Delivery Mechanism Research Articles

Enhanced Tumor-Targeted Delivery of Arginine-Rich Peptides via a Positive Feedback Loop Orchestrated by Piezo1/integrin β1 Signaling Axis.

Peptide-based drugs hold great potential for cancer treatment, and their effectiveness is driven by mechanisms on how peptides target cancer cells and escape from potential lysosomal entrapment post-endocytosis. Yet, the mechanisms remain elusive, which hinder the design of peptide-based drugs. Here hendeca-arginine peptides (R11) are synthesized for targeted delivery in bladder carcinoma (BC), investigated the targeting efficiency and elucidated the mechanism of peptide-based delivery, with the aim of refining the design and efficacy of peptide-based therapeutics. It is demonstrated that the over-activated Piezo1/integrin β1 (ITGB1) signaling axis significantly facilitates tumor-targeted delivery of R11 peptides via macropinocytosis. Furthermore, R11 peptides formed hydrogen bonds with integrin β1, facilitating targeting and penetration into tumor cells. Additionally, R11 peptides protected integrin β1 from lysosome degradation, promoting its recycling from cytoplasm to membrane. Moreover, this findings establish a positive feedback loop wherein R11 peptides activate Piezo1 by increasing membrane fusion, promoting Ca2+ releasing and resulting in enhanced integrin β1-mediated endocytosis in both orthotopic models and clinical tissues, demonstrating effective tumor-targeted delivery. Eventually, the Piezo1/integrin β1 signaling axis promoted cellular uptake and transport of peptides, establishing a positive feedback loop, promoting mechanical delivery to cancer and offering possibilities for drug modification in cancer therapy.

Trends on Novel Targets and Nanotechnology-Based Drug Delivery System in the Treatment of Parkinson's disease: Recent Advancement in Drug Development.

Parkinson's disease (PD) is a neurodegenerative disease (ND) that affects many people. However, there remains no cure for PD and difficulties exist with conventional medicines. There has been a lot of discussion about using nanotechnology to increase the bioavailability of smallmolecule drugs to target cells in recent years. It is possible that PD treatment might become far more effective and have fewer side effects if medication delivery mechanisms were to be improved. Potential alternatives to pharmacological therapy for molecular imaging and treatment of PD may lie in abnormal proteins such as parkin, α-synuclein, leucine-rich repeat serine and threonine protein kinase 2. Published research has demonstrated encouraging outcomes when nanomedicine-based approaches are used to address the challenges of PD therapy. So, to address the present difficulties of antiparkinsonian treatment, this review outlines the key issues and limitations of antiparkinsonian medications, new therapeutic strategies, and the breadth of delivery based on nanomedicine. This review covers a wide range of subjects, including drug distribution in the brain, the efficacy of drug-loaded nano-carriers in crossing the blood-brain barrier, and their release profiles. In PD, the nano-carriers are also used. Novel techniques of pharmaceutical delivery are currently made possible by vesicular carriers, which eliminate the requirement to cross the blood-brain barrier (BBB).

Investigation of pH-dependent Paclitaxel delivery mechanism employing Chitosan-Eudragit bioresponsive nanocarriers: a molecular dynamics simulation

Before embarking on any experimental research endeavor, it is advisable to do a mathematical computation and thoroughly examine the methodology. Despite the use of polymeric nanocarriers, the regulation of bioavailability and drug release at the disease site remains insufficient. Several effective methods have been devised to address this issue, including the creation of polymeric nanocarriers that can react to stimuli such as redox potential, temperature, pH, and light. The present study has been utilized all-atom molecular dynamics (AA-MD) and coarse-grained molecular dynamics (CG-MD) methods and illustrated the drug release mechanism, which is influenced by pH, for Chitosan-Eudragit bioresponsive nanocarriers. The aim of current work is to study the molecular mechanism and atomistic interactions of PAX delivery using a Chitosan-Eudragit carrier. The ability of Eudragit polymers to dissolve in various organic solvents employed in the process of solvent evaporation is a crucial benefit in enhancing the solubility of pharmaceuticals. This study investigated the use of Chitosan-Eudragit nanocarriers for delivering an anti-tumor drug, namely Paclitaxel (PAX). Upon analyzing several significant factors affecting the stability of the drug and nanocarrier, it has been shown that the level of stability is more significant in the neutral state than the acidic state. Furthermore, the system exhibits higher stability in the neutral state. The used Chitosan-Eudragit nanocarriers exhibit a stable structure under alkaline conditions, but undergo deformation and release their payloads under acidic conditions. It was demonstrated that the in silico analysis of anti-tumor drugs and carriers’ integration could be quantified and validated by experimental results (from previous works) at an acceptable level.Graphical abstract

