Degree Of Synergy Research Articles

Metabolic stress in patients with acute severe ulcerative colitis - a single-center cohort study

Background and aimsAcute severe ulcerative colitis (ASUC) is characterized by systemic inflammation, which may initiate an acute-phase response leading to hypercatabolism. Patients with ASUC are usually treated with high-dose steroids that may further accelerate the metabolic response and lead to hyperglycemia and insulin resistance. Nevertheless, the degree of synergy between inflammation and steroid treatment and their influence on the insulin resistance remains unknown. We aimed to measure the degree of metabolic stress including insulin resistance in patients with ASUC during admission and three weeks after discharge.MethodsThis single-center cohort study was conducted in adult patients with ASUC, defined and assessed by Truelove and Witt’s criteria. Indirect calorimetry, bioelectrical impedance analysis, and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were applied at baseline and at follow-up three weeks after discharge.ResultsAmong the 22 patients admitted during the project period, 15 provided consent for participation in the study. Median C-reactive protein at inclusion was 37.6 [4; 154.7]. Both median HOMA-IR and fasting plasma glucose were markedly increased at inclusion (median 8.6 [3.8; 14.1] and 7.1 [6; 8.7], respectively), and both had decreased significantly three weeks after discharge (p=0.0036 and p=0.0039, respectively). No significant differences were observed in resting energy expenditure or anthropometric measurements from baseline to follow-up.ConclusionPatients with ASUC presented with marked insulin resistance, indicating that the days following admission and high-dose steroid treatment are particularly vulnerable. Despite improvement at three-week follow-up, patients still exhibited insulin resistance compared with relevant control groups.Clinical trial registrationClinicalTrials.gov, identifier NCT0527183.

Research on the Synergistic Development of China’s Pension Industry and Pension Career

To adapt to the new demographic trends and foster high-quality and sustainable population growth, this study analyzes the synergistic development of the pension industry and pension career based on the data of 31 provinces in China from 2016 to 2022, using a distance coordination model, the latest Vague set similarity measure method, new grey relational analysis, kernel density estimation, and Markov chain. The findings indicate that (1) the development levels of China’s pension industry and pension career have shown a steady upward trend, with the gap between them gradually narrowing, though the overall development of the pension career remains higher than that of the pension industry. (2) The synergistic degree of China’s pension industry and pension career is high, with the degree of synergy fluctuating but generally increasing. (3) The synergistic development degree of the pension industry and pension career has continued to rise. The increase in the synergistic development degree shows a spatial distribution pattern of “Central > East > West”. (4) The spatial distribution of synergistic development of China’s pension industry and pension career is uneven, and in the long term, regions with higher synergistic development levels tend to positively influence less developed regions.

Spatio-temporal Evolution of Land Use in Guangdong-Hong Kong-Macao Greater Bay Economic Area, 1985-2022 and Analysis of Influencing Factors

This research employs GIS and remote sensing technology, along with time-series Land cover data, to examine the evolving patterns of various land use categories (such as forest land, cultivated land, and impervious surfaces) within the Guangdong-Hong Kong-Macao Greater Bay Area. The results indicate that the predominant spatial configuration of land use in this region follows a sequence of "forest land-cultivated land-impervious land." Notably, the key transformation observed involves the conversion of cultivated land to impervious surfaces, resulting in a cumulative expansion of impervious areas by 3,346,985 hectares between 1985 and 2022. Moreover, the level of spatial integration among land use types in the Greater Bay Area is progressively standardizing, with notable advancements in scientific, technological, economic, and transportation sectors leading to a high degree of synergy. The system as a whole demonstrates effective coordination and operational efficiency. The methodology section outlines the data sources and analytical techniques employed, encompassing the utilization of the land use transfer matrix, individual land use degree assessment, and spatial coupling function model. Through these methodologies, the study identifies urban economic development as the primary driver behind the proliferation of impervious surfaces, offering valuable insights to inform regional development strategies and environmental governance policies.

