Clinical evidence suggests that various problem behaviors in adolescence can be expressions of dysphoria that have not reached threshold for the diagnosis of depressive disorders. Formulations of two major types of dysphoria distinguish between disruptions of interpersonal relatedness (e.g., feelings of loss or abandonment) and diminished self-esteem (e.g., feelings of self-criticism, failure, or guilt). Adolescents in a suburban high school were given the Achenbach Youth Self-Report, the Adolescent Depressive Experiences Questionnaire, and the Community Epidemiological Survey of Depression for Children (CES-DC). Even after level of depressive symptoms (CES-DC) was partialled out in hierarchical multiple regressions, interpersonal dysphoria significantly accounted for additional variance in predicting internalizing disorders, while self-critical dysphoria added significantly to the explained variance of both internalizing and externalizing disorders, specifically delinquency and aggression in both males and females.