The liquefaction in saturated sands under blast loading is an important research topic in geotechnical engineering. The effect of blast loading on the liquefaction characteristics of saturated sands was studied through a large-scale millisecond delay blasting (MDB) liquefaction field test. Based on the field test, a numerical model was established by the LS-DYNA finite element program to study the propagation of blast waves and the effects of explosive mass, scaled distance, and blast delay on the liquefaction characteristics of saturated sands. The results show that there was a significant sand boiling phenomenon in saturated sands under blast loading, and high values of the excess pore water pressure ratio were observed at monitoring points during the field test. The numerical simulation results show that the scaled distance and the blast delay significantly affected the excess pore water pressure. While the blast delay increased from 110 ms to 330 ms, the excess pore water pressure of the central area can increase by more than 18%. Based on the field and numerical tests, an empirical equation is established that can take into account both the scaled distance and blast delay, which provides a theoretical basis for future large-scale liquefaction sites by MDB.