Limits on inferring T cell specificity from partial information

A key challenge in molecular biology is to decipher the mapping of protein sequence to function. To perform this mapping requires the identification of sequence features most informative about function. Here, we quantify the amount of information (in bits) that T cell receptor (TCR) sequence features provide about antigen specificity. We identify informative features by their degree of conservation among antigen-specific receptors relative to null expectations. We find that TCR specificity synergistically depends on the hypervariable regions of both receptor chains, with a degree of synergy that strongly depends on the ligand. Using a coincidence-based approach to measuring information enables us to directly bound the accuracy with which TCR specificity can be predicted from partial matches to reference sequences. We anticipate that our statistical framework will be of use for developing machine learning models for TCR specificity prediction and for optimizing TCRs for cell therapies. The proposed coincidence-based information measures might find further applications in bounding the performance of pairwise classifiers in other fields.

Impact of the degree of synergy between patient and nurse perceptions on the clinical outcome of pressure injury prevention: a mixed-methods systematic review protocol

IntroductionPressure injuries are a common and significant concern in clinical practice, often serving as a vital quality indicator. While (clinical) practice guidelines have been established to offer recommendations for mitigating...

Research on the synergy of the water–energy–food composite system in the Beijing–Tianjin–Hebei region

ABSTRACT Water, energy, and food are interdependent and mutually restrictive, and changes in any one resource may have an impact on the others. In order to promote the sustainable utilization of resources, it is important to study the synergy of the water–energy–food composite system (WEFCS). Taking the Beijing–Tianjin–Hebei region as an example, this study adopts the composite system synergy degree model to quantitatively measure the synergy degree of WEFCS from 2011 to 2021, then constructs an evolutionary model to identify the interactions between the subsystems, and finally analyzes the interactions dynamically by using the panel vector autoregression model. The results show that the WEFCS synergy level in the Beijing–Tianjin–Hebei region is generally basic and shows low stability during the study period. Regional subsystems are more dependent than collaborative or competitive. Moreover, the regional water subsystem has a short-term positive impact on the energy subsystem, the energy subsystem has a short-term negative impact on the food subsystem, and the food subsystem has a delayed and complex influence on the water and energy subsystems, with the water subsystem being particularly affected. This study provides a decision-making basis for policymakers to optimize resource allocation.

Multi-Scale Analysis of Ecosystem Service Trade-Offs/Synergies in the Yangtze River Delta

The transformation of ecosystem structure leads to changes in ecosystem services (ESs) and their relationship. However, most research in this area has focused on particular scales and timeframes, often overlooking the significance of spatial and temporal variations. Therefore, we used the equivalent value method to evaluate seven typical ESs in the Yangtze River Delta (YRD) between 2000 and 2020: food production (FP), water supply (WS), climate regulation (CR), environmental purification (EP), soil conservation (SC), biodiversity maintenance (BM), and aesthetic landscape (AL). We further employed the Spearman correlation coefficient and bivariate Moran’s I to evaluate the relationship of ESs and their spatial heterogeneity at grid, township, county and city scales. Our results show that (1) All ESs except AL exhibited a fluctuating upward trend from 2000 to 2020, resulting in a total increase in ecosystem service (ES) value of RMB 650.63 billion. (2) Approximately 70% of the ES pairs demonstrated a synergistic relationship, with the exception of FP and other ESs, which mainly showed a trade-off. (3) With the scale increased from grid to city level, the degree of trade-off between FP and other ESs strengthened at different levels, while the synergy degree of among other ESs gradually decreased. (4) The relationship between ESs demonstrated strong spatial heterogeneity, with FP and other ESs exhibiting trade-offs primarily in the northern and southern YRD, while other ES pairs exhibited mostly synergy in these regions. This study provides scientific information for governments to optimize land use distribution and improve ESs.

Urban Lake Health Assessment Based on the Synergistic Perspective of Water Environment and Social Service Functions.