Retraction Note: Energy efficient congestion free and adaptive mechanism for data delivery in underwater wireless sensor networks using 2H-ACK

Retraction Note: Energy efficient congestion free and adaptive mechanism for data delivery in underwater wireless sensor networks using 2H-ACK

DNA Origami Vesicle Sensors with Triggered Single-Molecule Cargo Transfer.

Interacting with living systems typically involves the ability to address lipid membranes of cellular systems. The first step of interaction of a nanorobot with a cell will thus be the detection of binding to a lipid membrane. Utilizing DNA origami, we engineered a biosensor with single-molecule Fluorescence Resonance Energy Transfer (smFRET) as transduction mechanism for precise lipid vesicle detection and cargo delivery. The system hinges on a hydrophobic ATTO647N modified single-stranded DNA (ssDNA) leash, protruding from a DNA origami nanostructure. In a vesicle-free environment, the ssDNA coils, ensuring high FRET efficiency. Upon vesicle binding to cholesterol anchors on the DNA origami, hydrophobic ATTO647N induces the ssDNA to stretch towards the lipid bilayer, reducing FRET efficiency. As the next step, the sensing strand serves as molecular cargo that can be transferred to the vesicle through a triggered strand displacement reaction. Depending on the number of cholesterols on the displacer strands, we either induce a diffusive release of the fluorescent load towards neighboring vesicles or a stoichiometric release of a single cargo-unit to the vesicle on the nanosensor. Ultimately, our multi-functional liposome interaction and detection platform opens up pathways for innovative biosensing applications and controllable stoichiometric loading of vesicles with single-molecule control.

Perceived barriers and opportunities for the introduction of post-discharge malaria chemoprevention (PDMC) in five sub-Saharan countries: a qualitative survey amongst malaria key stakeholders

BackgroundPost-discharge malaria chemoprevention (PDMC) is an intervention aimed at reducing morbidity and mortality in patients hospitalized with severe anaemia, with its effectiveness established in several clinical trials. The aim of this study was to better understand factors that would influence the scale up of this intervention, and to identify preferences for two delivery mechanisms, facility-based or community-based.MethodsForty-six qualitative individual interviews were conducted in five sub-Saharan countries amongst malaria key opinion leaders and national decision makers. Findings were analysed following a thematic inductive approach.ResultsHalf of participants were familiar with PDMC, with a satisfactory understanding of the intervention. Although PDMC was perceived as beneficial by most respondents, there was some unclarity on the target population. Both delivery approaches were perceived as valuable and potentially complementary. From an adoption perspective, relevant evidence generation, favorable policy environment, and committed funding were identified as key elements for the scale up of PDMC.ConclusionsThe findings suggest that although PDMC was perceived as a relevant tool to prevent malaria, further clarification was needed in terms of the relevant patient population, delivery mechanisms, and more evidence should be generated from implementation research to ensure policy adoption and funding.

