Degree Of Maturity Research Articles

Evaluation of Cervical Vertebral Maturation Angular Measurements as a Tool to Assess Skeletal Maturity: A Radiological Study.

The purpose of the present research was to evaluate the comparison between the Skeletal Maturation phases of Fishman's hand-wrist skeletal maturation index (SMI) and cervical vertebral maturation angle (CVMA). Assessment and comparison of Skeletal Maturation utilizing the hand-wrist bone radiograph by Fishman's system of skeletal maturation indicator (SMI), cervical vertebra maturation stages (CVMS), and lateral cephalogram by cervical vertebral maturation angle (CVMA) conducted on 150 subjects (75 male and 75 female). Chi-square was used to reveal the significance of study parameters on a categorical scale between SMI, CVMS, CVMA, and multiple regression analysis conducted to envisage the connotation of the dependent variable. Multiple regression analysis models exhibited 61.9% of the variance for CVMA with autonomous variables. In multiple regression analysis, there is no substantial association (P > 0.05) between age and CVMA. The correlation of SMI and CVMA values utilizing Pearson's correlation coefficient for males and females presented positive association with R value of 0.801 for males and 0.834 for females and a P value of < 0.001. As compared to other maturity indicators like hand and wrist, cervical vertebral angular measurements were reliable enough for assessing the degree of skeletal maturation.

Effect of the Chemical Composition of Coals on Surface Wettability and Filtration Properties

The method of liquid filtration through a layer of coal powder was used for a comprehensive characterization of surface wettability in conjunction with the determination of the contact angle. The effect of the degree of chemical maturity (metamorphism) of coal on the filtration characteristics of a layer with fractured porous properties was evaluated. Different activity of coal surfaces to water wettability upon a change from the native state to the surface-oxidized one was established. It was shown that the wetting and filtration properties of the coal surfaces increased from native to surface-oxidized coals and decreased as the degree of metamorphism increased from low to medium metamorphosed coals.

Thermal History of the Lithosphere of the Koltogor-Urengoi Graben, West Siberian Basin, in the Vicinity of the SG-6 Well: Numerical Reconstruction Using GALO Flat Basin Modeling System

The GALO basin modeling system is used to numerically reconstruct the thermal regime of the West Siberian basin lithosphere in the Koltogor-Urengoi graben in the vicinity of the Tyumenskaya SG-6 superdeep well. The reconstruction explains the features in the formation of the thermal regime of the basin, which were not considered in the previous reconstructions of the region. These features include anomalously high growth of the maturity level of the organics in the Jurassic and Triassic rocks, high temperature gradients observed in the upper basement and Triassic–Permian sedimentary complex, the anomalously low rock temperatures in the upper layers of the recent sedimentary section of the basin. The temporal changes in the tectonic subsidence of the basin are analyzed to estimate the intensity and duration of thermal activation events and the extension of its lithosphere. The thermal impact of the sill that intruded into the upper basement horizons in the Lower Jurassic explains the high degree of maturation of the organic matter in the Lower Triassic rocks. Taking into account the abrupt climatic fluctuations in the Pliocene–Quaternary together with hydrothermal activity in the bottom part of the sedimentary cover in the Upper Pliocene–Lower Pleistocene, we obtained the depth profiles of temperatures and vitrinite reflectance, which agree well with the measured values.

Cases of Spontaneous Increase of Methemoglobin Concentration in Fish Blood during the Annual Cycle

The dynamics of the content of erythrocytes number and concentration of methemoglobin in the blood of the thermophilic mullet (Chelon auratus Risso, 1810) and the cold-loving flounder (Platichthys flesus L., 1758) during the annual cycle was studied. The degree of maturity of the circulating erythrocyte mass was judged on the basis of acid erythrograms construction. A pronounced negative relationship was found between the number of red blood cells and the concentration of methemoglobin in the blood of both types (r = –0.681; –0.778). It has been shown that the youngest generation of red blood cells appears in the peripheral bed of both species in the post–spawning period (1.5–2.0 months), which reflects the active production of erythrocytes by hematopoietic tissue. The rest of the time, there is a gradual aging of the circulating erythrocyte mass. This leads to a decrease in the number of red blood cells in the blood and is accompanied by an increase in the concentration of methemoglobin. The latter, apparently, determines the production of erythropoietins in the kidneys and activates the processes of erythropoiesis in hematopoietic tissue (pre-spawning period).