Urban lakes serve as vital ecological and recreational anchors within built environments, essential for enhancing urban resilience. Evaluating lake health predominantly focuses on water quality, assessing indicators such as nutrient levels, toxicity, pH balance, and water clarity to monitor changes. This study proposes a comprehensive evaluation framework that systematically describes specific spatiotemporal manifestations and periodic exogenous regulation characteristics across five dimensions: physical structure, water quality, shoreline dynamics, external regulation, and social service. Furthermore, it introduces an urban lake health assessment model based on synergistic development to evaluate the integrated development and interaction between water environments and social services. This model is applied across urban lakes in various developmental stages in China. Key findings include: 1) Urban development often impacts lake health disparately, with varying degrees of synergy observed between water environments and social services across different urban lakes. However, shifts in urban ideologies and improvements in governance, along with protective policies and project implementations, have contributed to improving water quality to some extent. 2) Engineering interventions do not consistently correspond with improvements in water quality, and governance measures sometimes yield mixed outcomes, underscoring the necessity for systematic solutions to lake health. Restoring hydrological processes emerges as crucial for enhancing sustainability.

Assessment of the synergy degree of China's food safety risk governance policy tools based on text mining and machine learning methods

SummaryImplementing proactive and effective policy tools is essential for governments to manage food safety risks. Existing studies have overlooked the synergistic effects among policy tools for governing food safety risks in China. This study uses policy tool synergy to develop a quantitative model to evaluate the degree of synergy among policy tools for food safety risk governance by considering its vertical, horizontal, and temporal dimensions. Using the Top2Vec topic model and text mining techniques, we examined 558 policy documents implemented by the central and six provincial governments. The findings reveal that China's food safety risk governance system has established a collaborative mechanism, with the Administration for Market Regulation, the Department of Agriculture and Rural Affairs, and the Health Commission playing crucial roles in policy implementation. Vertical and horizontal synergies between the upper and lower levels of government and among departments at the same level are crucial for enhancing comprehensive synergy.

Research on the Synergistic Evolution of Comprehensive Transportation Network System in the Yellow River Basin Aimed at High-Quality Development

The high-quality development of the Yellow River Basin is still facing the issue of imbalance and inadequacy, and it urgently requires the backing and assistance of a well-coordinated and efficient comprehensive transportation network system. Based on this purpose, this study uses a composite system synergy degree model incorporating “mode dimension + regional dimension” to analyze the evolution of this network. The results indicate the following: (1) Railway and air transportation surpass highway transportation in growth and synergy, though overall system synergy is still low. (2) Downstream areas are gradually taking the lead, and the orderliness of each subsystem is gradually becoming consistent. The complexity and variability of the composite system’s synergy are high, with an overall low level of synergy. Overall, despite improvements in service capacity and quality, better integration of different transport modes and enhanced cross-regional cooperation are needed. This study reveals and analyzes in depth the complexity of the comprehensive transportation network system in the Yellow River Basin and its spatiotemporal characteristics of synergistic evolution. We propose suggestions for high-quality development at national, regional, and industry levels, fostering the continuous improvement of the system structure, which aids in overcoming the tangible obstacles faced by the high-quality development of the Yellow River Basin.

Integrated Benefits of Synergistically Reducing Air Pollutants and Carbon Dioxide in China.

China's advancements in addressing air pollution and reducing CO2 emissions offer valuable lessons for collaborative strategies to achieve diverse environmental objectives. Previous studies have assessed the mutual benefits of climate policies and air pollution control measures on one another, lacking an integrated assessment of the benefits of synergistic control attributed to refined measures. Here, we comprehensively used coupled emission inventory and response models to evaluate the integrated benefits and synergy degrees of various measures in reducing air pollutants and CO2 in China during 2013-2021. Results indicated that the implemented measures yielded integrated benefits value at 6.7 (2.4-12.6) trillion Chinese Yuan. The top five contributors, accounting for 55%, included promoting non-thermal power, implementing end-of-pipe control technologies in power plants and iron and steel industry, replacing residential scattered coal, and saving building energy. Measures demonstrating high synergies and integrated benefits per unit of reduction (e.g., green traffic promotion) yielded low benefits mainly due to their low application, which are expected to gain greater implementation and prioritization in the future. Our findings provide insights into the effectiveness and limitations of strategies aimed at joint control. By ranking these measures based on their benefits and synergy, we offer valuable guidance for policy development in China and other nations with similar needs.