A Study on General Staffing Services and Manpower Providing Services of QUESS CORP LTD. in Ahmedabad

This research paper presents a comprehensive study of general staffing services and manpower providing services offered by Quess Corp in Ahmedabad. The study aims to explore the operational frameworks, client engagement strategies, and service delivery mechanisms that make Quess Corp a significant player in the staffing industry. Through a combination of qualitative and quantitative research methods, including interviews with company executives, surveys of client companies, and analysis of industry reports, the paper delves into the challenges and opportunities faced by the company in the rapidly evolving employment landscape of Ahmedabad. Key findings indicate that Quess Corp's emphasis on technology- driven solutions, robust training programs, and strategic partnerships has significantly enhanced its service efficiency and client satisfaction levels. Additionally, the study highlights the critical role of adaptive workforce solutions in addressing the dynamic needs of businesses in Ahmedabad. The paper concludes with recommendations for leveraging technological advancements and optimizing human resource management practices to further strengthen Quess Corp's market position. Quess Corp’s general staffing services encompass temporary staffing, contract staffing, and permanent staffing solutions. The company’s comprehensive approach ensures that it can meet the diverse staffing needs of its clients, ranging from short- term project-based requirements to long-term strategic hires. The study explores how Quess Corp tailors its services to suit the specific demands of various sectors, including IT, manufacturing, retail, and healthcare. The company utilizes advanced technology platforms to manage its talent pool, ensuring quick and accurate matching of candidates to job requirements. This technological integration is a significant factor in Quess Corp’s ability to deliver high- quality staffing solutions efficiently

PH-sensitive nanoformulation of acetyl-11-keto-beta-boswellic acid (AKBA) as a potential antiproliferative agent in colon adenocarcinoma (in vitro and in vivo)

BackgroundDeveloping a drug delivery system that can transport a higher concentration to the target cells can improve therapeutic efficacy. This study aimed to develop a novel delivery system for acetyl-11-keto-beta-boswellic Acid (AKBA) using chitosan-sodium alginate–calcium chloride (CS-SA-CaCl2) nanoparticles. The objectives were to evaluate the antiproliferative activity of these nanoparticles against colorectal cancer (CRC) cells and to improve the bioavailability and therapeutic efficacy of AKBA.ResultsWith an extraction efficiency of 12.64%, AKBA was successfully extracted from the gum resin of B. serrata. The nanoparticle delivery system exhibited superior cytotoxicity against HT29 cells compared to free AKBA, AKBA extract (BA-Ex), and 5-FU. Furthermore, the nanoformulation (nano-BA-Ex) induced apoptosis in HT29 cells more effectively than the other treatments. In vivo results showed that nanoformulation inhibited chemically induced colon tumorigenesis in mice and significantly reduced the number of aberrant crypt foci (ACFs).ConclusionsThe developed CS-SA-CaCl2 nanoparticles loaded with AKBA extract exhibit potential as a potent drug delivery mechanism for the colorectal cancer model. Nano-BA-Ex is a promising strategy for enhancing the solubility, bioavailability, and therapeutic efficacy of BA derivatives. With its multiple effects on cancer cells and controlled drug release through nanocapsules, nano-BA-Ex stands out as a compelling candidate for further preclinical and clinical evaluation in CRC therapy.

The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging.

Mitochondria are central to cellular energy production, and their dysfunction is a major contributor to oxidative stress and chronic inflammation, pivotal factors in aging, and related diseases. With aging, mitochondrial efficiency declines, leading to an increase in ROS and persistent inflammatory responses. Therapeutic interventions targeting mitochondrial health show promise in mitigating these detrimental effects. Antioxidants such as MitoQ and MitoVitE, and supplements like coenzyme Q10 and NAD + precursors, have demonstrated potential in reducing oxidative stress. Additionally, gene therapy aimed at enhancing mitochondrial function, alongside lifestyle modifications such as regular exercise and caloric restriction can ameliorate age-related mitochondrial decline. Exercise not only boosts mitochondrial biogenesis but also improves mitophagy. Enhancing mitophagy is a key strategy to prevent the accumulation of dysfunctional mitochondria, which is crucial for cellular homeostasis and longevity. Pharmacological agents like sulforaphane, SS-31, and resveratrol indirectly promote mitochondrial biogenesis and improve cellular resistance to oxidative damage. The exploration of mitochondrial therapeutics, including emerging techniques like mitochondrial transplantation, offers significant avenues for extending health span and combating age-related diseases. However, translating these findings into clinical practice requires overcoming challenges in precisely targeting dysfunctional mitochondria and optimizing delivery mechanisms for therapeutic agents. Continued research is essential to refine these approaches and fully understand the interplay between mitochondrial dynamics and aging.