An example of lettuce (Lactuca Sativa) seedling selection using deep learning method for robotic seedling selection system

Lettuce is a type of vegetable that is widely cultivated and consumed in our country and in the world. The seedling period, which is the beginning of production, is the most sensitive time for the plant. Starting production with healthy seedlings is an important parameter for quality and efficient production. In this study, a sample program for automatic seedling selection was developed for a robotic system to be used in seedling production. With the developed program, it was aimed to select seedlings with the same degree of maturity in multi-well pots. In this study, Yolo5n was used for the training model. A learning system was established on two types of lettuce (curly salad), and red curly lettuce leaf (lolo-rosso) seedlings. As a result of the training, F1 score was found as 83%; Precision was 100%; Recall was 95%; Precision Recall was 86.7%. The learning rate was 0.0005 for all given images. In view of these data, positive results were obtained for the mentioned method in seedling selection.

Microstructure reconfiguration of duplex high entropy alloy/BCC ferrite bimetallic interface under electropulsing

Additive manufacturing of multi-materials is one of the effective pathways to enrich the performance diversity of metallic materials, and it is generally acknowledged that the bimetallic interface is the weakest position because of stress concentration and compositional mutation. Here it was found that the stress concentration along the BCC + FCC duplex Al-Co-Cr-Fe-Ni high entropy alloy/BCC ferrite bimetallic interface can be significantly released by electropulsing, and the compositional mutation region was also reasonably widened from 2 μm to 10 μm. Meanwhile, the neighboring grains rotated to form High Angle Grain Boundaries, which can reduce the Gibbs free energy of the system. Additionally, the nano-scale second phase including spherical BCC NiAlFe and rod-like B2 NiAl particles was generated at the interface. The BCC NiAlFe phase is coherent with the matrix and has numerous crystal defects inside the precipitates, whereas the B2 NiAl phase has a stable structure without stress fluctuation because of its greater maturation degree.

Сравнительная характеристика литохимических особенностей черноземов северного Приазовья и Крыма

The article discusses modern approaches to the study of weathering and soil formation processes in soils. It offers comparative characteristics of migration-segregation (ordinary carbonate) chernozems and textural-calcareous (southern) chernozems formed under conditions of the steppe regions in the Crimea and Rostov region. Lithochemical indices were used to determine the relative age of soils and establish the relationship between soil formation and weathering. CIA index characterizes the degree of soil weathering and its mineralogical features, while CIW index determines the degree of maturity of fine aluminosiliciclastics. The determined gross chemical (elemental) composition of soils and rocks formed the initial data for such reconstructions. In addition, the research included calculations of the molar ratios of silica to sesquioxides (SiO2:R2O3) and the eluviation coefficient (Ke) (excluding sodium) in soils and soil-forming rocks. It has been established that the relative age of chernozems in the Crimean Peninsula is less compared to the similar subtypes of chernozems in the Rostov region. This is due to the peculiarities of the soil-forming material. In the Rostov region, chernozems are formed on more weathered clay parent rocks, while the formation of Crimean chernozems is confined mainly to the eluvium of sedimentary rocks. Down the profile, the intensity of soil formation and weathering processes in the soils of the South and South-East of the East European Plain noticeably decreases due to a lower rate of secondary weathering of minerals. This can be explained by the limited energy characteristics of the environment in which these processes occur. Among such limiting environmental factors, on the major factors are an insufficient amount of moisture in the spring-summer period.