The impact and mechanism analysis of Clean Development Mechanism on the synergistic effects of pollution mitigation and carbon reduction

The establishment of the Clean Development Mechanism (CDM) has greatly improved China's carbon emission trading system. However, due to the unbalanced development of CDM in China, the effects and mechanism of CDM on reducing pollution and carbon are still unclear. In order to explore the effects and mechanism of CDM on the synergistic effects of pollution mitigation and carbon reduction, we first set up a theoretical analysis framework. Utilizing panel data from 254 prefecture-level cities across China spanning from 2004 to 2021, we employ a synergy degree model of composite system to evaluate the synergistic effects of pollution mitigation and carbon reduction. By treating CDM as a quasi-natural experimental research subject, we construct a multi-period difference-in-difference model to assess the CDM projects' effects. Our findings indicate a positive association between CDM projects and the synergistic effects of pollution mitigation and carbon reduction. Heterogeneity analysis reveals that CDM projects located in the western region, areas with lower levels of economic development, non-resource cities, non-old industrial bases, and projects with Certified Emission Reductions issued exhibit the most pronounced synergistic effects. Specially, dynamic policy effect analysis shows that only non-resource cities and non-old industrial bases exhibit enhanced policy implementation regarding CDM. Mechanism analysis demonstrates that CDM primarily enhances synergistic effects through improved energy efficiency, technological innovation and energy transition. These findings enrich empirical investigations concerning market-driven emission reduction policy in China, shedding light on pivotal pathways for synergistic control of pollution mitigation and carbon reduction and offering valuable policy insights for comprehensive economic and social green transformation in China.

Dynamic measurement for the impact of project portfolio synergy

Measuring the impact of project portfolio synergy (PPSI) is crucial for making informed decisions to improve the strategic realization of a project portfolio. However, the literature has failed to measure PPSI effectively from the perspective of project element flow and to explore the differences in synergy relationships between homogeneous and heterogeneous projects. Consequently, this study proposes a framework for measuring PPSI from the perspective of project element flow. First, based on analyzing the synergistic relationship between projects, the corresponding project element datum quantity is determined according to the different types of element flow forms. Second, the synergy degree between homogeneous and heterogeneous projects is quantified through project similarity and correlation. Third, a dynamic measurement model is constructed using System Dynamics to solve the complex interactive feedback and dynamics in the PPSI measurement system. Finally, the framework is demonstrated and validated by a numerical example of project management in Xi'an, Shaanxi Province. The results indicate that the model can effectively measure PPSI and identify the key factors generating it. In implementing the portfolio, managers must focus on sharing and integrating newly developed technologies and information, thus facilitating the generation of PPSI. This study extends the boundary of project portfolio synergy theory and contributes to the literature on measuring PPSI by focusing on the elements flow within portfolios. Additionally, the model provides an effective tool for managers to forecast PPSI and determine appropriate optimization strategies.

Whether Wheat–Maize Rotation Influenced Soil Organic Carbon Content in Sushui River Basin

Enhancing soil organic carbon (SOC) content in farmland is crucial for soil quality maintenance and food security. However, the relationship between crop rotation and SOC sequestration remains unclear. We used sample data on SOC, collected in September of every year, from cultivated land for quality monitoring from 2017 to 2021, combined with spatially extracted planting system information, and focused on the effects of wheat–maize crop rotation on SOC in the Sushui River Basin. An analysis of variance (ANOVA) indicated that the SOC content was only significantly different between wheat monoculture and maize monoculture. Among the three cropping systems, wheat–maize rotation did not show absolute superiority. The Geodetector analysis showed that the planting system dominated the spatial distribution of soil organic carbon (p = 0.05), but its explanatory factor was only 5%, and the explanatory power was significantly improved after interaction with other factors. Geographically weighted regression showed that wheat–maize rotation had a trade-off effect with elevation and synergistic effects with rainfall and pH. It displayed a synergistic effect with temperature in the southwest and a trade-off effect in the northeast. The degrees of trade-offs and synergy varied spatially among all interacting factors. We focused on the spatial heterogeneity of soil organic carbon in a small watershed, and the results had scientific significance for the layout of planting systems according to local conditions and the improvement in soil organic carbon levels.