Cis-regulatory elements driving motor neuron-restricted viral payload expression within the mammalian spinal cord.

Spinal motor neuron (MN) dysfunction is the cause of a number of clinically significant movement disorders. Despite the recent approval of gene therapeutics targeting these MN-related disorders, there are no viral delivery mechanisms that achieve MN-restricted transgene expression. In this study, chromatin accessibility profiling of genetically defined mouse MNs was used to identify candidate cis-regulatory elements (CREs) capable of driving MN-selective gene expression. Subsequent testing of these candidates identified two CREs that confer MN-selective gene expression in the spinal cord as well as reduced off-target expression in dorsal root ganglia. Within one of these candidate elements, we identified a compact core transcription factor (TF)-binding region that drives MN-selective gene expression. Finally, we demonstrate that selective spinal cord expression of this mouse CRE is preserved in non-human primates. These findings suggest that the generation of cell-type-selective viral reagents, in which cell-type-selective CREs drive restricted gene expression, will be valuable research tools in mice and other mammalian species, with potentially significant therapeutic value in humans.

Intranasal Delivery of Lipid Nanoparticles: A Ground-breaking Approach for Brain Targeting

Abstract: In the present scenario, various novel delivery systems are available for drug delivery to systemic circulation. So, to accomplish a greater therapeutic effect, the nature of the drug delivery is very important. This delivery is one of the innovative approaches where the drug is targeted to the brain through the nasal cavity. As we know, the human brain is the most crucial part of the body that controls various functions of our system. So, safely reaching the targeted site of the brain is necessary to achieve brain specificity. This delivery system helps us to tackle the problems that may arise in the other delivery system and helps the drug reach the brain without any difficulties. The major obstacles we faced during this delivery were the blood-brain barrier (BBB) and the brain-cerebrospinal fluid barrier. So, if we target the drug to the brain, then we have to overcome these challenges, and before that, we must have a clear understanding of the targeted site and the mechanism behind the drug targeting. Advancements in science and technology have helped discover many recent strategies and formulations available for intranasal delivery. The development of lipid nanoparticles is one of the primitive approaches for targeting any type of drug(hydrophilic/lipophilic) in the brain. So, the aim of this review mainly focused on the mechanism of intranasal delivery, the devices used, and some recent strategies like the development of lipid nanoparticles, surface-modified lipid nanocarriers, and noseto-brain patches. This review article also includes a few FDA-approved formulations for nose-to-brain delivery and their regulatory aspects related to clinical trials and future perspectives.

Nanotechnology: Current Developments, Applications and Patents for Non-invasive Topical Cosmetics and Dermatological Therapeutic Delivery

: Nanotechnology exhibits the advancement in the field of invention, by improving the potency of the formulation through the delivery of inventive solutions. To resolve several limita-tions related to conventional formulations, nanotechnology applications are increasing in the cosmetics and dermatological area. Cosmetic and dermatological preparations are considered a thriving branch of the body care arena and their usage has increased dramatically through the past years. Scientists are designing innovative delivery mechanisms and emerging innovations that are presently being utilized in the development of cosmetics. Inventive nanocarriers such as nio-somes, liposomes, microemulsions, nanoemulsions, solid-lipid nanoparticles, nanospheres, and nanostructured (lipid) carriers have substituted the use of traditional drug delivery. These innova-tive nanocarriers have the convenience of better skin permeation, sustained and controlled drug delivery, precise location, higher stability, and greater incorporated capability. Since the usage of cosmetics has increased, the usual delivery system has been substituted by modern delivery ap-proaches. The introduction of newer advancements and novel drug delivery systems make cos-metics and cosmeceuticals more popular with increased market share. This review article on nan-otechnology employed in cosmetics and dermatology emphasizes the numerous innovative nanocarriers designed for cosmetic and dermatologic drug delivery, their negative and positive aspects, and their toxicity.