The problem of academic dishonesty in the global and Russian research discourse: The bibliometric analysis based on science databases

The findings of bibliometrical study are discussed to asses and compare the arrays of scholarly publications on the subject of academic dishonesty in Russia and in the world. The research method is based on interlinking the degree of scientific discourse maturity with terminological system sophistication. The dynamics of terminological system development in the area of academic dishonesty is examined with the search tools of Scopus as the largest reviewed scientific database, and Russian Science Citation Index. The title terms making the core of the terminological system for “academic dihonetsy” are identified, as well as the variants of their translation into the Russian language in the context of the problem. Based on the list of the title terms, the strategy for searching of scientific texts on the topic is built; the search results are visualized in the tables and graphs included. The author concludes that the array of the studies on the topic of academic dishonesty have been intensively developing in the academic community since 2000; she also argues that the stable long-term growth of publication is the trend in this area. However, based on RSCI, the scientific discourse of academic dishonesty in Russia has been developing just for the recent decade, with the trend of acceleration in the recent few years, though with insignificant accumulation of scientific texts array. The originality of the paper lies in the application of the approach of terminological system analysis with bibliometrical tools to estimate the maturity of research discourse in the individual subject area.

Blueberry Ripeness Detection Model Based on Enhanced Detail Feature and Content-Aware Reassembly

Blueberries have high nutritional and economic value and are easy to cultivate, so they are common fruit crops in China. There is a high demand for blueberry in domestic and foreign markets, and various technologies have been used to extend the supply cycle of blueberry to about 7 months. However, blueberry grows in clusters, and a cluster of fruits generally contains fruits of different degrees of maturity, which leads to low efficiency in manually picking mature fruits, and at the same time wastes a lot of manpower and material resources. Therefore, in order to improve picking efficiency, it is necessary to adopt an automated harvesting mode. However, an accurate maturity detection model can provide a prerequisite for automated harvesting technology. Therefore, this paper proposes a blueberry ripeness detection model based on enhanced detail feature and content-aware reassembly. First of all, this paper designs an EDFM (Enhanced Detail Feature Module) that improves the ability of detail feature extraction so that the model focuses on important features such as blueberry color and texture, which improves the model’s ability to extract blueberry features. Second, by adding the RFB (Receptive Field Block) module to the model, the lack of the model in terms of receptive field can be improved, and the calculation amount of the model can be reduced at the same time. Then, by using the Space-to-depth operation to redesign the MP (MaxPool) module, a new MP-S (MaxPool–Space to depth) module is obtained, which can effectively learn more feature information. Finally, an efficient upsampling method, the CARAFE (Content-Aware Reassembly of Features) module, is used, which can aggregate contextual information within a larger receptive field to improve the detection performance of the model. In order to verify the effectiveness of the method proposed in this paper, experiments were carried out on the self-made dataset “Blueberry—Five Datasets” which consists of data on five different maturity levels of blueberry with a total of 10,000 images. Experimental results show that the mAP (mean average precision) of the proposed network reaches 80.7%, which is 3.2% higher than that of the original network, and has better performance than other existing target detection network models. The proposed model can meet the needs of automatic blueberry picking.

The promise of BIM? Searching for realized benefits in the Nordic architecture, engineering, construction, and operation industries

Benefits of BIM are not being achieved as expected in the mainstream architecture, engineering, construction, and operation (AECO) industries. Here, we aim to contrast expected and realized BIM benefits in AECO companies and discuss explanations for why benefits proposed in literature have, or have not, been realized. A qualitative research approach is applied to collect and analyse interview data from 47 companies in Finland, Norway and Sweden. Findings show that realized benefits typically occur “within the current practice” of individual organizations' project-related work. In contrast, expected but not realized benefits are long-term, lifecycle oriented and challenge current business and practice. Our proposed explanations acknowledge that fully realizing the expected benefits of BIM suggested in the technology-driven research is restrained by the current sector state-of-practice and assumes a high degree of BIM maturity among all cooperating companies. Thus, we discuss how explanations relate to the fundamental change required to radically leverage the benefits of BIM, challenging both current ways of work and the ubiquitous assumption of clients as drivers for BIM implementation in the sector. Based on our research, we argue that client demand is insufficient to realize the promise of BIM. Suggested research implications include a need for greater supply-driven logic among suppliers of BIM expert services, and the integration of multi-disciplinary competencies within and beyond the traditional disciplines. The research demonstrates the gap between state-of-the-art BIM predicted in literature and mainstream industry's adoption and highlights the importance of extending BIM research to better account for socio-organizational and process aspects of benefits and adoption.

