Degree Of Compensation Research Articles

Frontal Sinus Volume in Normocephalic Nonsyndromic Sagittal Craniosynostosis: A Comparative Study.

This study aimed to investigate frontal sinus volume as a potential indicator of cranial compensatory growth in unoperated normocephalic nonsyndromic sagittal craniosynostosis (NNSC) patients compared with age-matched and sex-matched controls. Previous studies have suggested that frontal sinus volume is suppressed in unoperated craniosynostosis and may be an intracranial space conservation phenomenon. Head computed tomographies (CTs) from 22 unoperated NNSC patients at our institution were utilized in this study and matched with age-matched and sex-matched control subjects. Frontal sinus volumes were measured using Syngo.Via, and statistical analysis was performed. Inclusion criteria for patients included the presence of a frontal sinus with unoperated sagittal craniosynostosis, whereas inclusion criteria for controls included the presence of a frontal sinus and no craniofacial trauma. Pearson correlation coefficient and significance values were calculated to evaluate the relationship between frontal sinus volume and craniosynostosis. Six of 22 patients with NNSC were found to have the presence of a frontal sinus volume, compared with controls where all patients had the presence of a frontal sinus. When compared with age-sex matched controls, our analysis revealed a Pearson correlation coefficient of 0.993 and a high significance of P < 0.001, indicating a strong association between decreased-to-absent frontal sinus volume in unoperated NNSC patients. The findings of this study demonstrate a correlation between decreased-to-absent frontal sinus volume in patients with NNSC in comparison to normal controls. These findings highlight the potential utility of frontal sinus volume as a diagnostic tool in identifying the degree of compensation that the skull has undergone in nonsyndromic sagittal craniosynostosis.

Prognostic analysis of endovascular mechanical thrombectomy in stroke patients with acute internal carotid artery obstruction based on circle of Willis variation.

Endovascular mechanical thrombectomy (EVMT) is widely employed in patients with acute intracranial carotid artery occlusion (AIICAO). This study aimed to predict the outcomes of EVMT following AIICAO by utilizing anatomic classification of the circle of Willis and its relative position to the thrombus. In this study, we retrospectively analyzed a cohort of 108 patients with AIICAO who underwent endovascular mechanical thrombectomy (EVMT) at Shaoxing People's Hospital. Based on variations in the circle of Willis, as well as the size and location of the thrombus occluding the middle cerebral artery (MCA), anterior cerebral artery (ACA), and posterior cerebral artery (PCA), we classified AIICAO into four grades using digital subtraction angiography (DSA). EVMT was initiated upon admission, and baseline data including demographic characteristics, vascular risk factors, angiographic features, initial National Institutes of Health Stroke Scale (NIHSS) scores, Alberta Stroke Program Early CT Score (ASPECT), and etiology classification were compared across these four grades. The prognosis and mortality rates at 90 days post-stroke were evaluated for the different grades and within each grade, patients were further categorized into two subtypes based on vascular compensation and occluded vessels. Significant differences were observed among the four grades of Willis compensation concerning etiologic classification (p = 0.008), postoperative modified treatment in cerebral ischemia (mTICI, p = 0.017), postoperative symptomatic intracranial hemorrhage (sICH, p = 0.007), NIHSS score at admission (p = 0.001), and favorable outcomes at 90 days (modified Rankin Score 0-2) (p = 0.003). The mortality rate at 90 days exhibited a significant difference across the four grades of Willis compensation (p = 0.05). However, prognosis did not reveal any significant differences among the various subtypes within the same grade (p > 0.05). The assessment of the degree of Willis compensation can be improved by evaluating the integrity of the circle of Willis, as well as the size and location of the clot in cases of isolated internal carotid artery occlusion (iICAo). This approach provides valuable prognostic indicators and important insights for the pre-selection of patients prior to endovascular mechanical thrombectomy (EVMT).