Prospective Approaches of Herbal Novel Delivery System with Special Reference to the Herbal Nanosciences

: Medicinal and culinary uses of plants date back centuries. Projects on a global scale are conducting laboratory research to identify plants with therapeutic properties, with the ultimate goal of developing such compounds into medicines with acceptable drug delivery mechanisms and bringing them to market. Non-synthetic medications derived from plant or herbal sources have attracted a lot of interest because of their high tolerability and low likelihood of adverse medication reactions. All diseases, the theory goes, can be cured by something found in nature. Medicines can be taken in a wide variety of forms, including tablets, capsules, powders, semi-liquid extracts, tinctures, decoctions, medicinal teas, solutions, and more. Longer release, patient adherence, and other objectives necessitate adjustments to herbal medications. Researchers into novel drug delivery systems had hitherto overlooked herbal remedies due to a lack of scientific validation and the challenges inherent in processing, standardizing, extracting, and identifying them. Transdisciplinary research and cuttingedge isolation, purification, and identification techniques have led to the development of novel herbal compositions. Bioactive plant extracts and phytoconstituents are used in a wide variety of Nano- Emulsions, microspheres, transferosomes, implants, and ethosomes. Compared to herbal remedies, novel formulations fared better. Among these advantages are increased solubility, bioavailability, toxicity, pharmacological activity, stability, delivery duration, and resistance to physical and chemical degradation. As a result, the pharmacokinetic and pharmacodynamic properties of herbal medications can be enhanced by the use of novel drug delivery systems, making them safer and more effective. : This article aims to provide a concise description of the many new drug delivery techniques that have been created for the administration of herbal medications. The ultimate goal is to increase the efficacy of therapies and to learn more about their significance and worldwide appeal.

Virtualization of Service Consumer Behavior in Poland – A Post-Pandemic Perspective

ABSTRACT This article explores the impact of the COVID-19 pandemic on the virtualization of consumer behaviors in the Polish service sector, emphasizing shifts in service delivery mechanisms. The pandemic acted as a catalyst, accelerating the adoption of virtual solutions across various sectors including tourism, gastronomy, culture, education, and healthcare, as necessitated by social distancing and other restrictive measures. The article first outlines the integration of digital solutions into various service sectors, focusing on the impact of these technologies on consumer behaviors and service delivery. Next, utilizing an online survey conducted in November 2022 with a sample of 1,100 respondents, whose socio-demographic profile corresponds with that of Polish internet users (Ariadna panel), the study examines consumer perceptions and the effectiveness of digital transformations during the pandemic. The findings indicate a high appreciation among Polish consumers for virtual solutions that improved access to and use of services during restrictive periods. However, the continuation of these virtual engagements post-pandemic appears selective, with significant inclination towards solutions in administrative, food delivery, and telemedical services, while long-term engagement in virtual cultural services is less favored. This study underscores the dual role of necessity and technological advancement in reshaping consumer interactions with service sectors, suggesting a sustained yet selective future for virtual service consumption post-pandemic.

Skin Delivery and Innovative Carrier’s Effectiveness

The skin serves as the body first protecting barrier against the external attacks of chemicals and microorganisms. On the other hand, it is an obstacle to penetration and transdermal delivery of any substance applied on its surface. Thus, a need to report some news on the skin composition for a better understanding of the transdermal delivery mechanisms of topical products applied on its surface. Therefore, due to the actual increased use of topical drugs, cosmetics, and diet supplement treatments, further feasibility research studies have been carried out to extend the knowledge of the percutaneous absorption ‘rules and means. These studies are retained necessary to control the release through the skin layers of various selected active ingredients, loaded and carried out by different vehicles. The paper will focus on the effectiveness of innovative tissue carriers that, are able to deliver active ingredients throughout the skin layers, are made by a very low consumption of water, and are free of chemicals also. In conclusion, these novel eco-sustainable carriers, resulting skin- and environmentally friendly, might be used as innovative vehicles in substitution of the normal emulsions that, made by the use of preservatives, emulsifiers, fragrances, and other chemicals may often cause allergic and/or sensitization phenomena, consuming a great quantity of water also.