USE OF CYTOLOGICAL SMEAR AND CELL BLOCK TECHNIQUE FOR THE DIAGNOSIS OF PLASMA CELL MYELOMA INFILTRATION IN THE MANDIBLE

Fine-needle aspiration cytology (FNAC) is a diagnostic tool using a needle to collect samples for cytopathological examination. We report a case of a 49-year-old male patient with previous medical history of plasma cell myeloma (PCM), who had osteolytic lesions in the mandible, diagnosed by FNAC. Imaging exams exhibited multiple osteolytic lesions with ill-defined margins in the bilateral mandibular body. FNAC of the intraosseous lesion of the mandible was performed. Cytological smear and cell block technique revealed plasma cells in different degrees of maturation, predominantly eccentric pleomorphic nuclei and abundant, eosinophilic cytoplasm without a paranuclear halo. Immunohistochemistry exhibited positivity for CD138, lambda light chain and Ki-67 (proliferation index was ∼50%). Based on clinicoradiographic, microscopic, and biochemical findings, the diagnosis was PCM infiltration in the mandible. The patient underwent chemotherapy and autologous hematopoietic stem cell transplantation, and had partial remission after 10 months of follow-up. Fine-needle aspiration cytology (FNAC) is a diagnostic tool using a needle to collect samples for cytopathological examination. We report a case of a 49-year-old male patient with previous medical history of plasma cell myeloma (PCM), who had osteolytic lesions in the mandible, diagnosed by FNAC. Imaging exams exhibited multiple osteolytic lesions with ill-defined margins in the bilateral mandibular body. FNAC of the intraosseous lesion of the mandible was performed. Cytological smear and cell block technique revealed plasma cells in different degrees of maturation, predominantly eccentric pleomorphic nuclei and abundant, eosinophilic cytoplasm without a paranuclear halo. Immunohistochemistry exhibited positivity for CD138, lambda light chain and Ki-67 (proliferation index was ∼50%). Based on clinicoradiographic, microscopic, and biochemical findings, the diagnosis was PCM infiltration in the mandible. The patient underwent chemotherapy and autologous hematopoietic stem cell transplantation, and had partial remission after 10 months of follow-up.

Media as an institution of legal informing the population of Russia

This article is devoted to the current issue of legal informing the population through the media. At the present stage, information law is in its infancy and this explains such a variety of terms with the use of which, experts try to determine its content. The article analyses the concepts of various approaches to the definition of the concept of ‟information law”. The main subjects of legal regulation in information law, as well as information relations as a basis in information law, are determined. The connection of information law with the mass media is argued. Applying the main idea of defining the institutions of information law, based on the analysis, the author formulates the category of ‟the institution of legal informing the media”. Particular attention is paid to the concept of legal culture, as the degree of maturity, education of a person, its way of thinking and norms of behaviour in the legal sphere. The content of the legal culture of society is determined, which includes the legal awareness of a person; its beliefs and attitudes in the field of law enforcement; the nature and level of legal activity, as well as legal behaviour. From the foregoing, the author comes to the conclusion that it is advisable to determine the place of legal informing the media in the system of law as a legal institution in the field of information law.

Characteristics of bioelectric processes in the myocardia of premature newborn children

The article presents the features of bioelectrical processes in the myocardium of premature babies with different gestational age in the neonatal period. The analysis of quantitative electrocardiographic indicators revealed the features of the parameters of the terminal part of the ventricular complex associated with the degree of maturity and age of newborns. At the same time, it was found that during the first month of life in very premature babies significant changes in homeostasis and morphofunctional state of various vital organs and systems occur.

Temporal and inter-individual changes in the integrated biochemical condition of the gonads of female swordfish (Xiphias gladius) from the Southeastern Pacific Ocean.