Synergy of Inter-Regional Knowledge Innovation System from the Perspective of Industry-Science-Research Collaborative Networks

Abstract Knowledge innovation networks formulated by the collaborations between entities (industry department, school, research center and laboratory) evolving over time, varying by regions, is an indicator of inter-regional knowledge innovation linkages. In this work, we proposed a novel synergy analysis approach, taking the structural value of industry-science-research collaborative network as knowledge innovation subsystem parameter. The changing of this parameter indicates the synergy of Inter-Regional Knowledge Innovation System (IRKIS), incorporating the network structure evolution and systematic collaboration, also analyzing the IRKIS synergy capability. We collected 18,776 articles from 2009–2020 that are related to Alzheimer’s disease participating in China from Web of Science, and 7,941 patent data from the USTPO database. Then, we extracted knowledge innovation departments based on the dimensions of industry-science-research, constructed inter-regional knowledge innovation network, selected Degree Centrality, Close Centrality and Structure Hole as parameters of industry-science, industry-research, and science-research subsystems to analyze the synergy degree of IRKIS. The results indicated that evolution law of IRKIS could be explained through the perspective of industry-science-research collaborative network. The trend of more international collaborations illustrated by the rapid increasement of inter-regional knowledge innovation network parameter, however, the average synergy level of IRKIS in Alzheimer’s research is still low.

Abstract B022: TEAD inhibition overcomes YAP/TAZ-driven resistance to RAS(ON) inhibitors

Abstract Acquired resistance poses a significant challenge to the long-term efficacy of RAS inhibitors in clinical settings (Awad et al, 2021). Genome-wide CRISPR screening efforts, conducted by us and others in the field, have identified key components of the Hippo pathway as major mediators of resistance to RAS inhibitors (Mukhopadhyay et al., 2023, Edwards et al., 2023). Specifically, the oncogenic transcriptional co-regulators YAP and TAZ, which require binding to the TEAD transcription factors to elicit their activity, have emerged as pivotal players in resistance mechanisms to MAPK pathway targeted therapies. In this work, we demonstrate that YAP overexpression is a driver of resistance to RAS(ON) multi-selective and RAS(ON) G12C-selective inhibitors. The YAP transcriptional signature is elevated in cells with acquired resistance to RAS(ON) inhibitors, and combination with TEAD inhibitors enhances their sensitivity to RAS(ON) inhibition. Notably, phosphoproteomics and imaging studies revealed that the YAP cytoplasmic retention mark is reduced upon treatment of cancer cells with RAS(ON) multi-selective inhibitor, leading to the translocation of YAP to the nucleus and its subsequent activation. Furthermore, a pan-TEAD inhibitor exhibits a high degree of synergy with RAS(ON) inhibitors in a panel of KRAS mutant cell lines in vitro. We are currently investigating the combination of RAS(ON) and TEAD inhibitors in vivo. Our studies support further investigation of combination strategies using RAS(ON) and TEAD inhibitors to mitigate the emergence of persister cells and overcome resistance to monotherapy. Citation Format: Vidyasiri Vemulapalli, Phuong Dinh, Mariela Moreno Ayala, Zheng Zhang, Mark Labrecque, Ida Aronchik, Jingjing Jiang, Mallika Singh, Elsa Quintana, Caroline Weller, David Wildes. TEAD inhibition overcomes YAP/TAZ-driven resistance to RAS(ON) inhibitors [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr B022.

Evaluation and Spatial–Temporal Pattern Evolution of Synergy Degree of Emergency Management for Urban Flood Disasters from the Perspective of Sustainable Development—The Case of Henan, China

The management of urban flood disasters is a systematic engineering project that requires a great amount of manpower, material resources, and financial resources, and the interaction and coordination degrees of various elements in the system deeply affect the efficiency of the final governance. According to the theories of synergy, composite systems, and sustainable development, this research first established an evaluation index system to determine the synergy degree of urban flood disaster emergency management from the four dimensions of prevention and preparation, monitoring and early warning, response and rescue, and recovery and reconstruction. Then, the synergy degree was explored by using the developed composite system synergy degree model on the basis of the panel data of 18 prefecture-level cities in Henan Province from 2013 to 2021, and synergy level change characteristics were analyzed from the perspectives of time and space. Finally, the obstacle degree model was applied to explore the obstacle factors affecting synergy degree development. The results showed that the overall level of the urban flood disaster emergency management coordination degree in Henan Province was relatively low, and there were significant differences in synergy among cities. Among them, 12 cities presented mild synergy, and 6 cities showed mild nonsynergy. The spatial correlation of the synergy degree was not stable, which revealed a lack of mature coordination mechanisms for flood disaster emergency management among cities. The analysis of obstacle factors showed that recovery and reconstruction subsystems were the main obstacle systems that affected the synergy degree.