A blueprint for success? Exploring business models of additive manufacturing ventures

Additive Manufacturing (AM) was expected to be the next great technological revolution, yet the predicted market growth has fallen short by 40%. Using a proprietary, cross-sectional data set of 350 ventures in the AM field founded between 2000 and 2017, this study analyses AM companies from a business model perspective. Specifically, we explore which value delivery and value capture mechanisms are decisive for AM venture success, measured via their operational and ownership state. We reveal that targeting the B2B market and selling via partner networks significantly increases firm survival likelihood. Further, applying a recurring revenue model increases the likelihood of an IPO. Our main contributions are two-fold: first, our research complements the business model literature by evaluating value delivery and capture in the AM entrepreneurial space, revealing that customer segments, sales channels, and revenue models are key to venture success. Second, we provide business model design guidelines to entrepreneurs as well venture capitalists in the AM field.

Searching for application areas for using AI and VR in the Higher Education classroom in Ireland

The changing landscape of education for all, internationally, has led to education policy and operationalisation mis-matches, we advocate for active learning and critical pedagogy in our modern society but our society and resources are not sufficiently welcoming to adopting emerging hardware and software in the classroom. Resource constraints restrict the move from experiential learning to implementation where resistance is in-built within our culture to hold on to traditional teaching and learning methods and delivery mechanisms. We are familiar and open to science requiring apparatus, but using tools such as virtual reality and artificial intelligence in our everyday teaching and learning is uncommon and warrants further evidence to support its implementation to becoming the norm. Education is the keystone for progress, we promote education as a sustainable, complementary activity to economic social and caring aspects of our society. As an integral part of the UN Sustainable developmental goals how we meet the objectives are contextual and in Ireland we currently adopt a traditional in-person educational experience with many online programmes affiliated with options for lifelong learning rather than mainstream education. Thus the experience of the authors through SEERLab (South East Education Research Lab) to design and develop teaching and learning artefacts is presented in this paper. SEERLab focuses on strategies to build a sense of community in HE (virtually) of educationalists who through their own learning experiences gain empowerment to dramatically change the classroom composition, using both physical hardware (VR headsets) and software (AI) to accentuate critical thinking and immersive learning in the classroom. There is evidence to support the use of VR in the classroom toward enhanced engagement of students (Kavanagh et al., 2017 and Campos et al., 2022). However, the emergence of new education policies based on data, learning analytics, tertiary market demand and access is not easily understood in our communities. We purport that educationalists need to embrace change at HE to administer and deliver curriculum using non-standard applications. This research initiated by lecturers in the design of pilots to meet learning outcomes through using VR is gathering evidence to further develop HE policy using VR in the classroom. There are tensions in global societal research discourses in relation to emerging technologies such as AI and scant social scientific research on societal attitudes towards AI; its value and limitations in education, fears and emotions about AI technology which requires redress. Without guidance lecturers advocating for the use of VR and AI in the classroom are challenged to demonstrate understanding the socio-cultural legitimacy of AI in Irish society. We present the cases of SEERLab that has been established to scaffold educationalists toward enhancing their attitudes towards VR and AI. These challenges can be overcome using an innovative pedagogical approach to link the needs of teachers and lecturers and students to untangle the complexity of emerging technology and deliver educational solutions globally and nationally. The pilot cases presented include modules from Nursing, Business and PhD postgraduate programmes. The piloting of this technology is moving to implementation stage and along with evidence from open educational communities we present the potential benefits and limitations of VR and AI in HE classrooms, which can lead to engaged students, innovative pedagogies, misperceptions, heightened sense of risk, inertia and resistance to its adoption. Universities, governments and organizations can work together to raise awareness about VR and AI through education and outreach initiatives aimed at different student cohorts but this necessitates greater knowledge in relation to accessibility, usability and educational ‘buy in’ and exposure to VR and AI technologies that combine scientific expertise with pedagogical know-how.