The integrated biochemical condition (IBC) of gonads is closely related to the reproductive success of highly migratory marine species. The IBC of gonads can be influenced not only by size and/or age, but also by environmental conditions. Here, female swordfish, Xiphias gladius, that migrate to temperate regions with a marked seasonality (e.g., the Southeastern Pacific Ocean, SEPO) were compared in relation to the IBCs (lipids, proteins, glucose and, fatty acid profiles) of their gonads; individuals with two body size ranges and distinct degrees of sexual maturity were evaluated, and considered as: small and/or virginal (SV: <170 cm lower jaw fork-length (LJFL), oocyte size (OS) <0.08 mm) vs large and/or maturing females (LM: >190 cm LJFL, OS >0.133 mm). This comparison was conducted in two environmentally contrasting seasons (winter vs spring). Our results showed that the gonadosomatic index (GSI) was significantly higher in LM than SV. Lipid contents varied significantly between seasons and body sizes. The highest lipid concentrations were recorded in the spring in large females. No significant differences were found when comparing the protein and glucose contents of the two evaluated seasons or body size ranges of the studied females. In turn, the fatty acid (FA) profiles of female gonads significantly varied for both seasons and body size ranges. A high content of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and poly-unsaturated fatty acids (PUFAs) were recorded in female gonads in the spring. The SFAs C16:0 and C18:0, the MUFA C18:1n9, and the essential PUFA C22:6n3 were the main contributors to the observed differences between spring and winter. These results could be used as indicators of the nutritional condition and health status of swordfish individuals. Hence, the IBC of female swordfish gonads have great potential to aid in estimating survival rates and stock abundances of this species. The integration of this information constitutes an asset in fishery management models with an ecosystem approach.

Organization of the Fibrous Component of Connective Tissue Paraneural Structures in Different Periods of Ontogenesis

Background: The steady increase in road traffic accidents, seasonal injuries leading to damage to the peripheral nerves of the extremities, as well as the military conflicts that are becoming more frequent now actualize research aimed at improving the diagnosis, treatment, and prevention of post-traumatic changes in the nerve trunks of the extremities. The frequency of peripheral nerve injuries varies from 1.5% to 13% of all injuries in peacetime; and during hostilities, it reaches 20%, and disability is 60%. At the same time, specific destructive changes in the nerves of the extremities after their traumatic injury require extraordinary organizational, therapeutic, and functional approaches to their restoration. The purpose of this study was to evaluate the dynamics of changes in the fibrous component of the paraneurium connective tissue structures in different periods of ontogenesis. Methods and Results: The study consisted of two stages. At the first stage, to study changes in the paraneurium connective tissue of the sciatic nerve (SN) in vivo, ultrasound was performed using an RS85 ultrasound scanner (Samsung Medison, South Korea, 2021) and two linear transducers, LA4-18B and LA2-9A. The thickness of the SN and the surrounding paraneurium were measured, and their structural organization was evaluated. The inclusion criterion was the absence of pathology from the peripheral nervous system. All subjects were divided into four age groups (15 people in each group): Group 1 (0-11 years), Group 2 (12-25 years), Group 3 (26-40 years), and Group 4 (41-60 years). The second stage was performed on cadaveric material of the paraneurium connective tissue of the SN of persons of both sexes, of different ages, whose cause of death was not related to diseases or injuries of the nervous system. To determine the qualitative and quantitative ratio of collagen fibers of different degrees of maturity in the connective tissue structures of the paraneurium tissue of the sciatic nerve, polarization microscopy (MicMed-6, Lomo, Russia) was applied, and the basic principle of double refraction, which in combination with Sirius red staining, made it possible to differentiate types I and III collagen. The amount of each collagen type was determined by analyzing the color gamut after Sirius red staining in polarizing light. Fibers containing type I collagen had a red glow, while those containing type III collagen had a green glow. The ratio of collagen types was calculated using the Fiji program (USA, 2022). US examination revealed the presence of a non-pronounced bilateral asymmetry in the structural organization of the paraneurium and an increase in the thickness of the SN with age, from 0-11 years to the age group of 41-60 years. Polarization microscopy of micro-preparations of the human sciatic nerve with paraneurium structures made it possible to analyze the density of the fibers of the paraneurium connective tissue and identify types I and III of collagen. At the age of 11, the amount of type I collagen fibers was maximum (69.74±0.41%), and type III collagen fibers amounted to 30.26±0.44%. Further, with increasing age, the amount of collagen III significantly diminished. The ratio of type I to type III collagen increased with patient age, with the highest ratio in the age group 41-60 years. Conclusion: The revealed dynamics of changes are quite comparable with the age-related features of connective tissue since it is this tissue that makes up the morphological substrate of the paraneurium of the sciatic nerve.