Induction arrow spatial and temporal variations

The induction arrow C is a characteristic of the variable geomagnetic field at one observation point (x, y) for a certain period T of geomagnetic variations B. It visually describes the magnitude and direction of the deviation of the geomagnetic field vector from the horizontal plane. The induction arrow is nonzero only when the vertical component Bz appears. Bz appears in three cases: 1) electrical conductivity’s horizontal gradients under the surface of the globe; 2) incomplete compensation of the vertical component of the primary field of the ionosphere-magnetosphere source by the secondary field induced in the horizontally layered Earth. The degree of compensation systematically changes during the day, year..., leading to temporal variations in the induction arrow (source effect); 3) the appearance of not-removed noise or lithosphere emission containing Bz. This article presents the spatial and temporal variations of the induction arrows. Real (in-phase) and imaginary (out-of-phase) induction arrows (vertical response functions or tippers) were obtained for every day with proper observations from 1991 to 2014 years for five intervals of periods: 150—300 s, 300—600 s, 600—1200 s, 1200—2400 s, 2400—3600 s, calculated from three components of geomagnetic field recorded at 137 observatories of the global network INTERMAGNET. To reduce the scatter, the daily values were recalculated to monthly values. Such global material from +87° to –88° of geomagnetic latitude was obtained for the first time and its analysis yielded new scientific results. The annual variations (with a period one year) are visible at about 2/3 of the observatories (at the other observatories, they are below the background level of shorter period variations and/or noise). Its amplitude strongly depends on the geomagnetic latitude and sometimes reaches such a high value as 0.4—0.5 (peak-to-peak) at high (&gt;65°) latitudes and varies within 0.01—0.15 at middle and low latitudes. Previous studies at middle latitudes discovered that the annual variations in the northern component Au is positive everywhere (maximum in June, minimum in December) and proposed, as a global source model for the annual variations explanation, the ring current at the height 3―6 Earth’s radii. We discovered that at high latitudes, Au is usually negative. We propose to explain all the observed features of the induction arrow’s annual variations by variations of the ionosphere currents in the aurora zone. 11-year variations are found at ≈30 % of observatories located at all latitudes but more frequently in aurora zones. At a few observatories, trends (monotonous changes in arrows) were found. The largest trend of magnitude 0.2 for all periods was found in southern Greenland, where glaciers have been melting rapidly over the past 30 years, which makes it possible to associate both trends with global warming. In a few aurora observatories of North America trends of magnitude ≈0.1 were noticed. In these same years, the North Magnetic Pole unusually rapidly migrated for 1100 km in 23 years. It can be assumed that these trends are related to changes in the aurora oval position. At geomagnetic latitudes from –78° to +78°, the main harmonic (24 hours=86400 s) of daily variations of the geomagnetic field is always accompanied by at least one higher order harmonic 24/n (n=1÷7). At higher latitudes &gt;78° of both hemispheres only the fundamental 24-hour harmonic is visible. Induction arrow temporal variations create difficulties in determining its constant component used to study the electrical conductivity of the Earth’s crust and upper mantle but can be very useful for geodynamic processes study

Video head impulse test (vHIT) unravels the hidden pathology in chronic vestibular deficit

BackgroundThe caloric test is persistently altered in chronic peripheral vestibular hypofunction (PVH). So, we cannot depend on it to measure the degree of compensation in chronic vestibulopathy patients who are still complaining. So our aim was to assess the utility of vHIT to discover the unrevealed pathology in those patients. Our study included 20 subjects with unilateral chronic PVH who were still complaining (study group) and 20 healthy volunteers (control group). Videonystagmography (VNG) and video head impulse test (vHIT) were applied to all the subjects.ResultsVNG and caloric test results showed compensation signs in the study group. The caloric test indicated unilateral weakness in the affected side. According to vHIT results, a comparison between the affected lateral canal, contralateral healthy lateral canal among the study group, Rt. lateral canal, and Lt. lateral canal among the control group revealed no significant difference (P = 0.789), while comparing anterior and posterior canals showed significant differences (P = 0.005, 0.025) respectively.ConclusionThe caloric test assesses only the horizontal semicircular canal and it is persistently altered in unilateral chronic PVH. So, we cannot depend on it to measure the degree of compensation in chronic vestibulopathy patients who are still complaining nor to detect unrevealed pathology regarding ant or post semi-circular canal. So we can use the vHIT test to discover the unrevealed pathology in those patients.