Predicting future adoption of early-stage innovations for smart farming: A case study investigating critical factors influencing use of smart feeder technology for potential delivery of methane inhibitors in pasture-grazed dairy systems

Globally, livestock farmers are challenged with reducing greenhouse gas emissions to mitigate climate change. A potential option for pasture-based dairy farmers involves including methane-inhibiting compounds in the diet. A novel approach to deliver these compounds with the required frequency and precision is via smart-feeders, an existing smart farming technology used to feed supplements automatically to animals in-paddock. For this innovation to be successful, however, it must integrate with farm systems and provide farmers with a positive value proposition. The aim of this study was to examine the farm system and technology factors influencing potential uptake of in-paddock smart technologies for delivering methane inhibitors in pasture-grazed systems. We utilized an adoption prediction tool (ADOPT) to model the adoption outcomes of smart-feeders as methane inhibitor delivery mechanisms on dairy farms, with input from industry experts and farmers via focus groups. The results indicated low adoption of smart-feeders in a pasture-based system context. This was further explored with a sensitivity analysis of seven critical ADOPT factors which were identified as influential through the farmer focus groups. We modelled the impact of the seven critical ADOPT factors for two smart-feeder concepts to evaluate their relative adoption potential. The adoption modelling showed that while factors such as technology cost and function were important, adoption would also be highly influenced by future regulation settings, innovation uncertainty, and the alignment with farmer values and worldviews about their farm system. This research highlighted that in-paddock delivery technology, and processes for its use on-farm, represents an early-stage innovation and therefore is vital that farmers and other stakeholders are involved in further development to ensure adoption factors are addressed.

Ribavirin in Modern Antitumor Therapy: Prospects for Intranasal Administration.

Ribavirin has been used as an antiviral agent to treat a variety of viral infections since the 1970s. Over the past few decades, studies have been conducted on the pharmacology of ribavirin, and the possibility of its use in new indications has been explored. According to the results of a number of studies, ribavirin efficacy in the therapy of malignant neoplasms of various genesis has been proven. Furthermore, due to the complexity of brain tumor therapy using surgical methods, targeted delivery of ribavirin to the brain becomes a promising alternative to existing treatment methods. Targeting of active pharmaceutical ingredient (API) to the brain tumor is achieved by intranasal drug delivery via a Nose-to-Brain mechanism. In addition, using this delivery mechanism, it is possible to reach the brain while bypassing the blood-brain barrier (BBB), thus avoiding the effects of the first passage through the liver. Despite the significant advantages of the method, there are limiting factors to its application - mucociliary clearance, which aims to remove foreign bodies from the surface of the nasal mucosa. In situ, systems are able to reduce the intensity of interfering factors on API and allow the achievement of maximum bioavailability during intranasal administration.

Exploring Research on the Drug Loading Capacity of Quantum Dots.

Quantum dots (QDs), also known as quantum nanodots or colloidal nanocrystals, possess unique visual and electrical properties that have enabled various applications in biomedicine, particularly in drug delivery. Quantum dots offer significant advantages, such as a high surface area for drug attachment, the ability to modify solubility and drug release patterns, and the potential for targeted delivery. This review covers various aspects of QD research, including their synthesis, properties, and the challenges associated with their use. Key challenges include concerns about QD toxicity, stability, and environmental impact. Additionally, the article discusses using quantum dot-Förster resonance energy transfer (QD-FRET) to study in vivo drug release kinetics. This capability is essential for evaluating the performance of QDs as drug carriers and understanding their interactions within biological systems. In summary, while QDs present promising opportunities for advancing drug delivery mechanisms, ongoing research is necessary to mitigate toxicity concerns and enhance their biocompatibility, paving the way for their clinical application in targeted therapies.