Degree Of Inflammatory Reaction Research Articles

Treatment of Prostatitis in the Rat

A spontaneous, nonacute, age-dependent prostatitis was found in a high incidence in the lateral prostatic lobes of Lewis rats. Such rats were treated with methylprednisolone, indometacin , testosterone, hexyloxyphenylproprionate , polyestradiol phosphate, various antibiotics, or were caged together with female rats. The effect of the different treatment modalities was evaluated microscopically by blind observation of the degree of inflammatory reaction in the lateral prostate. Methylprednisolone and the testosterone ester caused a reduction of the inflammatory reactions and so did caging with female rats. The similarity of the rat prostatitis to the human condition may suggest the possibility of using corticosteroids or androgens for the treatment of patients with nonacute prostatitis.

Experimental evaluation of bladder closure techniques

Two methods of bladder closure have been evaluated in dogs. A conventional two-layer closure including the mucosa and a single layer running horizontal mattress extramucosal closure have been compared. Observations including adequacy of healing, strength of scar, degree of inflammatory reaction, and degree of bladder adhesions have been made. The extramucosal running horizontal mattress closure appears to approach the ideal bladder closure.

Mallory bodies in liver biopsies with fatty changes but no cirrhosis. A morphological, biochemical and clinical investigation.

A comparison of histologic and biochemical parametres between 16 patients with fatty change of the liver and Mallory bodies and 67 patients with fatty change without Mallory bodies is performed. Greater activity expressed by the number of liver‐cell necroses, degree of inflammatory reaction, fibrosis of the parenchyma, and transaminase elevation is found in the group with Mallory bodies. The importance of Mallory bodies for the development of fatty change into cirrhosis is discussed, and the importance of a follow‐up investigation is stressed.

Treatment of eczema with cortisone ointment.

IT HAS BEEN demonstrated that systemic administration of cortisone or corticotropin (ACTH) improves atopic eczema 1 in the majority of cases and that cessation of treatment is almost invariably followed by a relapse. Continued treatment with maintenance doses may delay such relapses but would be too costly and not without risk. For these reasons, systemic treatment of eczema with these hormones has not been recommended. 1i Cortisone injected intradermally together with tuberculin has been shown 2 to suppress the skin reaction to tuberculin in sensitized persons and to decrease itching as well as the degree of inflammatory reaction. The question arose whether local action of cortisone could be utilized for the treatment of eczema. If it was possible to avoid large systemic doses and to apply cortisone to the skin in such a way that sufficient quantities would be absorbed locally, therapeutic results could be anticipated without