Quantifying and Zoning Ecological Compensation for Cultivated Land in Intensive Agricultural Areas: A Case Study in Henan Province, China

Cultivated land ecological compensation (CLEC) is an important way to solve regional development imbalance and cultivated land problems, and the scientific quantification of the ecological value of cultivated land is the key to CLEC. This study quantified the total amount and urgency of CLEC in China’s main grain-producing region using the cropland ecological footprint (EF) and ecosystem service value (ESV) methods. Furthermore, this study analyzed the comprehensive zoning of CLEC considering natural and economic development. The results showed that the spatial distribution of EFs and the ecological carrying capacity of cultivated land in Henan Province are similar, presenting the spatial characteristics of being high in the southeast and low in the northwest; the cultivated land in most of the counties and districts is in a state of ecological surplus, and the cultivated land resources are sufficient to support their own consumption needs. Henan Province as a whole is an ecologically compensated region, with a compensation amount of CNY 1.39 billion, and the total amount of compensation is in a positive value of 94.94%. The Southwest Yu and North Yu economic zone of Henan are the areas of high and low values of cultivated land compensation. The priority compensation region is the most extensive and widely distributed type in the five regions of Henan Province, accounting for 55% of the counties and districts. The degree of compensation is most urgent in the Huanghuai, Southwest Yu, and North Yu economic zones. This study’s findings provide new ideas for the development of differentiated ecological compensation policies, and provide references for the participation of multiple market participants and the diversification of compensation forms.

Perinatal HIV infection and opportunistic infectious pathology: morphological features of the placenta

Opportunistic infections account for more than 90% of all deaths associated with immunosuppression resulting from exposure to the human immunodeficiency virus (HIV). Fatal opportunistic infections include Pneumocystis pneumonia, cryptococcosis, cytomegalovirus infection, and viral hepatitis B and/or C. HIV-infected pregnant women have a high incidence of cytomegalovirus infection, which increases the risk of transplacental transmission of HIV from mother to fetus. In addition, an important factor in perinatal transmission of HIV is a genital infection caused by herpes simplex virus type 2 detected during pregnancy in HIV-infected women. Also, at present, there is no doubt about the possibility of damage to placental cells by the SARS-CoV-2 virus and its transplacental transmission.The aim of this study was to study the morphological features of the placenta in the presence of opportunistic infections caused by viruses of the herpes family (herpes simplex viruses types 1/2, cytomegalovirus, Epstein-Barr virus), as well as SARS-CoV2 in HIV-infected pregnant women.Materials and methods. A study was conducted of 21 placentas with various pregnancy outcomes in HIV-infected women, including 12 placentas obtained as a result of term birth, 1 placenta from premature birth at 29 weeks, and 8 observations of failed miscarriages (non-developing pregnancy).Results and discussion. Viral lesions were represented by the action of HIV with giant cell metamorphosis of trophoblast cells and placental macrophages, as well as infiltration by immunocompetent cells and fibrosis of the villous stroma. In addition, groups of immature villi were identified, the edematous stroma of which contained an increased number of large cells with light nuclei. In HIV-infected pregnant women with immunosuppression, the outcome of pregnancy in 8 cases was a miscarriage with a morphologically detected and immunohistochemically confirmed infection caused by herpes simplex virus types 1/2 (3 observations), cytomegalovirus (2 observations), and SARS-CoV-2 (3 observations), in 1 case the outcome of pregnancy was premature birth with morphologically identified and immunohistochemically confirmed infection caused by the Epstein-Barr virus.Conclusion. The placentas of HIV-infected pregnant women are characterized by impaired villous maturation with stromal fibrosis, which is the morphological substrate of chronic placental insufficiency with varying degrees of compensation. If HIVinfected pregnant women have opportunistic infections caused by viruses of the herpes family (herpes simplex viruses types 1/2, cytomegalovirus, Epstein-Barr virus), as well as SARS-CoV-2, pronounced involutive-dystrophic changes are observed in the placentas — perivillous deposition fibrinoid, petrification, which increases the likelihood of an unfavorable pregnancy outcome in the form of miscarriage or premature birth.

Aerobic exercise elevates perceived appetite but does not modify energy intake over a 3-day postexercise period: A pilot study.

