Abstract Background: The cancer health justice lab [CHJL] formed in 2019, is a multidisciplinary lab comprised of underrepresented undergraduate, graduate, and postgraduate students and diverse professionals in public health, social work, nutrition, medicine, nursing, and criminal justice. Using a social determinants of health framework, CHJL focuses on mentoring and training students from underrepresented backgrounds to increase participation in cancer health disparities research and practice. Methods: In collaboration with the Northeast Regional Alliance HCOP Academy Program (NERA), a program that supports minority and economically disadvantaged undergraduate and high school students interested in health careers, and the Rutgers Bloustein School of Public Policy and Planning, CHJL recruits 3-4 interns per semester. Didactics include leading journal clubs focusing on social determinants of health, health disparities, adverse childhood experiences, and health equity topics. Responsibilities include developing, designing, and implementing a community-based initiative that serves vulnerable populations, grant writing, and peer-reviewed article publications in high impact journals. Results: CHJL currently has 24 members - 14 members are active, including seven interns. Two former interns have been hired as research assistants and are currently pursuing a master's degree in public health. Past members are pursuing postgraduate level education in public health and biomedical sciences. CHJL has generated seven peer-reviewed articles on areas including: systematic reviews of digital cancer education, mental health and social ties of people who are incarcerated and implementing evidence-based practices in state prisons. Current projects include research to understand smoking and vaping behaviors among sexual and gender minority groups; Cancer 101 videos, a short video on COVID-19 for Spanish speakers; auto-complete searches language bias in COVID-19, medication-assisted treatment in jails, group-based counseling, and smoking cessation treatment in prisons, and colorectal cancer screening in urban populations. Conclusion: CHJL addresses health inequities through education, mentoring, advocacy, training, and research. It serves as a model to increase diversity in the health-related workforce and a mechanism for historically underrepresented groups in medicine and public health to contribute to science. This multidisciplinary approach may be useful in educating the next generation of public health and health-related professionals. Furthermore, CHJL could serve as a venue to reduce social isolation and feelings of otherness that may contribute to health inequities. Citation Format: Nadia Smith, Sarah Malarkey, Pamela Valera, Luis Alzate-Duque, Humberto Baquerizo. A health and justice lab to address cancer related health disparities and social determinants of health in marginalized communities: The Cancer Health Justice Lab [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 2554.