Forecasting study of food-related patents protected by the University of Brasilia, Brazil: Case study

Patents are important tools to protect innovations in the food industry. They are also indicators of the research and development of an institution. Universities play a significant role in generating and developing innovative technologies. Center for Support to Technological Development (CDT is the Technological innovation center (NIT) that is responsible for protecting the technologies developed by the academic community of the University of Brasilia (UnB). This case study analyzes the patents and patent applications related to food deposited by the UnB. For this purpose, a search was conducted on the National Institute of Industrial Property (INPI) institutional page through the patent database. The results show diverse applications to the food area that are mainly related to biotechnology. Half of the protections are still in progress in the INPI workflow. The requirements issued were primarily related to national genetic heritage. Archiving processes were identified due to non-payment, but we highlighted that it could be a strategic decision of NIT/CDT. Rejections were mainly related to the lack of novelty or inventive steps. Currently, two food-related patents are in force that took, on average, nine and a half years to be granted. Although UnB exclusively owns the majority, the results also evidence co-ownership with other universities and companies. Finally, this study highlights possible partnerships between UnB and the food industry through technology transfer. The technology transfer indicators pointed out that UnB has expertise in this area and that there is a potential to be explored. These results contribute to strategic decision-making in developing new technologies related to food and nutrition and their transfer to society. The scale-up and the increased degree of maturity require greater interaction with the productive sector to ensure the transfer of technology for innovation arising from the research conducted at UnB.

Post-traumatic ischaemic stroke in a teenager after head trauma: A case report

Lacunar strokes in the pediatric population are very uncommon, as well as trauma-induced strokes. It is extremely rare for a head trauma induced ischaemic stroke to occur in children and young adults.We describe a case of a 13-year-old boy who reported acute ischaemic lesions, and in particular a right basal ganglia ischaemic stroke after falling from a height of 10 m, presumably secondary to the stretching-induced occlusion of the recurrent artery of Heubner, with a favorable outcome.Ischaemic strokes can rarely be subsequent to head trauma in young adults, in relationship with the degree of maturity of the perforating vessels. Although very rare, it is important to avoid the lack of recognition of this condition, thus awareness is necessary.

Applications of Delayed Luminescence for tomato fruit quality assessment across varied Sicilian cultivation zones.

The food industry places significant emphasis on ensuring quality and traceability as key components of a healthy diet. To cater to consumer demands, researchers have prioritized the development of analytical techniques that can rapidly and non-invasively provide data on quality parameters. In this study, we propose to use the Delayed Luminescence (DL), an ultra-weak and photo-induced emission of optical photons, as a tool for a rapid evaluation of quality profile associated with fruit ripening, in support of traditional analysis methods. Delayed Luminescence measurements have been performed on cherry tomatoes, with and without the PGI "Pomodoro di Pachino" certification, harvested from two different growing areas of south-eastern Sicily (Italy). Then, DL emissions were correlated with soluble solid content and titratable acidity values, which are known to affect the flavor, the commerciality and the maturity degree of tomato fruits. In addition, we evaluated the changes in the DL parameters with respect to the geographical origin of the cherry tomatoes, with the aim of testing the possibility of applying the technique for identification purposes. The signals of Delayed Luminescence appeared to be good indicators of the macromolecular structure of the biological system, revealing structural changes related to the content of total soluble solids present in the juice of tomatoes analyzed, and they appeared unsuitable for authenticating vegetable crops, since the differences in the photon yields emitted by tomato Lots were not related to territory of origin. Thus, our results suggest that DL can be used as a nondestructive indicator of important parameters linked to tomato fruit quality.