While a low degree of energy compensation is typically reported over the 24 h following a session of exercise, the prolonged impact of a bout of exercise on energy intake remains unclear. To overcome the challenge associated with accurately measuring energy intake in a free-living environment, this study employed the use of a meal replacement beverage to assess the 3 day impact of an exercise session on energy intake. In a randomized, crossover study, 14 participants (8 male, 6 female) completed two trials: (1) EX: 75 min exercise on a motorized treadmill (75% VO2peak); and (2) SED: 75 min sedentary control session. Each condition was followed by 3 days of exclusive adlibitum consumption of a meal replacement beverage. Appetite-regulating hormones, subjective appetite, energy intake, and energy expenditure were assessed. Exercise transiently suppressed the orexigenic hormone acyl-ghrelin (p < 0.05) and elevated the appetite-supressing hepatokine GDF-15 (p < 0.05). Despite these acute changes, overall perceived appetite was elevated over the 3 day assessment period with exercise (p < 0.05). No increase in energy intake or change in postexercise physical activity patterns were observed. One acute session of moderate to vigorous exercise is unlikely to affect short-term, three-day energy balance in healthy individuals.

Application of lysine as a potential alternative to sodium salt in frankfurters: With emphasis on quality profile promotion and saltiness compensation

This study aimed to investigate the effect of lysine (Lys) on quality profile promotion and saltiness compensation in reduced‑sodium salt frankfurters. The results showed that the cooking loss of reduced‑sodium salt frankfurters decreased from 5.63 to 3.45% when the Lys level increased from 0.1 to 0.7%, as well as enhanced water contents and saltiness in a Lys dose-dependent manner. Moreover, the corresponding peak area percentage (A21) of reduced‑sodium salt frankfurters remarkably increased from 79.63% to 81.48% with the increased level of Lys. However, a higher level of Lys (≥ 0.5%) obviously reduced the textural properties of reduced‑sodium salt frankfurters, which was clearly verified by looser and rougher microstructures. Furthermore, hydrogen bonds were found to be the dominant molecular force in Lys-added reduced‑sodium salt frankfurters. Meanwhile, 0.3% Lys was found to exhibit the optimal sodium salt-replacing effect due to the highest degree of quality profile promotion and saltiness compensation. Additionally, directional triangle sensory evaluation further confirmed that the reduced‑sodium salt frankfurters treated with 0.3% Lys was perceived to be similar to control frankfurters, resulting a 50% salt-reduction effect. Thus, our results suggested that Lys could be applied as an efficient sodium salt alternative in reduced‑sodium salt frankfurters.

Сравнение характеристик линий высокого и сверхвысокого напряжений при выборе параметров управляемого устройства продольной компенсации

The use of series compensation devices leads to an increase of the transmission line capacity. However, it also increases the risk of an oscillatory violation of the stability of the electric power system. Cumulative hunting and self-excitation of the system is observed in the systems with controlled series compensation devices with a high degree of capacitive compensation. It is known that automatic excitation control of generators partially eliminates the negative effect of series capacitive compensation on oscillatory stability. Therefore, when choosing the tuning parameters of controlled devices, it is necessary to consider their combined effect on the system modes. The developed methods to study steady-state stability make it possible to analyze the modes of power systems with controlled power transmission of various voltage levels. Thus, it is advisable to conduct a comparative analysis of the influence of the adjustable parameters of the series compensation device on the steady-state stability of systems of various voltage levels, considering synchronous generators automatic excitation control. Methods of mathematical modeling of the electric power system, the theory of long-distance power lines and electromechanical transients, methods of analyzing the stability of electric power systems are used. The original software in the C ++ programming language has been used as a modeling tool. The choice of controlled series compensation device and the automatic excitation control regulation laws parameters is made, provided that steady-state stability is maintained. The stability regions of the studied electric power-engineering system are constructed depending on the tuning parameters of the considered devices of various voltage levels. A comparative analysis of the characteristics of the modes of high and extra-high voltage lines has been carried out. The regulation coefficients values of controlled series compensation device and automatic excitation of generators have been determined, under which there is no violation of oscillatory stability for different voltage levels. The conducted comparative analysis of the characteristics of high and extra-high voltage power lines demonstrates the need to consider the power transmission rated voltage when comprehensively selecting the tuning parameters of the controlled series compensation device and the automatic excitation control regulator.

