Knowledge of the genetic factors which influence eye color in guinea pigs has developed parallel to the study of the inheritance of coat color. Castle and Allen (1903) showed that albinism in the guinea pig was due to a recessive factor ca, wh:ch greatly reduced the pigment in the skin, hair, and eyes. The allelomorphic series C, ck, cd, cr, and ca, representing degrees of albinotic dilution, was described by Wright (1915, 1923). He showed that the factor cr was responsible for the absence of red pigment in the coat, and for a certain translucence of the iris whiclh gave the eye a reddish gleam in strong light. The factor C represented the h!ghest degree of intense pigmentation in the hair and eye, while the factors ck and cd represented degrees of dilution intermediate between C and cr. Bogart and Ibsen (1937) recognized black and chocolate pigments as two different kinds of granules. They found both granular and diffuse pigments present in the hair, and they interpreted the actions of the factors in terms of relative amounts of diffuse and granular pigments in the hair. Following the work of Bogart and Ibsen (1937), Harman and Case (1941) studied the development and histology of the skin and hair in a number of genetic types of guinea pigs. They observed red granules in red hairs, and were able to explain the action of the extension factors in terms of the kind, rather than the amount of pigment granules in the hair. Genetic factors which have been studied primarily with regard to their influence upon eye color include the recessive factor p (pink eye) described by Castle (1912), and the recessive factor sm (salmon eye) studied by Gregory and Ibsen (1926). The factor p has a marked diluting effect upon the black and chocolate pigments of the coat. Ibsen (unpublished) has since shown that the factor sm has a slight diluting effect upon these pigments, and that both factors dilute red pigment to some extent. Sollas (1909) described the eyes of chocolate guinea pigs as ruby in 'color, indicating that they were more brownish than the eyes of black guinea