Histopathology of Ganglion Cells in the Proximal Resected Bowel Correlates With the Clinical Outcome in Hirschsprung Disease: A Pilot Study

IntroductionIntraoperative leveling biopsy by identifying ganglion cells is crucial to determine surgical margin during surgery for Hirschsprung disease (HSCR). The anastomosis should be performed at least 5 cm proximal to the ganglionic segment to prevent transition zone pull-through. However, the length of the transition zone could be much longer than expected and the histological evaluation of the entire circumference of the proximal margin is recommended, which is time-consuming and not applicable for leveling biopsy. We found that the histopathologic features of ganglion cells varied in the examined bowel specimens and demonstrated a pattern similar to immature and degenerated neuron cells. We assumed that the histopathologic features of ganglion cells in the proximal resected bowel were associated with the clinical outcome and might guide the leveling biopsy. In this study, we described a histopathologic grade of ganglion cells based on the degree of maturity and degeneration. We assessed the correlation between the histopathological grade of ganglion cells in the proximal surgical margin and clinical outcome. MethodsThree hundred fifty seven patients with HSCR treated between 2013 and 2020 were included. The ganglion cells were divided into six grades based on the histopathologic features in frozen sections. Medical records and detailed histopathologic results of intraoperative frozen sections were reviewed. Follow-up data were collected to evaluate clinical outcomes. The pediatric incontinence and constipation scoring system was used to predict bowel function. ResultsThe histopathologic results of proximal resected bowel from 357 HSCR patients were presented as follows: Grade I in 52 patients (14.6%), Grade II in 186 patients (52.1%), Grade III in 107 patients (30.0%), and Grade IV in 12 patients (3.4%). The median follow-up time was 46.8 mo (13.0-97.6 mo). The histopathologic grade of ganglion cells from the proximal resected margin was significantly related to postoperative constipation problems and the incidence of Hirschsprung-associated enterocolitis. The results from the pediatric incontinence and constipation scoring system indicated a positive correlation between better postoperative bowel function and lower histopathologic grade of ganglion cells. ConclusionsThis pilot study showed an association between the histopathologic features of ganglion cells in the proximal surgical margin and the clinical outcome. It may provide additional information for intraoperative pathologic consultation in leveling biopsy to prevent insufficient resection of the affected colon. A prospective study is warranted to validate these findings before clinical application.

Development of a Zonal Model for Forecasting the Oil and Gas Potential of the YUS1 Formation by Geochemical Parameters

The distribution of geochemical properties of rocks of the Bazhenov Formation (BF) by area and section has been refined, regularities have been searched, and conclusions have been obtained that have predictive power. Due to the high cost of continuous core sampling and pyrolysis of samples from BF intervals, the fragmentation and heterogeneity of the accumulated information, as well as the high value of knowledge about the oil-generating properties of BF rocks and their changes over the area, there is a need to increase the information content of the database of geochemical core studies and adapt its application in conditions of limited data. To solve this problem, a database of results of geochemical studies was collected and analyzed, consisting of 5272 samples from 123 wells of 32 fields. As a result of the analysis, conclusions were obtained about the oil-generating properties of BF within the study area and the degree of maturity of the organic matter of the rock. Two regression models were developed to predict the geochemical parameters of free hydrocarbon content, residual generation potential and total organic carbon from well logging data. An algorithm was implemented in the Python programming language to automate the calculation process. Using this algorithm and the resulting regression equation, the calculation of geochemical parameters was carried out in 390 wells in the study area that were not presented by core data, which significantly increased the detail and information content of predictive maps of the distribution of parameters over the area. Using the data obtained, a geological and mathematical model was developed for predicting oil content by geochemical parameters. The developed model reflects the probability of oil content depending on the oil source properties of the rocks of the Bazhenov formation in the study area. The developed forecast model included the parameters of the organic carbon content in the rock, the current reservoir temperature and the thickness of the rocks of the Bazhenov formation.