A 42-year-old woman with abnormal uterine bleeding—leiomyoma (AUB-L) reporting a hemoglobin of 1.6 g/dL: a case report

BackgroundAbnormal uterine bleeding, formerly known as menometrorrhagia, is estimated to occur in up to one-third of women, commonly at menarche or perimenopause. Among many other causes, abnormal uterine bleeding is known to be caused by leiomyomas, and is itself a leading cause of severe iron deficiency and iron deficiency anemia in women. Rarely, abnormal uterine bleeding can lead to critically low hemoglobin values of less than 2 g/dL. We report here a case of a woman with abnormal uterine bleeding caused by leiomyomas presenting with severely low hemoglobin.Case presentationWe report the case of a 42-year-old Asian American woman who presented to the emergency department with chronic abnormal uterine bleeding and symptoms of anemia, including multiple syncopal episodes and abnormally pale skin but otherwise alert and oriented. Laboratory tests found a record-low hemoglobin of 1.6 g/dL and hematocrit of 6%. Transabdominal pelvic ultrasound revealed a lower uterine segment/cervical fibroid measuring 7.5 × 5 × 7.8 cm (length × depth × width). Patient was diagnosed with abnormal uterine bleeding–leiomyoma and received five units of packed red blood cells, one unit of fresh frozen plasma, Venofer infusions, tranexamic acid, and medroxyprogesterone. She was discharged from the hospital after 4 days.ConclusionTo date, only a handful of cases have been reported of female patient survival following severely low hemoglobin caused by abnormal uterine bleeding. This case adds to this literature, highlighting the remarkable degree of compensation that can lead to an alert, ambulatory, and oriented patient with abnormal uterine bleeding caused by leiomyoma.

Evaluation of the soft tissue facial profile in different skeletal malocclusions in relation to age

BackgroundThe aim of the study was to assess the thickness of the soft tissue facial profile (STFP) in relation to the skeletal malocclusion, age and gender.MethodsAll patients, aged 7–35 years, who were seeking orthodontic treatment at the Department of Orthodontics, Medical University of Warsaw between 2019 and 22 were included in the study. All patients had lateral head radiographs taken before the treatment. The cephalometric analysis was performed including the STFP analysis. The patients were allocated to one of six groups based on age and skeletal relations (ANB angle). The minimum number of patients in each group was 60 with equal gender distribution. The STFP analysis included ten linear measurements.ResultsA total of 300 patients were included in the study and allocated to five groups. Group 6 (growing patients with skeletal Class III malocclusion) was not included in the study as it failed to achieve the assumed group size. There were significant differences in the thickness of the STFP in relation to the skeletal malocclusions. Adults with skeletal Class III malocclusion had significantly thicker subnasal soft tissues compared to patients with skeletal Class I and Class II malocclusions. The thickness of the lower lip in patients with Class II skeletal malocclusion was significantly bigger compared to the other groups. Children and adolescents with Class II malocclusions had thicker lower lip in comparison to the group with Class I malocclusion. The majority of the STFP measurements were significantly smaller in children and adolescents compared to adults. The thickness of the STFP in males was significantly bigger in all age groups compared to females.ConclusionsThe thickness of facial soft tissues depends on the patient’s age and gender. The degree of compensation of the skeletal malocclusion in the STFP may be a decisive factor during orthodontic treatment planning regarding a surgical approach or a camouflage treatment of skeletal defects.

Bone remodeling parameters in patients with type 1 diabetes mellitus and diabetic peripheral polyneuropathy of varying severity

BACKGROUND: Diabetic peripheral polyneuropathy (DPPN) is a common and early chronic complication of diabetes mellitus (DM). This complication can be associated with bone tissue damage and low-trauma fractures, particularly in type 1 DM. Therefore, evaluating the relationship between DPPN and bone metabolism parameters is crucial for clinical practice.AIM: To assess bone remodeling parameters in patients with type 1 DM with varying degrees of DPPN.MATERIALS AND METHODS: The study included 90 patients with type 1 DM and DPPN aged 18 to 55 years on stable insulin therapy for the past 3 months. Assessment was conducted for levels of HbA1c, 25(OH)D, total calcium (Ca), phosphorus (P), parathyroid hormone (PTH), osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX), fibroblast growth factor 23 (FGF-23) in serum. The degree of neurological deficit was determined using the Neuropathy Disability Score (NDS), Neuropathy Symptoms Score (NSS), and Michigan Neuropathy Screening Instrument (MNSI). Dual-energy X-ray absorptiometry (DXA) was performed to determine bone mineral density (BMD) and trabecular bone score (TBS).RESULTS: Regardless of the degree of DPPN severity, patients with type 1 DM were comparable in HbA1c and 25(OH)D levels. A direct correlation was found between the severity of neurological disorders and BMI (r=0.214; p=0.044) and duration of DM (r=0.246, p=0.019). Vitamin D insufficiency and deficiency were diagnosed in 79% of examined patients with type 1 DM, but the level of 25(OH)D in serum did not depend on the degree of DPPN severity, HbA1c level, duration of DM, and daily insulin dose (p&gt;0.05). A positive correlation was established between PTH level and severity of neurological symptoms, and a ­negative one with HbA1c level. Patients with type 1 DM and varying degrees of DPPN did not differ in BMD and TBS. A Z-score of less than -2.0 SD was only recorded in six patients, and partially degraded microarchitecture of bone tissue was observed in 8 patients.CONCLUSION: Therefore, BMD, TBS, and bone remodeling markers in patients with type 1 DM and DPPN were independent of the degree of neurological deficit, degree of compensation, and duration of DM. Vitamin D deficiency is common in most patients with type 1 DM, but the 25(OH)D level is not influenced by HbA1c level, duration of the disease, and daily insulin dose.

