, and PC-3), while evaluating cellular uptake of EVs. Ethics amendments have been approved for two capitalising studies to share data, implement acute exercise sessions and collect additional samples from the patients.DiscussionIf findings show a differential impact of exercise mode on the establishment of an anti-cancer systemic environment, this will provide fundamental knowledge for developing targeted exercise prescriptions for patients with PCa across different disease stages. Findings will be reported in peer-reviewed publications and scientific conferences, in addition to working with national support groups to translate findings for the broader community.Trial registrationThe registration for the two capitalising studies are NCT02730338 and ACTRN12618000225213.

Bioadhesive polymer in antifungal drug delivery for therapeutic treatment of candidiasis.

Candida species are the primary cause of candidiasis, a common yeast infection, with Candida albicans being the most prevalent pathogen. These infections often infiltrate the body through cutaneous and vaginal routes. Given the potential severity of some Candida infections, particularly invasive cases, there is a critical need for effective antifungal treatments. Controlled drug delivery strategies have been developed to achieve optimal release kinetics and precise targeting of active agents, especially in fungal infection therapeutics. Consequently, significant attention has been focused on exploring and utilizing bioadhesive polymers to enhance the performance of drug delivery systems for antifungal medications. Bioadhesive drug delivery systems aim to sustain the release of therapeutic agents, reducing the need for frequent dosing. This article provides a comprehensive review of scientific investigations into the use of antifungal drugs within bioadhesive drug delivery systems for treating candidiasis, locally and systemically. The evaluation covers the efficacy of these systems against candidiasis, factors affecting prolonged contact at the application site, and the underlying mechanisms of drug delivery.

The ephemeral state of ice in micro cold traps on the Moon

Micro cold traps stand out as promising targets for future investigation missions to the lunar polar regions, due to their greater accessibility compared to macro cold traps. However, this advantage naturally comes at the cost of their size, which limits the amount of ice they can potentially harbor. Here, we investigate the permanently shadowed volume (PSV) of micro cold traps — an upper limit for their potential ice capacity. We find that, as expected, the PSV depth increases with latitude and surface roughness, but is on average much shallower (∼0.5−1%) compared to the topographic baseline. By comparing the expected destruction and accumulation rates of ice to the potential maximum capacity of micro cold traps, we predict their infill as a function of lateral size, and the lifetime of the ice they harbor. Our results could be used by future investigation missions to the lunar polar regions to constrain the delivery rate and delivery mechanism of ice to the Moon.

Chitosan-coated liposomal systems for delivery of antibacterial peptide LL17-32 to Porphyromonas gingivalis

Periodontal disease is triggered by surface bacterial biofilms where bacteria are less susceptible to antibiotic treatment. The development of liposome-based delivery mechanisms for the therapeutic use of antimicrobial peptides is an attractive alternative in this regard. The cationic antimicrobial peptide LL-37 (human cathelicidin) is well-known to exert antibacterial activity against Porphyromonasgingivalis, a keystone oral pathogen. However, the antibacterial activity of the 16-amino acid fragment (LL17-32) of LL-37, is unknown. In addition, there are still gaps in studies using liposomal formulations as delivery vehicles of antibacterial peptides against this pathogen. This study was designed to examine the influence of the different types of liposomal formulations to associate and deliver LL17-32 to act against P. gingivalis. Chitosans of varying Mw and degree of acetylation (DA) were adsorbed at the surface of soya lecithin (SL) liposomes. Their bulk (average hydrodynamic size, ζ-potential and membrane fluidity) and ultrastructural (d-spacing, half-bilayer thickness and the water layer thickness) biophysical properties were investigated by a panel of techniques (DLS, SAXS, M3-PALS, fluorescence spectroscopy and TEM imaging). Their association efficiency, in vitro release, stability, and efficacy in killing the periodontal pathogen P. gingivalis were also investigated. All liposomal systems possessed spherical morphologies and good shelf-life stabilities. Under physiological conditions, chitosan formulations with a high DA demonstrated enhanced stability in comparison to low DA-chitosan formulations. Chitosans and LL17-32 both decreased SL-liposomal membrane fluidity. LL17-32 exhibited a high degree of association with SL-liposomes without in vitro release. In biological studies, free LL17-32 or chitosans alone, demonstrated microbicidal activity against P. gingivalis, however this was attenuated when LL17-32 was loaded onto the SL-liposome delivery system, presumably due to the restrained release of the peptide. A property that could be harnessed in future studies (e.g., oral mucoadhesive slow-release formulations).