Olfactory perceptual interactions of maltol with key food odorants in binary mixtures: Scatter matrix statistical analysis of odor intensity in heterogeneous perceptual situation

To study the olfactory perceptual interaction of odorants (OPIO) in binary mixtures containing maltol, a simple and efficient analysis method was developed. This method correlated three variables of the binary mixture: two rates of change in perceived odor intensities of two odorants within the binary mixtures, and the degree of overall odor synergy exhibited by the binary mixtures. By creating a three-dimensional scatter matrix with the variables, the changes in odor intensity of the binary mixture due to OPIO were visualized. The results revealed that the proportions of mutual antagonism, opposite effect, mutual independence, and mutual synergy in the binary mixtures were 64.7%, 32.9%, 1.9%, and 0.5%, respectively. The odor of maltol was mainly masked, and those of esters (68%), aldehydes and ketones (33%) in the mixture were enhanced. In terms of overall odor intensity, 67% of cases involved partial addition, followed by 22.2% overshadowing, and 19.6% stronger component effect.

Analyzing the impact of energy synergy and renewable energy generation on energy security: Empirical evidence from China's Yangtze River Delta region

As a representative region with poor energy resource endowment in China, the Yangtze River Delta (YRD) region poses a pressing and vital issue for research on energy security. This study offers a comprehensive assessment of energy security levels (ESL) in the YRD region of China from 2000 to 2019, emphasizing the pivotal role of electricity indicators in energy transition using a combination optimization model of the entropy method and CRITIC method. Subsequently, we employed a coupling synergy degree model to further quantify the energy synergy among different YRD provinces and to verify the effects of energy synergy and renewable energy generation (REG) on the ESL of the YRD region. The findings highlight supply security as the central concern for safeguarding energy security. The YRD region's ESL ranking is as follows: Zhejiang, Jiangsu, Anhui, and Shanghai. There is a significant linear correlation between energy synergy and ESL, with Zhejiang and Jiangsu experiencing a notably greater effect of energy synergy on ESL than Anhui. A pronounced U-shaped relationship between REG and ESL is evident in the Jiangsu and Anhui provinces. The impact of REG on ESL is significant in Zhejiang province but negligible in Shanghai.

Correlations in abnormal synergies between the upper and lower extremities across various phases of stroke.

The flexion synergy and extension synergy are a representative consequence of a stroke and appear in the upper extremity and the lower extremity. Since the ipsilesional corticospinal tract (CST) is the most influential neural pathway for both extremities in motor execution, damage by a stroke to this tract could lead to similar motor pathological features (e.g., abnormal synergies) in both extremities. However, less attention has been paid to the interlimb correlations in the flexion synergy and extension synergy across different recovery phases of a stroke. We used results of the Fugl-Meyer assessment (FMA) to characterize those correlations in a total of 512 participants with hemiparesis after stroke from the acute phase to 1 year. The FMA provides indirect indicators of the degrees of the flexion synergy and extension synergy after stroke. We found that, generally, strong interlimb correlations (r > 0.65 with all P values < 0.0001) between the flexion synergy and extension synergy appeared in the acute-to-subacute phase (<90 days). However, the correlations of the lower-extremity extension synergy with the upper-extremity flexion synergy and extension synergy decreased (down to r = 0.38) 360 days after stroke (P < 0.05). These results suggest that the preferential use of alternative neural pathways after damage by a stroke to the CST enhances the interlimb correlations between the flexion synergy and extension synergy. At the same time, the results imply that the recovery of CST integrity or/and the fragmentation (remodeling) of the alternative neural substrates in the chronic phase may contribute to diversity in neural pathways in motor execution, eventually leading to reduced interlimb correlations.NEW & NOTEWORTHY For the first time, this article addresses the asynchronous relationships in the strengths of flexion and extension synergy expressions between the paretic upper extremity and lower extremity across various phases of stroke.