AT-rich interactive domain-containing protein 1A (ARID1A) expression in placentas with late fetal growth restriction

BACKGROUND: Fetal growth restriction, which is considered as a multifactorial pathology, is a critical problem in obstetrics. The role of mitochondrial dysfunction in the pathogenesis of fetal growth restriction is not yet clear. However, it is known that it leads to oxidative stress, damage to cells and tissues, and dysfunction of key mechanisms for maintaining energy balance, the outcome of which may be the development of placental insufficiency. It is likely that AT-rich interactive domain-containing protein 1A (ARID1A) is involved in the development and function of the human placenta and may be an important marker in the development of fetal growth restriction. AIM: The aim of this study was to evaluate ARID1A protein expression in the placental villous tree in late fetal growth restriction. MATERIALS AND METHODS: This study included 50 placentas from children born at full-term gestation (37–40 weeks). The main study group consisted of placentas with late fetal growth restriction and without major extragenital pathology (n = 35). The control group comprised 15 placentas without fetal growth restriction (n = 15). Histological (n = 50) and immunohistochemical examinations of placentas (15 placentas in the main group and 10 placentas in the control group) using primary monoclonal antibodies to ARID1A were performed. RESULTS: In the study group with fetal growth restriction, chronic placental insufficiency was verified in all cases, dissociated chronic placental insufficiency (25 cases; 71.4%) being predominant, of which 23 cases (92%) were compensated, including 16 cases (69.6%) with moderate circulatory disorders. Hypoplastic chronic placental insufficiency was diagnosed in ten cases (28.6%) and was subcompensated with the presence of pronounced circulatory disorders. In the arteries of the stem villi, the ARID1A protein expression area did not differ between the study groups (p = 0.096), while in the veins in the stem villi with fetal growth restriction, we verified a decrease compared to control (p = 0.05). In the vascular bed of the villi with subcompensated dissociated chronic placental insufficiency, ARID1A protein expression was higher compared to hypoplastic chronic placental insufficiency (p = 0.041). CONCLUSIONS: Chronic placental insufficiency combined with fetal growth restriction is a serious complication of pregnancy with the development of structural and functional abnormalities and dysregulation of placental mechanisms. The ARIDA1A protein expression data obtained, depending on the degree of compensation for chronic placental insufficiency, may indicate the activation of compensatory metabolic mechanisms to maintain the functional activity of the placenta and preserve the viability of the fetus.

The phenomenon of drug-coating embolism during lower extremity endovascular interventions with paclitaxel-coated balloon.

There is a risk of distal embolization lower extremity endovascular interventions. Possibly a drug-coating embolism caused by coating detachment from intravascular devices. This review focuses on providing updated information on distal embolism in endovascular revascularization of lower extremity arteries, including the use of drug-coated balloons. Drug-coating embolism is a special case of distal embolization during recanalization of the arteries of the lower extremities. Preclinical studies have demonstrated embolization of drug-coated balloons during angioplasty of lower extremity arteries. However, the clinical role of drug-coating embolism is not completely clear. A 2020 meta-analysis found an increased risk of major lower extremity amputation after drug-coated balloon angioplasty in patients with critical limb ischemia. But long-term research is emerging to support the safety of using these devices. Perhaps a more thorough assessment of the quality of life and the degree of compensation of lower limb ischemia with an intraoperative assessment of the frequency of peripheral embolizations using ultrasound emboli detection, as well as microcirculation with transcutaneous oximetry and laser Doppler flowmetry of the operated lower limb will allow a more detailed study of the phenomenon of drug-coating embolism and its impact on long-term clinical outcomes. According to the results of preclinical studies, the use of paclitaxel-coated balloons leads to an increase in the concentration of paclitaxel in distal skeletal muscles. However, paclitaxel concentration in skeletal muscle was significantly higher in first-generation DCBs. The non-target effects of drug-coating balloon are not fully understood and require further study. Understanding the phenomenon of drug-coating embolism can help physicians to better assess the patient risk and to minimize complications.

Is spinopelvic compensation associated with unstable gait?: Analysis using whole spine X-rays and a two-point accelerometer during gait in healthy adults

BackgroundPelvic incidence (PI)–lumbar lordosis (LL) mismatch has a significant destabilizing effect on the center of gravity sway in the static standing position. However, the association between spinopelvic alignment and balance during gait in healthy volunteers is poorly understood. Research questionThe degree of PI–LL mismatch and trunk anterior tilt in the static standing posture influences dynamic balance during gait. MethodsIn this study, 131 healthy volunteers were divided into two groups: harmonious group (PI − LL ≤ 10°; n = 91) and unharmonious group (PI − LL > 10°; n = 40). A two-point accelerometer system was used for gait analysis; accelerometers were attached to the pelvis and upper trunk to measure acceleration in the forward–backward, right–left, and vertical directions so that sagittal (front–back) deviation width, coronal (right–left) width, and vertical width and their ratios were calculated. Measurements were compared between the two groups, and correlations between alignment and accelerometer data were examined. ResultsThe harmonious group showed a negative correlation between pelvic sagittal width and PI – LL, pelvic tilt (PT), and sagittal vertical axis (SVA) (correlation coefficient ρ = −0.42, −0.38, and −0.4, respectively), and a positive correlation between sagittal ratio and PI − LL (ρ = 0.35). The unharmonious group showed a positive correlation between pelvic sagittal width and PI and PT (ρ = 0.43 and 0.33, respectively) and between sagittal ratio and SVA (ρ = 0.32). The unharmonious group showed a positive correlation between upper trunk sagittal width and PI − LL and PT (ρ = 0.38 and 0.36, respectively). SignificanceThe association between spinal alignment and gait parameters differs depending on the presence or absence of PI–LL mismatch. The degree of pelvic compensation and trunk anterior tilt during static standing were associated with unstable gait balance.

Swin enhancer: A low-light smart meter image enhancement method with a multi-layered window attention network

Accurate and efficient identification of visual faults in smart meters is significant to the stable operation of the power acquisition system. However, the electricity meter images collected in dim environments have low brightness problems and lack of detail, which will impact subsequent fault identification based on computer vision. From an unsupervised perspective, this paper proposes a low-light smart meter image enhancement method, Swin enhancer. Originating from the Swin Transformer’s window attention mechanism, this paper designs a Multi-layer Swin Transformer Block (MSTB) to extract regional brightness features through the local window’s attention calculation and provide varying degrees of illumination compensation. At the same time, a shift window mechanism is introduced to interact features among the regions and reduce the possibility of overexposure. Extensive experiments on several benchmark and electric meter datasets demonstrate that our method outperforms state-of-the-art methods on multiple image evaluation metrics.

Pre- and post-operative semicircular canal function evaluated by video head impulse test in patients with vestibular schwannoma

ObjectivesTo evaluate pre- and post-operative semicircular canal function in patients with vestibular schwannoma (VS) by the video Head Impulse Test (vHIT). MethodsNineteen patients with VS who underwent surgery were enrolled in this study. The gain in vestibulo-ocular reflex (VOR) and the degree of scatter in catch-up saccades were examined pre- and post-operatively for the semicircular canals in VS patients. ResultsTen of 19 cases (52.6 %) with VS were defined as demonstrating both superior vestibular nerve (SVN) and inferior vestibular nerve (IVN) impairment from the results of pre-operative vHIT. Hearing level and subjective vestibular symptoms showed significant correlations with pre-operative semicircular canal function. Compared to pre-operative vHIT results, VOR gains within 1 month after surgery were significantly reduced in all three canals; however, significant differences had disappeared in the anterior and posterior semicircular canals at 6 months after surgery. Cases of unknown origin had a significantly greater reduction in posterior semicircular canal function after surgery compared with those with disease of IVN origin. ConclusionsAs vHIT could evaluate pre-operative vestibular nerve impairment, post-operative VOR gain reduction and the degree of vestibular compensation, semicircular canal function evaluated by vHIT provides a good deal of useful information regarding VS patients undergoing surgery compared to caloric testing, and vHIT should be performed pre- and post-operatively for patients with VS.

Quantitative evaluation of motion compensation in post-stroke rehabilitation training based on muscle synergy.

Introduction: Stroke is the second leading cause of death globally and a primary factor contributing to disability. Unilateral limb motor impairment caused by stroke is the most common scenario. The bilateral movement pattern plays a crucial role in assisting stroke survivors on the affected side to relearn lost skills. However, motion compensation often lead to decreased coordination between the limbs on both sides. Furthermore, muscle fatigue resulting from imbalanced force exertion on both sides of the limbs can also impact the rehabilitation outcomes. Method: In this study, an assessment method based on muscle synergy indicators was proposed to objectively quantify the impact of motion compensation issues on rehabilitation outcomes. Muscle synergy describes the body's neuromuscular control mechanism, representing the coordinated activation of multiple muscles during movement. 8 post-stroke hemiplegia patients and 8 healthy subjects participated in this study. During hand-cycling tasks with different resistance levels, surface electromyography signals were synchronously collected from these participants before and after fatigue. Additionally, a simulated compensation experiment was set up for healthy participants to mimic various hemiparetic states observed in patients. Results and discussion: Synergy symmetry and synergy fusion were chosen as potential indicators for assessing motion compensation. The experimental results indicate significant differences in synergy symmetry and fusion levels between the healthy control group and the patient group (p ≤ 0.05), as well as between the healthy control group and the compensation group. Moreover, the analysis across different resistance levels showed no significant variations in the assessed indicators (p > 0.05), suggesting the utility of synergy symmetry and fusion indicators for the quantitative evaluation of compensation behaviors. Although muscle fatigue did not significantly alter the symmetry and fusion levels of bilateral synergies (p > 0.05), it did reduce the synergy repeatability across adjacent movement cycles, compromising movement stability and hindering patient recovery. Based on synergy symmetry and fusion indicators, the degree of bilateral motion compensation in patients can be quantitatively assessed, providing personalized recommendations for rehabilitation training and enhancing its effectiveness.

Computational Performance Analysis of an Electromagnetic Dynamic Voltage Restorer: Physical Conception and Operational Approaches

The present paper focuses an electromagnetic device to restore busbar voltages to acceptable limits using an electromagnetic arrangement conception. The new device has been called by electromagnetic dynamic voltage restorer (EDVR) due to its physical structure. As for the insertion of the degree of the series voltage compensation, two approaches are considered. The first can be recognized as a discrete procedure as the restoring voltage procedure makes use of electronically switched tap changers. The second relies on a continuous voltage variation offered by a single tap supply and a controllable electronic device. It is shown that the overall compensator idea lies on positive or negative insertion of a variable voltage in series with de feeder so as to achieve a consumer supply voltage in accordance with acceptable levels. The device comprises a traditional shunt autotransformer linked to a series transformer which provides the necessary restoring property. The paper highlights the EDVR physical structure, the control units, the ATP platform models and results associated to case studies to show the overall compensation equipment and control performance offered by the given solutions.

Evolutionary game analysis of factors influencing green innovation in Enterprises under environmental governance constraints

The key to controlling environmental pollution is to promote green innovation in relevant enterprises and achieve a healthy development of the environmental governance system. This paper constructs a tripartite evolutionary game model of environmental protection enterprises, polluting enterprises, and governments, and conducts in-depth research on the influencing factors that promote green innovation in two types of enterprises. MATLAB software is used to analyze the impact of different degrees of influencing variables on system evolution. It has found that (1) increasing the intensity of environmental governance and the level of innovation subsidies by the government can effectively promote green innovation in both types of enterprises. (2) The varying degrees of innovation compensation from polluting enterprises to environmental protection enterprises have a significant impact on system evolution. (3) The initial intention and population size of two types of enterprise entities will have a significant impact on system evolution. In the initial state, subjects with more green innovation are less willing to change their strategies during the evolution process, while the willingness of the other party to green innovation will be suppressed.